A UCLA-led international collaboration has unveiled a new technology that enables scientists to directly compare how different molecules compete for the same binding site on a protein, all in a single experiment. The results show promising interactions between two cancer drugs and reveal previously unknown interactions.
The US Department of Energy has selected four companies to participate in its Nuclear Energy Launch Pad initiative, which aims to support the development and deployment of advanced nuclear technologies. The selected companies will receive technical, regulatory, and deployment support from the National Reactor Innovation Center.
Researchers at UTHealth Houston have been awarded a three-year, $7.8 million grant to better understand how Parkinson’s disease occurs in the brain. The project aims to identify proteins and cellular pathways involved in brain damage, with the goal of developing novel strategies for intervention.
Researchers found striking, decades-long cycles in US suicide rates, influenced by broad social forces. Suicide risk has been rising steadily for over half a century among young people, affecting each new generation earlier in life.
Researchers found that distinct patterns on lung scans can signal disease severity and predict breathing problems. The study's findings may help doctors tailor treatment approaches for patients with sarcoidosis.
Researchers at UIC developed an anti-cancer therapy using a bacterial protein called aurB, which prevents energy production in tumor cells' mitochondria. The treatment was tested in combination with radiation and showed highly effective results in animal models of prostate cancer, effectively shutting down tumor growth.
Researchers found that fish lineages adapted to scrape algae and shellfish from hard surfaces evolved in more diverse ways than those living in open water. Coral reef fish are thought to have benefited from this adaptation, driving the acceleration of diversification.
A four-decade long study found that even 'stable' carbon in forest soils can break down as temperatures rise, releasing more CO2. Microbial communities play a critical role in soil ecosystems and their changes can speed the loss of carbon from soils.
New study finds anaerobic digestion of hemp hurd-based bioplastic systems delivers the best environmental outcome, generating up to 6.1 kg less CO2 emissions per 1 kg mulch film treated. The production process significantly affects the final carbon footprint of biocomposites.
The BBVA Foundation Frontiers of Knowledge Award recognizes the Institute for Social Research (ISR) at the University of Michigan and NORC at the University of Chicago for their work in developing reliable data series on social sciences. The award acknowledges their contributions to objective measurement of public opinion, survey metho...
Research in Amazonas reveals that small amounts of Amazonian dark earth can increase the height and diameter of two tree species by up to 55% and 88%, respectively. The study attributes this growth to the reorganization of beneficial microorganisms around plant roots.
Engineers developed an adhesive gel that can deliver substances into plants' tissues, clearing bacterial infections within 48 hours. The gel sticks to various surfaces, including hairy leaves and stems, and can be removed without damage.
Chronic liver disease in the US costs $41.57 billion, with prescription medication expenditures accounting for nearly half of all-cause healthcare expenditures. Poor adherence to antiviral medications is a key factor in preventing disease progression and treatment, with high out-of-pocket costs increasing non-adherence risk.
A $456,000 grant from Critical Path Institute will support the development of a brain-penetrant therapy for glycosphingolipid storage disorders. The therapy aims to address neurological symptoms in patients with current limited treatment options.
Biofortifying staple crops like rice, wheat, and maize can reduce the risk of non-communicable diseases and improve nutrition. Researchers have developed high-protein rice with elevated essential amino acids, which can also help manage blood sugar levels.
Simulations by a team of scientists show that unrestricted information sharing can lead to less accurate collective beliefs, particularly in socially homogenous settings. This phenomenon is driven by homophily and the amplification of erroneous ideas within groups.
Researchers have developed a perovskite diode that can convert sunlight to electricity and emit light with high efficiency, resolving the challenge of doing both. The device achieves a world-record 26.7% efficiency in converting sunlight to electricity and 31% efficiency in emitting light.
A first-in-human clinical trial found that setidegrasib, a targeted therapy drug, demonstrated early antitumor activity in advanced lung and pancreatic cancers. The therapy shrank tumors and delayed disease progression in some patients, providing a potential new treatment approach for KRAS G12D-driven cancers.
A new study reveals that releasing goldfish into the wild can trigger a regime shift in freshwater ecosystems, leading to degradation and harm to native wildlife. The research calls for stronger public education campaigns and prevention strategies to control invasive goldfish populations.
Researchers at Indiana University School of Medicine developed a new method to analyze brain energy network patterns, revealing insights into Alzheimer's disease progression. The study found that brain networks reorganize as the disease progresses, with memory and language functions showing increased metabolic demand in early stages.
