Proteomics-driven precision oncology combines multi-omics integration to reveal tumor heterogeneity and functional regulatory networks. Emerging single-cell and spatial proteomics technologies with AI analysis facilitate clinically relevant biomarker discovery.
High-speed particles bounce higher on wet walls due to a morphological transition in the post-collision liquid film, which shifts from a bridge to a dome shape. This phenomenon is crucial for predicting high-speed particle collisions and designing safer equipment.
Researchers found that Adgrl2 plays a crucial role in building both brain synapses and blood vessels, with different cell types producing distinct versions of the protein. Removing Adgrl2 from endothelial cells caused blood vessels to become leaky and lose their integrity.
Researchers propose two physical embedding solutions to improve machine learning force fields' accuracy and stability in organic systems. The first method uses adaptive bond length sampling, effectively covering high-energy bond length regions prone to simulation collapse. The second method employs top-down model correction using physi...
A team of researchers at The University of Osaka has created a wireless EEG transmission system that can operate without external power sources. The system harnesses energy from the temperature difference between the human body and surrounding air, allowing it to function reliably even in hot summer conditions.
Researchers analyze brain imaging data, microbiome profiles, and clinical assessments to identify biomarkers for precision mental healthcare. Early findings suggest certain electroencephalography features serve as non-invasive biomarkers indicating disease severity and treatment response.
An international study has found bowhead whales are recovering in stocks where large areas of hazardous sea ice conditions limited whaling centuries ago. This provides important natural sanctuaries for the species, allowing populations to recover more quickly today.
Researchers found three distinct trajectories of cognitive decline: stable, slow and fast decline. Biomarker data showed that participants who declined faster had higher P-tau217 levels and smaller hippocampi.
A team of researchers from The University of Osaka used supercomputer simulations to study how vortices generated by dolphin kicks power fast swimming. They found that large, powerful vortices created by the movement of the dolphin's tail are responsible for most of the propulsion, while smaller ones contribute little to forward motion.
Scientists discovered a method to predict cellular protein makeup from Raman light measurements, leveraging the power of Raman spectroscopy. The technique reveals globally coordinated abundance ratios across various conditions, with a core of proteins maintaining stability while smaller groups adapt to environmental changes.
A breakthrough in computer-designed thermoelectric generators has achieved more than eight times better efficiency than conventional designs. The innovative approach uses topology optimization to precisely control heat flow and minimize electrical resistance.
A study published in PNAS reveals that endothelial cells can repair DNA damage caused by disturbed flow, slowing atherosclerosis progression. Supplementing purines reverts these effects, suggesting future therapies targeting endothelial DNA repair could complement cholesterol-lowering drugs.
Researchers at the University of British Columbia have developed a new method to target intrinsically disordered proteins, which are difficult to treat with medication. The approach has shown promise in slowing prostate cancer growth and could lead to new treatments for various diseases.
A study using the Meta Ad Library found that gambling companies are reaching young men on social media at more than double the rate of women, with 91% of ads targeting men only. The age group most exposed to advertising was 25-34-year-olds, who accounted for over a third of all unique accounts reached.
Researchers developed a hybrid material combining biochar with polyzwitterionic hydrogel, achieving an evaporation rate of 3.57 kg/m²/h under standard sunlight conditions. The biochar enhances light absorption, water transport, and energy efficiency, making it suitable for seawater desalination applications.
Process water from hydrothermal carbonization contains substantial amounts of nutrients and organic compounds, making it a nutrient-rich resource for crop production and environmental management. Diluting the liquid or using pre-treatment methods can reduce risks associated with its use.
A new study from the University of Pittsburgh found that mindfulness training can help students build resilience in the face of emotional threats, leading to increased engagement in college physics. After five days of training, students reported feeling less threatened and more motivated to learn.
A minimally invasive catheter ablation procedure has been shown to provide substantial benefits for patients with advanced forms of atrial fibrillation. By targeting faulty electrical signaling in the heart, the procedure can lead to improved control of the disease and reduced risk of serious adverse events.
Astronomers using astroseismology have found that massive stars' rotation rates decrease with age, but a new study suggests this may not be the case. The research team used 3D simulations to investigate how magnetic fields affect rotation inside massive stars, revealing that some configurations can spin the core up.
The report highlights the operational wins of health systems utilizing digital twin technology, including reduced ER wait times, increased patient throughput, and optimized surgical blocks. Successful deployment depends on data integrity and a shared definition of reality across the organization.
