Alzheimer Disease
Articles tagged with Alzheimer Disease
Blood-based 'ageing clock' predicts dementia risk and earlier onset
Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging
Alzheimer's therapeutic breakthroughs may be financially inaccessible, warns Trinity College Dublin
Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging
The APOE2 gene variant is linked to exceptional longevity and reduced Alzheimer's risk, thanks to its ability to help human neurons keep their DNA intact and resist cellular senescence. This study reveals a previously underappreciated function of the gene, shifting attention away from its role in cholesterol transport.
Cardiovascular and metabolic diseases are primary drivers of excess US deaths compared to other high-income countries
New study finds higher dementia risk in insulin-requiring diabetes
Researchers discovered new therapeutic targets for lithium in Alzheimer’s disease
A study from the University of Eastern Finland reveals that lithium chloride may affect various cellular level changes in Alzheimer's disease, including Tau phosphorylation and Rho GTPase signaling. The researchers identified new AD-relevant phosphosites affected by lithium chloride treatment.
At-home blood test and brain testing could screen people for dementia risk
A new study found that at-home blood tests combined with online brain tests can accurately predict dementia risk. The study used a finger-prick blood test and performance on brain tests to categorize participants into low, medium, or high risk groups.
Study: Egg consumption is associated with a lower risk of Alzheimer’s Disease
A study published in the Journal of Nutrition found that moderate egg consumption is associated with a lower risk of Alzheimer's disease. Researchers discovered that eating one egg per day for at least five days a week reduces the risk of Alzheimer's by up to 27%.
FAU review: Obesity and Alzheimer’s linked by disease-driving metabolic pathways
A review from Florida Atlantic University links obesity to Alzheimer's disease through disruptions in metabolism, highlighting the importance of mitochondrial function and gut-brain axis balance. Early detection and whole-body prevention may become possible through monitoring metabolic health.
Inexpensive material compresses light, paving the way for photonic microcircuits in the terahertz range
Researchers developed a new photonic material using lead iodide, enabling high-speed data transmission in the terahertz frequency range. The material confines light within submicrometer regions, paving the way for integrated photonic circuits that could replace or complement electronic circuits.
Anne Bang joins $13M research project on age-related RNA pollution and brain degeneration
Researchers studying RNA pollution's impact on aging brains seek to develop therapeutic strategies for neurodegenerative diseases like Alzheimer's. Sanford Burnham Prebys scientist Anne Bang will use advanced robotics to test thousands of compounds.
At what age does Alzheimer’s disease begin? Mayo Clinic study points to changes decades before symptoms
A new study from Mayo Clinic suggests that Alzheimer's disease may start as early as the late 50s, with subtle biological changes accelerating over time. Researchers analyzed data from 2,082 participants and found that biomarkers of tau pathology and neurodegeneration show more pronounced increases around ages 68 to 72.
Scientists map ‘energy network patterns’ in brain to track Alzheimer’s disease across disease spectrum
Researchers at Indiana University School of Medicine developed a new method to analyze brain energy network patterns, revealing insights into Alzheimer's disease progression. The study found that brain networks reorganize as the disease progresses, with memory and language functions showing increased metabolic demand in early stages.
Hydraulic brain: Body motion linked to fluid movement in the brain
A study using mice and simulations found that abdominal contractions compress blood vessels connected to the spinal cord and brain, enabling gentle brain movement that facilitates cerebrospinal fluid flow and potentially removes neural waste. This mechanism may explain why exercise is thought to benefit brain health.
UT Health San Antonio researchers awarded grant to study how circadian rhythm disruptions may contribute to Alzheimer’s
Researchers investigate how environmental stressors like jet lag and high-fat diets affect Alzheimer's risk. They aim to determine if restoring metabolic rhythms can prevent the progression of the disease, taking a holistic view of health and natural rhythms.
Study sheds new light on impact of Alzheimer’s screening for caregivers and family members
A randomized clinical trial examined the impact of Alzheimer's disease and related dementias (ADRD) screening in older adults on family members. The study found that primary care screenings did not worsen quality of life, depression, or anxiety over two years.
