Articles tagged with Genomic Methylation
Researchers at Salk Institute create a body-wide single-cell atlas of two major epigenetic systems, revealing that cell-type-specific epigenetic features can affect disease risk. The study identifies over 1.36 million differentially methylated regions and 283,606 differential chromatin loops across the human body's cell types.
A recent study reveals that ORC2 subunit regulates epigenetics and gene expression by compacting chromatin and attracting repressive histone marks at some sites, but activating gene expression at others. This regulation also prevents CTCF binding at certain sites, leading to changes in chromatin structure and gene expression.
Researchers developed a new method to measure changes in DNA that can help predict a person's age, focusing on how random chemical tags become over time. The study found that methylation entropy predicted age as accurately as traditional methods, with an average error of just five years.
The study identified over 34,000 genomic regions with distinct ON/OFF methylation patterns, including novel imprinted regions and tissue-specific variability. This atlas provides valuable insights into epigenetic regulation and may help explain the inheritance patterns of genetic diseases such as CHARGE syndrome.
Researchers developed a new tool called SigRM to analyze single-cell epitranscriptomics data, enabling the study of RNA modifications in individual cells. This can provide valuable insights into gene regulation and its impact on health and disease, particularly in complex conditions like cancer.
Researchers at St. Jude Children's Research Hospital have discovered DNA methylation patterns that help identify the root cause of developmental and epileptic encephalopathies, a condition affecting 1 in 590 children. The findings provide a new tool for diagnosing children with DEE and could lead to more effective treatments.
A new study published in Aging explores the potential of three large DNA methylation datasets to identify biological age signals in dogs. The researchers found that biological age methylation clocks are affected by population stratification and require heavy parameterization to achieve effective predictions.
Researchers investigate chemical modifications to genetic regulation mechanisms, finding that Set8 controls gene activity through a mechanism other than histone modification. This study refines our understanding of genetic regulation relevant to human diseases like cancer.
A new study from the Van Andel Research Institute reveals that loss of two key 'protector' proteins, TET and RYBP, transforms healthy lung cells into cancerous ones through epigenetic changes. The research found that deficiency of these proteins leads to widespread aberrant methylation and malignant transformation.
Researchers have identified potential targets for COPD treatment through high-resolution epigenetic profiling of lung fibroblasts. Early epigenetic changes in the genome of COPD fibroblasts may trigger aberrant signaling pathways leading to impaired functions, suggesting new therapeutic avenues.
Researchers found that abnormal methylation processes lead to disruption of gene expression essential for brain development in people with Williams syndrome. The study suggests targeting treatments to correct these disruptions.
Researchers developed a new epigenetic biomarker, GrimAge version 2, which leverages two DNAm-based estimators of plasma proteins to predict mortality risk. The study found that GrimAge 2 outperforms existing clinical biomarkers in predicting mortality across multiple racial/ethnic groups and associations with age-related conditions.
Researchers uncovered distinct DNA methylation profiles in ocean microbes, shedding light on population dynamics and interactions. The study's findings have significant implications for understanding pathogenicity and developing new approaches to monitoring environmental health.
Researchers found that centenarians have a lower epigenetic age than expected, suggesting slowed biological aging. The study used four epigenetic clocks based on small CpG sites to reveal these differences.
Researchers have identified associations between DNA methylation patterns and gene expression levels in children's blood samples. The study provides a powerful tool to understand the link between early environmental exposures, epigenetic changes, and disease.
Researchers at UC Davis MIND Institute found a novel gene linked to autism spectrum disorder in newborns. The study analyzed DNA methylation signatures in the placenta, which reflected fetal brain development and early autism diagnosis.
Researchers discovered that glioblastoma (GBM) causes epigenetic changes in CD4 T-cells, affecting their function and differentiation. The study found significant inter-patient variability in these changes, which could help select patients for immunotherapy.
Researchers found that DNA methylation increases stiffness of DNA, affecting its 3D structure and gene activation. This discovery reveals a cryptic mechanism connecting epigenetic footprinting and gene programming.
A recent study by Duke University researchers reveals that male baboons who attain high social status experience accelerated aging due to the physical and energetic demands of competing for dominance. This is in contrast to humans, where high social status typically predicts better health.
A new study led by University of Maryland researchers found that DNA from tissue samples can be used to accurately predict the age of bats in the wild. The study showed age-related changes to DNA are different between long-lived and short-lived bat species, especially near genes associated with cancer and immunity.
