Articles tagged with Notch Pathway
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Researchers have developed a novel synthetic ligand using AI-based computational protein design, activating the Notch signaling pathway in T-cells. This breakthrough enables broadened clinical T-cell production and advances immunotherapy development.
Researchers have identified LINC01235 as a crucial regulator of NFIB expression and NOTCH pathway in TNBC, suggesting potential therapeutic targets for this aggressive form of breast cancer. The study provides new insights into the role of non-coding RNAs in cancer progression.
Pro-B cells, a stage in B cell development, exhibit unusual plasticity when YY1 is knocked out. This enables them to generate T lineage cells, which help B cells produce antibodies. The study published in Genes & Development reveals the potential for regenerative medicine applications.
A study published in Food Innovation and Advances found that M3G supplementation improved colonic mucosal barrier function, reducing inflammation and increasing physical barrier strength. The compound inhibited the over-activation of the Notch signaling pathway, suggesting its potential therapeutic application for intestinal health.
Researchers measured dielectric properties of 11 polyimides to establish correlation between molecular structure and dielectric behavior. The study revealed that higher fluorine content resulted in lower dielectric constant values, enabling potential applications for 6G technologies.
The study reveals that non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play a crucial role in regulating the Notch signaling pathway in breast cancer. These molecules can modulate gene expression and affect cancer cell proliferation, invasion, and metastasis.
Researchers at Karolinska Institutet used DNA origami to activate the Notch receptor in a new way, revealing it can be activated 'on demand' with the help of a protein called Jag1. The study opens new avenues for understanding the Notch signalling pathway and its role in serious diseases like cancer and Alagille Syndrome.
A recent study reveals that the tethering of mitochondria to the endoplasmic reticulum plays a crucial role in muscle development, regeneration, and maintenance. The researchers propose targeting the Notch signaling pathway as a potential therapeutic option for muscle atrophy caused by mitochondrial abnormalities.
The study reveals that hepatoblasts along the portal vein receive Notch signaling and differentiate into bile duct epithelial cells. Hematopoietic cells fail to transmit signals, resulting in the failure of differentiation. This discovery provides molecular biological support for mathematical analysis results.
Researchers at the Centro Nacional de Investigaciones Cardiovasculares discovered the molecular mechanisms behind proper heart valve formation and prevention of calcification. They found that Notch signaling pathway disruption causes both valve defects and calcification.
A recent study by researchers at the University of Zurich found that the Notch signaling pathway plays a crucial role in shaping and varying tooth enamel. The team used genetically modified mouse models to analyze the effects of the Notch-ligands on teeth, revealing that their absence affected tooth morphology and enamel formation.
Researchers at Osaka University identified T-cadherin as a factor that feeds back a lack of insulin to pancreatic β cells, inducing their proliferation. This finding suggests a potential new treatment for diabetes by targeting T-cadherin.
Scientists at Heidelberg University have identified a second stem cell population in the mouse brain, which is primarily involved in producing new neurons in the olfactory bulb. This discovery refutes the single stem cell type theory and suggests that both apical and basal stem cells are responsible for adult neurogenesis.
A study conducted at the University of Zurich has identified a key gene network responsible for severe tooth enamel defects. The researchers found that mutations in the Adam10 molecule lead to disorganization of ameloblasts and severe defects in both structure and mineral composition of enamel.
The DeFi trial shows targeting the Notch pathway with nirogacestat improves progression-free survival and reduces symptoms in patients with desmoid tumours. Patients reported a statistically significant benefit in reduced pain, symptom burden, and improved quality of life.
Researchers at Buck Institute discover that blood-brain barrier cells influence neuron function and can cause problems rather than just being protective. This finding opens up new avenues for therapies targeting neurodegenerative diseases like Alzheimer's and Parkinson's.
A recent review article highlights the crucial role of macrophages in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The study suggests that targeting specific signaling pathways and altering macrophage activation can prevent renal fibrosis and CKD. Therapeutic strategies such as clodronate liposomes an...
Researchers at Karolinska Institutet identified a novel protein mechanism that inhibits tumour growth in ER-negative breast cancer, leading to improved prognosis. High levels of GIT1 were associated with reduced tumour growth and better outcomes in ER-negative patients.
Researchers found that radiation therapy triggers heart muscle cells to express different genes and increase sodium ion channels, reducing arrhythmias. The treatment also continued to show benefits for at least two years in surviving patients.
Researchers at the University of Minnesota Medical School discovered a novel gene, JAG2, associated with a specific form of muscular dystrophy. The study found a distinct pattern of abnormalities on muscle MRI that may aid in identifying patients with this condition.
