A randomized clinical trial found that proactive outreach for care coordination did not lead to better outcomes compared to usual care post-hospitalization coordination. Many participants declined the offer. The study suggests that current strategies may need to be reassessed.
Researchers developed a coarse-to-fine saliency-driven maritime ship detection network to improve detection accuracy in complex scenes. The framework achieves high F1 scores and mean average precision, outperforming strong baseline detectors.
Researchers found that soil fungi are essential for native forest re-growth and ecosystem health on Palmyra Atoll. The symbiotic relationship between Pisonia trees and fungal partners is critical for the atoll's unique ecosystem.
A nationwide Swedish study of 27,789 individuals with confirmed celiac disease found no link between antibiotic use and increased risk of developing the autoimmune disorder. The study also revealed a higher proportion of prior antibiotics used among those with normal mucosa, suggesting other factors may contribute to its development.
Researchers developed a Fe-Mg dual-atom catalyst that regulates spin states to optimize the oxygen reduction reaction, achieving exceptional electrocatalytic metrics and surpassing platinum benchmarks. The optimized catalyst delivers outstanding stability and viability for real-world applications.
Researchers have created a detailed diagram of smell receptors in the nose, revealing a highly organized receptor map that mirrors the organization of smell maps in the brain. The discovery sheds light on how information moves from the nose to the brain and could lead to therapies for loss of smell.
University of Oregon researchers have created an electrochemical tool that can quantify and separate the factors influencing coffee taste. The innovation allows cafes to improve quality control with a simple measurement, while also helping scientists understand individual tastes at a molecular level.
Researchers developed a new method to identify cellular features supporting metastatic cancer growth, revealing an unexpected driver of immune suppression in bone metastasis. Estrogen receptor alpha-activated macrophages play a key role in immunosuppression and tumor progression.
Researchers develop solar-powered technology to convert plastic waste into valuable fuels, including hydrogen and syngas, reducing reliance on fossil fuels and addressing pollution challenges.
A recent study published in JAMA Network Open found that half of older patients with dementia remain on psychotropic drugs a year after starting them. The medications, including antipsychotics and benzodiazepines, are often prescribed in acute and post-acute settings such as emergency rooms and skilled nursing facilities. This raises c...
Researchers created a detailed diagram of smell receptors in the nose, revealing that they form horizontal stripes based on receptor type from top to bottom. The study provides foundational information for developing therapies for loss of smell and offers insights into how information moves from the nose to the brain.
A study by the University of Cambridge found that racism and socioeconomic stress can alter key physiological processes in the body during pregnancy, leading to higher rates of preeclampsia and preterm birth in black women. These changes are not due to genetic differences but rather persistent socio-environmental stressors.
Engineers at MIT and their collaborators create a new type of soft magnetic hydrogel that can be made into complex, magnetically activated three-dimensional structures. The new gel enables the creation of microscopic, magnetically responsive robots and materials with micron-scale precision.
Researchers designed a force-sensing miniature robot to handle delicate cell spheroids with precision. The mobile microgripper uses magnets for controlled movement and gentle gripping, allowing successful assembly of spheroids into patterns.
Researchers developed meta-earplugs with Helmholtz resonators to address low-frequency sound issues. The earplugs use precise tuning of reflected sound waves to relieve pressure and increase protection.
A new study reveals the developmental mechanism of bone marrow formation, identifying septoclasts as early organizers followed by LepR-expressing bone marrow stromal cells. These specialized cell populations work together to build the bone marrow environment through a hardwired process supported by RANKL.
Researchers found that exposure to aggressive diplomatic messaging reduces favorability towards China in Japan, South Korea, and Taiwan. In contrast, perceptions of the US are less affected, with limited persuasive power.
Independent academic clinical trials are essential for improving patient outcomes, reducing inequalities in care, and strengthening healthcare systems. The Lancet Oncology Commission aims to deliver actionable recommendations to ensure these trials continue to benefit patients and society worldwide.
A study by researchers at the University of Basel reveals that the immune system fights lifelong viral infections acquired at birth, with partial success. The body gradually produces antibodies to reduce virus amounts, supported by T helper cells, but the response remains limited.
A new AI model, PLGMamba, improves hyperspectral image super-resolution by combining local spectral similarity with global feature modeling. The approach achieves stronger reconstruction accuracy than several leading super-resolution methods and overcomes limitations of existing models.
A cross-sectional study found that older adults are disproportionately prescribed medications affecting cognition from acute or postacute care settings. This highlights the need to target prescriptions from these settings to reduce such prescribing.
