Articles tagged with Testosterone
A randomized clinical trial found that rapid access to testosterone therapy significantly reduced feelings of gender dysphoria and depression among transgender adults. The study also showed a 50% reduction in suicidal ideation compared to those on a standard waiting list.
Research in mice suggests that prostate cancer cells adapt to testosterone-deprivation therapy by producing cholesterol and generating their own testosterone. Treating aggressive tumors with inhibitors slows tumor growth. The study also points to a possible drug combination and sheds light on racial disparities in prostate cancer.
Sons of women with PCOS are two times more likely to develop obesity and have high levels of male hormones, leading to insulin resistance and type 2 diabetes. A mouse study confirms these findings, showing fat tissue and metabolism problems in the offspring despite a healthy diet.
ENZAMET, a new drug combination, has shown significant improvement in survival rates for men with advanced prostate cancer. After five years, the treatment led to a 67% survival rate, compared to 57% for standard therapy.
A new study published in Evolutionary Psychology examines the relationship between parental income and the sexual behavior of their adult children. The research found that children from low-income families had higher frequencies of same-sex attraction, while those from high-income families had lower frequencies.
A Northwestern Medicine study found that online platforms are offering therapies to men who don't meet guidelines for testosterone deficiency, while failing to convey the risks and benefits of therapy. The study recommends seeing a provider with expertise in hypogonadism for accurate care.
A recent meta-analysis published in Human Reproduction Update reveals a significant worldwide decline in sperm counts of over 50% in the past 46 years. The study also shows an accelerated post-2000 decline in sperm counts globally.
Experts found that large differences in finger length between left and right hands are associated with COVID-19 severity. The study may help identify those at greatest risk of hospitalization across age groups.
A study analyzing nearly 1,500 young men found that standard cutoff points for low testosterone levels may not be accurate. Age-specific thresholds ranged from 409 ng/dL at 20-24 years to 350 ng/dL at 40-44 years, indicating the need for a more personalized approach to diagnosing testosterone deficiency in younger men.
Recruitment of tumor-fighting macrophages depends on testosterone. Administering testosterone to females increases macrophage ability to eradicate tumor cells.
A study of 15 transgender women found they exceeded the cardiopulmonary capacity and muscle strength of their cisgender peers even after years of hormone therapy. However, their performance was lower than that of cisgender men. The findings could inform policy on transgender women's sports participation.
A randomized phase III trial found that combination hormonal therapy, delivered for a finite treatment interval of 12 months, more durably suppresses PSA levels compared to hormone injections alone. The treatment approach improved disease progression in patients with high-risk biochemically relapsed prostate cancer.
A study by researchers at Washington University School of Medicine found that low testosterone levels are an independent risk factor for COVID-19 hospitalization in men. Men with chronically low testosterone who developed COVID-19 were 2.4 times more likely to require hospitalization than those with normal testosterone levels.
Research by Saint Louis University School of Medicine and Washington University School of Medicine found that low testosterone levels are associated with an increased risk of hospitalization from COVID-19. Men with low testosterone were twice more likely to require hospitalization than those with normal levels.
A new animal study finds that testosterone can foster friendly, prosocial behavior in males, in addition to aggression. The hormone appears to help animals rapidly pivot between prosocial and antisocial responses as the social world changes.
A new study explores relationships between domestic cats' hormone levels, gut microbiomes, and social behaviors in cohabitating groups. The research found that low testosterone and cortisol concentrations enabled cats to share space, while high oxytocin levels were associated with less affiliative behavior.
Researchers found higher AR signaling and better response rates for female patients treated with BRAF/MEK inhibitors. Blocking the AR improved response to BRAF/MEK targeted therapy in both males and females.
A mouse study suggests that active testosterone therapy can lead to fewer and less developed eggs retrieved during IVF. Discontinuing testosterone therapy appears to have no significant impact on reproductive capacity, however.
Two experimental male contraceptive pills, DMAU and 11β-MNTDC, have shown promising results in lowering testosterone levels without unacceptable side effects. The study found that 75% of men who took the active drug were willing to use it in the future, compared to 46.4% of those taking a placebo.
A randomized controlled trial shows significant improvements in testosterone replacement therapy for men with poorly-controlled type 2 diabetes and hypogonadism. The treatment improved symptoms, libido, and quality of life, as well as delayed verbal recall, a potential early sign of dementia.
Research finds no significant increase in cardiovascular events among men with low testosterone undergoing testosterone treatment. Testosterone was found to reduce serum total cholesterol and triglycerides, but no significant differences were seen in other parameters.
