Articles tagged with Neurodegenerative Diseases
A study by UC San Diego researchers identified CgA-centered stress-response pathways as key drivers of cognitive resilience in individuals with asymptomatic Alzheimer's disease. The findings also introduce a new framework to accelerate the discovery of preventive therapies for Alzheimer's disease.
A new study reveals that people with Parkinson's disease have a distinct gut microbiome, as do those at genetic risk but without symptoms. This could lead to early detection and potential prevention strategies.
Researchers found SIRT6 is essential for maintaining protein homeostasis, regulating the protein life cycle to prevent protein aggregates that contribute to neurodegenerative diseases. Reduced SIRT6 levels play a critical role in aging and age-related neurodegeneration.
NYU Langone Health experts present platform talks on practical strategies to counter medical misinformation, phase 3 X-TOLE2 trial results for novel epilepsy treatment, and exploring healthcare accessibility for patients with disabilities. The Department of Neurology features over 80 presentations from faculty members.
Researchers identify senescent macrophages as a driver of fatty liver disease, inflammation and aging. Clearing these cells reversed liver damage in mice on unhealthy diets.
A new Cochrane review of 17 clinical trials found that anti-amyloid Alzheimer's drugs have no significant impact on cognitive decline or dementia severity, but may increase the risk of brain swelling and bleeding. The evidence suggests that these drugs are unlikely to provide clear benefit to patients.
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
A new study from Edith Cowan University found that higher sodium intake is associated with a faster decline in episodic memory in men. The study of over 1,200 participants suggests that diets high in salt may have broader cognitive impacts than previously understood.
A team led by Jiefu Li developed a new method to examine proteins lining the inside surface of blood vessels, revealing two proteins and pathways that play a role in opening and closing the blood-brain barrier. This discovery could help scientists understand how the barrier functions and develop better ways to deliver medicines for neu...
A new study by POSTECH researchers found that the protein tau interacts with DNA during cell division, forming condensates that capture microtubules. This interaction affects chromosome alignment and can lead to cellular abnormalities even in healthy cells.
Researchers at the University of Waterloo have discovered a safer and more effective way to treat Alzheimer's disease by combining anti-amyloid antibodies with molecules found in grapes, berries, peanuts, and turmeric. This combination approach neutralizes amyloid protein clumping in the brain, leading to better outcomes.
The Barrow Neuro Analytics Center has nearly doubled its dedicated research space to 18,000 square feet, supporting growing neurological research programs. Researchers at the center are globally renowned for their work on Parkinson's disease, Alzheimer's, and other neurological disorders using data-focused methods.
Scientists at NTU Singapore found that glycerol-3-phosphate acyltransferase (GPAT) amplifies α-synuclein toxicity by altering fat metabolism in brain cells. Targeting GPAT activity may offer a new strategy for treating Parkinson's disease.
A Georgia State University study found that Alzheimer's affects men's and women's brains differently, with women showing steeper and more widespread decline. The research suggests that brain compensation mechanisms may help maintain cognitive performance in women earlier in the disease.
Gladstone Institutes investigator Ryan Corces receives $750,000 to investigate unknown genetic variants contributing to Alzheimer's disease. He aims to identify new drivers and therapeutic targets using artificial intelligence and CRISPR tools.
Scientists have found that the APOE4 gene variant causes hyperactivity in two regions of the hippocampus, an important memory center of the brain, even before middle age. In mice with the APOE4 gene, reducing Nell2 levels reverses neuronal changes and improves cognitive function.
A team of researchers, led by Bistra Iordanova and Liang Zhan, are developing multiscale models of brain metabolism to predict cognitive decline and dementia. They will analyze data from brain imaging, blood flow, and neural activity to identify metabolic changes that affect brain function in aging.
The NIH has renewed support for the USC-led AI4AD initiative, expanding its efforts to better classify Alzheimer's and related diseases, predict progression, and identify new treatment targets. The $12.6 million award will develop AI tools to uncover biological causes of Alzheimer's and improve disease diagnosis.
The review highlights LRRK2's diverse cellular functions and pathogenic mechanisms in various diseases, including Parkinson's disease and inflammatory disorders. Therapeutic strategies targeting LRRK2, such as kinase inhibitors and emerging approaches like PROTACs and gene therapy, show promise for correcting cellular imbalances and re...
Researchers developed an AI model that can detect several neurodegenerative diseases, including Alzheimer's and Parkinson's, from a single blood sample. The model uses protein measurements from over 17,000 patients and outperforms previous models.
