A new study by Carnegie Mellon University researchers found that opioid consumption intensity varies enormously across different populations and contexts. The study suggests that tracking average intensities of use could improve our understanding of consumption patterns and inform drug policy and treatment strategies.
A pilot clinical trial has been initiated to test the efficacy of alpelisib in treating Dent disease 2, a rare genetic disorder affecting kidney function. The trial aims to improve abnormal kidney function and potentially provide a breakthrough treatment for patients with life-threatening complications.
Researchers compared prey-capture behaviors in five fish species, revealing distinct strategies that differ from zebrafish. These differences suggest species-specific sensory inputs and motor control, shedding light on how brain circuits support behavior and evolution shapes those circuits.
A UCL-led study suggests that community-based technician-led virtual review clinics could significantly reduce wait times for patients with stable chronic eye conditions. The research found that appointment delays decreased by an average of 8.1 days per week after the clinic's launch, leading to a faster reduction in waiting times.
Stanford researchers introduce a cost-effective way to evaluate AI language models, accounting for question difficulty to ensure fair comparisons. The new approach reduces costs by half and enables rapid progress in the field of artificial intelligence.
SmartCatch, an AI tool developed by WorldFish, has won the AI for Planet Prize at the 2025 AI for Good Global Summit. The tool helps small-scale fishers record their catches with a simple mobile phone photo, aiming to make catch reporting faster and more accurate in coastal areas with limited internet connectivity.
Researchers developed a novel computational approach that predicts alloy microstructures in minutes, compared to years. The new model streamlines older approaches and avoids the 'curse of dimensionality', enabling rapid and accurate calculations of solidification and alloy microstructures.
Twisted trilayer graphene creates a pattern that changes the material's properties and can turn it into a superconductor. Researchers used a microscope to probe the properties of supermoiré patterns, revealing new states of matter with precisely controllable properties.
A newly developed AI-based tool uses protein expression to create a stemness index that analyzes tumor similarity to pluripotent stem cells. The model predicts tumor aggressiveness and identifies potential targets for new therapies, offering hope for improved cancer treatment.
The study reveals how nutrients and lipids shape bone marrow blood stem cells from health to aging and leukemia, identifying choline as a key player. Healthy stem cells had high choline levels, which decreased with specialization and aging, suggesting nutritional interventions could maintain stem cell function.
A new study finds that the copper-based molluscicide used to treat invasive mussels in Idaho's Snake River has devastating effects on the local ecosystem. Nearly half of the original mass of copper is gone after just 10 days, but dissolved copper concentrations remain toxic for over two weeks.
The Society for Laboratory Automation and Screening's two scientific journals, SLAS Discovery and SLAS Technology, have achieved substantial impact factor increases due to open access publishing. This shift has led to higher citations and visibility for authors, with SLAS Technology experiencing a notable rise of 1.2 points to 3.7.
The Deutsche Forschungsgemeinschaft (DFG) has elected six new members to the Senate, with expertise in various fields including life sciences, natural sciences, engineering, and humanities. The new members will begin their term on January 1, 2026.
A study led by MSU researchers reveals that Staphylococcus aureus possesses a surprising level of metabolic redundancy, allowing it to survive even when key enzymes are knocked out. The discovery uncovers mechanisms that could be targeted by new antibiotics, particularly when two specific enzymes are removed.
A 40-meter long ice core from Mont Blanc's Dôme du Goûter holds clues to 12,000 years of human and environmental history. The record provides insights into Europe's past climate, including a temperature difference of about 3 degrees Celsius between the last Ice Age and the current Holocene Epoch.
Current Molecular Pharmacology seeks talented young professionals for its editorial board. The journal focuses on cellular and molecular pharmacology advancements, genomics, proteomics, and drug action mechanisms.
The American Heart Association is launching a nationwide initiative to accelerate the adoption of effective surgical approaches for intracerebral hemorrhage, with a focus on minimally invasive techniques like MIPS. Research shows that MIPS may lead to better recovery outcomes at six months compared to standard treatments when performed...
A study found that automated insulin delivery pumps improved quality of life and reduced diabetes-related complications, with a cost-effectiveness ratio of 11,184 euros per quality-adjusted life-year. The technology is now supported for patients with type 1 diabetes in Finland.
Researchers found that early sensory processing, including touch and hearing, diverge in people with autism compared to those without the condition. The study suggests that understanding these early differences may lead to breakthroughs in treating autism.
Researchers developed a biodegradable liquid slow-release mulch film based on bamboo residue for selenium-enriched crop cultivation. The film showed enhanced moisture retention, insulation properties, and weed suppression, improving soil temperature and humidity.
