Articles tagged with Antibody Therapy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have developed a new type of precise therapeutic vaccine against leukemia utilizing self-healing polylactic acid microcapsules. The vaccine co-encapsulates a new epitope peptide and PD-1 antibody, demonstrating superior performance over commercialized adjuvants in various models.
Researchers at Pohang University of Science & Technology developed a novel immunotherapy platform called imuGlue, which connects mussel adhesive proteins to antibodies used in immune checkpoint inhibitors.
Researchers develop a combination therapy using near-infrared light-induced heat and anti-CD47 antibody to enhance cancer treatment. The treatment promotes local and systemic anticancer immune responses, showing great potential for solid tumors.
Researchers at University of Pittsburgh isolated the smallest biological molecule to date that neutralizes SARS-CoV-2. The tiny antibody component, known as Ab8, is 10 times smaller than a full-sized antibody and has been shown to be highly effective in preventing and treating SARS-COV-2 infection in mice and hamsters.
Researchers at the University of Texas at Austin have developed an antibody test for COVID-19 that is highly accurate and can handle a large number of donor samples. The test measures antibodies against specific proteins on the virus's spike protein and has been shown to be comparable to the gold standard of antibody testing.
Scientists have observed interaction between therapeutic antibodies and target protein for first time, describing molecular mechanisms. This discovery opens way to development of new synthetic antibodies controlling patient's immune response.
Researchers have discovered that a single molecular descriptor can predict the solution behavior of therapeutic antibodies with greater than 90% accuracy. This finding could enable faster and more efficient drug development for monoclonal antibody-based therapies.
Researchers at Mayo Clinic have found that investigational convalescent plasma is safe to use in a diverse group of 20,000 patients, with a significant decline in seven-day mortality rates compared to previous studies. The study also found lower serious adverse events and a more rapid availability of plasma for treatment.
A team of researchers at the University of Maryland School of Medicine has developed a potent antibody cocktail that can treat COVID-19 by targeting the virus's spike protein. The cocktail will be tested in a clinical trial to evaluate its effectiveness in improving patient outcomes.
Researchers have identified pairs of highly potent individual antibodies that can simultaneously bind SARS-CoV-2's spike protein, increasing chances against 'virus escape mutants'. The double-antibody approach aims to minimize odds of virus escape and deliver optimal antiviral potency.
A randomized trial found that rituximab reduces the risk of relapse by 64% compared to azathioprine, with fewer severe adverse events. The study suggests that rituximab may be a superior treatment option for patients with ANCA-associated vasculitis, particularly those with history of relapses.
A monoclonal antibody targeting mutant huntingtin protein effectively binds and depletes the protein from cell culture supernatants, blocking its secretion and uptake. This suggests that mAB C6-17 could interfere with pathological processes of mutant huntingtin spreading in vivo.
Two neutralizing antibodies, B38 and H4, have been identified against SARS-CoV-2. Preliminary tests in a mouse model show reduced virus titers, suggesting therapeutic benefits and potential for vaccine development.
A new approach using harmless viruses to deliver antibody genes has led to sustained production of HIV antibodies for over a year in a NIH clinical trial. The technology shows promise for preventing and treating various infectious diseases with further development.
Researchers have found that combining two anti-HIV antibodies with ART can suppress the virus and boost T cell responses, offering new hope for HIV treatment. The study suggests a potential interaction between humoral immunity and cell-mediated immunity, which could lead to improved control of the virus.
A new non-invasive imaging technique using 89Zr-immuno-PET can measure target engagement of therapeutic antibodies in tumors, enabling personalized treatment. This method provides a significant advance over current invasive methods and has important implications for patient care.
Researchers at Boston Medical Center identified specific virus characteristics that can help predict the efficacy of HIV-1 treatments using antibody-based treatments. These findings will enable physicians to make better-informed decisions on treatment plans for patients with HIV-1, ultimately treating the virus to slow it down earlier.
Antibodies recognize viruses and cancer cells via Fab arms, but now researchers know the Fab portion also directly binds to Fc receptors. This discovery opens up a new strategy for developing therapeutic antibodies with enhanced binding properties.
A novel antibody-enzyme fusion has virtually eliminated Lafora bodies in LD mouse brains, restoring normal brain metabolism. The therapy has potential treatment applications beyond Lafora Disease, including other glycogen storage diseases.
Scientists developed a tumor-activatable antibody nanoparticle to overcome immunological tolerance in tumors. The nanoparticle releases PD-L1, triggering tumor antigen release and CTL infiltration, leading to efficient antitumor immunity and long-term immune memory effects.
Scientists have developed edible antibodies that can survive digestion and reach the gut, offering an alternative to traditional treatments. The technology has potential applications in fighting gut infections, treating inflammatory disorders, and preventing diarrhea in pigs and humans.