Researchers at the Garvan Institute of Medical Research have discovered a new form of DNA methylation in zebrafish, specifically at TGCT repeats. This discovery could lead to the development of new experimental models for studying how DNA modifications impact human development and disease.
Amanda De La Torre is studying the genome of sugar pines to understand what makes some trees resistant to white pine blister rust. The research aims to find epigenomic changes that can help control external factors and produce resistant trees.
Researchers developed an algorithm that can predict DNA methylation sites throughout the genome using deep learning. This method has been successful in identifying potential therapeutic targets for human diseases and could improve conventional screening methods.
Salk researchers mapped DNA methylation changes over time in mice to better understand developmental disorders. The data help identify regions of the human genome that play roles in diseases such as schizophrenia and Rett Syndrome.
Researchers developed a new set of computational tools to identify cell-type specific methylation patterns, known as molecular barcodes, in complex cell mixtures. These new methods can distinguish between different cell types in tissues made up of multiple cell types.
Researchers at EMBL Rome reveal that protein glycosylation plays a central role in DNA methylation, inducing gene silencing by modifying regulatory factors. This breakthrough sheds light on the mechanism behind the most studied epigenetic modification.
Researchers at St. Jude Children's Research Hospital created an 'atlas' of gene-regulatory mechanisms in immune cells that facilitate Type 1 diabetes. The study revealed a dual biological personality of T cells, enabling them to retain the ability to attack insulin-producing cells across successive generations.
Researchers successfully studied DNA methylation loss in human cells, revealing the activation of transposons that can lead to serious diseases. The study provides new insight into how changes in DNA methylation contribute to diseases and opens up potential for a new understanding of genome function.
Scientists have identified a unique fraction of the genome that can be used to predict epigenetic causes of disease. The 'treasure map' of correlated regions of systemic interindividual variation (CoRSIVs) comprises a previously unrecognized level of molecular individuality in humans, associated with diseases such as obesity and cancer.
A newly discovered rDNA clock can accurately determine an individual's chronological and biological age. The study found that calorie restriction interventions accelerate or slow aging in mice, as well as in humans, making it a potentially widely applicable predictor of individual age.
A new study reveals that male wild guinea pigs pass on epigenetic modifications to their offspring in response to environmental changes, such as diet and temperature. This discovery suggests that fathers play an important role in shaping the adaptability of future generations.
A novel DNA methylation regulator Stella has been identified to safeguard the unique epigenome of oocytes. The dysregulation of Stella results in aberrant DNA methylation during postnatal oogenesis, affecting preimplantation embryo development. DNMT1 is found to be responsible for this aberrant methylation.
Researchers from the University of Cambridge found that epigenetic marks are reprogrammed from one generation to the next, contradicting previous theories. Only a small percentage of variably-methylated transposable elements showed evidence of epigenetic inheritance.
Scientists have discovered how epigenetic marks behave in the first few days after conception, shedding light on their role in shaping later health. The study found that these marks are sensitive to external environmental factors and may be linked to adverse health outcomes in later life.
Researchers at Salk Institute identify a small family of proteins controlling DNA methylation marks, crucial for gene regulation. This discovery sheds light on epigenetic mechanisms in plants and animals, potentially leading to new strategies for correcting genetic defects associated with diseases like cancer.
Researchers found that the offspring of elderly mouse-fathers had a shorter lifespan and featured exacerbation of histopathological and molecular aging traits. Epigenetic changes in paternal sperm and offspring were also observed, suggesting intergenerational influences on aging processes.
New findings help clarify genetic influence on brain disorders by analyzing 3 million genomic locations, revealing links to schizophrenia and other disorders. The study identifies specific variable locations in the genome that affect gene expression and DNA methylation.
Temple researchers discover that calorie restriction slows down epigenetic drift, which is associated with lifespan across species. The study reveals that the speed at which epigenome changes with age varies among species and that a slower rate of change is linked to longer lifespan.
Researchers have identified a new major gene expression regulator in fungi, which is preferentially deposited based on gene function and conservation. The discovery was made using DNA sequencing data from 16 fungal genomes, revealing high levels of DNA base modifications, including the methyl group addition to adenine (6mA).
A new study from Karolinska Institutet reveals that certain 'master' regulatory proteins can activate normally inactive genome regions due to epigenetic changes, leading to embryonic development and cancer. The findings contribute to a better understanding of gene regulation and its role in diseases.