A phase 2 study published in the Journal of Clinical Oncology found that a stem cell product called dilanubicel safely enabled umbilical cord blood transplants in 28 patients with leukemias and myelodysplastic syndrome, resulting in a 96% survival rate. The pooled stem cells provided essential early immune support, helping patients est...
A new study published in the American Journal of Obstetrics and Gynecology finds that approximately 11.8% of reproductive-age Latina women have fibroids, lower than previously estimated rates. The study, led by Michigan Medicine researchers, used ultrasound-confirmed diagnoses to confirm fibroid cases.
Researchers from UH, Baylor College of Medicine and MD Anderson Cancer Center propose a new treatment approach for Crohn's disease by targeting the stress signal that fuels inflammation. They found that repurposing two existing cancer medications can promote natural repair and regeneration of the intestinal lining.
Illinois Tech Professor of Applied Mathematics Fred Hickernell has been named a SIAM fellow for his outstanding research and contributions to high-dimensional integration and approximation. He is developing software libraries that make cutting-edge computational methods accessible to researchers.
Researchers at Rutgers University tested the efficacy of Bright IDEAS, a problem-solving skills training intervention, in reducing depression and anxiety symptoms and improving health-related quality of life among young adults with cancer. The study found significant reductions in symptoms and improvements in quality of life compared t...
Researchers have discovered a vulnerability in pancreatic cancer that could be targeted as a potential therapy. Damaged mitochondria leak double-stranded RNA within cancer cells, causing inflammation that fuels cancer growth.
A new theoretical framework shows that when interactions shift away from familiar contacts, activity can spread more widely. The study suggests that whether something spreads or stalls may hinge on a simple choice: revisit the same connections or explore new ones.
A study found that policies reducing deforestation in Brazil have failed to stop forest degradation, a slower and more dangerous form of destruction. Forests are becoming increasingly fragile due to fires, logging, and other human activities.
The University of Michigan study reveals that Napata, an ancient city in Sudan, benefited from the Nile's relatively stable flow and deposits of clay and silt. This landscape feature reduced flood risk while maintaining access to water, allowing for successful settlement and cultural development.
A team of Rice University researchers has developed a faster and more energy-efficient way to recover critical minerals from spent lithium-ion batteries. The new method uses aqueous solutions of amino chlorides, which can extract valuable metals in minutes rather than hours.
A new study reveals that the disappearance of large mammals led to significant changes in food webs across different continents. The researchers found that regions with more severe past extinctions had distinct differences in their current mammal populations, indicating a lasting impact on food webs.
Recent vaccine developments targeting H5N1 avian influenza reflect growing urgency of the threat. The Global Virus Network (GVN) supports these efforts and emphasizes the need for strengthened pandemic preparedness, including rapid production and deployment of effective vaccines.
A study in Brazil found that analyzing intracranial compliance using developed technology reduced mortality and neurological damage. The device uses a non-invasive sensor to monitor cerebral dynamics and intracranial pressure, allowing for early intervention before brain damage occurs.
Private firms with potential family successors in Sweden grew faster and invested more after the abolition of inheritance tax, which led to higher corporate taxes. The study suggests that rents from the tax abolition were shared with society through taxes and employee salaries.
Researchers from Weill Cornell Medicine and Boston University School of Public Health have developed a national Medicaid claims data platform to illuminate spending variation across states, plans, and populations. The project aims to provide actionable data for policymakers to improve care and efficiency.
A study by Brown University and Columbia University found that road infrastructure isolates communities, leading to increased schizophrenia-related hospital visits. The Community Severance Index measures physical and social disconnection using roads, traffic, and lack of pedestrian infrastructure.
Researchers tune Pt d electrons to boost LOHC dehydrogenation, achieving volcano-shaped correlation between Pt d electron density and turnover frequency. The optimized catalyst, Pt/MgO, maintains stable performance with lower coke deposition.
Rural youth experience elevated firearm exposure and mental health risks, with suicide rates surpassing urban areas. Researchers recommend holistic interventions focusing on safe storage practices and school-based education.
Researchers found strong associations between better cumulative cardiovascular health in young and mid-adulthood and lower risks of cardiovascular disease and death. Higher LE8 scores were associated with a 73% lower risk of CVD compared to those at the lowest quartile.
A five-year, T32 grant supports a multidisciplinary training program in cardiovascular epidemiology, graduating postdoctoral scholars in four tracks. The program aims to reduce global cardiovascular disease mortality by identifying risks and prevention strategies.
