Articles tagged with Metabolomics
Researchers identified 14 proteins and 2 metabolites associated with prediabetes progression to diabetes, including DCXR and GSTA3. Inflammation and immune system pathways also play a key role in glucose homeostasis.
Researchers identified distinct metabolic profiles in skeletal muscle of Taoyuan Black pig compared to Duroc pig, with correlations to intramuscular fat content and lipid metabolism. The study provides insights into the muscle-adipose axis and potential targets for nutritional regulation.
A small preliminary study reveals that fearful dog microbiomes differ significantly from those of non-fearful dogs. These findings suggest a possible link between the gut and brain, potentially influencing fear behaviors.
The study proposes a novel approach for simultaneous extraction of metabolites and lipids from zebrafish embryos to shed light on PFOS-induced neurotoxicity. The researchers found that sphingolipids are a reliable biomarker of PFOS-induced neurotoxicity, and the method can be expanded to various biomolecules.
The article reviews metabolomics-driven approaches for identifying therapeutic targets in drug discovery, highlighting the challenges and limitations of current methods. Emerging technologies like single-cell metabolomics, artificial intelligence, and mass spectrometry imaging are explored to enhance target discovery.
The study found that individuals with accelerated biological ageing had poorer health outcomes, while those with decelerated ageing had weaker links to good health. Metabolomic ageing clocks have the potential to identify early signs of declining health and inform preventative strategies.
This study found that adolescents who used cannabis exhibited unique metabolomic patterns associated with psychotic-like experiences, including variations in lipid metabolism and oxidative stress. In contrast, non-users showed correlations between inflammatory metabolic changes and hallucinations.
Skirycz's five-year grant will support a novel method to characterize the 'dark matter' of the metabolome, identifying previously unknown functions of compounds. By comparing multiple interaction networks across different organisms, researchers aim to validate potential targets for understanding organismal health.
A new study reveals that fecal microbiota transplants can increase Lachnospiraceae bacteria, which outcompete C. diff for resources and alter bile acids to create an environment favorable for other good bacteria to thrive.
This study analyzed soil VOC levels and their correlation with soil physical properties, ionome, microbiome, metabolome, and rhizosphere chemicals. The results reveal that soil VOC profiles can be reliable indicators for evaluating soil health in agricultural environments.
A new study by Bar-Ilan University researchers found a significant link between the gut microbiome and aggression in mice, with reduced diversity in gut bacteria causing increased aggression. The study also identified key brain regions and biochemical mechanisms underlying these behavioral changes.
A research team developed a computational workflow for analyzing large data sets in metabolomics, speeding up the process to capture chemical profiles of coastal environments. The tool, accessible to researchers worldwide, highlights potential sources of pollution and enables statistical insights within minutes.
Researchers found that early diet and physical activity intervention can profoundly influence metabolism even years after the intervention ends. The study identified 80 metabolites linked to cardiometabolic diseases, with some changes persisting for eight years.
Researchers investigated whole genome duplication's effects on greater duckweed's metabolome, finding increased metabolite abundance and changes in cell size. The study sheds light on the immediate phytochemical effects of WGD, highlighting the need for cell-level impacts analysis.
Researchers developed more resilient varieties of cotton by analyzing its genes and physical traits. They found two key regulatory genes that help cotton plants manage water stress while maintaining fiber production.
A novel tool called BitterMasS harnesses mass spectrometry to predict bitterness without prior knowledge of chemical structures. The tool achieved remarkable precision and recall rates in internal and external tests, streamlining compound screening processes.
A multidisciplinary team developed GeneMAP to probe gene function in metabolism. They identified SLC25A48 as necessary for mitochondrial choline transport and associated it with eight human diseases.
Researchers analyzed blood plasma samples from 110 patients infected with Plasmodium vivax to understand how metabolisms were affected during initial episodes versus recurrent cases. The study found that patients with recurrence exhibited modulation in lipid pathways involved in immune system production, while those with first-episode ...
Researchers used machine learning to integrate high-throughput transcriptomic, proteomic, metabolomic, and lipidomic profiles to identify four distinct molecular profiles of Alzheimer's Disease. These profiles were associated with varying levels of cognitive function and neuropathological features.
The study reveals age-related changes in lipid metabolism, including increased BMP-type lipids in kidneys and liver, and sex-specific differences in galactosylceramide levels. These findings may lead to better understanding of chronic diseases and the development of targeted treatments.
