A team of materials scientists developed novel microstructures to enhance the properties of silicon nitride ceramics. The study reveals that a twisted intergrowth mechanism promotes high strength and toughness by reducing grain coarsening and improving phase transformation.
Researchers at McGill University have developed a rapid way to engineer blood clots that stop severe bleeding and support tissue healing more effectively. The technique, called 'click clotting,' links red blood cell surface proteins through a chemical reaction, resulting in a biocompatible clot.
Researchers warn of potential risks associated with evolvable AI systems, which can tap into the power of biological evolution to create 'selfish' actors that break alignment with human goals. The study recommends guardrails to maintain centralized control over AI reproduction and mitigate risks.
A new study investigates plasma biomarkers' role in early-onset Alzheimer's disease and frontotemporal dementia. The findings suggest distinct trajectories and clinical associations, supporting their potential utility for risk stratification.
A study by the University of Vaasa and Aalto University finds that mandatory cybersecurity disclosure in the US has increased internal documentation and made cyber risks more visible to senior management, but not affected investor behavior. Companies produced new content describing their cybersecurity governance structures, suggesting ...
Researchers at Penn Medicine have identified a previously unrecognized form of diabetic kidney disease marked by clusters of immune cells, specifically B cells, that are linked to faster disease progression. The study's findings could guide more targeted treatments in the future.
Researchers identify mechanical stability as a crucial factor in antibody effectiveness against SARS-CoV-2. The study found that conventional antibodies distribute mechanical load unevenly and that viral mutations influence both binding affinity and mechanical resistance.
The Urban Bee Concept aims to enable coexistence of honeybees and wild bees in urban areas by reducing competition for resources. This is achieved through measures such as heat stress management and floral resource increase initiatives.
A new study reveals that climate models are less confident in predicting regional rainfall patterns due to uncertainties in large-scale wind patterns. This limits confidence in forecasts of floods and droughts, particularly in regions vulnerable to these events.
Research reveals two dimensions of neuroticism: one linked to mental disorders and life well-being, the other to emotional reactivity and internal stability. High-ERIS individuals live longer due to healthier habits and risk avoidance.
Researchers used a new AI-powered computational method to discover that most nucleosomes contain sections of DNA that are partially accessible to the cell. The study found that more than 85% of nucleosomes showed some degree of distortion, with 14 distinct structural states associated with different levels of gene activity.
A study by the Sant Pau Research Institute found that placental insufficiency during pregnancy is associated with higher risk of memory alterations years after childbirth. Women with angiogenic imbalance had a higher frequency of memory problems, even after accounting for other clinical factors.
Researchers found that nerves of the sympathetic nervous system inhibit tumor growth by reducing local tumor-supportive macrophages, a type of immune cell. The findings may inform future therapeutic strategies targeting sympathetic nerves within tumors or alpha adrenergic receptors on tumor-associated macrophages.
A new vaccine strategy has generated antibodies capable of neutralising highly divergent HIV variants in an animal model. The study provides new insights into how the immune system can be guided towards a particularly protected part of the virus, which is important for developing an effective HIV vaccine.
The publication provides an overview of advances in acoustic waves in solids, with a focus on their potential to manipulate physical processes in solid-state systems. Key findings include the increasing application of SAWs in quantum technologies, optomechanics, and advanced signal processing.
A study by Kobe University researchers found that the size of sperm and egg cell nuclei competes after fertilization, maintaining regulatory modifications necessary for embryonic development. The team introduced a new concept where separate pronuclei engage in a race to absorb growth factors, helping maintain proper regulation.
A scalable digital mental health care model and anti-stigma campaigns reduced depression, self-harm, and suicide risks among Indian adolescents. The ARTEMIS project reached over 70,000 adolescents and showed significant improvements in knowledge, attitude, and behavior toward mental health.
A study by University of Pittsburgh researchers found that eating creates a temporary metabolic state that influences T cell function, leading to improved responses to infection. The findings have particular relevance for cancer immunotherapy and may inform when immune cells are collected or activated.
A nighttime response during out-of-hospital cardiac arrest is associated with lower odds of sustained return of spontaneous circulation, neurologically favorable survival, and postresuscitation survival. Emergency care factors only account for a portion of the decreased survival rates at night.
This qualitative study examines the role of prognostic uncertainty in serious illness conversations, finding that it can be a constructive element supporting patient preparation for end-of-life. Clinicians' attentiveness to patients' and caregivers' readiness enabled effective prognostic dialogue, promoting meaningful life continuation.
