Articles tagged with Testosterone
Researchers found a significant connection between anxiety disorders and the brain receptor TACR3, as well as low testosterone levels. Testing showed that inhibiting TACR3 resulted in increased receptors on the cell surface, blocking long-term synaptic strengthening.
Researchers have documented cannibalism in the mainland dusky antechinus during its breeding period. The behavior is linked to stress-induced death and provides an opportunity for energy gain via eating dead males or females of other species.
Researchers investigated role of estrogen receptors in lateral septum regulating social anxiety in male mice, finding that ERβ plays a crucial role in neural circuitry. Knockdown effects on ERβ gene expression showed increased social anxiety, highlighting its importance in social situations.
Mount Sinai researchers have found that testosterone treatment is safer than previously reported, with a smaller degree of change in hematocrit levels. The study, involving over 6,670 transmasculine patients, suggests that providers can feel more comfortable prescribing testosterone as part of gender-affirming hormone therapy.
Researchers identified a correlation between the HSD3B1 biomarker and resistance to combined hormone therapy and radiotherapy in men with prostate cancer. The study found that high levels of the enzyme led to increased testosterone production, promoting resistance to treatment.
Jenny Wilkerson receives $1.94 million grant to develop novel models and investigate antinociceptive profiles of basal sex hormone alterations in patients with chronic post-op pain. The study aims to answer questions about the impact of altered sex hormone levels on recovery times, drug effectiveness, and long-term health.
Researchers investigated the role of estrogen receptor beta-positive neurons in the medial amygdala, a region involved in social information processing. They found that MeA-ERβ+ neurons exhibit different roles for receptivity-based and sex-based preferences.
A worldwide audit of testosterone deficiency in men with type 2 diabetes found that testosterone replacement therapy improves glycaemic control for up to 2 years. The study suggests that the ongoing effect of testosterone on insulin resistance and fat reduction contributes to the improvement in blood sugar levels.
A study found that severe erythrocytosis, where hematocrit is over 54%, is a rare outcome of testosterone therapy in adults. Researchers recommend reevaluating the need for frequent lab screenings to minimize unnecessary draws among patients who prefer not to undergo regular checks.
UTHSC researchers are studying the role of balanced sex hormones in DNA repair in human melanocytes to determine if hormonal imbalances contribute to melanoma risk. The study aims to find novel prevention methods to decrease melanoma cases and potentially save lives.
A randomized clinical trial found immediate testosterone therapy significantly reduced gender dysphoria, depression, and suicidality in transgender and gender-diverse individuals. The study included 64 participants and compared immediate testosterone therapy to no treatment.
Women with polycystic ovary syndrome (PCOS) who follow a keto diet for at least 45 days may experience significant weight loss and improvements in reproductive hormone levels. Lower testosterone levels can also help reduce excess hair growth and other symptoms associated with PCOS.
A USC Stem Cell-led mouse study reveals that lowering testosterone can improve the resilience of male kidneys by reducing their vulnerability to disease. The researchers also found that three months of calorie restriction has a similar effect, suggesting new potential treatments for kidney diseases.
The study found that rising testosterone levels trigger full song development and territorial behavior in thrush nightingales. Full songsters were never found to settle close to each other, while plastic songsters settled close to both full and plastic songsters, indicating a connection between song and territoriality.
Two studies demonstrate that artificial intelligence in colonoscopy can increase adenoma detection rates and reduce miss rates, but also lead to increased removal of non-neoplastic polyps. The findings suggest the need for additional research on more defined detection parameters before AI can be integrated into routine clinical care.
New study finds that men who suffered from mild COVID-19 have lower sperm concentrations and motility even three months after recovery. The researchers believe that the virus may cause permanent damage to male fertility, leading to long-term decline in semen quality.
Higher testosterone levels during adolescence enhance emotion control, but decrease in young adulthood; the study suggests a shift in testosterone's role across developmental periods. The findings may be related to mood disorders that arise during adolescence.
A randomized clinical trial found that rapid access to testosterone therapy significantly reduced feelings of gender dysphoria and depression among transgender adults. The study also showed a 50% reduction in suicidal ideation compared to those on a standard waiting list.
Research in mice suggests that prostate cancer cells adapt to testosterone-deprivation therapy by producing cholesterol and generating their own testosterone. Treating aggressive tumors with inhibitors slows tumor growth. The study also points to a possible drug combination and sheds light on racial disparities in prostate cancer.
