Articles tagged with Yellow Fever
A new study suggests that preexisting autoantibodies in a small subset of the population can cause severe reactions to the live-attenuated Chikungunya vaccine. Researchers recommend screening people with these autoantibodies before vaccination, especially for those over age 65.
Public Health Alerts provide concise, data-driven information on disease outbreaks and urgent health events. The new series, launched by NEJM Evidence and CIDRAP, offers expert-reviewed reports to support public health evidence-based care.
Researchers developed a genetic method to produce dark males and pale females, making it easier to sort sex in mosquito control. The approach uses CRISPR gene editing to create an engineered sex-linked trait that enables fast and accurate sex separation without complex equipment.
Researchers at the University of Queensland have captured high-resolution images of the yellow fever virus, shedding light on its structural differences between the vaccine strain and disease-causing variants. The study reveals that these differences impact how the immune system recognizes the virus.
A new class of insecticide, called spatial emanators, provides protection for up to a year against mosquitoes that spread malaria, as well as dengue, West Nile, yellow fever, and Zika. The breakthrough offers lasting protection in areas where malaria is prevalent and can be used day and night without heating or electricity.
A team of researchers investigated the immune response to the yellow fever vaccine, discovering that specific cell types respond to interferons and a key molecule SIGLEC-1 becomes prominent after vaccination, associated with rapid antibody formation.
Researchers at the University of Kansas are analyzing noninfectious mosquito saliva to understand how it affects the immune system and changes at a molecular level. The goal is to identify specific proteins that can serve as candidates for vaccine development.
Researchers discovered that male mosquitoes listen for specific sound frequencies made by females of their own species to avoid mating with the wrong species. This finding has implications for developing innovative mosquito control strategies using artificial flight sounds. The study aims to prevent mosquito populations from reaching u...
Researchers found that Aedes aegypti mosquitoes' thermal tolerance and biological traits can shift in response to temperature, leading to variation in disease transmission. This study challenges traditional models by highlighting the importance of local adaptation in predicting mosquito-borne disease risk under climate change.
A recent study published in EBioMedicine found that yellow fever virus causes myocardial fibrosis, cardiomyocyte hypertrophy, and vascular endothelium alterations, leading to cardiac conduction system disruption. The research provides new insights into the pathogenesis of YF-associated heart injury.
A recent study published in Cell Host and Microbe reveals how flaviviruses hijack human cells to promote replication. The discovery of KAT5γ's critical role in viral replication paves the way for designing inhibitory molecules to stop viral replication.
Researchers have found lab-made antibodies that can strengthen the body's fight against yellow fever, a disease with no current treatment. The monoclonal antibody infusions were able to remove all signs of infection from research animals, offering potential hope for a cure.
Researchers at University of California - Riverside discovered a chemical cocktail in human skin that summons disease-spreading mosquitoes. The combination of carbon dioxide plus two chemicals, 2-ketoglutaric and lactic acids, elicits a scent that attracts female Aedes aegypti mosquitoes, vectors of Zika and other viruses.
Researchers developed a new quantitative RT-qPCR assay to detect and quantify the Omicron variant of SARS-CoV-2 in wastewater. The assay revealed that Omicron displaced Delta as the dominant variant within just 3 weeks in an Italian population.
Researchers discovered a molecular switch in flavivirus that controls virus assembly, maturation, and entry into new cells. This switch is triggered by pH-dependent conformational changes in viral envelope proteins.
Researchers at the University of Malaga study the global risk of yellow fever transmission to humans, finding high zoonotic potential in southeastern Brazil and western Amazon basin. The team proposes prioritizing vaccination efforts in regions with favorable conditions for virus presence and mosquito vectors.
Researchers found that infected mice and humans emit a specific molecule, acetophenone, which attracts mosquitoes. This altered scent allows the viruses to spread faster. A potential preventative, isotretinoin, was also tested and shown to reduce mosquito attraction.
A UC Riverside genetic discovery found that mosquitoes lack the primary ecdysone transporter, allowing researchers to develop a mosquito-specific insecticide. This breakthrough could help control Zika, dengue, and other virus-carrying mosquitoes without harming beneficial insects.
A molecule in mosquito spit called sialokinin has been identified as a potential new target for vaccination against Yellow Fever, Dengue and Zika. Researchers found that sialokinin causes blood vessels to become permeable, allowing viruses to infect the host.
A WHO-supported series has collected 13,700 new database records on mosquito-borne diseases, providing valuable resource for studying and containing infectious diseases. The data can be used to train machine-learning models for vector detection and classification, improving global human health.
