Articles tagged with Epigenomics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Research finds age-related DNA methylation alterations in sperm may contribute to autism risk in offspring. Advanced paternal age is associated with specific changes in sperm DNA, influencing early development in children.
The German Research Foundation (DFG) has funded a three-year project to investigate epigenetic memory in nerve cells. The goal is to understand how gene expressions are preserved via epigenetic regulation, which plays a key role in learning ability, memory function, and healthy brain development.
Dr. Maria Margarita Behrens' work deciphers the molecular signatures defining every human brain cell type, shedding light on neural development and psychiatric disorders. Her single-cell epigenomic atlases will enable researchers to target specific cell types with unprecedented precision.
A study led by Emory University researchers has identified epigenetic changes that help Indigenous people of South America adapt to high altitudes. The research found strong differences in DNA methylation between low- and high-altitude populations for genes associated with vascular system regulation and muscle growth.
Researchers have made breakthroughs in overcoming immune reactions behind human rejection of transplanted pig kidneys, paving the way for more successful clinical trials. The study reveals three major immune responses against the pig kidney and identifies potential biomarkers as early-warning systems for rejection.
A recent study identifies molecular markers in children and adolescents that link childhood maltreatment to long-term brain alterations and mental health outcomes. The researchers found four DNA methylation sites associated with child maltreatment, including the 'master switch' gene FOXP1, which regulates brain development.
A cohort study reveals a significant association between social adversity and increased incidence of triple-negative breast cancer in Black women. The findings suggest potential social genomic and gene-environment interactions that contribute to disparities in breast cancer survival.
Genomic imprinting discovered by Davor Solter and Azim Surani reveals maternal chromosomes contribute essential information missing in paternal chromosomes. This phenomenon, coined genomic imprinting, involves tiny methyl groups attached to DNA's four bases regulating fetal growth and development.
A new study reveals that Alzheimer's progression is characterized by a breakdown of epigenomic stability, leading to compromised compartmentalization and the loss of gene regulation. The research provides insights into the molecular mechanisms driving disease progression and resilience, shedding light on potential new treatments.
Researchers successfully modulate the activity of key immune system genes using CRISPR-Cas9 technology, revealing a new approach to treating inflammatory diseases. The study demonstrates precise control over gene expression and its impact on tumour growth and inflammation.
A study assessing twelve DNA methylation signatures of aging found that GrimAge2 is robustly and independently associated with all-cause mortality, surpassing other DNAm signatures and chronological age. The findings suggest GrimAge2 as a promising tool for assessing mortality risk and evaluating healthy aging interventions.
Researchers at UCLA have discovered a chromatin-based strategy that enables cells to rapidly produce proteins when nutrients are scarce. This 'priming' mechanism, driven by the MYC gene, allows cancer cells to adapt and survive under metabolic stress.
Researchers identified two distinct epigenetic profiles in Burkitt Lymphoma, one associated with a favorable clinical course and the other with early relapse and shorter survival. This discovery has implications for treatment strategies and may lead to personalized medicine approaches.
Researchers developed a cell-based reporter assay that can quantify epigenetic changes induced by chemicals and potential carcinogens. The epi-TK assay detects gene silencing and activation, reflecting epigenetic changes associated with both gene expression and DNA methylation.
Scientists have developed genome sequences for five duckweed species, revealing genes behind the plant's unique traits and versatility. The research holds promise for commercial applications, including carbon capture technology and biofuel production.
Researchers at UC Santa Cruz engineered cellular models of embryos using CRISPR technology, allowing them to study early developmental stages without experimenting with actual embryos. The team found that 80% of stem cells organized into embryo-like structures, showcasing a remarkable collective behavior and molecular composition.
A recent study found that childhood maltreatment is associated with specific epigenetic patterns in sperm, which may mediate effects on offspring brain development. The study also reveals changes in sperm DNA methylation and small non-coding RNA molecules in men with high levels of maltreatment.
The new textbook, Gene Regulation and Epigenetics: How Science Works, provides an in-depth understanding of gene regulation and epigenomics, essential for graduate students across biomedical fields. The book highlights the role of transcription factors, chromatin dynamics, and non-coding RNA in shaping gene expression.
Researchers from the Kind Group have gained new insights into the mechanism behind the spatial organization of DNA within cells of early embryos. They found that DNA regions near the nuclear edge are repelled by a specific protein modification, leading to an unusual organization that enables cells to differentiate into various types.