Researchers analyzed DNA methylation levels in 1,900 participants to identify 58 CpGs linked to mortality. These epigenetic marks show stronger correlations with survival than previously studied genetic alterations.
A preliminary study found that biological age is a better predictor of stroke recovery than chronological age. Researchers analyzed DNA structure changes to estimate biological age and found that it's an important factor in patient recovery after stroke.
A recent study has identified signatures of ethnicity in the genome that reflect shared culture and environment rather than genetic ancestry. The researchers found that only three-quarters of epigenetic differences between Mexican and Puerto Rican children could be accounted for by genetic ancestry, suggesting a biological stamp made b...
Researchers have found an epigenetic mechanism implicated in the regulation of blood sugar, with the TXNIP gene associated with diabetes mellitus type 2 and poor glucose control. The study's results could help identify patients at risk of developing diabetes and develop new therapies.
Scientists have identified a new type of epigenetic modification that directly affects the base A in human and mouse DNA. This discovery suggests that many more DNA modifications exist than previously thought, which could impact gene regulation and human health.
Researchers have mapped the wheat epigenome, identifying patterns of DNA methylation that regulate gene activity. This discovery could lead to improved crop breeding technologies and a better understanding of genetic variation in wheat.
A team of scientists has identified a key segment of DNA involved in the genomic imprinting process, which regulates gene expression based on an individual's parental origin. This discovery provides new insights into the mechanisms underlying imprinting disorders and may lead to breakthroughs in understanding genetic diseases.
Research at ASHG 2015 Annual Meeting found that smoking and heavy alcohol use cause epigenetic changes reflecting accelerated biological aging. Moderate alcohol consumption was surprisingly correlated with the healthiest aging outcomes.
Researchers developed an epigenetic algorithm that accurately predicts male sexual orientation by analyzing DNA methylation patterns in nine specific regions of the genome. The algorithm achieved a 70% accuracy rate in predicting male sexual orientation, providing new insights into the molecular markers underlying human sexuality.
A new study reveals that long-term endurance training affects thousands of DNA methylation sites and genes associated with improved muscle function and health. The research also found epigenetic differences between male and female skeletal muscle, which may lead to gender-specific therapies in the future.
The black truffle genome contains a high rate of methylation, with transposon elements being more likely to be methylated than genes. Reversible epigenetic processes allow the truffle to adapt to its surroundings, increasing its plasticity and potentially playing a role in controlling traits like aroma and color.
Researchers from Children's Hospital Oakland Research Institute successfully mapped genome methylation in the fruit fly Drosophila melanogaster. The study, published in Genome Research, found that DNA methylation occurs at specific short motifs and is independent of DNMT2 activity.
A NIH study reveals that age-related DNA methylation changes may contribute to increased cancer incidence. The researchers identified sites across the human genome that become increasingly methylated with advancing age and are also disproportionately methylated in various human cancers.
Researchers have discovered that 37% of the placental genome has regions of lower methylation, called partially methylated domains (PMDs), where gene expression is turned off. This could enhance our understanding of epigenetics and its impact on human development, cancer research and autism.
A study by University of California, San Diego researchers describes markers and a model that quantify how aging occurs at the level of genes and molecules. The findings provide a way to determine a person's actual biological age from just a blood sample.
Researchers identified a DNA methylation site that can detect ovarian cancer recurrence in blood samples, offering potential enhancement to existing biomarkers. This epigenetic marker may help monitor disease status after surgery and improve detection of the disease.
A study by CSHL and USC researchers reveals that methylation patterns are dynamic and can influence cell fate. The team observed that subtle changes in methylation within specific regions can lead to the activation of genes associated with particular cell types, challenging traditional views on epigenetics.
Scientists discovered that epigenetic modifications in plants, such as DNA methylation, are unstable and often disappear after a few generations. These changes can occur frequently but usually do not contribute significantly to long-term evolution.
The study reveals that methylation changes in humans and chimps have co-evolved over 6 million years, driving changes in DNA sequences and characteristics. This finding challenges the conventional understanding of how methylation affects gene expression.
Researchers discovered a new genetic signature that correlates strongly with autism and involves the way genes are turned on and off. The finding may suggest new approaches to diagnosis and treatment of autism, potentially identifying individuals who will respond better to oxytocin treatment.