MIT-based team releases first AI foundation model for Alzheimer's prevention
FINGERS-7B integrates lifestyle, clinical, genomic, and proteomic data to discover multi-omic biomarkers for preclinical Alzheimer's. The model delivers 4× more accurate preclinical diagnosis and 130% better responder stratification than prior art.
Study finds three distinct patterns of cognitive decline in Alzheimer’s disease
Researchers found three distinct trajectories of cognitive decline: stable, slow and fast decline. Biomarker data showed that participants who declined faster had higher P-tau217 levels and smaller hippocampi.
How a chemical reaction triggers brain inflammation in Alzheimer's disease
Researchers at Scripps Research identify S-nitrosylation of protein STING as driver of chronic brain inflammation in Alzheimer's disease. Blocking this process protects brain cell connections and preserves synapses.
Not all Alzheimer’s leads to dementia
A team of researchers at the Netherlands Institute for Neuroscience discovered that immature neurons in the brain respond differently to damage caused by Alzheimer's disease. In resilient individuals, these cells activate programs to help them survive and cope with damage.
UC San Diego study links diabetes to early Alzheimer’s-related changes in the blood of Latino adults
A UC San Diego study found that diabetes is associated with changes in biological signals in the blood linked to Alzheimer's disease and brain damage in Latino adults. Researchers suggest that metabolic health may play a role in shaping future dementia risk.
Severe strokes linked to 5 times higher dementia risk
A national study found that people with severe strokes have a five times higher odds of developing dementia. Stroke severity also affects thinking and memory after stroke, highlighting the need for close monitoring and treatment of dementia risk factors.
Epigenetic aging linked to MRI signatures of neurodegeneration but not general brain aging
A recent study has found that epigenetic clocks are associated with cognitive impairment and dementia, but only specific epigenetic markers related to smoking exposure are linked to neurodegenerative changes. The study suggests that measures of epigenetic age acceleration capture different aspects of biological aging.
Texas Children’s researcher awarded $6. 7 million NIH grant to accelerate Alzheimer’s drug discovery and advance new therapies
Researchers will use DNA-encoded chemical libraries and artificial intelligence to screen hundreds of millions of potential drug compounds, identifying those most likely to succeed in treating Alzheimer's. The project aims to shorten the timeline for identifying new treatments, bringing them to patients faster and with greater precision.
Scientists map how Down syndrome reshapes brain development before birth
Researchers at UCLA mapped how Down syndrome disrupts prenatal neuron development, leading to cognitive and sensory processing differences. The study found altered developmental sequences and cell populations that may contribute to the condition's effects.
Dopamine deficiency found to drive memory impairment in Alzheimer’s disease
A study led by UC Irvine researchers found that dopamine dysfunction in the entorhinal cortex contributes directly to impaired memory formation in Alzheimer's disease. Restoring dopamine levels using optogenetic techniques and Levodopa restored memory function in a mouse model of Alzheimer's disease.
Digital reminiscence app could reduce grief and improve relationships between dementia patients and caregivers
A web tool called Living Memory Home for Dementia Care Pairs facilitates collaborative reminiscence therapy, reducing feelings of pre-death grief and improving relationship quality. The app promotes well-being and connection between dementia patients and caregivers, leading to better care outcomes.
Shifting the focus to white matter: A small lesion there is sufficient to trigger key features of neurodegenerative disease
Researchers discovered that small lesions in white matter can trigger a response in connected grey matter, leading to neuronal activity fall, microglia activation, and synapse loss. However, this response is part of the repair process, essential for brain regeneration.
Transcranial alternating current stimulation (tACS): Mechanisms and clinical applications in neuropsychiatric disorders
tACS modulates brain oscillations, induces synaptic plasticity, and regulates neurotransmitter release to alleviate symptoms of various neuropsychiatric conditions. Personalized approaches are essential for treatment efficacy.
Early immune changes may signal increased risk of Alzheimer’s and dementia
A new study found that an elevated NLR is significantly associated with both long-term and short-term risk of Alzheimer's and dementia. High NLRs were more prevalent among Hispanic patients and women, suggesting potential genetic or social factors at play.
