Articles tagged with Saliva
Researchers identified molecular differences in saliva after a full night's rest and 24 hours without sleep, creating a potential non-invasive test for sleep deprivation. The 'sleepiness fingerprint' holds promise for roadside checks and other situations where accurate detection is needed.
Researchers have shown that extracts from bioengineered chewing gum reduce levels of three microbes linked to worse outcomes in oral cancers, including HPV and bacteria Pg and Fn. The findings support the value of advancing these therapies to clinical trials as adjuvants or prophylaxis.
Mary C. Farach-Carson, an internationally recognized leader in extracellular matrix biology and salivary tissue engineering, has been awarded the IADR Distinguished Scientist Award. Her research reveals key functions of ECM components in organizing stem/progenitor cell microstructures and guiding cell migration.
Researchers discovered that inhibiting tick salivation prevents infection by targeting the tick's nervous system and salivary glands. The study found two distinct signalling pathways controlling saliva secretion, with acetylcholine playing a key role in stimulating salivation.
Researchers developed an artificial saliva containing sugarcane protein, CANECPI-5, to aid in treating teeth of patients with head and neck cancer. The solution significantly reduced bacterial activity and tooth demineralization when combined with fluoride and xylitol.
A new study found strong links between food-related xenobiotic compounds and elevated catecholamines in pregnant women's saliva, raising concerns about the impact of everyday exposures on maternal health. Saliva sampling offers a non-invasive tool to track environmental chemical exposures during pregnancy.
Researchers found that children unexposed to HIV had higher taxonomic turnover in their oral microbiomes, indicating less adaptability to environmental changes. Children living with HIV had more stable oral microbiomes and higher frequencies of cavity-causing bacteria.
Researchers identified hundreds of molecular markers in saliva associated with systemic pathological processes beyond the oral cavity. These markers can reflect genetic heritability of diseases such as prostate cancer, coronary disease, and Type 2 diabetes.
A new study has found that people with celiac disease can safely kiss their partners without worrying about gluten transfer. In a two-part study, researchers found minimal gluten in the saliva of partners with celiac disease, even when they kissed after consuming gluten.
Researchers developed a saliva test that uses AI to identify genetic mutations in the DPYD gene, which can affect how well cancer patients respond to chemotherapy. The study found several new mutations that could lead to severe side effects from 5-fluorouracil, a widely used chemotherapy drug.
Researchers identified three hotspots of hantavirus circulation in wildlife, including Virginia, Colorado, and Texas. The study found 15 rodent species as carriers, including six new hosts, and explored the impact of climate change on transmission.
Tulane University scientists developed a handheld device to deliver rapid and accurate tuberculosis diagnoses in under an hour. The device, called the lab-in-tube assay (LIT), can detect Mycobacterium tuberculosis DNA in saliva, blood, and sputum samples, offering a cost-effective tool for improving TB diagnoses in resource-limited areas.
A significant discovery has identified tricellulin as the root cause of dry mouth in Sjögren's syndrome, a chronic autoimmune disorder. The research found that restoring saliva secretion can be achieved through two separate treatments, offering a new approach to treating this condition.
A new study by researchers at McGill University found that annual COVID-19 vaccine booster doses help avoid breakthrough infections in people with immune-mediated inflammatory diseases. The study tracked 366 patients across Canada and used saliva PCR tests and antibody measurements, offering a more precise picture of infection risks.
Researchers found that chewing gum can release hundreds to thousands of microplastics per piece into saliva, potentially leading to ingestion. Synthetic and natural gums had similar amounts of microplastics released, with the most abundant polymers being polyolefins.
A natural citrus oil, when combined with a lipid formulation, may effectively relieve dry mouth in cancer patients. The new formula has demonstrated improved solubility and bioavailability compared to pure limonene.
A new test called EpiAgePublic estimates biological age using only three DNA sites in the ELOVL2 gene, simplifying traditional methods while maintaining accuracy. The study found that EpiAgePublic accurately tracks aging patterns and can identify factors accelerating the aging process.
Researchers investigated ozonated water's impact on SARS-CoV-2 in saliva, discovering that protein concentrations like amylase and mucin decrease ozone stability and effectiveness. This study provides insights into the applicability of ozonated water for disinfection in real-world settings.
A recent study has discovered that saliva contains special vesicles with extrinsic tenase complexes, which trigger rapid coagulation of the blood in haemophilic patients. This finding provides significant contributions to understanding the disease and its treatment options.
New discoveries by NYU researchers find that impaired regulatory T cells are a key contributor to Sjögren's disease in both mice and humans. Calcium signaling also plays a crucial role in the development of the autoimmune disorder, which affects glands producing saliva and tears.