An updated vaccination strategy is credited with averting an outbreak of urban yellow fever in São Paulo State, according to research published in Scientific Reports. The study found that the virus spread rapidly, reaching cities never affected before, and that a high number of cases were reported in areas with low vaccination coverage.
Researchers developed a machine learning model that identified promising compounds for treating yellow fever. The team synthesized five of the most active molecules and found one with a half-maximal effective concentration of 3.2 uM, suggesting a potential new antiviral drug.
A new study found that yellow fever mosquitoes have distinct genetic changes behind permethrin resistance, including mutations in VGSC and cuticle protein genes. These mutations enable the mosquitoes to survive exposure to the pesticide, posing a significant threat to disease control.
A groundbreaking study aims to create predictive models to monitor and combat epidemics of yellow fever and other mosquito-borne diseases. By analyzing factors such as deforestation, rainfall variations and non-human primate populations, researchers hope to develop models that can predict outbreaks and protect the public.
A KU Leuven vaccine candidate, RegaVax, has shown promise in protecting against Covid-19 and yellow fever in hamsters and monkeys. The vaccine works after a single dose and offers long-lasting immunity to Covid-19.
A study based on genomic analysis of 51 viral isolates extracted from mosquitoes and monkeys reveals three waves of the disease swept the state between 2016 and 2018. The use of MinION genetic sequencing technology allowed researchers to pinpoint the virus entry, spread speed, and geographical distribution of different lineages.
A University of Utah study found that genetic variations in brown howlers may have helped them survive the devastating yellow fever virus outbreak in Argentina's El Piñalito park. The researchers discovered three mutations in the immune genes of surviving brown howlers, which could affect their response to the disease.
A potential treatment for yellow fever has shown promise in early-stage clinical trials in Singapore, using a novel approach to develop an engineered monoclonal antibody that targets the virus. The therapy was developed in seven months, significantly reducing the time required for drug development.
The Asian tiger mosquito has become more abundant in Illinois over the past three decades, spreading diseases like chikungunya and dengue fever. The mosquito's spread is linked to global trade, particularly with used tires, which provide a conducive environment for its eggs to develop.
Researchers at Ludwig-Maximilians-Universität München have identified an earlier indicator of vaccine efficacy: specific white blood cells in the blood. The study shows that these cells can predict the quality of the immune response induced by vaccination, allowing for more rapid assessment of vaccine effectiveness.
A Dartmouth-led study found that counteracting myths about Zika in Brazil actually reduced the accuracy of people's other beliefs about the disease. Information intended to correct misperceptions may have unintended effects on public health campaigns.
A study found that a single dose of yellow fever vaccine may not offer lasting protection to all children, with levels of protective antibodies decreasing substantially over time. The research suggests that booster shots may be necessary for young children, and maintaining immunity is crucial for preventing epidemics.
Researchers have identified markers capable of predicting mortality in patients with symptoms of yellow fever, potentially helping to prevent severe conditions. The study found that older patients, high neutrophil counts, and high viral loads at hospital admission are significantly associated with mortality.
Researchers have retraced the pathogen's route as it spread from Pará State in North Brazil. Yellow fever virus was detected in dead monkeys and mosquitoes, revealing a 40-year-old strain behind current epidemic.
A new mass-spectrometry-based assay has been developed to detect flaviviruses like Dengue, Zika, West Nile, and Yellow Fever viruses. The assay can distinguish between multiple flaviviruses or strains of a single virus within the first 8 days of symptom onset.
Scientists have developed a new vaccine against the Zika virus, which can prevent microcephaly and other serious conditions in unborn babies. The vaccine is based on the yellow fever vaccine and offers complete protection.
Researchers found that a fractional dose of the 17D yellow fever virus vaccine provided protective levels of antibodies for over 10 years after vaccination. This finding supports the use of fractional doses in mass vaccination campaigns before outbreaks and eliminates the need for booster shots.
A study published in Scientific Reports found Zika virus in dead monkeys in Brazil, indicating a potential sylvatic transmission cycle. The infected animals were more vulnerable to attack by humans, highlighting the need for further research on the role of wild animals in maintaining the urban cycle of Zika.
Researchers at Rutgers University develop a citizen-led mosquito control approach that mobilizes neighbors to address local problems with scientific guidance. The program, called Citizen Action through Science (Citizen AcTS), resulted in a significant reduction of invasive Asian tiger mosquitoes in targeted areas.
Researchers at the University of York have discovered a protein in fruit flies that regulates insulin and is also found in mosquitoes carrying diseases like malaria and yellow fever. This finding opens new pathways for drug design and could lead to better understanding of neurological diseases such as Alzheimer's.