Researchers identified Notch as a key molecule involved in cervical cancer progression, contrary to previous thought that Ras was the primary culprit. The review highlights the complex nature of cervical cancer progression, suggesting that local proliferation and metastasis occur through parallel routes.
A faulty signalling pathway is linked to left ventricular non-compaction (LVNC), a congenital heart condition where muscular projections fail to transform into compact heart muscle. The study provides new insights into the molecular mechanisms underlying LVNC and may lead to potential therapies.
Researchers found that altering Sox9 gene expression modifies Alagille syndrome liver disease severity, from mild to severe cases. Increasing Sox9 levels improved biliary duct development without tumor formation.
Researchers found a retromer protein complex helps prevent brain tumors by recognizing and disarming harmful proteins that cause them. The discovery could lead to new treatment approaches for brain tumors.
Researchers discovered colon cancers are composed of two different cell types that can replace each other when one is killed. Targeting both cell populations simultaneously showed strong repressive effects on tumor cell proliferation and increased cell death, resulting in slower tumor growth and prolonged survival times.
Researchers identified a novel rare mutation in the TM2D3 gene associated with an increased risk of late-onset Alzheimer's disease. The variant is approximately 10 times more common in Icelanders than in the European population, yet remains rare and present in fewer than 1% of the Icelandic population.
A study by Purdue University researchers reveals that overactive Notch signaling can drive the formation of cancerous fatty tumors, while normal signaling is required for healthy cell differentiation. The findings suggest a potential new approach for treating a subtype of liposarcomas and other metabolic conditions.
Researchers discovered how queen honeybees control worker bees' fertility through the Notch cell-signalling pathway. The study found that inhibiting Notch signalling can overcome the effect of queen pheromone and promote ovary activity in adult worker bees.
Researchers found that blocking specific cell signaling pathways may reduce the risk of preterm labor caused by inflammation or stop it altogether. The study also identified key molecules in the Notch signaling pathway, paving the way for therapies to control preterm labor in humans.
A study reveals that Frizzled7 is uniquely controlled by the Notch signaling pathway in human breast epithelial cells. This interaction may provide a new target for treating breast cancer. The researchers hope their findings will help identify an underlying cause of breast carcinogenesis.
University of Oregon scientists have identified a molecular change in aging stem cells that stops them from making tumors. The discovery, detailed in the journal Current Biology, focuses on the larval stage of fruit fly development and reveals that a protein called Eyeless plays a crucial role in regulating Notch signaling.
A new study by Johns Hopkins researchers links the Notch cell signaling pathway to pilocytic astrocytoma, a common and slow-growing brain tumor in children. The study found that Notch was abnormally active in nearly all samples of PA brain tissue, suggesting it may be a therapeutic target for treatment.
Scientists at UC San Diego School of Medicine discovered the Notch signaling pathway's early role in establishing hematopoietic stem cell fate during development. They found JAM proteins serve as co-receptors for Notch signaling, facilitating HSC precursor cells' growth.
Researchers discovered that the Notch signaling pathway is involved in adult fear memory formation. MicroRNAs, specifically miRNA-34a, regulate the pathway and are increased after fear learning occurs. This study provides a starting point for developing new treatments against PTSD.
A Purdue University study reveals that blocking Notch signaling in fat cells can transform white fat into a healthier beige fat type, potentially reducing obesity and related health issues. The research also found that suppressing Notch signaling improves glucose balance and insulin sensitivity.
Researcher Avinash Bhandoola's team discovered the mechanism of action of Hes1, a repressor protein that prevents T cells from defaulting to a myeloid developmental pathway. This knowledge may provide clues about how to stop T-cell leukemias.
A recent study found that in K9 osteosarcoma samples, NOTCH signaling was elevated overall but aspects of Notch signaling were noticeably deactivated in the worst cancers. The researchers also discovered that HES1 protein expression was lower in aggressive tumors, contradicting previous expectations.
A study by University of Pennsylvania researchers found that younger mice exhibit a more robust healing response compared to older mice. The team identified the Notch signaling pathway as critical to fracture healing, with reduced baseline activity in geriatric MSCs.
Researchers have discovered a new method to prevent graft-versus-host disease, a severe complication of bone marrow transplants. By inhibiting the Notch signaling pathway, they were able to block the disease without compromising the anti-cancer effects of transplantation.
Researchers clarify how cells line up at the right time to receive signals about the next phase of their life by visualizing single-cell activity in living zebrafish embryos. The findings increase understanding of cyclical behaviors in all types of cells and could lead to new ways to treat certain human conditions.