A recent study by Nara Institute of Science and Technology reveals a new mechanism for dynamic gene silencing and reactivation, highlighting the intricate roles of proteins like SDG7. The research team identified a competitive interaction between SDGs and PRC2 at PREs, allowing for efficient gene activation through H3K36 methylation.
Researchers found that inflammation in the gut affects ISCs' regenerative capacity even after resolution of inflammation. The study used cellular and animal models to show that exposure to inflammation reprograms the epigenome, leading to reduced regeneration.
This special issue of JAMA Network Open highlights scientific progress in combining social determinants and health outcomes to understand mechanisms underlying health disparities. The studies demonstrate the importance of interdisciplinary integration in transforming health disparities research.
Researchers have developed a modular epigenome editing platform to study the impact of chromatin modifications on transcription. The system allows for precise programming of nine biologically important chromatin marks, enabling the discovery of causal relationships between chromatin marks and gene regulation.
Researchers analyzed epigenetic modifications in motor neurons from nearly 400 ALS patients, identifying 30 locations with modifications linked to disease progression. The findings may help develop targeted treatments for specific types of ALS.
A new study has identified a deficit in the placental expression of IGFBP1 and low circulating levels as associated with insulin resistance during pregnancy. The findings suggest that measuring IGFBP1 levels could help identify people at risk of developing gestational diabetes early in pregnancy.
A new study finds that e-cigarette users with a limited smoking history experience similar DNA changes to specific cheek cells as smokers. The researchers also found that some smoking-related epigenetic changes remain more stable after giving up smoking, suggesting that e-cigarettes may not be completely safe.
A large-scale study has found a significant link between smoking and DNA methylation, with two new epigenetic markers identified that differ by race or ethnicity. The research could lead to better ways to predict smoking-related disease risk and improve early detection and treatment.
The study maps over 32 million cells in the mouse brain, describing their type, location, and molecular information. This atlas paves the way for a greater understanding of the human brain and development of precision therapeutics for mental and neurological disorders.
Researchers developed a new technique called MAbID to study multiple mechanisms of gene regulation simultaneously, enabling the connection between different gene expression processes. This technology can be applied to various fields, including human development and disease research.
A massive research consortium has created the largest human brain cell atlases to date, revealing over 3,000 different kinds of brain cells. This breakthrough study provides new insights into the cellular organization of the human brain and its modular, functional nature.
The study aims to identify genetic and molecular factors associated with susceptibility and progression of liver disease in Hispanics/Latinos. Researchers will collect data from 300 participants, including those with metabolic-associated fatty liver disease and healthy controls.
Researchers analyzed over 2 million cells from 400 postmortem brain samples to identify cellular pathways that could become new drug targets for Alzheimer's treatments. They found impairments in mitochondrial function, synaptic signaling, and protein complexes, as well as disrupted lipid metabolism.
Peter A. Jones, Ph.D., D.Sc., receives a seven-year, nearly $7.9 million grant to study epigenetic errors driving cancer development and explore potential new treatments. The funding will support his research into the molecule DNMT3A, which is involved in brain development and cancer development.
The Keck School of Medicine of USC has launched a five-year, $50.3 million multi-omics study to better understand the causes and prevention of various diseases, including NAFLD, in underrepresented racial and ethnic groups.
A study by Children's Hospital of Philadelphia found that COVID-19 affects mitochondrial function in multiple organs beyond the lungs, leading to long-term damage. Mitochondrial gene expression was suppressed in the heart, kidneys, and liver, while recovering in the lungs.
A study by Dana-Farber Cancer Institute researchers found that gliomas can arise from epigenetic changes, which affect gene activity without altering DNA sequence. The findings pinpoint two genes, an oncogene and a tumor suppressor, whose activities are epigenetically altered in human gliomas.
An epigenetic study of over 18,000 people in Scotland identified associations between certain DNA modifications and increased risks of breast cancer, type II diabetes, and chronic obstructive pulmonary disease (COPD). The findings provide new insights into the underlying mechanisms of these diseases.
Researchers have successfully mapped the dog epigenome, creating a high-quality reference map that provides insights into gene regulation and environmental influences. The study offers fresh perspectives on complex traits, genetic disorders, and diseases like cancer, with potential implications for human health.
A study found that childhood adversity between ages 3-5 affects epigenetic patterns in adolescence, particularly in individuals exposed to single-parent households. The researchers suggest that early life experiences can shape biological processes and influence health outcomes.
Researchers developed a new biological age indicator, DNAmFitAge, that incorporates physical fitness parameters, showing a correlation with lower mortality risk, coronary heart disease risk reduction, and improved disease-free status in physically fit individuals.