Sons of women with PCOS are two times more likely to develop obesity and have high levels of male hormones, leading to insulin resistance and type 2 diabetes. A mouse study confirms these findings, showing fat tissue and metabolism problems in the offspring despite a healthy diet.
ENZAMET, a new drug combination, has shown significant improvement in survival rates for men with advanced prostate cancer. After five years, the treatment led to a 67% survival rate, compared to 57% for standard therapy.
A new study published in Evolutionary Psychology examines the relationship between parental income and the sexual behavior of their adult children. The research found that children from low-income families had higher frequencies of same-sex attraction, while those from high-income families had lower frequencies.
A Northwestern Medicine study found that online platforms are offering therapies to men who don't meet guidelines for testosterone deficiency, while failing to convey the risks and benefits of therapy. The study recommends seeing a provider with expertise in hypogonadism for accurate care.
A recent meta-analysis published in Human Reproduction Update reveals a significant worldwide decline in sperm counts of over 50% in the past 46 years. The study also shows an accelerated post-2000 decline in sperm counts globally.
Experts found that large differences in finger length between left and right hands are associated with COVID-19 severity. The study may help identify those at greatest risk of hospitalization across age groups.
A study analyzing nearly 1,500 young men found that standard cutoff points for low testosterone levels may not be accurate. Age-specific thresholds ranged from 409 ng/dL at 20-24 years to 350 ng/dL at 40-44 years, indicating the need for a more personalized approach to diagnosing testosterone deficiency in younger men.
Recruitment of tumor-fighting macrophages depends on testosterone. Administering testosterone to females increases macrophage ability to eradicate tumor cells.
A study of 15 transgender women found they exceeded the cardiopulmonary capacity and muscle strength of their cisgender peers even after years of hormone therapy. However, their performance was lower than that of cisgender men. The findings could inform policy on transgender women's sports participation.
A randomized phase III trial found that combination hormonal therapy, delivered for a finite treatment interval of 12 months, more durably suppresses PSA levels compared to hormone injections alone. The treatment approach improved disease progression in patients with high-risk biochemically relapsed prostate cancer.
Research by Saint Louis University School of Medicine and Washington University School of Medicine found that low testosterone levels are associated with an increased risk of hospitalization from COVID-19. Men with low testosterone were twice more likely to require hospitalization than those with normal levels.
A study by researchers at Washington University School of Medicine found that low testosterone levels are an independent risk factor for COVID-19 hospitalization in men. Men with chronically low testosterone who developed COVID-19 were 2.4 times more likely to require hospitalization than those with normal testosterone levels.
A new animal study finds that testosterone can foster friendly, prosocial behavior in males, in addition to aggression. The hormone appears to help animals rapidly pivot between prosocial and antisocial responses as the social world changes.
A new study explores relationships between domestic cats' hormone levels, gut microbiomes, and social behaviors in cohabitating groups. The research found that low testosterone and cortisol concentrations enabled cats to share space, while high oxytocin levels were associated with less affiliative behavior.
Researchers found higher AR signaling and better response rates for female patients treated with BRAF/MEK inhibitors. Blocking the AR improved response to BRAF/MEK targeted therapy in both males and females.
A mouse study suggests that active testosterone therapy can lead to fewer and less developed eggs retrieved during IVF. Discontinuing testosterone therapy appears to have no significant impact on reproductive capacity, however.
A randomized controlled trial shows significant improvements in testosterone replacement therapy for men with poorly-controlled type 2 diabetes and hypogonadism. The treatment improved symptoms, libido, and quality of life, as well as delayed verbal recall, a potential early sign of dementia.
Two experimental male contraceptive pills, DMAU and 11β-MNTDC, have shown promising results in lowering testosterone levels without unacceptable side effects. The study found that 75% of men who took the active drug were willing to use it in the future, compared to 46.4% of those taking a placebo.
Research finds no significant increase in cardiovascular events among men with low testosterone undergoing testosterone treatment. Testosterone was found to reduce serum total cholesterol and triglycerides, but no significant differences were seen in other parameters.
A comprehensive analysis of testosterone replacement therapy found no increased risk of heart attack, stroke, and other cardiovascular events in the short-to-medium term. Testosterone treatment was also found to reduce serum cholesterol levels, but no significant differences were observed in blood pressure or glycaemic parameters.
Patients with lower levels of sex hormones are more likely to undergo surgery for rotator cuff tears, according to a study published in The Journal of Bone & Joint Surgery. Estrogen deficiency was associated with a 48% higher incidence of rotator cuff repair in women, while testosterone deficiency was linked to an 89% higher rate in men.
