Articles tagged with Glutamates
Rice scientists develop simple method to study pyroglutamate, unlocking new insights into how proteins function and form. The technique uses blueish light to initiate chemistry that allows researchers to find out the roles of this ubiquitous modification.
A new PET imaging study reveals that ketamine relieves treatment-resistant depression by altering AMPAR in brain regions, providing potential biomarker for personalized treatment. The study found that ketamine increased AMPAR density in several cortical regions and decreased it in reward-related areas, strongly correlating with reducti...
Researchers discovered that pancreatic tumors form pseudosynapses, exploiting the body's nervous system to drive tumor growth. Calcium waves triggered by glutamate binding promote metastasis and cancer progression.
Researchers found that astrocytes transmit signals, revealing new ways the brain processes information. The study provides direct evidence for the real-time action of astrocytes in live brains of fruit flies, suggesting their role in mediating neurophysiology and behavior.
Researchers at Ruhr University Bochum found that energy depletion causes unusual glutamate releases that contribute to nerve cell damage. These abnormal events are self-reinforcing and can be reduced by inhibiting specific receptors.
Scientists have used a cryo-electron microscope to capture detailed images of glutamate molecules interacting with AMPA receptors, revealing the chemical flow that enables learning and thinking in brain cells. The findings could lead to the development of new drugs to treat conditions like epilepsy and intellectual disorders.
Researchers have discovered a previously unknown mechanism of liver regeneration triggered by glutamate, which accelerates liver regeneration in minutes through changes in macrophage metabolism. Hepatocytes producing glutamine synthetase play a key role in this process.
Scientists introduce a novel approach to construct robust electrode/electrolyte interphase layers on both cathode and anode of aqueous zinc batteries. The use of glutamate additives enables efficient suppression of undesirable side reactions, leading to improved electrochemical performance and cycling stability.
Researchers found that SYM2081 suppressed mast cell degranulation and proliferation in mouse models and human skin samples, paving the way for new topical treatments to prevent itching and inflammation. The study suggests that activating GluK2 could be a promising way to prevent rosacea and other inflammatory skin conditions.
Salk researchers created tools to study neuropeptides, finding they control the brain's fear response in mice. Neuropeptides are released during a mild stimulus, triggering fear behaviors, which can be reduced by silencing their release.
Scientists at The Hospital for Sick Children discovered a molecule called LK-2 that can protect neurons during stroke and prevent brain damage. LK-2 works by blocking glutamate's binding to acid-sensing ion channels, reducing calcium flow and cell death.
Researchers uncover the importance of kainate receptors in enabling synaptic plasticity and transmission in the cerebellum. The study's findings have significant implications for understanding neurological disorders and developing new treatments.
Scientists at Johns Hopkins Medicine have discovered the mechanism of action of the widely-used epilepsy drug perampanel, which targets the AMPA receptor to dampen brain cell excitability. The study provides new insights into the potential applications of perampanel in treating other neurological conditions such as Alzheimer’s disease,...
Scientists at Okinawa Institute of Science and Technology identify a positive glutamate-NO-glutamate feedback loop that blocks long-term potentiation and impairs learning and memory. The study suggests that this loop may explain memory loss in stroke patients and potentially offer a solution for treatment.
A study of 30 volunteers found that a poor diet can lead to changes in neurotransmitters and grey matter volume, commonly associated with depression and anxiety. Adhering to a Mediterranean-style diet was shown to prevent these changes.
A study published by USTC reveals that age-dependent accumulation of Glu-5’tsRNA-CTC impairs mitochondrial protein translation, accelerating brain aging and Alzheimer’s disease. This abnormal accumulation disrupts cristae structure, resulting in reduced synaptic glutamate levels.
A new study suggests that incorporating seafood rich in umami, such as fish and shellfish, into vegetable dishes can boost their flavor and make them more appealing. The research uses a mathematical equation to calculate the umami content of various seafood options, finding that even small amounts can greatly enhance the taste.
Researchers have identified genetic variants linked to cognitive control and social problems in schizophrenia, potentially paving the way for more effective treatments. The study found that these variants are not targeted by current medications, which often focus on dopamine pathways.
A study from the University of Surrey suggests that anxiety in girls and young women is connected to an imbalance between GABA and glutamate. As young women mature, the levels of GABA increase while those of glutamate decrease, indicating a vital indicator of anxiety levels.
Researchers found that bullied adolescents have lower levels of glutamate in the brain's anterior cingulate cortex region, which regulates emotions and decision-making. This imbalance is linked to higher levels of subclinical psychotic experiences in early adolescence.