The new robotic system combines artificial intelligence, data-driven alignment planning, patient-specific implants, navigation, and robotic screw delivery to enhance precision and coordination. This technology streamlines operating room workflows, reducing procedure time and supporting recovery for patients undergoing spine fusions.
Researchers have captured the most detailed structural images to date of a specific type of protein's DNA repair process, revealing key steps in its repair activities. The findings provide insights for drug targets that could halt the process in cancer cells empowered by mutated BRCA genes.
The NRL Plasma Physics Division has advanced understanding of plasma, supporting technologies critical to national defense, space science, and advanced materials. Researchers have developed novel concepts for detecting and removing space debris, as well as technologies for high-energy density physics and pulsed power.
A new study suggests that language and theory of mind, two complex cognitive functions, have distinct origins in the brain in young children. Researchers found separate but related brain regions for these skills, which do not overlap or grow more distinct as the mind matures.
MIT researchers have created an 'EnergAIzer' method that generates reliable results in seconds, allowing data center operators to optimize resource allocation and reduce energy waste. The tool leverages patterns from AI workloads and software optimizations to provide fast but accurate power estimates.
Researchers developed RF-SIRF, a quantitative method to detect and map reversed DNA replication forks with single-cell resolution. The study identified unique epigenetic codes for DNA replication stress that can be further examined to understand genomic stability, aging, and treatment response.
Research explores how differences in brain development, age, and sleep affect EEG signals recorded from awake individuals. The study reveals that brain signals during wakefulness depend on prior sleep, with effects differing between children and adults.
A new study found that nearly 1,200 TBI respondents used psychedelics to treat or manage physical health conditions, with 208 participants using them to manage brain injury-related symptoms. Researchers reported a 90% self-reported symptom improvement rate.
A new study finds that specialty-specific clinical practice guidelines can significantly impact postoperative pain management and reduce long-term risk of opioid exposure. The AAO-HNSF opioid prescribing guideline was effective in reducing opioid prescribing after parotidectomy, promoting a multimodal approach to pain management.
A study by Universidad Carlos III de Madrid proposes Proportional Justified Representation (PJR), a balanced and flexible tool that ensures mathematically perfect solutions, preventing significant groups from being excluded. The method has applications in electoral voting systems, expert committee selection, and recommendation systems.
A new study found that apixaban is associated with fewer major complications and more days at home for older adults with venous thromboembolism than other blood thinners. Apixaban was also linked to a lower combined risk of recurrent blood clots or death within one year compared to warfarin.
A UB-led team has found a way to help chiral semiconductors, electronic materials whose structures are left- or right-handed like many of life's building blocks, absorb visible light. Researchers chemically combined a chiral semiconducting material with a non-chiral molecule that more readily absorbs visible light.
Alison A. Moore, MD, MPH, FACP, AGSF will begin her term as President of the American Geriatrics Society (AGS) in April 2026. She has dedicated her career to advancing health and well-being for older adults, with a focus on technology, health equity, and HIV.
The new facility enables scientists to observe and measure detonation forces in unprecedented detail, shedding light on industrial safety risks and potential breakthroughs. Researchers aim to develop safer designs and protocols by examining detonation disasters like the Buncefield Fire.
Lancaster University researchers created a new toolset to guide developers in designing digital technologies that support mindful eating. The toolset, MEDEC cards, provides practical guidelines for designers and health practitioners, aligning with evidence-based health research and ensuring safe and effective solutions.
A new framework proposes a continuum of urbanity, challenging traditional thinking about urban and rural spaces. The study explores how urban, rural, and wild features are interconnected, affecting livelihoods, ecosystems, and human well-being in the Mid-Hudson Valley region.
Researchers found a higher risk of acute lymphoblastic leukemia among children exposed to PFAS compounds at birth. The study suggests that early-life exposure may contribute to cancer risk in children and highlights the need for further research on PFAS contamination.
FINGERS-7B integrates lifestyle, clinical, genomic, and proteomic data to discover multi-omic biomarkers for preclinical Alzheimer's. The model delivers 4× more accurate preclinical diagnosis and 130% better responder stratification than prior art.
A free self-efficacy survey has been developed for informal science educators, aiming to fill the gap in evaluation systems that leave them struggling to improve. The survey assesses pedagogical success using widely used measurements and provides a way for educators to identify areas needing support.
Researchers at McGill University have developed a novel device that generates sound-like particles known as phonons at extremely cold temperatures. The technology has potential applications in high-speed communications, sensing tools, biological materials, and medical systems.