A new model of brain wiring could shorten the path to developing medicines for multiple sclerosis and other degenerative brain diseases. The model, made of a water-filled gel, replicates the physical properties of human axons and has been successfully grown from human cells in the laboratory.
Researchers at Nagoya University found that a brief spike in testosterone after birth causes muscle-wasting disease to develop decades later. Treating the disease at birth significantly reduced nerve cell breakdown in adult mice.
The Preventing Alzheimer’s with Cognitive Training (PACT) study, led by USF researchers, aims to delay the onset of dementia through computerized brain training exercises. With over $50 million in federal grant funding, the trial has enrolled 7,600 older adults and is expected to conclude in January 2028.
The Linda and Mike Mussallem Foundation has donated to USC's Keck School of Medicine to enhance clinical trials for individuals with Down syndrome at risk for Alzheimer's. This will increase domestic and international sites, accelerating the development of treatments specifically for this population.
The Brain Health Collaboratory aims to accelerate the discovery, validation, and delivery of non-invasive neuroprotective therapies for cognitive decline and Alzheimer's disease. Cognito Therapeutics' Spectris technology platform will be combined with Ochsner's clinical network to explore new approaches to brain health care delivery.
A new book by Swansea University researchers argues that attention impairments, rather than memory dysfunction, are a key aspect of dementia. The authors suggest that recognizing these changes could lead to earlier identification, improved diagnosis, and better care for those affected.
A new biomarker in cerebrospinal fluid significantly improves the diagnosis of Parkinson's disease and dementia with Lewy bodies. The test is highly specific, distinguishing between patients with these conditions and Alzheimer's disease.
A comprehensive protein atlas has been developed to understand the molecular underpinnings of neurodegenerative diseases. By analyzing protein levels, modifications, and interactions across six major diseases, researchers identified alterations unique to and shared between diseases, as well as distinct subtypes within individual diseases.
Researchers at Lund University have developed a new blood marker that significantly improves the accuracy of Alzheimer's diagnosis. The study found that combining two biomarkers, p-tau217 and eMTBR-tau243, can identify people with established Alzheimer's disease with an accuracy rate of around 80%. This breakthrough reduces false posit...
Older adults with and without Parkinson's disease have increased brain activity and muscle signals when recovering from balance disturbances. This makes it more difficult for them to recover their balance.
Huntington's disease is caused by a toxic protein that builds in brain cells and spreads to other cells through tunneling nanotubes. Disrupting this pathway reduces the spread of the disease-causing protein, suggesting a new target for therapy.
A Finnish clinical imaging study found that rest tremor in Parkinson's disease is associated with relatively well-preserved dopamine function, challenging the long-held assumption of greater dopamine loss. The study analyzed data from 414 patients and demonstrated a clear correlation between higher dopamine transporter binding and tremor.
The Robert A. Winn Excellence in Clinical Trials Award Program is expanding its career development award to include neuropsychiatry researcher-physicians. This expansion aims to improve clinical trial enrollment and represent diverse patient populations affected by complex disorders.
Researchers found that patients with both conditions exhibited different neuropsychiatric symptoms, which could inform diagnosis and treatment plans. The study's findings may help clinicians better understand the complex disease course of patients with multiple disorders, including Alzheimer's and frontotemporal lobar degeneration.
Developed by CU Anschutz experts, the tool helps patients weigh treatment options and boosts confidence. The majority of patients reported it was helpful in their decision-making process, finding it useful and satisfied with the tool.
Researchers at the University of Edinburgh have developed a method to transform post-consumer plastic into L-DOPA, a frontline medication for Parkinson's disease. The process harnesses the power of bacteria to break down PET waste and produce L-DOPA, providing a sustainable solution to the production of pharmaceuticals.
Researchers tracked daily behaviors of African turquoise killifish for four years, identifying 100 distinct 'behavioral syllables' that predicted lifespan. Fish that lived longer tended to sleep at night, swim with greater vigor, and be more active during daylight hours.
A new study found that functional impairment worsened over time in individuals with early Parkinson's disease, despite plateaued symptoms, with gait, balance, and posture being the most bothersome issues. The study's results underscore the importance of incorporating real-world measures of disease progression in clinical trial design.
Patients with neurological diseases face profound questions about identity, purpose, and meaning, but neurologists often lack training and tools to address these concerns. A new paper offers practical strategies for incorporating spiritual assessment into routine neurological care.
A cancer medication, eFT508, has been shown to lower hyperconnectivity in early Alzheimer's disease by reducing amyloid-beta protein levels. This finding suggests a promising treatment avenue for memory loss in mild cognitive impairment and early Alzheimer's disease.