Researchers have created a new technique to rapidly assess paracetamol levels from saliva using Mass Spectrometry technology. The Paper-Arrow Mass Spectrometry (PA-MS) test is non-invasive, fast, and cost-effective, with the potential to improve patient care and outcomes.
Researchers at the University of Kansas are analyzing noninfectious mosquito saliva to understand how it affects the immune system and changes at a molecular level. The goal is to identify specific proteins that can serve as candidates for vaccine development.
A new biosensor prototype can measure biomarkers for heart failure in saliva, promising a more accessible and affordable way to screen for the condition. The device, which resembles a COVID-19 test, could enable people with limited access to medical facilities to check on their health regularly.
A saliva test has been found to be more accurate than a blood test in assessing the severity of recurrent respiratory infections in children. The test measures broadly protective antibodies in saliva, which indicate disease burden and predict treatment needs. Saliva testing also holds promise for new treatments and therapies.
A new system developed by universities of Córdoba and Valencia can detect THC in saliva with high sensitivity and speed. This technique uses dispersive microextraction by sorption and needle-based electrospray ionization emitters for mass spectrometry, reducing the analysis process to just two steps.
Researchers found that matcha mouthwash significantly reduced levels of Porphyromonas gingivalis in saliva samples from people with periodontitis. Matcha's bactericidal activity against the pathogen was confirmed through lab experiments.
Researchers characterized the microbial composition of oral fluid, feces, and environment of nursery piglets on commercial farms in Brazil. The study found distinct oral fluid bacterial profiles differing from those in feces and environment, with potential implications for swine health and production.
Researchers developed a bioelectronic chip that can detect vitamins C and D in body fluids, offering a low-cost and easy-to-use solution for micronutrient monitoring. The chip is disposable, flexible, and can be adapted for wearable devices, enabling personalized diets and prevention of deficiencies.
A new study from Binghamton University found that couples who receive more negative social support tend to experience higher levels of cortisol, a hormone associated with stress reactions. In contrast, those who receive positive support exhibit lower cortisol levels and feel more understood, validated, and cared for by their partner.
A new EU study has found that over-60s are six times more likely to acquire pneumonia-causing bacteria Streptococcus pneumoniae after daily contact with young children. Pneumococcal infections mainly affect children under two and the elderly, claiming almost two million lives worldwide every year.
Researchers successfully implemented pooled saliva testing to detect congenital cytomegalovirus (cCMV) infection in newborns, achieving an empirical efficiency of 6 and reducing required tests by 83%. The study highlights the significance of early detection through this method, particularly for asymptomatic cases.
A new hand-held device screens for breast cancer biomarkers from a tiny spit sample, offering quick and efficient results. The portable tool distinguishes between healthy tissue, early cancer, and advanced cancer in a small group of women.
Researchers have developed a hand-held biosensor that can detect breast cancer biomarkers from saliva with high accuracy and efficiency. The device is portable, reusable, and cost-effective, making it an excellent choice for communities or hospitals without access to advanced technologies like MRI.
A study found that saliva biomarkers sTNFR2 and sIgA can effectively detect pain in people with dementia, providing an alternative to invasive methods. The researchers discovered a decrease in sTNFR2 levels and an increase in sIgA in patients with dementia compared to a control group.
A study conducted by Eurac Research Institute found that cigarette use alters the oral microbiome, leading to an increased risk of periodontitis and cardiovascular disease. Quitting smoking results in a gradual increase in aerobic bacteria, which can lead to improved blood pressure regulation.
Researchers have developed a device that detects glucose and adenosine monophosphate biomarkers in saliva with high sensitivity, enabling easy at-home health monitoring. The electrochemical aptamer-based biosensor is simple, accurate, and stable, making it suitable for use without laboratory equipment.
A novel aqueous lubricant technology has been developed at the University of Leeds, providing a longer-lasting solution for people with dry mouth conditions. The substance, composed of microgel and hydrogel, binds strongly to the surface of the mouth, reducing desorption and offering up to five times more effective relief.
Researchers at the University of Cincinnati have developed a new at-home test that uses saliva to detect early signs of gingivitis, the earliest form of gum disease. The device can identify periodontal disease caused by bacteria in saliva, providing an opportunity for consumers to protect their oral health.
A KAUST researcher has created a highly sensitive glucose detector based on a thin-film transistor that can measure glucose levels in saliva with high accuracy. The device uses an enzyme to oxidize glucose present in the saliva, producing electrons that indicate the glucose concentration.
Researchers identified a link between high white blood cells in saliva and compromised flow-mediated dilation, an early indicator of poor arterial health. The study suggests that low levels of oral inflammatory load may have an impact on cardiovascular health.