The Cambridge Elements series has reached a major milestone with the publication of over 2000 formats, offering original and peer-reviewed research from leading scholars. The series provides comprehensive coverage of key topics in various disciplines, filling the gap between journal articles and monographs.
Researchers have developed new artificial nitrite reductases that can precisely generate nitric oxide under conditions relevant to medicine, food safety, and environmental protection. These synthetic catalysts promise low-cost supplements for hypertension or ischemia and precise antibiofilm treatments.
A study found that five-day-old newborns prefer watching videos of helpful actions over hindering ones, indicating an innate sense of social goodness. The research suggests that humans may be born with basic social preferences that shape moral understanding.
Researchers found that indirect effects of tropical cyclones contribute more than twice the direct effect to rainfall during the Habagat season, with 51.5% coming from the monsoon itself. This new understanding can improve extreme weather anticipation and disaster response.
A team of researchers has discovered the regulation of de novo genes in fruit flies, finding that transcription factors and genomic neighbors play a crucial role in switching these genes on. The study also reveals that de novo genes often share regulatory elements with adjacent genes, suggesting a mechanism of co-regulation.
A new study suggests that erythritol, commonly used in low-carb products, can alter the function of brain microvascular endothelial cells, leading to increased risk of stroke. The sugar substitute was found to constrict blood vessels and reduce the production of natural clot-busting compounds.
Researchers have analyzed four model-free predictive control (MFPC) approaches, showcasing their flexibility and robustness in motor drives. The study highlights the potential for MFPC to address challenges in various industries, including cybersecurity, power grids, and aerospace.
Researchers found that CAR-T cells age and lose effectiveness due to premature senescence, a previously unrecognized mechanism of therapy failure. The discovery highlights the need for next-generation therapies with improved durability.
NASA microbiologist James Holden is searching for signs of microbial life in Earth's deep-sea volcanoes, which he believes could be similar to those on Jupiter's moon Europa. The hydrothermal vents, where these microbes thrive, provide a unique environment that may support alien life.
The researchers developed a five-level pyramid model to assess energy supply security, taking into account dynamic effects and higher resolution. Switzerland can increase its energy security by diversifying its energy sources and increasing domestic production, with additional storage facilities also contributing.
Scientists have identified compounds that can help cells fend off viral infection by activating the integrated stress response pathway. These compounds show promise as broad-spectrum antivirals against multiple types of viruses and have been tested in human cells and a mouse model with positive results.
The Endocrine Society guideline suggests universal screening for primary aldosteronism in people with hypertension. This condition is associated with a higher risk of cardiovascular disease if left undiagnosed and untreated.
The article highlights the need for healthcare providers to understand autism and its diversity, as well as actively ask about patients' lived experiences. Additionally, suggestions are provided on adapting healthcare delivery and environments, tailoring communications, and addressing barriers faced by autistic individuals with margina...
A new study finds that cleaner air in East Asia, particularly China, has contributed to the recent acceleration in global warming. The region's aerosol reductions account for most of the observed warming since 2010, even after accounting for natural fluctuation events.
Current Pharmaceutical Analysis seeks ambitious individuals to join its young editorial board, promoting pharmaceutical analysis development and enhancing academic influence. The journal focuses on multidimensional explorations in pharmaceutical analysis and pharmacological research.
Researchers reviewed medical records to identify disparities in stroke treatment and post-stroke health among patients from different racial and socioeconomic groups. The studies found that telestroke networks can help reduce racial disparities but highlight the need for further research into long-term recovery and rehabilitation dispa...
A Michigan State University study found that better handling of daily stress is associated with increased extroversion, agreeability, and openness to new experiences over a nearly 20-year period. Conversely, poor stress management leads to reduced extroversion, decreased agreeableness, and increased introversion.
A nationwide Danish cohort study found no evidence linking cumulative aluminum exposure from early childhood vaccination to autoimmune, atopic, or neurodevelopmental disorders. The study followed over 1.2 million children and used national health registries to track their aluminum exposure and chronic disorder development.
A potent new dual lipid kinase inhibitor, RMC-113, selectively inhibits PIKfyve and PIP4K2C, providing a potential strategy to combat emerging viruses. The study reveals that PIP4K2C plays a crucial role in SARS-CoV-2 entry, replication, and assembly/egress, making it an understudied kinase with significant antiviral potential.
Researchers developed a novel optogenetic screening platform to control biological systems, unlocking new therapeutic opportunities. The platform enables precise and dynamic control of biological targets, resolving compound effects in real time.
