Articles tagged with Regulatory Networks
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers created an 'encyclopedia of sugar utilization pathways' in 263 Bifidobacterium genomes. This resource helps predict which strains thrive in different conditions, enabling personalized probiotics to match children's lifestyles and dietary needs. The study suggests a potential solution to improving outcomes for preterm infants.
A team of researchers found that a gene regulatory network in gut microbes plays an auxiliary role in bacterial fitness and adaptability. By maintaining basal levels of genetic activity, the network allows bacteria to adapt to their constantly changing environment.
Researchers developed a new tool called SigRM to analyze single-cell epitranscriptomics data, enabling the study of RNA modifications in individual cells. This can provide valuable insights into gene regulation and its impact on health and disease, particularly in complex conditions like cancer.
Researchers found that blood cancer cells rewired their gene regulatory networks to evade drug treatment in Acute Myeloid Leukemia (AML), disrupting normal differentiation and growth. The study identified key findings, including changes in open chromatin regions and the loss of binding of RUNX1 and AP-1 transcription factors.
A study published in Nature Communications reveals a cellular signaling pathway that promotes heart cell survival. The Mst1-FoxO1-C/EBP-β interaction stimulates protective mechanisms in cardiac myocytes, potentially paving the way for new therapies.
Researchers have developed a smart RNA capable of regulating gene expression in response to various signals, enabling the precise design of gene therapies and advanced personalized treatments for diseases.
Researchers investigate gene preservation after loss of male traits in stick insects and find that genes involved in multiple biological processes are more likely to be maintained. This suggests that the molecular ground plan for the lost male reproductive process may persist due to pleiotropic effects on other traits.
Researchers create largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. The study uses postmortem brain tissue from over 2,500 donors to map gene regulation networks across different stages of brain development and multiple brain-related disorders.
A Kyoto University research group developed RENGE, a computational model to estimate gene regulatory networks in multicellular organisms. The method measures time-series gene expression and uses the proprietary model to infer regulatory dynamics.
Researchers uncover intricate interplay between enhancers and silencers influenced by DNA methylation, providing crucial insights into dynamic gene control. High-resolution mapping reveals how genes are controlled and modified, paving the way for precision medicine tailored to individual patients.
Researchers from Austria and France join forces to unravel the secrets of gene regulation during mammalian development using stem cell-derived 3D culture models. The project aims to understand how key molecular events influence gene transcription and regulation over hours and days.
Researchers at Penn State discovered that bioluminescent bacteria use a small RNA molecule called Qrr1 to coordinate their behavior and colonize the squid's light organ. This mechanism is likely widespread among bacteria, enabling them to exploit quorum sensing pathways.
A new study explores the genetic mechanisms underlying honey bee colony defense and aggression, revealing that gene regulation influences collective behavior and division of labor. Researchers found that brain gene regulatory networks differ between soldiers and foragers, particularly in more aggressive colonies.
Researchers have identified two novel DOF family transcription factors that enhance wheat regeneration and genetic transformation. These findings provide new insights into the transcriptional regulatory network involved in boosting wheat regeneration, offering opportunities for improving crop improvement.
A study published in Circulation Research identifies the FHL5 gene as a key regulator of vascular disease, including heart attacks and aneurysms. The discovery advances our understanding of the underlying causes of vascular disease and provides new insights into genetic risk factors.
Researchers have identified a gene network underlying rice grain size regulation, revealing a phosphorylation-driven auxin signaling pathway. The study found that OsTIR1–OsIAA10–OsARF4 plays a crucial role in controlling rice grain size and weight.
Researchers at Dartmouth Cancer Center developed a new approach for detecting and quantifying tumor heterogeneity in breast cancer. High levels of heterogeneity are linked to poor patient outcomes, while specific proteins regulate its extent. The study aims to utilize this approach in therapeutic decision-making.
Researchers created a detailed map of how immune genes function together, shedding light on the basic drivers of immune cell function and immune diseases. The study found interconnected regulatory networks that can help explain why mutations in different genes lead to the same disease or how drugs impact multiple immune proteins.
Researchers have identified a regulatory network controlling zinc accumulation in marine cyanobacteria, allowing them to vary their internal zinc levels by over two orders of magnitude. This network is unique among bacteria, enabling the extraordinary capacity to accumulate zinc.
Researchers found that butterfly eyespots evolve from a pre-existing gene regulatory network used to build antennae, legs and wings. The study discovered specific genes and regulatory connections underlying the development of complex traits.