Researchers discover enzyme ANKIB1 crucial for innate immune signalling, driving type I and type III interferon induction. This finding solves a long-standing puzzle in innate immunity and provides opportunities for new therapies for devastating diseases.
Researchers at Worcester Polytechnic Institute developed an AI tool that analyzes brain scans to predict Alzheimer's disease. The method is accurate in detecting the disease among normal brains and those with mild cognitive impairment, highlighting key anatomical changes such as volume loss in the hippocampus and entorhinal cortex.
Researchers demonstrate that genetically engineered human pluripotent stem cells can overcome immune rejection in mice, surviving for five months with humanized immune systems. The findings provide proof-of-principle for a potential universal donor hPSC line designed to resist immune attack.
Researchers at WashU Medicine have developed a new cellular immunotherapy that uses brain cells called astrocytes to clear away dementia-related proteins, such as amyloid beta. The treatment requires just a single injection and has shown promise in mice by reducing the amount of plaques in half.
A pilot clinical trial suggests that low-dose oral lithium may help slow the decline of verbal memory in older adults with mild cognitive impairment, particularly those with evidence of amyloid beta. The study found that participants receiving lithium showed a slower rate of decline on a sensitive test of verbal memory.
A preliminary study found that people with drinking water from newer groundwater had a higher risk of developing Parkinson's disease. The study suggested that groundwater age and location may be potential environmental risk factors for the disease, with older groundwater from carbonate aquifers showing a protective effect.
Chronic sleep disruption persistently impairs social memory by differentially encoding oxytocin release in hippocampal CA2 during novelty encoding and prelimbic cortex during retrieval of familiar individuals. Restoration of PVN-OXT neurons enhances OXT release and produces sustained behavioral recovery.
Researchers found that noninvasive measures of brain blood flow and oxygenation are associated with hallmark brain changes in older adults with and without cognitive impairment. Higher values on these indicators were linked to lower levels of amyloid plaques and larger hippocampal volume, indicating a lower risk of Alzheimer's disease.
Researchers found NfL levels increase with age in various animals, including mammals, birds, and reptiles. The protein can help assess biological age and predict life expectancy across species.
A new study from Houston Methodist suggests that the outer area of the retina may hold clues to early Alzheimer's detection, potentially allowing for non-invasive diagnosis and monitoring. Researchers found that changes in retinal cells and blood vessels can indicate the onset of AD years before symptoms appear.
Researchers develop novel method to manipulate cell structures using weak magnetic fields and isotopes, bridging structural biology, biophysics, and quantum biology. This work offers a potential new strategy for stabilizing damaged brain proteins, typical of neurodegenerative diseases.
Researchers developed a free-to-use software tool, PSBench, to verify the accuracy of artificial intelligence-based protein structure predictions. The database includes 1.4 million annotated protein models, verified by experts, and provides reliable information for building more accurate AI systems.
Scientists have discovered a mechanism that explains how exercise improves cognition by shoring up the brain's protective barrier. The study found that an exercise-induced liver protein strengthens the blood-brain barrier, reducing inflammation and cognitive decline associated with Alzheimer's disease.
The JAX-NYSCF Collaborative and GSK are working together to develop human cellular models of neurodegenerative diseases. This collaboration aims to generate disease-relevant cellular models that can help scientists understand the underlying biology of neurodegenerative conditions like Alzheimer's disease.
Research finds a specific link between hearing loss and cognitive decline in presbycusis, a neurodegenerative disorder. The Functional-Structural Ratio (FSR) identifies reduced connections between brain areas involved in sound processing and memory, associated with worse hearing thresholds and poorer performance on memory and executive...
Researchers isolated native SOD1 monomers using coordination cages, revealing the dimer interface and enabling targeted ligand binding. This approach provides a promising new strategy for finding drugs that inhibit disease-causing protein aggregation.
Researchers have identified astrocytes as a promising cellular target for Alzheimer's therapy. Senescent astrocytes, which lose functional capacity, are found in Alzheimer's patients' brains, leading to neuronal damage and inflammation. The study opens an avenue for therapeutic strategies like senolytic drugs.
Researchers found that Parkinson's patients experience weight loss due to selective fat depletion, not muscle loss, driven by impaired carbohydrate-based energy production. This metabolic shift highlights a disorder of both the brain and body, driving disease progression.
Researchers at the University of Michigan School of Public Health found a strong association between bone lead concentrations and increased risk of dementia. The study analyzed data from over 30 years of follow-up and estimated cumulative lifetime exposure to lead using machine learning algorithms.