Researchers at Penn State found a significant association between salivary cotinine and heavy metals such as copper, zinc, lead, in children exposed to tobacco smoke. The study suggests that environmental tobacco smoke exposure may be a source of increased children's exposure to heavy metals.
Researchers discovered that squash bug nymphs are attracted to the feces of adults of their own species, even in the dark or from a distance. This behavior is crucial for the bugs' survival as they need a healthy microbiome to grow and stay alive.
Scientists from Forsyth Institute develop CRISPR-based diagnostic tool that can detect specific oral pathogens with high sensitivity and specificity. The test can be performed in a dental office without technical expertise, providing comprehensive information on oral health and systemic diseases like diabetes, heart disease, and cancer.
A recent study published in PLOS ONE found that patients with Type 2 diabetes who have full chewing function have significantly lower blood glucose levels compared to those with impaired chewing ability. The research highlights the importance of dental care and occlusal function in managing blood sugar levels.
Researchers developed an ecofriendly disposable sensor that can check levels of glucose and other biomarkers in saliva using a wooden tongue depressor. The device uses low-power diode lasers to create conductive electrodes, making it cheaper and easier to produce on-site at medical facilities.
Researchers developed a simple sensor to monitor paracetamol levels in saliva in real-time, enabling personalized treatment and reducing toxic side effects. The device is low-cost, portable, and uses non-invasive collection methods, making it an attractive alternative for therapeutic drug monitoring.
The study used LED imaging to visualize droplet spreading during dental procedures and found that extra-oral and intra-oral suction devices reduced droplet and aerosol spread by 97.8% and 92.1%, respectively. Understanding the dynamics of aerosols and droplets is crucial for preventing infectious diseases like COVID-19.
Researchers found that infected mosquito saliva contains molecules called sfRNAs that can blunt the body's immune response. These molecules are injected during the mosquito bite, making it more likely for people to become infected with dengue virus.
Researchers found that airborne particles carrying a mammalian coronavirus remain infectious for twice as long in drier air, thanks to the protective effect of saliva. The study suggests that managing indoor air filtration and ventilation is crucial to mitigate airborne disease spread.
Researchers at NYU College of Dentistry have developed a single score to describe the level of cytokines in saliva, which correlates with the severity of clinical gum inflammation. The study found that higher levels of cytokines in saliva match greater gum inflammation.
An international study led by the University of Trento revealed that social interactions play a key role in shaping the composition of our microbiomes. The researchers found that adults acquire microbes through close contact with family members, partners, and friends, while infants acquire them later on at birth.
A team of scientists at the University of Leeds has decoded the physical process behind chocolate's sensation in the mouth. They found that fat plays a key role in creating the smooth emulsion, and by understanding this mechanism, they hope to develop healthier luxury chocolates with the same feel and texture.
Researchers developed a new epigenetic biomarker, GrimAge version 2, which leverages two DNAm-based estimators of plasma proteins to predict mortality risk. The study found that GrimAge 2 outperforms existing clinical biomarkers in predicting mortality across multiple racial/ethnic groups and associations with age-related conditions.
Researchers have developed a sensor system that can detect seizure-preventing drugs in saliva, enabling patients with epilepsy to monitor their medication levels from home. The system aims to reduce the risk of toxic side effects and improve treatment outcomes.
A new testing method for tuberculosis may make diagnosis easier by using saliva instead of sputum, which can be unpleasant and impractical. The method has shown high sensitivity in detecting the bacteria that causes TB, but its effectiveness in people with HIV is less clear.
Researchers discovered that cross-kingdom assemblages of bacteria and fungi can form superorganisms that colonize teeth, causing extensive tooth decay. These superorganisms exhibit enhanced surface adhesion, increased mechanical and antimicrobial tolerance, and unique mobility, moving at speeds similar to fibroblasts.
A study by Hokkaido University researchers found that low concentrations of cetylpyridinium chloride in mouthwash can inhibit SARS-CoV-2 infectivity and viral load, regardless of variant. This antiviral effect is thought to be due to disruption of the lipid membrane surrounding the virus.
A new study from Uppsala University found that using a weighted blanket at bedtime increases melatonin production by about 30 percent. The researchers also discovered that the weight of the blanket (12% of participant's body weight) reduced stress system activity, but had no effect on oxytocin and cortisol levels.
A study by MedUni Vienna's Department of Dermatology reveals that tick saliva inhibits the skin's defense function, making it easier for pathogens to multiply. Climate change increases the danger from ticks, which now pose a threat in higher-altitude regions of Austria and well into late autumn.
Exosomes have been identified as possible vehicles for virus transmission, and a recent study found that the saliva protein exportin 6 plays a crucial role in this process. The researchers isolated exosomes from the saliva of insect vectors and showed that they can transport plant virions into rice plants.