A comprehensive analysis of testosterone replacement therapy found no increased risk of heart attack, stroke, and other cardiovascular events in the short-to-medium term. Testosterone treatment was also found to reduce serum cholesterol levels, but no significant differences were observed in blood pressure or glycaemic parameters.
Patients with lower levels of sex hormones are more likely to undergo surgery for rotator cuff tears, according to a study published in The Journal of Bone & Joint Surgery. Estrogen deficiency was associated with a 48% higher incidence of rotator cuff repair in women, while testosterone deficiency was linked to an 89% higher rate in men.
A study found that strength training activates androgen receptors to protect against muscle pain in mice. Resistance training also alleviated pain only in male mice, while females did not show similar benefits. The findings suggest exercise may be a useful treatment for chronic musculoskeletal pain.
A study published in Scientific Reports found that patients with 'feminized' short fingers tend to experience severe Covid-19 symptoms, while those with large right-hand-left hand differences have elevated probabilities of hospitalization. The research suggests a link between low testosterone and high oestrogen levels and Covid severity.
In meerkat societies, testosterone-driven aggression enables cooperative breeding by creating a hierarchy where subordinates help raise the matriarch's pups. Researchers found that matriarchs' high testosterone levels drive their aggressive behavior, which maintains group structure.
Scientists at Kobe University have successfully generated testosterone-producing Leydig cells from human iPS cells, a significant step towards developing a regenerative medicine treatment for late-onset hypogonadism. The induced cells expressed genes specific to Leydig cells and produced functional testosterone.
A study published in The Journal of Sex Research found that higher testosterone levels are associated with having multiple partners in men and solitary sexual activity in women. The research, which analyzed data from nearly 4,000 adults, highlights the complex relationship between hormones and human sexuality.
A study found that early weight loss in obese boys can improve reproductive function and reverse alterations in Leydig cell function, which could help prevent future fertility problems. The research suggests that managing childhood obesity may be necessary to prevent reproductive issues and lower the risk of other diseases.
Researchers found that UVB phototherapy increases levels of romantic passion and aggression in both men and women. Exposure to sunlight affects the endocrine system's regulation of sexual hormones.
A case study reports success in restoring hormone balance to a castrated dog, improving mobility, reducing anxiety, and alleviating various health issues. The treatment involved testosterone and GnRH agonist therapy, resulting in significant health improvements.
A University of Houston researcher is using cutting-edge techniques to study how testosterone affects the brain and social behavior. Using genetically modified African cichlid fish, Beau Alward aims to identify the specific genes and neurons involved in these processes.
A new study found that higher testosterone levels are linked to socioeconomic position in men but not women. In contrast, lower testosterone was associated with poorer health and risk-taking behavior in women. The research suggests that testosterone may be less important than previously thought in determining success.
A new study found that supplementing testosterone significantly reduces heart attacks and strokes in men with unnaturally low hormone levels. The 10-year study involved over 800 men from Germany and Qatar, showing a 25% reduction in risk for those under 55 and a 15% reduction for those over 60.
Research shows that men with symptomatic Covid-19 and low testosterone are more likely to become severely ill and die. The lower the testosterone levels, the higher the likelihood of severe illness and death, according to a study presented at the European Association of Urology congress.
A study found that wildfires alter male red-backed fairywrens' plumage, making them less attractive to females, while also lowering circulating testosterone. This suggests an evolved response to minimize breeding during unfavorable environmental conditions.
A two-year study found that testosterone therapy normalised testosterone levels, reduced NAFLD, and suppressed symptoms of hypogonadism in obese men. Testosterone therapy may help obese men with functional hypogonadism and type-2 diabetes reduce the prevalence of non-alcoholic fatty liver disease.
A new study from Washington University School of Medicine found that low testosterone levels in men are linked to more severe disease. Men with low testosterone had a higher risk of requiring intensive care or dying from COVID-19, while those with higher testosterone levels were less likely to experience severe symptoms.
A low-calorie ketogenic diet has been found to increase total testosterone and sex hormone (SHBG) levels in overweight men. After four weeks on the diet, body weight, fat mass, and BMI decreased significantly, while testosterone and SHBG levels substantially increased.
A diet high in pro-inflammatory foods may be associated with increased odds of developing testosterone deficiency among men. Men who consume refined carbohydrates and sugar, as well as polyunsaturated fats, are more likely to experience low libido, decreased energy, and depression.