A study found that strength training activates androgen receptors to protect against muscle pain in mice. Resistance training also alleviated pain only in male mice, while females did not show similar benefits. The findings suggest exercise may be a useful treatment for chronic musculoskeletal pain.
A study published in Scientific Reports found that patients with 'feminized' short fingers tend to experience severe Covid-19 symptoms, while those with large right-hand-left hand differences have elevated probabilities of hospitalization. The research suggests a link between low testosterone and high oestrogen levels and Covid severity.
In meerkat societies, testosterone-driven aggression enables cooperative breeding by creating a hierarchy where subordinates help raise the matriarch's pups. Researchers found that matriarchs' high testosterone levels drive their aggressive behavior, which maintains group structure.
Scientists at Kobe University have successfully generated testosterone-producing Leydig cells from human iPS cells, a significant step towards developing a regenerative medicine treatment for late-onset hypogonadism. The induced cells expressed genes specific to Leydig cells and produced functional testosterone.
A study published in The Journal of Sex Research found that higher testosterone levels are associated with having multiple partners in men and solitary sexual activity in women. The research, which analyzed data from nearly 4,000 adults, highlights the complex relationship between hormones and human sexuality.
A study found that early weight loss in obese boys can improve reproductive function and reverse alterations in Leydig cell function, which could help prevent future fertility problems. The research suggests that managing childhood obesity may be necessary to prevent reproductive issues and lower the risk of other diseases.
Researchers found that UVB phototherapy increases levels of romantic passion and aggression in both men and women. Exposure to sunlight affects the endocrine system's regulation of sexual hormones.
A case study reports success in restoring hormone balance to a castrated dog, improving mobility, reducing anxiety, and alleviating various health issues. The treatment involved testosterone and GnRH agonist therapy, resulting in significant health improvements.
A University of Houston researcher is using cutting-edge techniques to study how testosterone affects the brain and social behavior. Using genetically modified African cichlid fish, Beau Alward aims to identify the specific genes and neurons involved in these processes.
A new study found that higher testosterone levels are linked to socioeconomic position in men but not women. In contrast, lower testosterone was associated with poorer health and risk-taking behavior in women. The research suggests that testosterone may be less important than previously thought in determining success.
A new study found that supplementing testosterone significantly reduces heart attacks and strokes in men with unnaturally low hormone levels. The 10-year study involved over 800 men from Germany and Qatar, showing a 25% reduction in risk for those under 55 and a 15% reduction for those over 60.
Research shows that men with symptomatic Covid-19 and low testosterone are more likely to become severely ill and die. The lower the testosterone levels, the higher the likelihood of severe illness and death, according to a study presented at the European Association of Urology congress.
A study found that wildfires alter male red-backed fairywrens' plumage, making them less attractive to females, while also lowering circulating testosterone. This suggests an evolved response to minimize breeding during unfavorable environmental conditions.
A two-year study found that testosterone therapy normalised testosterone levels, reduced NAFLD, and suppressed symptoms of hypogonadism in obese men. Testosterone therapy may help obese men with functional hypogonadism and type-2 diabetes reduce the prevalence of non-alcoholic fatty liver disease.
A new study from Washington University School of Medicine found that low testosterone levels in men are linked to more severe disease. Men with low testosterone had a higher risk of requiring intensive care or dying from COVID-19, while those with higher testosterone levels were less likely to experience severe symptoms.
A low-calorie ketogenic diet has been found to increase total testosterone and sex hormone (SHBG) levels in overweight men. After four weeks on the diet, body weight, fat mass, and BMI decreased significantly, while testosterone and SHBG levels substantially increased.
A diet high in pro-inflammatory foods may be associated with increased odds of developing testosterone deficiency among men. Men who consume refined carbohydrates and sugar, as well as polyunsaturated fats, are more likely to experience low libido, decreased energy, and depression.
A study by The Endocrine Society finds oral testosterone therapy undecanoate (TU) is an effective treatment for men with low testosterone levels, with a safety profile consistent with non-oral products. TU has minimal effects on cholesterol levels and no liver toxicity was reported.
A new marker of testicular cell capacity identified as a promising biological marker, INSL3, shows suppressed levels in former steroid users compared to never-users. Long-lasting impaired gonadal capacity found in previous anabolic steroid users, increasing risk of hypogonadism later in life.
A new study published in Hypertension Journal Report found that a structured exercise program improved artery health and function in middle-aged and older men with low-to-normal testosterone levels. The study showed no benefits from testosterone therapy on artery health.