Researchers at JGI have developed a new protocol to study the effects of genetic variations on traits, using DNA affinity purification sequencing technology. The protocol allows for rapid capture of transcription factor binding locations in the genome, providing insights into gene regulation and function.
Researchers from the IPK Leibniz Institute identified regulatory networks and signalling pathways controlling barley floral meristem development. The findings provide a deeper understanding of spikelet formation and offer an important tool for future studies.
An interdisciplinary team of biologists and computational researchers designed a neural network named BPNet that can interpret regulatory code by predicting transcription factor binding from DNA sequences with unprecedented accuracy. The model revealed novel insights, including a rule governing the binding of the well-studied transcrip...
Two studies published in Genome Research provide new insights into the core regulatory networks governing cell types across different vertebrate species. The research highlights the importance of understanding RNA expression in establishing cell function, morphology, and behavior. Long non-coding RNAs were found to affect cell growth a...
Researchers at Penn State College of Medicine developed a new method to model gene interactions and predict changes over time. The idopNetwork can create personalized networks for individual patients, showing complex gene connections and predicting outcomes.
A study has identified TCF4 as a master regulator of schizophrenia during early human brain development. The gene is believed to play a crucial role in the disease's underlying genomic biology. Researchers hope that this discovery will pave the way for new treatments and precision medicine approaches.
The study identifies nine master regulators controlling key pathogenic pathways in Pseudomonas aeruginosa, offering potential targets for new antibiotics. An online platform and R package have also been developed to facilitate the analysis of the regulatory network.
Researchers at Monash University have identified two new epigenetic regulators, TAF5L and TAF6L, that maintain the self-renewal of embryonic stem cells by activating the oncogene c-Myc. These findings have significant potential for regenerative biology and cancer research.
Researchers at NC State University have identified a complex transcriptional regulatory network that regulates wood formation in woody plants. The study reveals novel interactions between key transcription factors and genes, providing insights into the regulation of lignin biosynthesis and its relation to disease resistance.
Researchers discovered that brain-enriched miRNA (miR-124) plays a crucial role in neuronal survival, contrary to previous assumptions. The study identified 98 miR-124 targeted genes that have direct physiological functions, protecting neurons from death.
Researchers discovered that highly robust regulatory proteins can acquire binding to new promoters in response to mutations, challenging the long-held assumption that robustness and evolvability are mutually exclusive. This finding has significant implications for understanding gene regulation and evolution.
A team of biologists and computer scientists have developed a time-based machine-learning approach to understand the temporal logic of nitrogen signaling in plants. This discovery has significant implications for global food production and sustainable agriculture by potentially offering new ways to monitor and enhance crop growth using...
By analyzing regulatory networks for 38 tissues, researchers found that core components are combined differently with added genetic and environmental information, governing unique tissue functions. This work emphasizes the need to consider tissue context when developing therapies to minimize potential side effects.
Researchers have developed a method for autonomous learning in self-taught systems, allowing them to evolve and adapt over time. This approach, which incorporates delayed dynamics and feedback loops, has been successfully applied to neural networks and phase oscillators, yielding robust performance with minimal external control.
Researchers developed new tools to infer context-specific regulatory networks from paired expression and chromatin accessibility data. This approach recovers significant information on binding locations and chromatin states, enabling accurate inferences for gene regulatory relationships.
A research team has identified the HAND2 gene as a key regulator that triggers the formation of cardiac valves in mouse embryos. This discovery advances our molecular knowledge of cardiac valve development and may also help provide genetic diagnosis for patients with congenital heart malformations.
Researchers at Michigan State University have discovered that DNA's regulatory regions resemble a poetic language, composed of coding and regulatory elements. By analyzing variants of a key protein and applying mathematical models, the team was able to identify conserved properties in other sequences, enabling them to 'read' the genome.
Researchers at Tufts University developed an algorithm that used evolutionary computation to predict the results of published laboratory experiments on planarian regeneration. The approach identified a comprehensive regulatory network that correctly predicted all 16 key experiments, shedding light on the mechanisms behind head-tail pat...
A study by the Stowers Institute for Medical Research reveals that the sea lamprey, a jawless vertebrate, exhibits a pattern of gene expression reminiscent of its jawed cousins, indicating that the genetic program used by jawed vertebrates was up and running ages before they possessed recognizable faces. This finding suggests that regu...
A Rice University study found that regulatory patterns in E. coli cells can arise from mutation, genetic drift, and neutral evolution, challenging the idea that environmental factors drive such patterns. The researchers generated computer models of random regulatory networks, which evolved through millions of generations without progra...