Researchers have identified an association between a MUC5B gene variant and systemic vasculitis, a lung disease prevalent in the Japanese population. The study found that patients with antineutrophil cytoplasmic antibody-associated vasculitis are more likely to have ILD if they carry this specific genetic variation.
The company has isolated rare inhibitory MAbs against CB1 using its MPS Antibody Discovery platform, offering a therapeutic solution for NASH. With over 10 million people affected in the US, this development could bring new hope to those suffering from liver disease and metabolic disorders.
Researchers at the University of Turku developed an immunotherapeutic antibody therapy that re-educates tumour-associated macrophages to activate cytotoxic T cells. The therapy showed promising results in a phase I/II clinical trial, inhibiting cancer progression and increasing activation of killer T cells.
Researchers at The Wistar Institute developed novel synthetic DNA-encoded monoclonal antibodies targeting PCSK9, which significantly reduced cholesterol levels in preclinical studies. This approach may provide a less frequent and cost-effective alternative to statins for treating high cholesterol and reducing cardiovascular risk.
Researchers found that a combination of multiple antibodies targeting distinct regions of HIV can suppress the virus and prevent resistance. In a pilot clinical trial, participants who received infusions of broadly neutralizing antibodies maintained viral suppression for over 15 weeks after stopping antiretroviral therapy.
Scientists have discovered a set of powerful broadly neutralizing antibodies in the blood of Ebola survivors, providing substantial protection against disease caused by three Ebola virus species. The researchers hope that these antibodies will serve as promising candidates for further development as therapeutic molecules.
Researchers at the University of Helsinki have identified a monoclonal antibody that inhibits capillary leakage in sepsis. The antibody targets β1-integrin, a key molecule in endothelial cells, and improves junctions between endothelial cells, decreasing vascular leakage and protecting against sepsis-induced heart failure.
A collaborative study led by the University of Miami Miller School of Medicine found that a monoclonal antibody cocktail therapy was effective in clearing the virus from pregnant women's blood but failed to prevent fetal transmission and treat infected fetuses. Researchers are now working on engineering antibodies to target the fetus.
Researchers develop therapeutic antibodies targeting the C-terminus of Sonic hedgehog, a protein involved in tissue homeostasis and repair. These antibodies show promise in inhibiting cancer cell growth and tumor formation in preclinical models.
AbeXXa Biologics has partnered with global pharmaceutical company Boehringer Ingelheim to develop a novel approach to cancer immunotherapy. The partnership aims to create personalized therapies tailored to each patient's tumor using atypical HLAs, which have less variability than classical HLAs.
Researchers from Osaka University have identified an antibody that alleviates symptoms in neuromyelitis optica in rats by suppressing RGMa. The study uses a new localized animal model to investigate the correlation between inflammation and motor function disruption.
Scientists at UTHealth and UT Health San Antonio are developing an innovative antibody-based drug to stem the spread of breast cancer to bone, linked to reduced survival rates. The goal is to create a less toxic treatment and reduce deaths tied to breast cancer's spread.
Researchers have developed a new leukemia therapy that combines inhibitors with immune therapies to eliminate cancer cells, showing promising results in preclinical trials. The combination of treatments worked better than using one active substance alone.
Researchers developed an efficient method to produce antibodies that can bind to two different target molecules simultaneously, enhancing cancer immunotherapy. The new approach uses a modified IgG antibody structure with only four key changes, allowing for more versatile formats and improved stability.
Researchers at The Wistar Institute have developed a gene-based delivery system that instructs the body to generate therapeutic antibodies against cancer cells. This technology has shown promising results in treating prostate cancer by binding to cancer cells and recruiting immune cells, resulting in tumor shrinkage and improved survival.
Researchers found that co-administering an antibody that neutralizes tumor-released soluble MHC I chain-related molecule (sMIC) improves anti-CTLA4 therapy effectiveness and reduces treatment-related colitis. The combination therapy dramatically improves CTLA4 therapy response and avoids colitis, suggesting a new powerful immunotherapy...
Researchers discovered that tumor-associated macrophages steal checkpoint blockade antibodies from T cells, leading to improved responses in mouse models. Blocking FcγR receptors allows checkpoint inhibitors to effectively target cancer cells.
Researchers have explored the potential of this novel therapeutic approach, demonstrating promising pre-clinical data with over 40 scientific papers. Vectored-antibody delivery using rAAV offers advantages in treatment of various chronic and infectious diseases.
Researchers have discovered an antibody that can detect tau in the serum of patients with tauopathies, a neurodegenerative disorder characterized by toxic protein clumps. The antibody, HJ8.5, has shown promise in increasing tau levels in human patients and mouse models, potentially paving the way for new treatments.
