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Why some breast cancer treatments stop working

A new review highlights how breast cancer cells change their communication and growth patterns, helping tumors survive, spread, and resist treatment. The review explores disrupted signaling pathways, including PI3K/Akt/mTOR and RAS/RAF/MEK/ERK, which can promote tumor progression and resistance to treatment.

SourceImpact Journals LLC·JournalOncotarget·TypeSystematic review·DateMar 25, 2025

Overcoming stacking constraints in hexagonal boron nitride via metal-organic chemical vapor deposition

Scientists at POSTECH and University of Montpellier successfully synthesized wafer-scale hexagonal boron nitride (hBN) with an AA-stacking configuration using metal-organic chemical vapor deposition (MOCVD). This achievement introduces a novel route for precise stacking control in van der Waals materials.

Anti-correlation between KLRG1 and PD-1 in tumor CD8 T cells

A new study published in Oncotarget discovered an anti-correlation between PD-1 and KLRG1 expression in human tumor infiltrating CD8 T cells. This finding suggests the potential for combination therapy to enhance cancer treatment by targeting both markers simultaneously, which could lead to more significant and long-lasting benefits.

SourceImpact Journals LLC·JournalOncotarget·TypeNews article·DateJan 21, 2025