A pinecone-inspired self-curling adhesive conduit was developed to provide adaptive wrapping for peripheral nerve repair, achieving faster curling speed and higher bending curvature than existing conduits. The material demonstrated good biocompatibility, promoting cell migration and creating a favorable repair microenvironment.
A novel circular RNA replicon was identified in a high-temperature hot spring ecosystem, showing profound divergence from previously known circular RNAs. The discovery reveals diverse self-replicating RNAs exist even in extreme environments, broadening the ecological scope of RNA-based replication systems.
Tomatoes have difficulty germinating under prolonged heat stress, but two mutant lines with the loss-of-function mutation in SlIAA9 showed little decline in germination and normal seedling development. The mutants exhibited elevated expression of antioxidant enzymes and heat shock proteins, leading to enhanced resilience to heat stress.
Researchers developed an ultrafast transient absorption microscope to analyze fluctuations and heterogeneities in light-harvesting antennae. The study revealed two kinetic components with nearly identical time constants and quantified photophysical properties associated with these components.
Researchers identified an ion channel that opens and closes in response to extracellular potassium ions in fruit flies, and found similar functionality in humans. This discovery reveals a novel sensor for extracellular K+ levels, potentially linking to diseases like epilepsy.
Dr Hendricks-Sturrup brings expertise in biomedical research, bioethics, and policy to lead the editorial board. Her experience will focus on disseminating high-quality research globally.
Researchers used LiDAR surveys to analyze medieval mountain castles' topography, distinguishing between human-made and natural landscapes. The study found that castle sites exhibit greater variability in slope compared to unmodified natural ridges, with high slope variability linked to landslide traces within the castle boundaries.
Researchers have developed a deep-learning framework to reconstruct a global, high-resolution nighttime light dataset from 1992 to 2024. The new product improves upon existing datasets by reducing saturation-related bias and better capturing temporal changes in urbanization, economic activity, and human development.
Researchers discovered that malaria parasite PI3K suppresses 'eat-me' signal to evade host immune system. By inhibiting PI3K, phosphatidylserine exposure increases, enhancing macrophage recognition and clearance of infected red blood cells.
Researchers found that Pseudomonas syringae triggers P-bodies to reduce protein synthesis, impairing plant defense mechanisms. This manipulation also involves reprogramming cellular stress responses and autophagy, adding layers of complexity to bacterial infection strategies.
A new 10-year project agreement advances US-EU collaboration on Wendelstein 7-X stellarator, a key experiment in fusion energy. The framework streamlines processes for joint research projects and provides a consistent legal structure for partnerships.
The new NCCN Guidelines for Patients: Prostate Cancer Screening provide a comprehensive guide to evidence-based recommendations for age-specific screening. The guidelines aim to balance the benefits of early detection with the risks of unnecessary procedures, emphasizing the importance of personalized care and monitoring.
A study on the phylogeography of Burmannia nepalensis, a rare mycoheterotrophic herb in subtropical China, found that historical climate fluctuations and geographic isolation shaped its evolutionary history. The research reveals limited gene flow due to mountain barriers and fragmented habitats.
A global research network, led by ASAP and MJFF, is expanding its efforts to map the biological blueprint of Parkinson's disease and develop a standardized toolkit of global research resources. This expansion aims to accelerate the development of personalized therapies by understanding the disease's inherent heterogeneity.
Researchers developed a machine learning model to identify insects based on radar reflection changes from wing flapping. The model achieved high accuracy in distinguishing between species, including bees and wasps, with an accuracy of 96% and 85%, respectively.
Researchers developed BikeButler to provide personalized bike routes for cyclists in Seattle. The app uses a visual language model to analyze street images and rate subjective attributes like greenery and pavement quality.
EGFR-TKIs have significantly improved OS and quality of life for EGFR-mutant NSCLC patients. However, ongoing research is needed to refine therapies for precise individualized treatment, addressing resistance mechanisms and optimal combination strategies.
Researchers found that integrating a mix of shade trees improves soil health and plant physiology, leading to stronger plant growth and consistent early fruit development. Proper management through spacing, pruning, and natural mulch can also make cacao farms more resilient to climate stress.
Researchers identified blocking ID1 and ID3 as a promising therapeutic strategy to halt and reverse lung scarring in idiopathic pulmonary fibrosis. The approach showed significant reduction in lung scarring and improvement in lung function across multiple experimental systems.
A recent CNIO study has identified a key mechanism in the development of liver fibrosis by targeting bile duct cells. The research reveals that these cells regulate liver health and form a barrier that prevents bile acid leakage and fibrosis, opening new avenues for personalized treatment.