Study shows links between Alzheimer’s and gut health can lead to prevention
A new study by the University of Technology Sydney and Massachusetts General Hospital/Harvard Medical School found that dietary patterns and a history of appendix removal are strongly associated with Alzheimer's risk. The research suggests that a healthy gut microbiome plays a crucial role in protecting the brain from neurodegeneration.
In Alzheimer’s disease, cancer mutations accrue in brain’s immune cells
Researchers discover cancer-driving genes in microglia of Alzheimer's patients, suggesting a link between blood cancers and the neurodegenerative disease. The findings could lead to new diagnostic tools and therapeutic options for Alzheimer's.
Want to reduce your risk of dementia? Pick up an instrument or take a foreign trip, say Trinity researchers
New research from Trinity College Dublin found playing an instrument, taking a foreign trip, and socializing boost cognition in midlife. Lifestyle interventions can strengthen cognitive reserve decades before disease onset.
Study uncovers hidden factor shaping dementia caregiving stress
A study from Rice University reveals that caregivers' relationships play a crucial role in their mental and physical health. Caregivers who are more self-reliant or emotionally distant experience worse health outcomes, but those with higher relationship satisfaction have stronger buffering effects.
The moment scents disappear, the clock of dementia begins ticking: DGIST identifies the cause of olfactory impairment for the first time
A study by DGIST researchers reveals that the olfactory system is the first to be damaged in Alzheimer's disease due to distinct immune responses in different brain regions. The findings provide new insights into the early warning signs of dementia and potential diagnostic markers.
UCF study suggests some Alzheimer’s symptoms may begin outside the brain
Researchers at UCF used human-on-a-chip technology to study how genetic mutations associated with familial Alzheimer's affect movement. They found that motor deficits may be an early indication of Alzheimer's disease, which could help delay central nervous system symptoms.
Facing Alzheimer’s fear, patients say yes to blood tests
A survey found 84% of primary care patients are unfamiliar with Alzheimer's blood tests, but 85% would take one if recommended. Patients value education and ease of use, and express concerns about test reliability and cost.
Scientists engineer a tool to “edit” brain circuits and enhance memory
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
Anti-amyloid Alzheimer’s drugs show no clinically meaningful effect
A new Cochrane review of 17 clinical trials found that anti-amyloid Alzheimer's drugs have no significant impact on cognitive decline or dementia severity, but may increase the risk of brain swelling and bleeding. The evidence suggests that these drugs are unlikely to provide clear benefit to patients.
New study finds blood test can predict Alzheimer’s disease progression years before symptoms or brain scan changes
Researchers found that a blood test for the biomarker pTau217 can predict the progression of Alzheimer's disease in cognitively healthy adults, detecting early signals years before symptoms appear. The study's findings may help push back the clock to enable simpler and earlier disease prediction.
Scientists reverse brain aging, with a nasal spray
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
High-salt diet linked to faster memory decline in men, ECU study finds
A new study from Edith Cowan University found that higher sodium intake is associated with a faster decline in episodic memory in men. The study of over 1,200 participants suggests that diets high in salt may have broader cognitive impacts than previously understood.
Gender matters in the brain/bone axis. APOE4, the Alzheimer’s risk gene, silently undermines bone quality in women
Researchers discovered that APOE4 causes bone quality deficits specifically in female mice, through a mechanism invisible to standard imaging. The study reveals an unexpected biological link between Alzheimer's risk and skeletal health, pointing to osteocytes as potential early warning signals for both conditions.
USC researchers awarded NIH grant to build a new model of hippocampal neurodegeneration in Alzheimer’s disease
The research team will analyze mouse models and human brain tissue to identify cell types that show early signs of stress before neurons die. The multiscale model simulates how the progressive loss or disconnection of specific neurons disrupts memory-related brain networks.
New drug combination doubles down on Alzheimer's treatments
Researchers at the University of Waterloo have discovered a safer and more effective way to treat Alzheimer's disease by combining anti-amyloid antibodies with molecules found in grapes, berries, peanuts, and turmeric. This combination approach neutralizes amyloid protein clumping in the brain, leading to better outcomes.
