Researchers identified nine distinct types of T cells that harbor inactive HIV cells, and persistent T cells with HIV even after antiretroviral therapies. This discovery brings medical experts closer to a cure for the infection affecting nearly 40 million people globally.
Researchers from ETH Zurich have developed a tiny plasmonic modulator that can transmit data at frequencies over a trillion oscillations per second. This breakthrough device reduces energy consumption and increases measurement accuracy, enabling efficient optical fibre technology for 6G mobile communications.
Early mammals that lived alongside dinosaurs were likely covered in dark and dusky greyish-brown fur, hinting at their ecological niche as nocturnal animals. Their pelage coloration played an important role in communication, camouflage, thermoregulation, and protection.
Researchers at University of North Carolina Health Care found that combination immunotherapy before surgery increased survival rates in people with head and neck squamous cell carcinomas. The treatment regimen doubled or tripled the response rate versus single immunotherapy, leading to a survival benefit for up to a third of patients.
Researchers discovered a novel coronavirus in bats in Brazil with similarities to the Middle East respiratory syndrome virus. The five bats belonged to two species and showed significant genetic diversity, prompting experiments to determine whether it can infect humans.
A significant association between high sugar-sweetened beverage intake and oral cavity cancer was found in this study involving nonsmoking women. The findings suggest a low baseline risk of oral cavity cancer in these women, highlighting the need for further research to validate the impact of this association.
Researchers found that individuals with lower acylcarnitine levels declined more slowly and showed fewer cognitive decline symptoms compared to those with high acylcarnitine levels. Healthy lifestyle interventions, such as a plant-based diet and exercise, may help lower bioenergetic age and potentially delay or prevent Alzheimer’s onset.
Experts propose evidence-based work design to mitigate administrative harms and improve patient safety, quality of care, and workforce well-being. The new framework aims to integrate short-term financial metrics with long-term outcomes, sparking a transformation in organizational decision-making.
Engineered platelets-based nano-aircraft carriers enhance targeted chemotherapy with graded drug release, promoting antitumor immune response and reducing metastasis. Researchers successfully develop Pts-based nanovesicles for precise cancer treatment.
The report finds that government efforts to censor media and disinformation are prevalent in autocratizing countries, with polarization increasing in a quarter of the world's democracies. Meanwhile, democracy levels are rising in 19 countries, including Ecuador and Sri Lanka, which have made democratic turnarounds.
Researchers discovered that the spatial arrangement of nearest Br-N atomic pairs is the major factor on organic-inorganic interactions, leading to emission enhancement under high pressure. The study provides valuable guidance for designing materials with targeted optical properties.
Researchers at Weizmann Institute create innovative method to track rapid material changes using two laser beams, enabling precise reconstruction of optical delay changes. This advance could lead to the development of fastest processors possible, increasing data transmission speed.
Researchers developed a 'nano-spring coating' technology to increase the lifespan and energy density of EV batteries. The technology, featuring multi-walled carbon nanotubes, absorbs strain energy generated from charging and discharging, preventing cracks and improving stability.
Researchers have developed a chiral semiconductor that emits circularly polarised light, potentially improving OLED display efficiency and enabling quantum computing. The innovation uses molecular design tricks inspired by nature to create ordered spiral columns of semiconducting molecules.
Yue Yu, Lehigh University mathematics professor, wins award for pioneering work in data-driven nonlocal models and integrating mathematical analysis into computational model design. The recognition honors her outstanding contributions to the field of computational mechanics at a young age.
A new type of hearing aid using an array of micro-epidermal actuators can significantly improve the hearing experience for patients with conductive hearing loss. The device uses vibrations on the skin behind the ear to bypass the ear canal and directly reach the inner ear, enhancing sound quality and control.
A study has established the importance of immunoglobulin A in generating a response to pneumonia vaccines. The research found that poor regulation of gut microbiota can lead to an inadequate immune response, leaving individuals vulnerable to respiratory infections.
Gayatri Chakravorty Spivak, a renowned literary theorist and philosopher, has been awarded the 2025 Holberg Prize for her pioneering work in comparative literature, translation, and postcolonial studies. Her research focuses on the subaltern, small social groups on the margins of history, challenging dominant discourses.
Researchers from IOCB Prague have developed a compound that could treat alopecia areata by targeting the immune system. The substance, a series of prodrugs based on derivatives of itaconic acid, has shown efficacy in mice tests and may be administered orally.
A new study found that viewing nature can help ease how people experience pain by reducing the brain activity linked to pain perception. The research suggests that the pain-relieving effect of nature is genuine and could provide an alternative way to relieve pain, potentially used in conjunction with medication.
