Researchers have identified GW406108X, a broad-spectrum antiviral compound, that can inhibit a range of enteroviruses, including EV-D68, by targeting a process in human cells. The compound showed activity against multiple viruses, including Rhinovirus A16, and reduced EV-D68 levels by 1,000-fold in laboratory experiments.
Researchers found that daunorubicin effectively inhibits bacteriophage infection in bacteria, triggering mutual destruction and killing the bacterial cell. The discovery opens up new avenues for phage therapy development, especially against antibiotic-resistant infections.
A study published in Scientific Reports confirms the anti-viral properties of galloylquinic acids extracted from Copaifera lucens leaves, inhibiting viral entry and replication. The substance's multi-target mechanism reduces the likelihood of resistance developing, making it a promising therapeutic candidate against COVID-19.
Researchers have shown that extracts from bioengineered chewing gum reduce levels of three microbes linked to worse outcomes in oral cancers, including HPV and bacteria Pg and Fn. The findings support the value of advancing these therapies to clinical trials as adjuvants or prophylaxis.
Keratinocytes play a more active role in rabies infection than previously thought, supporting viral replication and transmitting the virus to neurons. This discovery provides new insights into the risk of infection from superficial scratches or minor bites.
A study reveals dermcidin, a human body natural molecule, exhibits antiviral activity against the influenza virus. Higher baseline levels of dermcidin in individuals who don't develop flu-like symptoms may be associated with lower susceptibility to infection.
Researchers at Harvard Medical School have uncovered crucial insights into how a new class of antiviral drugs works, shedding light on an important tool for fighting drug-resistant strains of herpes simplex virus. The discovery may lead to new pathways for treating herpesviruses and other kinds of DNA viruses.
A new study from Mass General Brigham researchers found that hyperphosphorylated tau may help protect the brain from infection, potentially leading to Alzheimer's disease. The study suggests that tau could serve as an antiviral protein against certain viruses.
A study found that viral interactions inside cells influence antiviral resistance outcomes, while a less potent drug may ironically improve its future utility by promoting social interactions in viruses. The researchers suggest a trade-off between hitting the virus hard and allowing resistance to rise.
The Vaccine Innovation Center at Korea University College of Medicine has been selected as the lead institution for a health security research initiative focused on developing broad-spectrum antiviral agents and combination therapies to prevent severe disease in future pandemics. The project aims to create advanced therapeutics capable...
A team of scientists at HIPS has developed a chemo-enzymatic platform to produce large quantities of furanolides, a class of natural products with high structural diversity. The resulting substances have shown promising biological activities against bacterial pathogens and cancer cells.
Scientists at CUNY ASRC develop novel synthetic carbohydrate receptors that block infection from seven different viruses across five unrelated families, including Ebola and SARS-CoV-2. The breakthrough offers a promising path toward the development of broad-spectrum antivirals.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
Researchers discover iguratimod, a rheumatoid arthritis drug, effectively treats excessive COVID-19 inflammation in mice by maintaining antiviral immune responses. The study provides hope for patients with severe COVID-19-related cytokine storms.
A large cohort study has shown that supplementary treatment with statins can boost survival chances for critically ill patients with sepsis. The results indicate a 39% lower death rate over 28 days after hospital admission.
Researchers found that an inexpensive HIV drug can improve vision in patients with diabetic macular edema (DME) more effectively and at a lower cost than existing treatments. The drug, lamivudine, is taken orally and may represent a game-changing option for millions of patients worldwide.
A study by University of Fukui researchers reveals that two adjacent gene pairs in Neurospora crassa regulate antiviral response and symptom induction via RNA editing. The findings indicate that the modification of master transcription factor genes is crucial for controlling fungal antiviral responses.
Researchers have discovered that hydrogen boride nanosheets can inactivate a wide range of pathogens, including viruses, bacteria, and fungi, without the need for light activation. The nanosheets' ability to denature microbial proteins through strong physicochemical interactions confirms their effectiveness in combating various microbi...
Researchers developed organoids from Egyptian fruit bats' respiratory and intestinal tissue, showcasing a significantly higher baseline antiviral immune activity. These organoids demonstrated an exceptionally strong production of type III interferons, which played a crucial role in mucosal antiviral immunity.
Researchers at the University of Gothenburg discovered that the influenza A virus exploits a protein called AGO2 to regulate gene activity and weaken the immune system. An existing drug, arsenic trioxide, showed promise in increasing interferon production and reducing viral loads.
Researchers have developed new bat cell lines and reagents to study the bat's antiviral immune response, providing insights into susceptibility to hantaviruses and coronaviruses. The study aims to improve our understanding of viral infections in bats.
A recent study identifies 11 natural compounds that can inhibit the SARS-CoV-2 spike protein, including caffeine, which exhibits high binding stability and excellent solubility. The discovery highlights the potential of natural products in combating COVID-19 and demonstrates the versatility of widely known compounds like caffeine.
Researchers discovered Pradimicin A's molecular basis for binding to viral N-glycan, showing promise as an anti-SARS-CoV-2 drug. The compound inhibits SARS-CoV-2 infectivity by interacting with branched oligomannose-containing glycans.
Studies found that wood reduces viral infectivity on its surface, with pine and spruce showing the fastest onset of antiviral activity. The researchers concluded that wood's chemical composition is responsible for its antiviral functionality.
Research reveals memory T cells formed after Omicron breakthrough infection provide enhanced immunity against future variants. The study suggests the immune system adapts to combat emerging strains, leading to higher chances of inducing memory T cell defenses.
A study of over 2,300 patients found that HIV-1 neutralizing antibody response decreases over time but highly potent broadly neutralizing antibodies remain detectable. This finding suggests a possible permanent vaccine response and is an important step toward developing an effective HIV-1 vaccine.