Researchers have developed a new method to create antibodies with consistent sugar groups, enhancing their ability to signal the immune system. This breakthrough could lead to more effective therapies for cancer and autoimmune diseases, with the potential for customized antibody production.
A team from the University of Pennsylvania has demonstrated a new method to deliver safer and more cost-effective therapeutic antibodies using messenger RNAs. The technique involves injecting modified mRNAs into cells, which then produce the therapeutic proteins in a controlled manner.
Researchers have identified a specific site on the surface of the human astrovirus that can be targeted for development of a vaccine or antiviral therapy. By binding to this site, neutralizing antibodies can block the virus's ability to infect human cells, providing a potential roadmap for treatment options.
Researchers developed a neurodevelopmental chick model that demonstrates fetal death and brain damage similar to microcephaly caused by the Zika virus. The study suggests that identifying critical windows of susceptibility could lead to therapeutic innovation.
Research on therapeutic antibodies for spinal cord injury reveals potential applications in myelin repair, neuroprotection, axon outgrowth, and anti-immune reaction. Several antibodies are reviewed as reagents to promote neurite outgrowth and inhibit immune responses.
Selecta Biosciences' synthetic vaccine particles have been shown to induce antigen-specific immune tolerance, mitigating the formation of anti-drug antibodies and improving the efficacy and safety profile of biologic drugs. The technology has potential applications in treating rare diseases, allergies, and autoimmune diseases.
Researchers found that combining anthrax toxin proteins with chemotherapy drugs can selectively target blood vessel cells feeding tumors, reducing tumor growth. The treatment regimen showed durable anti-tumor effects in mice, warranting further exploration for cancer therapy.
Scientists at Aarhus University used X-rays to study eculizumab's mechanism. They found the antibody creates a physical barrier preventing C5 cleaving enzymes from forming contacts.
A research team has identified a new group of powerful antibodies to fight Ebola virus, isolated from the blood of a survivor of the 2014 Ebola outbreak. The antibodies showed significant protection against the virus in mouse models and could guide the development of a vaccine or therapeutic.
Researchers at Adimab isolated a broad panel of neutralizing anti-Ebola virus antibodies from a survivor of the 2014 outbreak. The study highlights the speed and effectiveness of Adimab's single B cell isolation platform, which was able to identify over 300 monoclonal antibodies within weeks of receiving a blood sample.
Researchers developed an antibody targeting a hormone in adipose tissue called aP2 to improve glucose regulation and reduce liver fat in obese mice. The study found that one of the antibodies effectively improved glucose regulation in two independent models of obesity, with beneficial reductions in liver fat.
Researchers discovered that anti-PlGF antibody treatments, such as aflibercept, may slow the progression of dry age-related macular degeneration. The study found that PlGF actually worsened retinal damage in mice, but an anti-PlGF treatment provided protection against light-induced degeneration.
Researchers discovered a malaria protein that binds to a common sugar molecule found on both placentas and cancer cells. A novel technology was developed to arm antibodies with high potency toxins to specifically kill cancer cells, showing promising results in clinical trials.
A novel two-hit therapy combining an immune-molecule-based mop-up therapy with a pathway-disabling approach eradicates specific breast tumors in mice. This therapy has the potential to reduce treatment costs and increase effectiveness for Her2-positive breast cancers.
Researchers developed targeted therapy using immunoglobulin-A antibodies to neutralize specific receptors in polycystic kidneys. The strategy enables repurposing of existing monoclonal antibodies for PKD therapy, opening up new class of therapeutics.
Zhiqiang An received a grant to research how tumors evade therapy, aiming to develop countermeasures for improved immunotherapy success and reduced mortality. The focus is on a type of leukemia affecting tens of thousands in the US.
Dr. Qizhen Shi's team aims to investigate a novel gene therapy approach that induces immune tolerance for hemophilia A, overcoming the challenge of inhibitory antibodies. The project seeks to develop a clinically translatable gene therapy protocol that provides therapeutic FVIII protein.
Researchers at Rockefeller University have discovered two antibody-binding receptors on immune cells that work together to kill tumors and create a memory of them. The study found that targeting specific antigens with antibodies can lead to the formation of immunological memory, which can suppress future tumor growth.
Researchers found that camel antibodies protected uninfected mice from MERS and helped infected mice expunge the disease. The study suggests these antibodies might be therapeutic for MERS patients and protect uninfected household members and healthcare workers.
Scientists have identified antibodies isolated from individuals with seasonal flu vaccinations that neutralize H7N9 and other influenza strains, providing broad protection. These antibodies account for a small percentage of the total immune response but show promise as potential therapeutics.