A recent study published in Scientific Reports has uncovered the crucial role of glutaminase 2 in maintaining glucose homeostasis in pancreatic β-cells, particularly under conditions of hyperglycemia. The research team found that impaired GLS2 activity drives the onset of diabetes mellitus by disrupting insulin and glucagon regulation.
Researchers found a disrupted balance between glutamate and GABA neurotransmitters in the brains of people with OCD, which may lead to new treatment strategies. The study also suggests that excess glutamate levels could serve as a biomarker for OCD.
A University of Ottawa team has discovered a vital role for the VGLUT3 transporter protein in modulating the development of Huntington's disease. The study shows that blocking glutamate release through this protein can lead to an amelioration of the disease progression, offering new hope for potential treatment approaches.
The study reveals that spontaneous waves of neurotransmitter glutamate facilitate dendrite pruning, while a unique protection/punishment machinery strengthens certain connections and eliminates others. Proper pruning is critical for neural development, with insufficient or excessive connections linked to neurophysiological disorders.
A study found that excitatory-inhibitory imbalance, characterized by higher glutamate levels and lower GABA levels, precedes psychosis in individuals with 22q11.2 deletion syndrome. This imbalance is associated with hippocampal atrophy and cognitive decline.
Researchers found a partial response in a patient with pancreatic acinar cell carcinoma, as well as stable disease in 11 patients, when combining riluzole with sorafenib in a phase I trial. The combination was safe and tolerable, and further exploration of its potential is warranted.
Researchers discovered a single amino acid mutation in glutamate transporter protein causes transient loss of muscle control. The mutation affects the protein's shape and transport rate, leading to reduced glutamate transport and increased anion imbalance in neural cells.
Researchers found age-related changes in the balance of inhibitory and excitatory neurotransmitters in the prefrontal cortex during adolescence. This study provides first-ever evidence of plasticity in the frontal cortex during this critical developmental period.
The study provides detailed pictures of NMDA receptors, which mediate essential signals between neurons. The findings have significant implications for treating schizophrenia, depression, and other neuropsychiatric conditions.
Researchers at John Innes Centre found that amino acid waves, not calcium waves, mediate plant responses to stress. Glutamate released from wounds triggers a wave of calcium responses in plant tissues.
Researchers studying fruit flies found that brain neurons adapt to help the flies stay awake despite tiredness in dangerous situations, and fall asleep after an intense day. Time-restricted feeding also improved sleep quality in the flies, suggesting a potential therapeutic approach for humans.
Astrocytes play a crucial role in regulating the response to drug cues, acting as brakes on neuronal communication. By slowing down overactive communication, astrocytes can reduce the drive to seek drugs and prevent relapse.
A study published in PLOS Biology reveals that glutamate signaling regulates the seasonal response of bean bugs' reproduction, controlled by circadian rhythm genes. The researchers found that extracellular glutamate levels were higher under short-day conditions and disrupted when reduced or increased.
A study reveals that four nonexcitatory amino acids can cause irreversible brain destruction after a stroke or traumatic brain injury. The amino acids flood the brain cells, leading to swelling and cell death.
A study found that prolonged mental labor leads to glutamate accumulation in the prefrontal cortex, causing cognitive fatigue and altering control over decisions. Researchers suggest taking rest and sleep as a solution to overcome this limitation.
Scientists from the University of Tsukuba discovered that the lateral habenula brain region plays a crucial role in amplifying aggressive behavior in response to social interactions. Blocking this pathway eliminated increased aggression caused by social instigation, highlighting its significance in promoting aggressive arousal.
Researchers identified two genes associated with recovery within the first 24 hours after stroke, linking neuronal excitability to stroke outcomes. Genetic evidence suggests that calming overexcited neurons may protect the brain after a stroke.
A new discovery by VUB professor Ann Massie's research group reveals a strategy that prolongs life expectancy and preserves hippocampal function in the aging brain. The absence of system xc- has positive effects on mouse longevity and cognitive function, challenging current understanding of the aging process.
Researchers found that astrocytes regulate cognitive flexibility by releasing D-serine and glutamate, which integrates synaptic plasticity. Heterosynaptic long-term depression is mediated by astrocytes, critical for memory modification.
Researchers develop system to image millions of brain cell connections in real-time, revealing key locations for learning and memory encoding. The new tool allows scientists to study synapse activity on a massive scale, with potential applications in understanding diseases such as Alzheimer's and autism.