In or out? Researchers uncover new controls on the brain’s ‘bouncer’
A team led by Jiefu Li developed a new method to examine proteins lining the inside surface of blood vessels, revealing two proteins and pathways that play a role in opening and closing the blood-brain barrier. This discovery could help scientists understand how the barrier functions and develop better ways to deliver medicines for neu...
Without the right tests, the best medicines make no difference
A new analysis from UC San Francisco argues that diagnostics are being overlooked, slowing progress against major diseases despite advances in targeted therapies. The study suggests that nearly half of the world's population lacks adequate access to diagnostics due to inadequate investment and insurance reimbursement.
Barrow Neuro Analytics Center doubles footprint to support growing neurological research programs
The Barrow Neuro Analytics Center has nearly doubled its dedicated research space to 18,000 square feet, supporting growing neurological research programs. Researchers at the center are globally renowned for their work on Parkinson's disease, Alzheimer's, and other neurological disorders using data-focused methods.
Alzheimer’s-linked protein tau play a role in cell division
A new study by POSTECH researchers found that the protein tau interacts with DNA during cell division, forming condensates that capture microtubules. This interaction affects chromosome alignment and can lead to cellular abnormalities even in healthy cells.
New research shows that tau protein spreads through connected neurons in people with Alzheimer’s disease
A recent study published in Neuron provides new insight into how tau tangles spread from one brain region to another in people with Alzheimer's disease. Researchers found that tau seeds travel along individual's natural communication pathways, influencing the spread of Alzheimer's pathology and suggesting a potential therapeutic target.
CAR therapies for neurodegeneration: a big challenge with increasingly plausible solutions
Researchers propose tailored approaches using CAR platforms, incorporating effector cells like macrophages and Tregs to modulate key processes in neurodegeneration. High-precision immunomodulation is essential for overcoming the complex nature of these diseases.
Healthier plant-based diet associated with lower risk of Alzheimer’s, other dementias
A study published by the American Academy of Neurology found that a higher quality plant-based diet is associated with a lower risk of Alzheimer's disease and other dementias. Researchers compared participants based on their diet scores, finding that those who followed healthier plant-based diets had a lower risk of dementia.
Gladstone’s Ryan Corces receives MIND Prize to uncover unknown drivers of Alzheimer’s
Gladstone Institutes investigator Ryan Corces receives $750,000 to investigate unknown genetic variants contributing to Alzheimer's disease. He aims to identify new drivers and therapeutic targets using artificial intelligence and CRISPR tools.
How an Alzheimer’s risk gene disrupts brain circuits long before memory loss
Scientists have found that the APOE4 gene variant causes hyperactivity in two regions of the hippocampus, an important memory center of the brain, even before middle age. In mice with the APOE4 gene, reducing Nell2 levels reverses neuronal changes and improves cognitive function.
NIH awards $15.8 million to UC Davis Health for major Hispanic-Latino brain health study
The NIH grant will support the creation of a comprehensive long-term dataset on Hispanic and Latino brain aging, examining the factors that matter most for healthy cognitive aging. The study aims to understand how Alzheimer's disease, vascular injury, and other brain changes develop over time in Latino adults.
Risk of Alzheimer’s dementia significantly reduced after high-dose influenza vaccination compared to the standard dose, study finds
A new study published in Neurology found that high-dose influenza vaccination is associated with a nearly 55% reduced risk of developing Alzheimer's disease in people 65 years and older compared to the standard dose. This increased protection is stronger among women, highlighting the importance of flu vaccination for this vulnerable po...
Is vitamin D associated with lower levels of Alzheimer’s biomarkers?
A study published in Neurology Open Access found that higher vitamin D levels in middle age are associated with lower levels of tau protein in the brain, a sign of dementia. The study suggests an association between vitamin D levels and lower tau burden, but highlights the need for further research.
NIH investment totaling 30.7M will expand USC-led AI effort to decode Alzheimer’s disease
The NIH has renewed support for the USC-led AI4AD initiative, expanding its efforts to better classify Alzheimer's and related diseases, predict progression, and identify new treatment targets. The $12.6 million award will develop AI tools to uncover biological causes of Alzheimer's and improve disease diagnosis.