Researchers at U of T have identified two compounds, diindolylmethane and diindolylethane, produced by gut bacteria that can regulate the nuclear receptor CAR, potentially treating diseases like diabetes, fatty liver disease, and small intestine ulcerative colitis.
Researchers found a genetic link between higher circulating levels of arachidonic acid and lower risk for bipolar disorder. The study suggests that altering arachidonic acid synthesis pathways may reduce bipolar disorder risk, particularly in those with compromised pathways.
Researchers explore plant-based therapeutic compounds and traditional Chinese medicine formulas as alternatives to treat IBD, while also developing advanced diagnostic tools using metabolomics analysis. The studies found significant improvements in symptoms of IBD and treatment outcomes for chemotherapy-related toxicity.
A study finds that gut microbiota play a key role in obesity development, with distinct differences between men and women. Researchers identified specific bacterial species and metabolites associated with higher BMI, fat mass, and waist circumference in women, but not men.
A study of over 2,500 adults found a correlation between PFAS levels and unfavorable lipid profiles, increasing cardiovascular disease risk. Researchers suggest stricter regulation of PFAS to protect health.
A Newcastle research team has investigated the genetics of circulating vitamin A and its role in psychiatric disorders. The study found that genetic variation influences retinol levels, which are linked to various complex health conditions such as inflammation, vision, and brain structure connectivity.
A new study has revealed a molecular fingerprint of biological aging, shedding light on why people age differently. The researchers identified 25 metabolites that can reflect biological age, known as the Healthy Aging Metabolic (HAM) Index, which was found to be more accurate than other aging metrics.
A new metabolomics method has been proven to be a reliable approach for grouping chemicals, potentially reducing the use of lab rats. The study's results show that the method can accurately group chemicals into categories, making it a viable alternative to traditional methods.
Researchers use machine learning to combine mismatched datasets and reduce variation by over 95%, retaining meaningful differences. The approach has potential to provide deeper understanding of normal metabolism and identify biomarkers for disease.
Researchers have developed a new search tool, microbeMASST, to study microbial metabolism, which could transform our understanding of human health and the environment. The tool instantly matches microbes to their metabolic signatures without prior knowledge.
Researchers at the Boyce Thompson Institute discovered a novel family of metabolites called acylspermidines that are linked to sirtuin activity. These compounds were found to influence lifespan in C. elegans and cell proliferation in mammals, providing new insights into the physiological functions of spermidine and sirtuins.
A Philippine sea cucumber species has been found to contain diverse classes of valuable small molecules with potential biomedical applications. These bioactive compounds, including terpenoid glycosides and saponins, have reported anti-cancer benefits.
Scientists at University of California San Diego develop a new approach to microbiome research, identifying hundreds of molecules never seen before in the human body. They found a strong association between these molecules and inflammatory bowel disease, potentially leading to new diagnostic and therapeutic applications.
Researchers analyzed leishmaniasis lesions on mouse skin to detect metabolic signaling pathways that differed from uninfected mice. They found pathways with pain-relief properties tied to the brain's endocannabinoid system, which is involved in a host of physiological processes, including the pain response.
A new study identified 60 alcohol-associated circulating metabolites that appear to produce counteractive effects on the risk of heart disease. The findings suggest that moderate alcohol consumption may trigger changes in metabolomic profiles, yielding both beneficial and harmful outcomes.
The study aims to identify genetic and molecular factors associated with susceptibility and progression of liver disease in Hispanics/Latinos. Researchers will collect data from 300 participants, including those with metabolic-associated fatty liver disease and healthy controls.
A new approach allows researchers to create maps of coral biochemistry, detailing the distribution of compounds integral to reef health. This innovation provides unprecedented insight into coral resilience and potential stressors like warmer ocean temperatures and acidification.
The Keck School of Medicine of USC has launched a five-year, $50.3 million multi-omics study to better understand the causes and prevention of various diseases, including NAFLD, in underrepresented racial and ethnic groups.
The study found that black soldier fly larvae oil exhibits anti-inflammatory properties, suppressing proinflammatory cytokines and improving colon health. BSFL oil's unique compound profile may offer a new approach to managing inflammatory diseases.
Scientists created a unique data process that provides valuable insights into how drugs are processed in the body and their impact on biochemical responses. The approach reveals detailed maps of drug transformation and allows for simultaneous discovery of fate and effects.
A German research team has successfully developed a novel NMR technique to quantify acute-phase proteins in human serum, which can serve as markers for inflammatory diseases. The study found significant changes in specific acute-phase proteins in patients with COVID-19 or cardiogenic shock, and offers a diagnostic potential.