Scientists at CRAG have made significant progress in understanding sorghum's molecular mechanisms and improving its breeding, focusing on enhancing drought tolerance. The team has identified key genetic mechanisms and developed an efficient transformation method using a ternary vector system.
A study by Frontiers found that cultural dimensions influence price endings, with individualistic cultures preferring round prices, uncertain cultures choosing just-below prices, and long-term oriented cultures opting for precise prices. These findings have implications for retailers operating in global markets.
Researchers discover edonerpic maleate enhances neural plasticity, supporting cortical reorganization and improving motor control in non-human primates with SCI. The compound promotes AMPA receptor movement to areas responsible for motor control, strengthening existing neural connections.
A new study of over 1,500 individuals in the US and Europe found that those prone to nostalgia have more close friends and work harder to maintain their relationships. Nostalgia is associated with a greater number of strong social ties and better overall health and wellbeing.
Incorporating neglected and underutilized species into school meal programs in Nairobi's informal settlements significantly improves nutrition for children while reducing costs. The study found that these climate-resilient crops, such as African nightshade and hyacinth bean, meet up to 30% of daily nutritional needs.
Research by Kobe University reveals that restoring abandoned grasslands requires at least 75 years of continuous management to regain plant diversity. Pollinators also take time to adapt, with generalist insects like flies and hoverflies dominating recently restored sites.
A recent study by Oregon Health & Science University and Weill Cornell Medicine has found that CMV lacking a certain viral protein complex can still be transmitted and cause significant harm to the developing fetus. The research suggests that additional vaccine targets need to be identified and explored to provide superior protection.
A pathway to more global climate finance is outlined in a recent study, highlighting the need for $500 billion annually between 2025 and 2035. This funding would support developing countries in reducing CO2 emissions in line with the 1.5-degree limit, resulting in significant economic benefits.
A study of 235 participants found that binge eating was perceived as the most trivial condition, with strong social stigma attached. This stigma can make it even harder for individuals to seek help and overcome their eating disorders.
A UMass Amherst Ph.D. student has been awarded a €20,000 grant to investigate a new therapeutic target for Lyme disease by targeting the GuaB enzyme necessary for Borrelia burgdorferi replication in mammals.
A new study from Edith Cowan University found that regular exercise significantly improved erectile function in patients with prostate cancer. The research suggests that exercise medicine should be considered a key part of their treatment, and may help address relationship issues caused by sexual dysfunction.
A new ontology for smart city infrastructure threats, cybercrime and digital investigation has been developed to assist digital forensic investigators. The ontology provides a consistent and structured representation of knowledge, allowing for increased efficiency and rapid remediation in future investigations.
A new diagnostic method called flicker optoretinography (f-ORG) analyzes the retina's reaction to light, helping to detect danger before symptoms appear. The technique detects even minor changes in photoreceptors, providing valuable insights into retinal health.
A new study suggests that violent supernovae caused at least two mass extinction events in Earth's history, including the late Devonian and Ordovician extinctions. Researchers believe a nearby supernova could have stripped the planet's atmosphere of ozone, sparking acid rain and exposing life to harmful ultraviolet radiation.
A recent analysis of US FDA data found over 1.2 million medical device adverse event reports were not submitted on time, with 400,000 reported more than six months after notification. Late reporting may prevent early detection of patient safety concerns and impact future device development.
Researchers identify methyl halides as a potential sign of microbial life on Hycean planets with thick hydrogen atmospheres. The gas could accumulate in exoplanet atmospheres and be detectable from light-years away, offering an optimal strategy for the search for extraterrestrial life.
A University of Queensland researcher has identified 66 fossilized footprints from 47 individual 3-toed dinosaurs that walked along a waterway during the Early Jurassic period. The footprints provide an unprecedented snapshot of dinosaur abundance, movement and behaviour from this time period.
A new type of antibody that stimulates the immune system to target cancer cells has shown promise in reducing tumor growth in treatment-resistant breast and ovarian cancers. The study found that the antibody, IgE, uniquely stimulated otherwise inactive immune cells to directly target HER2-expressing cancer cells.
Researchers developed a new technique to identify aggressive medulloblastoma in children, allowing doctors to tailor treatments and reduce unnecessary side effects. The MYC test can be performed in any pathology lab worldwide, providing faster and more accurate care for young patients with brain tumours.
Researchers emphasize the importance of regular screenings and treatment to prevent vision loss in patients with diabetes. Current guidelines recommend eye exams for adults with type 1 and type 2 diabetes, while adolescents and young adults are at higher risk due to difficulty controlling their condition.