Motif Neurotech has received FDA approval to begin the first clinical trial of its therapeutic BCI device, DOT, for treatment-resistant depression. The study will test the device's effectiveness in delivering electrical stimulation to brain circuits linked to depression.
Researchers at the UC Davis MIND Institute found that polychlorinated biphenyls (PCBs) alter genes more in females than males, with a key gene called XIST playing a protective role. Folic acid also shows promise in mitigating harmful effects of PCB exposure, particularly in women.
A new review found that lifestyle behaviors like physical activity and diet can positively modulate the gut microbiome of cancer patients, but these effects are often influenced by non-modifiable variables. The study also highlighted the role of intrinsic patient characteristics in shaping microbial composition.
Researchers at NYU Abu Dhabi developed soft, flexible sensors that measure force in real-time during minimally invasive surgeries. The sensors, made from silicone and liquid metal, can detect a wide range of forces and are easy to integrate with existing tools.
A study found that prey scarcity is a key factor in jaguar presence in protected areas of the Atlantic Forest, with reduced abundance and biomass due to human hunting. The researchers warn that this situation could lead to the biome losing its top predator population.
A large study found that individuals with difficulty recognizing and expressing emotions experience greater disruption to daily life from pain over time due to increased psychological distress. The study also suggests that addressing emotional processing difficulties may be key to improving long-term outcomes for people with chronic pain.
A new Cornell University study reveals that social media boycotts have less impact on music streams than platform sanctions. In several high-profile controversies, scandal-related attention coincided with short-term increases in streams. However, when platforms reduced visibility of the artists' music, clearest declines appeared.
Researchers have created lab-grown human skin organoids that can form complex microvascular networks similar to those in native human skin. These self-organizing structures function similarly to native skin, responding to inflammatory stimuli and re-growing after injury.
Researchers at the University of Illinois have developed a machine learning model that can predict chick embryo mortality using hyperspectral imagery, reaching accuracy of up to 97%. They also successfully identified male embryos with high accuracy, potentially reducing the culling of male chicks in hatcheries.
Researchers at Texas A&M University created HIPPO, a browser extension that generates unique passwords for each website without storing them. Participants preferred HIPPO over traditional password tools for ease and security, reporting higher satisfaction rates.
A preclinical study found that mice stopped and restarted GLP-1s gained less weight over time, with a significant decrease in muscle mass. The researchers suggest that clinicians help patients preserve muscle mass while on these medications through exercise or nutrition.
A team of scientists at the University of California, Davis, has discovered an inherited form of blindness directly comparable to autosomal dominant optic atrophy (ADOA) in rhesus macaques. The study could lead to a better understanding of ADOA and potentially new treatments.
Researchers discovered a molecular complex linking abscisic acid to sucrose metabolism in grape berries, accelerating sugar accumulation and berry ripening. The VvMYB44-VvERF045 pathway activates the key gene VvSPS4, enabling a clearer understanding of how hormone signaling translates into biochemical changes affecting fruit quality.
A Concordia-led study analyzed 53 green alleys and 23 conventional alleys in Montreal and Trois-Rivières, finding that results depend on alley design and purpose. The study suggests a middle ground between community-led projects and standardized approaches to achieve both biodiversity and social cohesion.
Visitors to a California region with numerous substance use disorder treatment centers experience higher levels of overdose, particularly out-of-state individuals. The study suggests that the industry's lack of oversight and predatory practices contribute to this hotspot.
CPSS cause hyperammonemia, hepatopulmonary syndrome, portopulmonary hypertension, and liver nodules/tumors. Detection relies on Doppler ultrasound, CT angiography, and MRI. Treatment depends on shunt type and severity, with endovascular or surgical options available.
A study identifies subtype-specific programs in pediatric ependymoma, linking metabolic patterns to clinical aggressiveness. The research reveals distinct metabolic profiles for each molecular subtype, providing a resource for understanding the biology of pediatric ependymoma and potential therapeutic vulnerabilities.
Researchers developed a fleet of cooperative robots that, like ants, can spontaneously organize to build and dismantle structures without central control. They identified key parameters needed for excavation and building performance using simple local rules.
Micro-gesture recognition is emerging as a key area of research in affective computing, focused on analyzing subtle, involuntary body movements that may reflect hidden emotional states. The field has expanded from RGB video to skeleton, audio, text, and privacy-preserving multimodal settings.
Researchers recorded single-unit activity in bats' inferior colliculus while they were freely vocalizing. The study found that 95% of neurons responded differently to self-generated vocalizations than to playback of the same calls.