A recent study by scientists at the Institut Pasteur has demonstrated that tiger mosquitoes (Aedes albopictus) can transmit the yellow fever virus. The research found that the virus can adapt to this species, which is widely present in urban and forest areas, posing a major public health threat.
Scientists investigate the recent yellow fever outbreak in Brazil, finding that it originated from nonhuman primates in the forest and spread to humans. The study highlights the importance of real-time disease monitoring and public health countermeasures.
Researchers used genomic and epidemiological approaches to understand the mode of transmission of the South America's largest yellow fever virus outbreak. The study revealed that the virus lineage had spread through a sylvatic cycle of transmission in primates before spilling over into human populations.
Scientists warn of increased infectious diseases transmitted through vectors in the coming decades. The Asian tiger mosquito, introduced via trade and tourism, has not yet filled its ecological niche globally, posing a threat to regional health.
A new study led by St. Michael's Hospital maps the potential risk of yellow fever virus spread to cities around the world, analyzing travel patterns and environmental conditions. The research highlights the need for countries to reexamine their policies to prevent yellow fever virus importation, protect travelers, and prevent exportation.
A yellow fever outbreak in Brazil highlights the need for tourists to get vaccinated before visiting affected areas, with the risk of severe illness and death being up to 60% among those who contract the disease. The Food and Drug Administration-approved vaccine is currently unavailable in the US due to manufacturing difficulties.
Researchers developed a new model that quantifies yellow fever dynamics across Africa using seasonal climatic measures, confirming the risk varies throughout the year. The model accurately captured geographic and temporal heterogeneities in transmission and offers insights for early interventions.
Researchers detected yellow fever virus in urine and semen samples from a patient who survived the disease almost a month after infection. The discovery suggests the virus may be contagious for a period longer than previously thought, potentially allowing asymptomatic individuals to transmit the disease.
Researchers found the Asian tiger mosquito vanished from Palmyra Atoll following rat eradication, as humans became the sole host for mosquitoes to feed on. The study highlights a potential new approach to combatting mosquito-borne diseases by eradicating key hosts.
A team of researchers has mapped the biochemical networks of Aedes aegypti mosquitoes, identifying key pathways that facilitate virus replication. The study's findings have significant implications for controlling mosquito-borne diseases like dengue, Zika, and chikungunya.
A phase 4 randomized clinical trial found that self-administered treatment for latent tuberculosis infection had a high rate of treatment completion in the United States, Spain, and Hong Kong. The findings suggest that once-weekly isoniazid and rifapentine by self-administration is noninferior to direct observation in completing treatm...
A new study found that prior dengue or yellow fever exposure does not increase susceptibility to severe Zika virus infection in rhesus macaques. The researchers observed no significant differences in clinical factors between previously infected and uninfected monkeys after Zika virus infection.
A recent study led by Colorado State University researchers found that Aedes aegypti mosquitoes can transmit multiple viruses simultaneously, including Zika, chikungunya, and dengue. The findings contradict existing research on coinfections and suggest that these simultaneous transmissions may be more common than previously thought.
Research detects fragments of Zika virus RNA in Asian tiger mosquito eggs collected in Brazil, highlighting potential role in Zika transmission. The findings emphasize the need for further research into additional vector species.
A cheap, temperature-stable, and easy-to-produce vaccine against both diseases is being developed by the RABYD-VAX consortium, led by KU Leuven. The vaccine has the potential to protect against two deadly diseases: rabies and yellow fever.
A study found that previous exposure to dengue, West Nile virus, or Zika can enhance the effects of Zika infection through antibody-dependent enhancement. The researchers used human antibodies from infected individuals in mice and observed reduced survival rates with low doses of these antibodies.
A large yellow fever outbreak in rural Brazil is causing concern among world health authorities, who are warning of the risk of spreading the disease to non-endemic regions. The outbreak, which has already claimed several lives, highlights the importance of rapid public health response and vaccination efforts.
Researchers found a protein produced by yellow fever and Zika viruses that suppresses the mosquito's immune response, allowing the virus to evade detection. This discovery could lead to new strategies for controlling mosquito-borne diseases like Zika.
The National Institute of Allergy and Infectious Diseases (NIAID) has begun a Phase 1 study to evaluate the safety and efficacy of an experimental yellow fever vaccine developed by Bavarian Nordic. The trial will assess whether the investigational vaccine can prevent yellow fever virus infection and induce a strong immune response.
The yellow fever virus, transmitted by Aedes aegypti mosquitoes, is a significant public health threat to the Americas. The recent resurgence of YFV in Africa and Asia, combined with vaccine shortages, highlights the need for urgent measures to prevent infection and control its spread.