A study by the University of Tsukuba found that changes in F1-hybrid metabolites lead to increased biomass in Arabidopsis plants. The researchers analyzed 202 Arabidopsis lines and found altered production of intermediate metabolites of the TCA cycle in high-heterosis combinations.
A recent study by researchers at UNICAMP found that low-load with many repetitions and high-load with fewer repetitions both promote similar muscle growth. Muscle activation patterns were different, but metabolic stress was the same in both groups.
A team of researchers used a capsule to collect data on digestion and microorganisms in the upper intestine, revealing nearly 2,000 metabolites and associations between diet and metabolite levels. The study provides new insights into human gut metabolism and microbiome interactions.
A recent study published in PLOS ONE found that pregnant and lactating dogs share similarities in certain blood metabolites with human pregnancy, including glucose and fatty acid concentrations. The research analyzed 27 dogs from 21 breeds and discovered intriguing correlations between canine metabolism and human physiological processes.
Researchers have developed a new extraction protocol for RNA-seq and metabolomic analysis, reducing variation and improving efficiency. The protocol preserves data fidelity and maximizes use of precious biospecimens, enabling the study of metabolic phenotypes in a unique way.
Researchers found that women with prediabetes after pregnancy had aberrations in their early pregnancy blood serum metabolomic profile, including higher concentrations of small HDL particles. These metabolic changes predicted prediabetes at postpartum and were associated with increased risk of type 2 diabetes.
Animals recycle biochemical waste to produce novel chemicals playing key roles in biology from behavior to aging. Genes previously thought to code for carboxylesterases contribute to ester and amide bond formation opposite initial predictions.
Scientists at the University of Utah Health have discovered a complex network of protein-metabolite interactions within cells that enable them to respond to environmental cues and maintain homeostasis. The study, published in Science, highlights the importance of these interactions in regulating metabolic processes and preventing disease.
A University of Massachusetts Amherst epidemiologist is leading a team to better understand the effects of chronic stress on future health risks. They will examine metabolites in blood samples from a large, racially diverse population to identify potential biomarkers for heart disease, diabetes and cognitive decline.
The study reveals unexpected mechanisms that enable Aromatoleum aromaticum EbN1 T to adapt to changing environments. By analyzing its metabolic network, researchers developed a model to predict growth under diverse conditions.
A new study links spontaneous preterm birth to chemicals in vaginal products, revealing a potential source of the condition. Researchers discovered that metabolites from cosmetics and hygiene products were associated with preterm births, offering hope for early diagnostics.
Researchers discovered a new mode of vertical mother-to-infant microbiome transmission, where microbes shared genes with each other. The study found links between gut metabolites, bacteria, and breastmilk substrates, influencing infant development before and after birth.
Researchers found anti-inflammatory proteins and lipids in long COVID patients, which may contribute to symptoms and suggest an alternative explanation for the condition. These findings support the theory that alternatively polarized macrophages play a key role in Long COVID disease.
Researchers developed an integrated approach to accelerate drug discovery by combining complex datasets from two screening platforms and next-generation metabolomics analysis. The new framework identified known compounds, confirmed mechanisms of action, and discovered novel compounds with unique biological signatures.
A recent human study published in Antioxidants found that consuming grapes protected against ultraviolet (UV) damage to the skin. The study showed increased resistance to sunburn and unique microbiomic and metabolomic profiles in subjects who consumed whole grape powder, suggesting a correlation between the gut and skin.
Researchers have developed a unique resource for understanding the impact of early life environmental exposures on health. The study, which analyzed data from 1,301 mother-child pairs, identified associations between 92 in pregnancy and 116 in childhood with molecular profiles at different levels.
ISB researchers found that the gut microbiome is responsible for variation in circulating blood metabolites across people. The study examined 930 blood metabolites and found that over 60% were associated with either host genetics or the gut microbiome.
Scientists from the University of Johannesburg identified ten times more volatile signal compounds from the bacteria, boosting plant growth and protection. Rhizobacteria can protect crops from abiotic and biotic stresses by producing valuable VOCs that trigger Induced Systemic Resistance (ISR) in plants.
Researchers at Leibniz-HKI discovered a yellow natural substance that regulates the multicellular stage of the amoeba <em>D. discoideum</em>. The polyketide, dictyoden, prevents premature hatching from spores, maintaining the development cycle. The study provides insights into the complex transition from single- to multicellularity.