Researchers from The Stuber Lab discovered that certain neurons in the brain light up in obese mice, preventing signals that indicate satiety. The study found that these neurons communicate with regions involved in depression and motivation, suggesting a link between eating disorders and addiction.
A new study found that people with chronic pain have lower levels of GABA, a neurotransmitter that helps regulate emotions, leading to increased negative emotions and impaired emotional regulation. The researchers hope their online emotional recovery program may provide a non-pharmaceutical solution for those affected.
Researchers found that higher GABA levels in young people were associated with greater math fluency, while lower glutamate levels were related to better math skills. In adults, the opposite was true: low GABA concentrations were linked to greater math fluency and high glutamate levels to poorer performance.
Researchers found a novel biomarker indicating resilience to chronic stress in the brain, which is largely absent in people suffering from major depressive disorder. This absence is associated with pessimism in daily life and reduced adaptive responses to stress.
Researchers at the University of Kentucky have developed a new technology that can simultaneously measure glutamate and gamma-aminobutyric acid (GABA) in the brain on a second-by-second basis. The study aims to explore the balance of these neurotransmitters in the aging brain and could lead to new treatments for Alzheimer's disease.
Researchers at IST Austria discovered that key synapses in the hippocampus can send information in both directions, influencing pre-synaptic plasticity. The mossy fiber synapse adapts to the post-synaptic neuron's activity status, improving information storage in downstream networks.
Researchers have identified a neurologic pathway that explains how non-damaging brain impacts cause long-term problems with learning and memory. A new treatment approach may reactivate and normalize cognitive function.
Researchers at Tohoku University discovered that neuronal and glial circuits form a loosely coupled super-network within the brain. Activation of metabotropic glutamate receptors in neurons can be influenced by the state of glial cells, suggesting potential for artificial control to enhance memory function.
A research team from INRS has developed a modified therapeutic molecule that reduces glutamate toxicity in the brain after an ischemic stroke. The treatment, which works on the periphery of the blood-brain barrier, is effective for six days and may also have potential applications for other neuronal diseases.
A University of Sydney-led team has revealed the shape of the glutamate transporter, a tiny protein controlling cell-to-cell communication. The discovery using cryogenic electron microscopy could help design drugs for diseases such as episodic ataxia and Alzheimer's disease.
A study published in Nature Communications investigates the impact of messenger substance GABA and glutamate on human decision-making. The researchers found that individuals with a higher ratio of GABA to glutamate in the dorsal anterior cingulate cortex (dACC) made quicker decisions in patch-leaving scenarios, while those with higher ...
Glutamate signaling is crucial for enabling synaptic plasticity, a process that restructures neural networks due to learning and memory acquisition. The new study demonstrates how glutamate works across synapses to activate this switch.
A new study from University of Copenhagen researchers found that sake has the most umami flavor, followed by champagne and wine. The study also showed that pairing certain beverages with specific foods can enhance the umami flavor.
Scientists have uncovered the mechanism of glutamate transport using X-ray crystallography and molecular simulations. The study revealed that sodium ions bind to glutamate, driving its uptake into cells via specialized transport proteins called EAATs.
Researchers discovered massive glutamate surges in brain, sparking spreading depolarizations, a precursor to migraine with aura. The study suggests an imbalance between glutamate release and reuptake may contribute to neurologic diseases, including stroke.
A new IU study found that low-level developmental lead exposure in mice may increase the propensity to relapse to alcohol consumption, making it harder for individuals to refrain from turning back to alcohol. The research also highlights the potential harm of even low levels of lead exposure and its association with cognitive impairments.
A recent study published in Neuron reveals that the brain's signal transmission is regulated by the environment, with certain processes allowing for more open communication between neurons. The researchers found that astrocytes, specialized cells in the brain, play a crucial role in shielding communication to some extent.
A new study in mice suggests that a molecular transporter, GLT-1, may play a crucial role in determining susceptibility to migraines. The researchers found that mice lacking the GLT-1 transporter were more prone to cortical spreading depression, a condition related to migraines, and had increased levels of glutamate outside of neurons.
A study from American University found that a diet low in glutamate and high in nutrients reduced symptoms in US veterans with Gulf War Illness. The study showed significant reductions in overall symptoms, pain, and fatigue after one month on the diet.
A study published in Neuropsychopharmacology found that the balance between glutamine and glutamate levels in the nucleus accumbens is crucial for sustained effort-based motivated performance. The research suggests a potential link to therapeutic strategies, including nutritional interventions, to address motivational deficits.