Researchers developed a new polygenic risk score (PRS) that estimates a person's inherited risk for eight common cardiovascular conditions. The test combines information from many genetic variants and evaluates a person's risk for coronary artery disease, atrial fibrillation, type 2 diabetes, and more.
A review of 23 randomized controlled trials found that both exercise-based and nutrition-based prehabilitation programs can improve recovery after surgery. Exercise-based programs were most often used in orthopedic cases, while nutrition-based programs were primarily used in gastrointestinal and cardiac surgeries.
Masters argues that age-based expectations and standardization are not serving all children well, leading to students being poorly served and left behind. He proposes personalized learning plans that track individual growth and empower teachers to design tailored experiences.
Multifunctional ferroelectric bioelectronic interfaces (FBI) integrate self-rolling, interfacial adhesion, and biomimetic electrical signals to enable long-term biosafe vagus nerve modulation. The device demonstrates durable efficacy in reducing inflammation and shows no signs of displacement after 60-day implantation.
The review systematically maps cyborg animal research, covering key components such as brain-computer interfaces and stimulation strategies. It highlights the importance of achieving a balance among adaptability, biocompatibility, control accuracy, system complexity, and real-world deployability in future progress.
The Cure Innovation Index ranks top US biomedical institutions based on their ability to translate scientific discoveries into real-world healthcare solutions. The index identifies key factors such as commercialization infrastructure, industry engagement, and entrepreneurial culture that enable translational success.
The American Gastroenterological Association recommends increasing dietary fiber and reducing time on the toilet as effective initial treatments for hemorrhoids. However, common remedies like sitz baths and over-the-counter creams have limited evidence supporting their effectiveness.
A new study analyzing over 40,000 comments in the public record found that Americans strongly support the federal government's reclassification of cannabis to a less dangerous Schedule III. The majority cited therapeutic benefits and economic impacts as motivations for rescheduling.
NCCN staff received awards and publications for advancing quality cancer care, including Dr. Alyssa Schatz's Leadership in Policy, Equity, and Advocacy award and Faviolla Baez-Cruz's publication on biochemical research. The National Comprehensive Cancer Network is recognized for its work to improve outcomes for people with cancer.
A phone-based teach-to-goal program improved correct inhaler use in Medicare Advantage beneficiaries with COPD. The study found that nearly 40% of participants used their inhaler incorrectly initially, but after the program, only about 7% were incorrect, resulting in a significant reduction.
Volume 39 of SLAS Discovery highlights novel assays and AI-assisted workflows to accelerate personalized cancer immunotherapy. The journal aims to advance life sciences discovery through education, knowledge exchange, and global community building.
Researchers at UTEP found strong connections between Valley fever and extreme weather, wind, and airborne dust, with the disease risk anticipated based on environmental signals. The study identified seasonal patterns, with peak cases in summer months.
Researchers at King's College London uncover a timing mechanism in cells that allows them to ignore brief mechanical stimuli while reacting to sustained changes. This discovery has huge implications for disease treatment and could lead to the development of better therapies for cancer and fibrosis.
A new study reveals that menopause causes profound and uneven transformations across the female reproductive system, rather than a uniform decline. The research identified molecular signals associated with aging detectable in blood, allowing for non-invasive monitoring and earlier detection of risks.
A new study by researchers at Mount Sinai overturns the assumption that immune cells are essential for generating immunity from mRNA vaccines. Instead, non-immune cells such as muscle and liver cells play a role in shaping the immune response.
Researchers from ISTA have explained the unusual superconducting behavior of UTe2, a material that exhibits zero electrical resistance under specific magnetic field conditions. By studying magnetic fluctuations, they revealed a new mechanism behind reentrant superconductivity, shedding light on this enigmatic phenomenon.
New research from McMaster University challenges existing theories of planet formation around mid-to-late M dwarfs. The study found that sub-Neptunes almost completely disappear around these stars, hosting many super-Earths instead. This suggests that water-rich worlds may be more common in these systems.
Researchers visualize immune synapse and cytotoxic granules with unprecedented level of detail, revealing new perspectives in immuno-oncology. The study uses cryo-expansion microscopy to provide a near-native view of T lymphocyte mechanisms.
A study by ETH Zurich and the University of Wisconsin found that urban development and transport are mutually dependent and have cause-and-effect relationships. The researchers correlated congestion data with city characteristics, such as road network structure, green spaces, and urban function.
Researchers at Nagoya University have developed a new method called SMART that accelerates enzyme evolution and reduces costs by accelerating the selection period from weeks to days. The system uses mRNA display, next-generation sequencing, and bioinformatics to identify superior enzyme variants.