A cross-sectional study of Ugandan adults with and without HIV found the prevalence of coronary atherosclerosis disease to be much lower than expected in similar populations in the Global North. The study's results refute prior notions that well-controlled HIV infection is associated with increased CAD risk.
Research at the University of Arizona Health Sciences found that certain terpenes in Cannabis sativa are effective at relieving post-surgical and fibromyalgia pain in preclinical models. Terpenes have been shown to provide significant pain relief in mouse models, with geraniol providing the most significant level of pain relief.
Research at Michigan State University found that dopamine plays a key role in reshaping memories of past rewarding events. This unexpected function challenges existing theories of dopamine and has implications for understanding addiction, depression, and other neuropsychiatric disorders.
A new gel impregnated with molecule T-5224 blocks key signaling pathway in scar tissue formation, reducing adhesions by nearly 300% in mice and minipigs. The gel is easy to apply and release the molecule over a period of two weeks.
Researchers are conducting a first-in-human clinical trial to test a modified herpes virus that targets spinal cord nerve cells to treat neurogenic bladder. The therapy, EG110A, aims to block sensory nerve signals causing involuntary bladder contractions and incontinence.
A new study using landscape transcriptomics identifies genetic signatures of stressors in bumble bees, suggesting this approach could accelerate conservation efforts for at-risk species. The method accurately identified stressors such as heat and cold, even in wild bees, with high accuracy rates.
Researchers at the University of Texas at Austin and Argonne National Laboratory have developed a comprehensive analysis of thermal stability in high-nickel cathode materials. The team discovered that each material has a critical state of charge defining its safe operating limit, which influences metal-oxygen bonds and surface reactivity.
A new study found that birds have lower cancer rates despite high blood sugar levels, challenging existing assumptions. The research suggests that some species have evolved natural biological defenses against cancer, which could inspire new approaches to prevention and treatment in humans.
The American Academy of Neurology, American Epilepsy Society, and Epilepsy Foundation of America have issued a consensus position statement on seizures and driving safety. The statement recommends that medical advisory boards conduct individualized risk assessments for people with seizures before allowing them to drive.
Researchers discovered that as birds age, their song gene networks change dramatically, with hub genes driving activity of other genes. This finding could lead to earlier diagnoses and better treatments for Parkinson's disease and Alzheimer's disease.
The launch of openRxiv aims to sustain and expand preprint sharing in life and health sciences, enabling scientists worldwide to communicate findings rapidly and openly. With a researcher-led governance model, openRxiv strengthens the foundation of preprint sharing, fostering collaboration and innovation across the sciences.
A study published in Physical Review Research reveals the intricate physical mechanisms involved in handclapping, including air flow, sound production, and resonance. The researchers found that the size and shape of the hand cavity affect the frequency of the clap, with cupped hands producing lower frequencies.
A study of over 32,000 people in rural India found scrub typhus infection affects up to 10% annually, leading to hospitalisations due to severe fever symptoms. The researchers highlight the need for improved diagnostic capabilities and community awareness to reduce unnecessary hospitalisations and fatal cases.
Researchers have developed a computational tool, Spotiphy, that uses generative AI to enhance the resolution of sequencing-based spatial transcriptomics without sacrificing gene coverage. This breakthrough enables single-cell resolution in tissue imaging while maintaining full transcriptome coverage.
Biomolecular condensates constantly shift their phase, affecting movement and chemical activities within the cell. Researchers have discovered that aging-associated interactions can lead to dysfunction and disease, and manipulating surface signals may help promote healthy biological reactions.
A study found that college athletes who experienced concussion showed persistent brain changes in scans even after being cleared to return to play and up to one year later. Brain function was also impaired, with reduced blood flow in the fronto-insular cortex.
Researchers have revamped a symptom assessment instrument to address pain, anxiety, and other symptoms of nursing home residents who are cognitively impaired. The new tool reliably captures physical and emotional distress, well-being, and end-of-life symptoms, providing guidance for expanding palliative care services in nursing homes.
A cross-sectional survey revealed high costs, inadequate training, and poor financing as major challenges to gastrointestinal endoscopy practice in Nigeria. Locally developed innovations have eased the practice, preventing it from collapsing.
When DNA is damaged by UV light, cells reorganize their genetic material in 3D space to prioritize repair. This dynamic process involves areas of high-activity DNA regions being prioritized for fix and gene activity changes, triggering emergency response genes.
A prospective cohort study found a significant association between food insecurity and incident cardiovascular disease in both Black and White US individuals. Food insecurity was also shown to be an important social deprivation measure for assessing CVD risk, highlighting its potential as a key factor in clinical assessment.