Researchers at UC Santa Barbara have discovered a way to break a biological signaling system in embryos, allowing them to change the destiny of cells. This breakthrough could lead to new ways of making replacement organs. The study used genetic manipulation and a model nematode worm to unlock cells' destinies.
Optical tweezers help researchers uncover key mechanics in cellular communication by detecting and measuring mechanical forces produced by cells bound to Notch. The findings provide compelling evidence that pulling on Notch opens a network to deliver instructions for specific cellular responses.
Studies show that ligand cells produce pulling force to pull on Notch, activating cellular responses. The findings provide compelling evidence for the role of mechanical force in Notch signaling, potentially leading to new therapeutic targets for diseases related to Notch signaling.
Researchers discovered that the Notch pathway contributes to the development of rheumatoid arthritis by influencing the differentiation and function of inflammatory macrophages. The study also shows that drugs under development for cancer could potentially be used to treat RA.
Cells can switch between sender and receiver mode, inhibiting their own signals while allowing them to receive information from other cells. This mechanism could lead to the development of cancer drugs that target specific cell communications, potentially stopping uncontrollable proliferation.
Notch signaling pathway plays a crucial role in controlling the differentiation of airway basal stem cells, with high levels leading to secretory cells and low levels resulting in ciliated cells. The findings have implications for developing therapies for airway diseases, which are a leading cause of death worldwide.
Researchers at Brown University have found that the Notch signaling pathway regulates sleep in nematode worms, and similar genes are expressed in human brains. The study suggests that targeting this pathway could lead to more precise and safer sleep aids.
Scientists have discovered a cell-to-cell signaling pathway that designates the future location of ear's sensory organs in embryonic mice. By activating this signal, they were able to induce patches of new sensory tissue with hair cells and support cells. This breakthrough suggests a potential avenue for regenerating sensory organs in ...
Researchers have found a key interaction between the Notch signaling system and the BCL6 gene that may be responsible for certain cancers developing. This discovery could lead to a better understanding of cancer formation and potential treatments.
Researchers found that Notch protein represses the pathway in cells emitting signals, but activates it in neighboring cells. This discovery may lead to more effective therapies against cancers such as leukemia and breast cancer.
Notch signaling pathway activation has been linked to tuberous sclerosis complex (TSC) tumors. Inhibition of Notch was shown to suppress tumor growth in rat cells deficient in either TSC1 or TSC2. These findings support a role for TSC proteins in regulating Notch activity.
Scientists at EMBL identify Notch signalling pathway as critical component of heart muscle cell communication, leading to heart defects and cardiac malformations in Alagille syndrome. Re-activating Notch improves adult mouse heart function after heart attack, offering new therapeutic potential.
Notch signaling plays a crucial role in determining cell fate in fruit flies. A study found that mutations in the WASp gene affect T-cell function, leading to Wiskott-Aldrich syndrome. The researchers suggest that defects in Delta presentation could explain the loss and dysfunction of T-cells in patients with the disorder.
Research from Boston University School of Medicine sheds light on how airways form and provide insights into lung diseases like asthma and COPD. The study reveals that Notch signaling controls the balance between ciliated and secretory cells in developing airways.
Researchers at Hospital for Special Surgery have identified a potential new therapeutic target for treating inflammatory disorders like rheumatoid arthritis. Manipulating the protein RBP-J could serve as a treatment, leveraging gamma secretase inhibitors already in trials for leukemia.
Researchers at the University of Pennsylvania School of Medicine have discovered that Notch signaling is not universally essential for maintaining stem cells in bone marrow. This finding opens up new possibilities for developing effective leukemia therapies without harming normal bone marrow.
Researchers at Albert Einstein College of Medicine found that aberrant Notch signaling plays a role in diabetic nephropathy and focal segmental glomerulosclerosis, two major causes of end-stage renal disease. They discovered that gamma secretase inhibitors can protect against kidney disease, sparking hope for new treatment options.
Researchers at Baylor College of Medicine found that Notch stimulates early proliferation of osteoblastic cells responsible for bone formation. However, when Notch function is abolished in these cells, osteoporosis occurs due to an imbalance between bone formation and resorption.
Researchers discovered the rumi gene's effect on bristles in fruit flies, finding a subtle loss of Notch activity at 25 degrees C. The protein associated with rumi is an O-glycosyltransferase that adds glucose to the Notch protein.
A new study reveals secretoneurin's neuroprotective role in a rat model of stroke. SN treatment improved survival of primary brain cell cultures and reduced cerebral tissue death in rats with ischemia-induced stroke.