A new handbook produced jointly by Chalmers University of Technology and the University of Gothenburg aims to improve decision-making and preparedness for future pandemics. The handbook provides practical guidance on how mathematical models can be used to inform decision-making, particularly in times of crisis.
A new report by the UN University finds that critical minerals extraction is causing severe environmental and health crises in vulnerable communities, while benefits accumulate mainly in wealthy nations. The investigation highlights intense water requirements, contaminated water, lost livelihoods and serious health consequences.
A new survey found that nearly half of women incorrectly believe annual mammograms should start at age 50. Experts recommend yearly mammograms starting at age 40 for average-risk women. This delay can lead to cancers being found at a later stage, when treatment can be more complex.
A KERI research team developed a nano-tin interlayer control technology to address interfacial instability between the lithium metal anode and solid electrolyte. The technology achieved high performance under low pressure, exceeding that of conventional lithium-ion batteries.
Researchers have discovered that marigold flower proteins have excellent emulsifying, hydrating, and antioxidant effects, making them suitable for nutrient-enriched food formulations. The study found that marigold proteins stayed stable up to 221 degrees Fahrenheit, outperforming other plant proteins in terms of structure retention.
A new Edith Cowan University study found that activewear is worn for activities beyond exercise, such as shopping and studying, and can lead to self-consciousness and body comparison. The research suggests a complex debate surrounding the role of activewear in promoting physical and mental wellbeing.
A new study combines dynamic full-field optical coherence tomography with deep learning to generate real-time virtual pathology images of fresh lymph nodes during surgery. The approach achieved high accuracy and sensitivity, reducing tissue consumption and manual workload.
A new study reveals how maternal antibodies program the mouth to resist aggressive bacteria and prevent bone loss associated with adult gum disease. Maternal IgG also regulates the timing of barrier sealing in the oral epithelium.
The study reveals two distinct types of unusual low-energy quasiparticle states in CsV3Sb5, including a zero-bias conductance peak within the superconducting gap and Kondo resonance peaks that break mirror symmetries of the kagome lattice.
A new study reveals that ESBL-producing E. coli can persist on farmland and transfer to irrigation water, contaminating lettuce with measurable health implications. Household washing and extended manure management intervals can substantially reduce human exposure and associated health risks.
A new review calls for prevention strategies focused on specific human-animal interfaces, incorporating behavior-centered risk communication. China's experience with major outbreaks demonstrates the country's capacity for rapid communication and community engagement.
Researchers identified ten previously unknown symptoms strongly associated with eclampsia, including twitching and impaired speech. These symptoms were rare among women without seizures but frequently occurred before an episode, increasing the risk of seizures.
A new study found that young men who viewed idealized fitness or supplement videos on TikTok reported lower fitness satisfaction and stronger intentions to use creatine, a popular muscle-building supplement. The researchers highlight the need for targeted media literacy education and responsible social media practices.
A research team at SKKU has developed specialized 'One-body' materials for dry processes, maximizing battery performance and productivity. The breakthrough technology eliminates toxic liquid solvents, reducing costs and environmental impact.
The Center for Cellular Language Intelligence will decipher the complex communications that govern tumor ecosystems, revealing principles of cellular organization and biological programs influencing cancer initiation and response. Led by Linghua Wang, the center aims to accelerate discovery and deliver new therapeutic targets, predicti...
Researchers at UCSF discovered that single-celled organism Stentor learns through modifying existing proteins with calcium signaling, which is similar to the mechanism used by animal neurons. This finding suggests that learning may be a fundamental feature of life and could have evolved before the emergence of brains.
Researchers at the Smithsonian National Museum of Natural History analyzed 18 scorpion species and found striking patterns in metal concentration and distribution among their pincers and stingers. The study reveals that zinc plays a role beyond hardness, possibly enhancing durability, and provides insight into how organisms adapt to pr...
Cancer cases are on the rise among younger adults in England, with a significant increase in bowel and ovarian cancer rates. The study found that excess weight is a key contributor, but it's unlikely to fully explain this trend, as trends in risk factors such as smoking and diet have been stable or improving over the past decade.
An AI model called REDMOD can pick up the very early subtle tissue changes of pancreatic ductal adenocarcinoma, which conventional imaging and the human eye find difficult to detect. The model detected 'invisible' signature of pre-clinical pancreatic cancer an average of 475 days before clinical diagnosis.
A study by King's College London found that babies exposed to high levels of air pollution in the womb show slower signs of development at 18 months compared to those exposed to lower levels. This is particularly true for premature babies, who experience poorer motor and language skills.