A new study reveals that at least 160 million patients annually are unable to receive surgery, with LMICs bearing the brunt of the crisis. The report emphasizes the need for urgent investment and highlights key recommendations to strengthen essential services for tomorrow's needs.
Researchers at King Abdullah University of Science and Technology (KAUST) have created a deep learning tool called deepBlastoid to study human embryo development in artificial laboratory conditions. The tool can evaluate images of blastoids equally well as expert scientists but 1000 times faster than traditional methods.
A randomized controlled trial found that vaporized nicotine products were more effective than nicotine replacement therapies for smoking cessation in a low socioeconomic status population. The study suggests that Vapes may have a critical role in promoting smoking abstinence among this disproportionately affected group.
Researchers identified over 250 proteins that change during malaria infection, enabling patients to be grouped according to severity. This allows for quicker identification of high-risk patients and more effective treatment.
Researchers found high acceptance and interest in autonomous shuttles among all population groups. The vehicles successfully completed over 430 trips with more than 1,600 passengers, traveling safely and reliably in automated mode.
Researchers used NASA's TESS mission data to estimate the sizes of over 200 exoplanets and found that many are likely larger than previously thought. This discovery could impact the search for life on distant planets, as water worlds may harbor life but lack features that help life flourish on Earth.
Researchers found pregnant women with arteriovenous malformations are more likely to experience ruptures than non-pregnant women. Hormonal shifts and increased blood demand exacerbate health issues during pregnancy, placing added strain on the brain.
The Hastings Center has released recommendations and practical tools for conducting ethical first-in-human pig kidney xenotransplant clinical trials. The guidelines focus on eligibility for participation, monitoring for infectious diseases, and metrics for evaluating the success of the trials.
This study uses Steady-State Isotopic Transient Kinetic Analysis to investigate the effects of microwave heating on Dry Reforming of Methane. The results show that microwave activation induces the formation of reactive coke, enhancing the reaction rate and reducing surface intermediate concentrations.
A new study found that obesity rates in Canada increased faster after the start of the COVID-19 pandemic, especially among younger adults and females. The prevalence of obesity measured by BMI rose at a greater rate during the 4 years following the pandemic's onset compared to the previous 11 years.
The study successfully demonstrated impedance tuning of a 250 GHz waveguide transition, validating the effectiveness of mechanical tuning as a method to compensate for fabrication-induced performance variation. Terahertz frequencies above 100 GHz offer extremely wide bandwidths suitable for next-generation wireless communications.
IBEC researchers develop new bioinks that incorporate extracellular matrix proteins, preserving biological function and allowing growth factors to be retained. The FACTORINK project aims to realise the potential of these bioinks for printing artificial tissues with multiphase models incorporating stem cells and the immune system.
The article provides practical strategies for managing symptoms in patients receiving GLP-1 RAs, focusing on diet and physical activity interventions to support muscle and nutrient preservation. Lifestyle factors remain crucial in GLP-1 RA treatment for effective weight management.
Researchers at Pusan National University have created novel materials called disulfide-based covalent adaptable networks (DS-CAN) that can change, fix, and retain their shape reversibly using magnetic fields and ultraviolet light. These materials enable UV- or heat-assisted shape fixation after deformation, which is also reversible.
A recent study reveals that discarded plastic materials are a significant hazard to young birds, causing entanglements that lead to deaths. The study found that soft plastics and synthetic ropes were the most prevalent materials in bird nests, with baler twine accounting for 63% of entanglements.
A new tool allows researchers to probe the metabolic processes of key citrus crop, clementine, to improve yields, flavor, and nutritional value. The comprehensive genome-scale model captures Citrus clementina's metabolism with exceptional accuracy, enabling simulating economically-relevant scenarios.
The UK Biobank has completed a groundbreaking imaging project, scanning the brains, hearts, abdomens, blood vessels, bones and joints of 100,000 volunteers to understand how diseases develop. The project is already improving patient care in the NHS and beyond, with over 1,300 peer-reviewed scientific papers published based on the data.
A new approach harnesses radiant cooling to reduce outdoor temperatures by up to 10 degrees Fahrenheit. The technique uses water-cooled aluminum panels and see-through, infrared-reflective thin polymer film to create a cooler space while maintaining visibility.
Scientists found that mesenchymal stromal cells (MSC) therapy improved immune recovery in cats with FIP, a disease similar to Long COVID. The study showed reduced systemic inflammation and increased regulatory T cells, suggesting potential benefits for human patients.
Researchers at Notre Dame's School of Architecture and the Lucy Family Institute for Data & Society developed EcoSphere, an AI-powered platform that visualizes embodied carbon emissions. The tool helps city planners identify strategies to reduce carbon emissions through renovation and extended building life.