A feasibility study suggests that UK price cap regulations for tobacco could raise £500 million every year, which is enough to fund smoking cessation services in England and anti-smuggling activities UK-wide. The proposed regulation would expose companies to stricter scrutiny, curb marketing to the young, and reduce lobbying efforts.
The ENCODE project has assigned biochemical functions to 80% of the human genome using data from 1,649 experiments. The team identified over 4 million sites that affect biological function through binding specific proteins. These findings provide a critical map of tens of thousands of genes and regulatory switches.
Biologists at Caltech created a computational model of gene networks that control the development of sea-urchin embryos. The model accurately reproduces experiments and allows for virtual experiments, revealing unprecedented detail about gene regulatory networks.
Researchers at RIKEN successfully developed a new experimental technique for producing cells with specific functions by reconstructing transcriptional regulatory networks. This technique enables faster and more efficient production of functional cells for cancer therapy and other applications.
New York University and University of Iowa biologists have identified a critical protein called Zelda that orchestrates gene networks in an exquisitely coordinated fashion. The researchers found that Zelda is essential for the proper order of gene interactions, leading to drastic changes in body plan formation if absent.
A research team at Caltech has outlined exactly how specific sets of cells in sea-urchin embryos differentiate to become the endoderm, the early domain of the embryo that eventually forms the gut. They found that certain regulatory genes are expressed in the cells of each domain and that this process is dynamic, with gene expression ch...
Researchers have discovered a gene regulatory network structure, 'medusa,' that governs gene expression profiles in cancer cells. Transcription factors play a central role, controlling the collective activity of thousands of genes.
A new study finds that corruption can help companies develop organizational capabilities to operate successfully in corrupt environments, leading to more success when investing internationally. The study identifies various strategies firms use to capitalize on corruption, including political networking and joint venturing.
Recent meetings discussed regulatory challenges for dengue vaccines, including issues with funding, ethics and trials. A registry has been established to track systematic reviews, promoting transparency in healthcare decision-making.
In complex organisms, regulatory networks are more democratic and collaborative, with master regulators controlling middle managers governing workhorse genes. These systems tend to be less autocratic, instead relying on mutually supporting partnerships for stability.
Scientists from University of Wisconsin-Madison present a new model of stem cell regulation in Caenorhabditis elegans, balancing stem cell maintenance and differentiation. The regulatory network defines two states - stem cell state and differentiated state - and regulates their balance.
Researchers at Caltech have discovered intricate gene regulatory networks in various organisms, including fruit flies, nematodes, sea urchins, lampreys, and mice. These networks play a crucial role in directing developmental processes, with subtle balances of regulatory signals being essential for proper cell differentiation.
Scientists have identified intricate biochemical networks involving a class of proteins that enable genes to express themselves in specific tissues. The discovery sheds light on gene regulation and its relevance to human diseases, including developmental illnesses such as autism and heart disease.
Researchers have made significant progress in understanding the complex metabolic networks involved in tomato fruit development. By analyzing over 1200 quantitative metabolic loci (QMLs), scientists identified associations between metabolites and genes that regulate fruit metabolism. This knowledge can be used to alter metabolic pathwa...
A study published in PLOS Biology reveals that multiple Arp2/3 regulatory proteins play distinct roles in regulating actin networks, which are crucial for cellular processes such as cell migration and intracellular transport. The research provides new insights into the coordination of protein activities to generate complex actin networks.
Researchers found that ancient retroviruses helped shape p53, a master gene regulator in primates, by inserting DNA sequences and rearranging the genome. This discovery provides new insights into how gene regulatory networks evolved in humans and other primates.
Genomatix Software GmbH has won a $1.6 million BioChance grant to research RNAi mediated regulatory networks. The two-year project will expand its competence in this field, complemented by academic partners from LMU Munich and DKFZ Heidelberg.
Researchers at UCSD found that E. coli exhibits only six distinct functional states regardless of the carbon source or electron acceptor used, suggesting a surprising level of simplicity in its metabolic processes. The study suggests that this principle may be generalizable to other species.
Yale researchers developed a complex map of regulatory networks governing protein kinase activity in yeast cells. The study reveals distinct patterns and provides insights into the coordination of proteins to carry out complex biological functions.
The team developed a genome-scale computational model of gene regulation in E. coli, uncovering surprising new details about how the cell responds to oxygen deprivation. The model includes 1,010 genes, including 104 regulatory genes, which regulate the expression of 479 genes involved in metabolism.