Researchers at Hokkaido University identified 2-thiouridine as a broad-spectrum antiviral drug candidate targeting ssRNA+ viruses. It inhibits viral replication and increases survival rates in mice models for dengue and COVID-19.
Researchers at University of California - Riverside uncover COVID's Achilles heel - its dependence on key human proteins. By understanding how the virus interacts with human cells, a new class of antiviral medication may be developed to block replication and treatment.
A new anti-virus has been discovered in a medical lecture. The lectin, known as H84T-BanLec, is highly effective against many different types of coronaviruses, including those causing COVID-19 and MERS-CoV. Its unique mechanism makes it difficult for viruses to develop resistance, making it a potential 'pan-coronavirus' antiviral drug ...
Experiments in cell cultures and mice showed that blocking the function of NSUN2 triggers a powerful innate immune response, dramatically lowering viral replication and protecting lung tissue. This finding could help change the approach to developing antiviral medications.
A study by Hokkaido University researchers found that low concentrations of cetylpyridinium chloride in mouthwash can inhibit SARS-CoV-2 infectivity and viral load, regardless of variant. This antiviral effect is thought to be due to disruption of the lipid membrane surrounding the virus.
Researchers developed DNA nets to detect and impede COVID-19, offering a fast, sensitive, and low-cost testing platform. The technique also showed potential as an antiviral treatment, inhibiting the virus's spread in live cell cultures.
The conference highlights recent discoveries on polyphenol applications in microbiota, adipose tissue, nervous system, senolytic activity, ageing, and endothelial function. Over 131 communications will be presented during three days.
The Polyphenols Applications 2022 World Congress will focus on the latest findings and emerging trends in polyphenol research, covering various topics such as microbiota, adipose tissue, nervous system, senolytic activity, ageing, endothelial function, radioprotection, atherosclerosis, and more. Over 300 international participants will...
Rensselaer researchers will use a five-year grant to develop novel inhibitors of the SARS-CoV-2 virus's CLpro and PLpro proteases. The team aims to create an orally bioavailable drug that can be administered at home, with the potential for improved antiviral activity when combined with other drugs like remdesivir.
Researchers developed a novel nanobody-based detection method for recombinant human interferon α2b (rhIFNα2b), which has a lower detection limit than existing methods. The assay's operation time was shortened from two days to a few minutes, making it suitable for rapid market counterfeit detection and early diagnosis of hepatitis.
Researchers developed a solid-state photocatalyst using TiO2 and CuO nanoclusters to inactivate various variants of SARS-CoV-2. The material is effective under both darkness and indoor light, making it suitable for reducing COVID-19 infection risk in indoor environments.
A new study found that bovine lactoferrin, a protein in cow milk, is effective against various SARS-CoV-2 variants, including the WA1, B.1.1.7, and Delta variants. The research suggests that bovine lactoferrin could be used as a preventive or post-exposure treatment for COVID-19.
Researchers have identified two new compounds that can inhibit the replication of human herpesviruses by targeting specific enzymes. This breakthrough offers new opportunities for developing agents against herpesviruses, which are currently difficult to treat effectively.
Scientists have engineered enzymes to manufacture molnupiravir, resulting in a shorter and higher-yielding synthesis. The new method reduces the risk of hospitalization and death from COVID-19 for newly diagnosed patients, showing promise as an antiviral treatment.
Scientists have developed stable peptide mimics called peptoids to treat viruses and prevent infections. Peptoids, such as those tested against SARS-CoV-2 and HSV-1, could one day cure or prevent many kinds of infections, including COVID-19.
Researchers have identified several drug contenders that can block or reduce SARS-CoV2 infection in cells, including lactoferrin and MEK-inhibitors. These findings suggest potential efficacy against COVID-19 variants, with ongoing clinical trials to examine their ability to reduce viral loads and inflammation.
Researchers discover a new way for an antiviral enzyme to detect and destroy viruses that hide inside cell membranes. The OAS1 p46 isoform enhances the immune response against SARS-CoV-2, flaviviruses, and other RNA viruses.
Researchers have found that Camostat and its metabolite GBPA inhibit SARS-CoV-2 infection in primary human lung tissue. The study supports further development of Camostat as a potential treatment for COVID-19.
Researchers at Tokyo Institute of Technology have developed a new material called cerium molybdate with high antiviral activity against SARS-CoV-2. The material exhibits improved antiviral properties compared to earlier works, and its potential applications include coatings for surfaces and everyday items.
Researchers are investigating the antiviral properties of Respiratory Detox Shot (RDS), a traditional Chinese medicine that blocks SARS-CoV and CoV-2 entry into human cells. Wu's lab aims to quantify RDS cytotoxicity in human cells.
Research suggests that inflammation-related genes are associated with biobehavioral factors like body mass index and smoking, while interferon-related genes are linked to individual demographic factors such as sex and race/ethnicity. The study's findings could help explain social disparities in chronic diseases that emerge decades later.
A novel small-molecule antiviral compound, GS-5734, has been shown to protect rhesus monkeys from Ebola virus infection when administered three days post-infection. This preclinical result demonstrates the compound's ability to block viral replication and reduce disease severity.
Scientists at Helmholtz Zentrum München discover that Cistus incanus extracts prevent human immunodeficiency viruses from infecting cells and block Ebola- and Marburg viral envelope proteins. The study demonstrates broad antiviral activity of Ci extracts against various major human viral pathogens.
A team of researchers has found that tansy may be a potential treatment for herpes due to its anti-viral properties. The study revealed that compounds such as 3,5-dicaffeoylquinic acid and axillarin contribute to the plant's supposed antiviral activity.