Researchers found that piglets born to stressed sows in concrete stalls showed epigenetic changes in brain regions related to emotion, learning, and memory. The study highlights the importance of animal welfare and suggests that even small improvements can have significant effects.
Researchers used a multiomics approach to analyze changes in transposable elements after influenza A virus infection, identifying transcription factors contributing to individual responses. The study provides insights into the variable severity of illness among individuals infected with the same virus.
A study reveals a unique epigenetic biotimer mechanism controlling floral meristem termination and stamen development in Arabidopsis thaliana. The team discovered that AGAMOUS serves as a master conductor orchestrating gene expression through cell cycle-coupled H3K27me3 dilution.
A new study from University of Michigan suggests that the perception of not enough food can be sufficient to slow aging in flies. The researchers induced hunger in flies through various methods, including altering amino acid levels and using optogenetics, and found that these flies lived significantly longer than controls.
Researchers from the ALFA Score Consortium explore how nutrition and physical exercise can positively impact the aging process by modifying epigenetic changes. They find that healthy aging is associated with more tightly condensed chromatin, fewer histone post-translational modifications, and greater regulation by non-coding RNAs.
The study found associations between prenatal maternal stress life events and adverse neurodevelopmental outcomes in offspring. DNA methylation likely plays a role in these associations. The research provides new insights into how the fetal environment influences neurodevelopment, metabolism and immunologic functions.
A recent study reveals the first high-quality nuclear genome sequence and assembly of Babesia duncani, a neglected species until now. The parasite's evolution and mechanism of virulence have been identified, providing leads for the development of effective therapies.
Recent studies have highlighted the importance of tumor microenvironment in developing and controlling triple negative breast cancer progression. Researchers suggest that technological advancements like genomics and epigenomics hold promise for overcoming TNBC's current limitations.
Researchers identified over 1,000 genes with age-related methylation changes in human sperm. These changes are associated with increased offspring disease susceptibility for neurodevelopmental disorders. The study found no correlation between paternal BMI or semen quality and age-related methylation changes.
A study by Kumamoto University researchers reveals LSD1's role in regulating skeletal muscle response to environmental stress. The findings suggest that LSD1 moderates muscle adaptation to environmental conditions, with potential implications for maintaining muscle health and preventing diseases such as sarcopenia.
A new study found that neutral maternal behavior at 12 months correlates with an epigenetic change in children related to stress response. The researchers analyzed data from a cohort of mother-infant pairs and found a small increase in methylation on the NR3C1 gene, which regulates the body's response to stress.
Researchers found 270 distinct differentially methylated regions (DMRs) in AD brains compared to normal controls, validating their key findings using an independent cohort. The study offers a novel approach to investigating the relationship between DNA methylation and gene/protein expression.
Eleni Tomazou's project aims to create in vitro and in vivo models of pediatric sarcomas to accelerate drug discovery and precision medicine. Her work could lead to a significant impact on the treatment of these deadly cancers.
Scientists have mapped and analyzed DNA methylation profiles in 580 different animal species, providing insights into the evolutionary conservation of epigenetic mechanisms. The study reveals that DNA methylation constitutes a cancer-protective mechanism in large animals with long lifespans, contradicting Peto's paradox.
Researchers at Baylor College of Medicine find that a widely used tool is not suitable for population epigenetics, leading to the discovery of 72 times more genetic variants associated with disease. This finding highlights the need for a better understanding of epigenetic causes of disease.
Researchers found that early prenatal alcohol exposure changes gene function and epigenome in placenta and human embryonic stem cells. These changes are associated with altered DNA methylation patterns, particularly in genes linked to nervous system development, such as DPPA4 and FOXP2.
Researchers found that differences in epigenetic DNA methylation predict behavioral differences between dogs better than genetic markers. Epigenetics are more informative for behavior than genetics, and the results open up new possibilities for screening and selecting desired behavioral traits in companion or service dogs.
Lei Zhang receives $1 million grant to study epigenomic analysis of premature aging syndromes, exploring DNA damage's role in aging. The award supports GerOmics research, a rapidly evolving field that combines genomics, epigenomics, and other omics disciplines.
A new study of twins found that consistent exercise can change the molecules in the human body that influence gene behavior, leading to lower signs of metabolic disease. The study suggests that markers of metabolic disease are strongly influenced by how a person interacts with their environment, rather than just their inherited genetics.
Researchers have developed a unique resource for understanding the impact of early life environmental exposures on health. The study, which analyzed data from 1,301 mother-child pairs, identified associations between 92 in pregnancy and 116 in childhood with molecular profiles at different levels.