A UK-led trial found that a procedure to reopen blocked heart arteries can reduce chest pain and improve quality of life. Patients who received the treatment had more angina-free days and better quality-of-life scores than those in the placebo group.
A new study published in BMC Medicine found that the experimental drug ZED1227 inhibits the activity of the transglutaminase 2 enzyme, reducing immune responses triggered by gluten. The results suggest that the drug has effects beyond the gut, dampening whole-body immunometabolic responses.
Scientists created hybrid macrophages that can simultaneously promote blood vessel and bone growth, potentially improving outcomes for patients with bone fractures. The discovery could lead to new cell-derived therapies that speed up recovery and improve healing.
The Harvard-led team demonstrates a micron-scale photonic device that generates two orders of magnitude more UV light on a chip than previous approaches. By converting red light to UV light through frequency upconversion, the researchers create high-power, low-loss, compact UV sources.
A recent study by Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau found that light pollution significantly alters the composition of predatory spiders' diets, leading to reduced hatching of insects. The invasive signal crayfish also contributes to altered feeding behavior under nighttime lighting.
A specific region of Dicer must be activated to achieve proper cell division and reproduction, a discovery that sheds light on the regulation of this enzyme's critical role in both cancer biology and fertility. This finding opens new avenues for studying how small epigenetic changes contribute to disease.
A new analysis of nearly 400 young participants found that those starting a healthy lifestyle program in spring showed weaker improvement than those beginning in summer, autumn, or winter. The study suggests that school calendars, daily routines, and long holiday breaks can impact treatment success.
A new study from Mayo Clinic suggests that Alzheimer's disease may start as early as the late 50s, with subtle biological changes accelerating over time. Researchers analyzed data from 2,082 participants and found that biomarkers of tau pathology and neurodegeneration show more pronounced increases around ages 68 to 72.
A review article analyzes InP quantum dot synthesis, core/shell optimization, ligands, and charge management for high-performance QLEDs. The study reveals the intrinsic relationship between microscopic material properties and macroscopic device performance.
Dampening, a phenomenon where positive emotions are diminished, can undermine well-being over time. Research found that future-focused thoughts, such as 'positive feelings won't last,' are strong predictors of depressive symptoms.
A large cohort study found that ABC risk factors carry greater cardiovascular significance at younger ages but become less relevant with age. The study supports an age-adapted approach to diabetes risk-factor management and highlights the importance of individualized treatment decisions in older adults.
Researchers from Lund University successfully harnessed the regenerative capacity of Scandinavian flatworms to accelerate wound healing in human skin models. The study found that signalling molecules from flatworm exosomes increased skin thickness and improved wound healing rates, including accelerated blood vessel regeneration.
Researchers discover zinc levels control endoplasmic reticulum redox enzymes necessary for proper protein folding. Zinc surge disrupts oxidative folding, leading to protein misfolding and cellular defects.
A study by the University of Trento reveals that ultra-stable glasses exhibit almost identical basic vibrations to normal glass, contradicting previous computer simulations. This finding suggests that vibrational modes are less sensitive to disorder than thought.
A Mayo Clinic study found that bariatric surgery reduces long-term cardiovascular risk more effectively than weight-loss medications. The study analyzed outcomes for 812 adults with obesity and found that greater weight loss led to larger reductions in lifetime cardiovascular risk.
Researchers at the University of East Anglia have discovered that light can be programmed using its natural geometry, allowing for the creation of structured light with unique properties. This breakthrough has far-reaching implications for fields such as medicine, data transmission, and quantum technologies.
The Patient-Centered Outcomes Research Institute (PCORI) has awarded funding for new patient-centered comparative clinical effectiveness research projects. These studies will examine different approaches to care across various health concerns, aiming to generate evidence for patients to make informed choices.
New research from the University of Texas at Austin finds that regulators with ties to Big Four accounting firms are less likely to detect financial statement errors and ask for amendments. A cooling-off period might increase confidence in regulatory oversight, but its implementation could be challenging due to staff limitations.
Dr. Indra Narang, a pediatric respirologist and sleep medicine specialist, has received the 2026 Inclusive Leadership Award for her work to broaden access and representation in sleep medicine. Her research focuses on improving diagnosis and treatment of childhood obstructive sleep apnea with an emphasis on equity-driven innovation.
A study reviews benchmark datasets, evaluation metrics, fusion strategies, and model development in multimodal deception detection. The field is moving toward more practical, scalable, and context-aware systems that combine verbal and nonverbal evidence.