A study by The Endocrine Society finds oral testosterone therapy undecanoate (TU) is an effective treatment for men with low testosterone levels, with a safety profile consistent with non-oral products. TU has minimal effects on cholesterol levels and no liver toxicity was reported.
A new marker of testicular cell capacity identified as a promising biological marker, INSL3, shows suppressed levels in former steroid users compared to never-users. Long-lasting impaired gonadal capacity found in previous anabolic steroid users, increasing risk of hypogonadism later in life.
A new study published in Hypertension Journal Report found that a structured exercise program improved artery health and function in middle-aged and older men with low-to-normal testosterone levels. The study showed no benefits from testosterone therapy on artery health.
A study published by The Endocrine Society found that testosterone therapy increases the risk of blood clots, heart attack, and stroke in transgender men. Over 11% of participants developed erythrocytosis, a condition characterized by excessive red blood cells.
Research suggests that lower testosterone during puberty increases the brain's sensitivity to it in adulthood. Men with lower testosterone levels throughout puberty showed greater brain activity in areas sensitive to faces when exposed to high levels of testosterone.
Research suggests that high-income mothers tend to produce higher levels of testosterone, leading to a more masculinized fetus, while low-income mothers produce lower levels of testosterone, resulting in a more feminized fetus. This phenomenon has been linked to increased disease risk, including cardiovascular disease and mortality.
Research by Mariana Muñoz-Romo and colleagues found that male fringed-lipped bats produce larger, more pungent forearm crusts in males with higher testosterone levels and larger testes. These findings suggest that the size of the crust is linked to mating and reproduction.
Researchers from the University of Queensland found that a vitamin D deficiency during pregnancy caused an increase in testosterone levels in male rats, potentially contributing to the higher prevalence of Autism spectrum disorder in boys. Vitamin D plays a critical role in brain development and may help prevent ASD-like traits when su...
A recent study published in the British Journal of Sports Medicine found that transgender women may still retain a competitive advantage in athletic performance even after more than 12 months of hormone therapy. The study, which reviewed fitness test results and medical records of 29 trans men and 46 trans women, suggests that governin...
A recent study found that COVID-19 can lead to lower testosterone levels in male patients, which may explain the better outcomes seen in female patients. The study also showed that hypogonadism, or low testosterone production, was present in over half of the male patients.
A Northwestern University study has identified the specific regions of brain tissue where a key gene named aromatase regulates male sexual behavior in mice. Aromatase converts testosterone to estrogen, driving male sexual activity. The discovery could lead to new treatments for disorders of low and compulsive sexual desire.
A longitudinal study of 167 children found that early adversity increases the risk of depression by flattening testosterone slopes, leading to reduced hippocampal growth and increased emotion dysregulation. The findings suggest a need for interventions targeting mental health problems resulting from early poverty.
A study published in The Journal of the American Osteopathic Association found that mindful yoga significantly reduced testosterone levels and improved symptoms of depression and anxiety in women with Polycystic Ovary Syndrome. The practice also showed promise in reducing androgen levels, including DHEA.
A recent study has found that men with erectile dysfunction are at a higher risk of death, even if their testosterone levels are normal. The research, which analyzed data from over 1,900 participants, suggests that sexual symptoms can be an early sign of increased cardiovascular risk and mortality.
Research suggests that low levels of sex hormone-binding globulin (SHBG) may be associated with an increased risk of ischemic stroke in postmenopausal women. The study, which examined data from over 13,000 women, found that those with the lowest SHBG levels were 51% more likely to have had a stroke.
A new study found that higher genetic testosterone levels increase the risk of type 2 diabetes by 37% in women and reduce it by 14% in men. Similarly, higher testosterone levels increase the risk of breast and endometrial cancers in women and prostate cancer in men.
Research published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that teens with obesity and PCOS have an altered gut microbiome compared to those without the condition. This altered microbiome is associated with higher testosterone levels, metabolic complications, and other health risks.
A new study published in The Journal of Urology found that a low-fat diet may be associated with lower testosterone levels in men. The study analyzed data from over 3,100 men and found that those on a low-fat diet had lower serum testosterone levels compared to those on an unrestricted diet.
The American College of Physicians recommends testosterone treatment for men with age-related low testosterone only to treat sexual dysfunction. Testosterone treatment has shown small improvements in sexual and erectile function, but not in energy, vitality, or cognition.
The American College of Physicians recommends treating testosterone deficiency for only sexual dysfunction, discontinuing treatment if symptoms don't improve, and avoiding other reasons for treatment. Testosterone treatment should not be initiated to boost energy or cognitive function due to lack of evidence.