A UCLA-led study reveals that airborne desert dust traps about twice as much heat as previously estimated, leading to improved climate and weather models. This increase in precision will help forecasters predict regional temperature shifts, rainfall patterns, and atmospheric motions.
Research highlights how everyday factors from early life through adulthood influence brain health and affect the risk of developing cognitive decline, dementia or stroke. Healthy lifestyle habits such as regular physical activity, healthy sleep habits, and balanced eating patterns can support brain development and healthy aging.
Orange County residents hold broadly positive but carefully qualified views on immigration, recognizing its benefits while drawing distinctions around enforcement. The UCI-OC Poll found that Orange County residents are pragmatic about immigration, supporting targeted enforcement against human trafficking and limiting immigration from u...
A new study suggests that an AI tool analyzing facial changes can serve as a prognostic biomarker for cancer prognosis. The researchers found that patients with higher biological aging rates had lower chances of survival, and the effect was strongest when photos were taken over longer intervals.
A decades-long study of oceanographic data shows that warm water has expanded and shifted towards the Antarctic continental shelf, posing a threat to ice shelves. The Southern Ocean's circulation has changed, allowing excess heat from global warming to reach Antarctica's vulnerable ice sheets.
A 30-country survey found that digital health literacy is highest in low- and middle-income countries, where social media plays a key role. The study also highlights variation in trust for credible sources, with medical providers being the most trusted, followed by verification through multiple sources.
The Mediterranean fin whale population is found to be genetically connected to North Atlantic populations, contrary to previous assumptions. This finding highlights the need for reevaluation of conservation strategies and increased connectivity between populations.
A new study by researchers at IMT School for Advanced Studies Lucca analyzed over 3,700 reports of dream and waking experiences to understand what determines the content of dreams. The findings show that both individual characteristics and shared life experiences play a key role in shaping dream content.
New research from the University of Waterloo shows that social media posts can speed up wildfire response but also trigger costly over-reaction. The study analyzed Twitter data on California wildfires and found that while emotional posts can amplify urgency, they also distort resource allocation.
Researchers have created an ultra-thin, lightweight shielding material that blocks 99.999% of electromagnetic waves and reduces neutrons by approximately 72%. The material is also stretchy like rubber, suitable for 3D printing and can withstand extreme temperatures.
A new peer-reviewed study finds that bottom trawling in European waters results in significant economic losses, with annual costs reaching up to €16 billion. The destructive fishing practice is also found to be a major contributor to climate change, with its impacts felt throughout the region's marine ecosystems.
Binghamton University Professor L. Nathan Tumey is working on developing new chemical technologies for antibody-drug-conjugates to push the boundaries of what can be accomplished in ADCs. The goal is to awaken tumor-associated immune cells and prevent cancer regrowth.
A new study led by Prof. YAN Xiaoyuan finds that most nitrogen gas emissions from rice paddies originate from soil organic nitrogen, rather than applied fertilizers. The researchers propose a novel mechanism to explain this phenomenon, suggesting that fertilizer activates soil nitrogen pools, indirectly driving larger nitrogen losses.
A new study developed China's high-precision, 1 km resolution soil moisture dataset using machine learning techniques. This dataset enables daily monitoring of soil dryness and wetness conditions across the country, providing critical support for drought early warning, flood forecasting, and agricultural management.
A new device combines high-performance single-photon generation with multidimensional state engineering, enabling flexible control over photon properties. The integrated platform delivers record-breaking source performance and opens up opportunities for resilient quantum entanglement and high-dimensional quantum communication.
Researchers have developed a new methodology for selective molecular transformations of polycyclic aromatic hydrocarbons (PAHs), targeting the challenging L-region. This enables the creation of larger PAH structures and new nanographenes, increasing versatility in technological applications.
A new tool estimates that global sewer systems emit 1.18 to 1.95 million tons of methane annually, contributing to global warming and climate change. The study confirms that urban sewers are a quantifiable source of methane emissions, highlighting the need for their inclusion in greenhouse gas accounting.
Researchers discovered that strokes cause a chain reaction within the brain, leading to neuronal cell death. They found that blocking collagen production can prevent this damage and even restore motor function in paralyzed monkeys. The new drug KDS12025 reduces hydrogen peroxide levels and prevents the entire process from being triggered.
Researchers successfully decoded the polarization cipher of light using high-energy electrons, confirming a key prediction of quantum electrodynamics. The study's findings offer a new pathway toward creating highly polarized, high-brightness gamma-ray sources.