A Duke-NUS study found that mandatory Nutri-Grade front-of-pack labels on beverages redirected household consumers to healthier drinks and encouraged manufacturers to reformulate products with less sugar. The study resulted in an 18% reduction in sugary drink consumption and a 44% decrease in purchases of unhealthy drinks.
Generative AI is transforming pharmaceutical RÝ into a highly efficient, end-to-end new era. Insilico Medicine has accumulated extensive experience in AI-driven drug discovery, sharing breakthroughs and latest advancements in molecular design, multi-target synergy, and clinical translation success rates.
Scientists from the University of Osaka have identified a previously unknown molecular mechanism linking mitochondrial morphology to innate immune activation. Abnormally long mitochondria can trigger the release of mitochondrial RNA into the cytosol, activating RNA-sensing proteins and leading to anti-tumor immunity.
A new device inspired by fish's lateral line senses the pulse of lab-grown heart tissue, enabling real-time monitoring of hundreds of tests. This breakthrough could revolutionize drug screening and personalized medicine with more accurate human tissue simulations.
Researchers identified a hierarchically organized nerve network in mouse aorta that drives blood pressure rise after cold exposure. Local ablation of sympathetic nerves in aPVAT prevents cold-induced hypertension, underscoring the specificity of aPVAT.
A large longitudinal cohort study of 64,371 men aged 50 and above found no statistically significant association between low handgrip strength and prostate cancer risk. The study suggests that grip strength is unlikely to be a reliable tool for early detection or predicting disease progression.
A new genome assembly provides insights into the genetic system behind oregano's valuable oil, revealing a JA-inducible transcription factor that directly regulates EO biosynthesis. The study identifies OvbHLH13 as a molecular target for improving EO yield and quality in Greek oregano.
A new SPR holographic microscope has been developed with high sensitivity, label-free, non-invasive, and real-time measurement capabilities. It achieves ultrahigh RI resolution of 2.58 × 10⁻⁷ RIU and sub-nanometer thickness profiling resolution of 0.6 nm for atomic layer materials.
Researchers have developed new catalytic routes for ammonia synthesis under mild conditions, including one-step thermal catalysis, electrocatalysis, and photocatalysis. These emerging strategies aim to reduce energy consumption and emissions, offering promising alternatives to the Haber-Bosch process.
The UJI Institute of Advanced Materials has developed a new methodology for producing advanced catalytic materials with improved catalytic activity and efficiency. The process uses transition metals, reducing the need for expensive noble metals and generating high-purity hydrogen.
Researchers analyzed tar-rich and tar-inclusive coals using thermogravimetry and differential scanning calorimetry. Tar-rich coal exhibited lower characteristic temperatures and activation energies, making it more prone to ignition but also suitable for in-situ thermal decomposition mining.
Researchers developed AdapGNN to improve graph neural network explainability in molecular property prediction. The framework achieves better predictive accuracy and explainability, especially for molecule energy prediction.
Endothelial CPT2 loss impairs long-chain fatty acid oxidation, activating an EndoMT-like program that promotes renal injury and fibrotic remodeling. Acetate supplementation partially suppresses this phenotype.
KAIST researchers have discovered a new way cancer 'hijacks' the blueprint for blood vessel development to fuel its growth. By reactivating a pre-existing gene regulatory program, tumors can drive angiogenesis without evolving entirely new mechanisms.
An international team of scientists has rediscovered a set of gigantic Megalodon vertebrae in Denmark, shedding new light on the prehistoric shark's biology and lifestyle. The discovery confirms the maximum vertebral diameter of 23 cm reported in literature and represents the largest fish vertebrae ever recorded.
A new scanning technique has shown that lithium levels in the brain and blood are closely matched across the day, regardless of dosing regimen. This finding could lead to more personalized treatment options for patients with bipolar disorder.
A new study led by King's College London finds that human-driven climate change has intensified the retreat of Pine Island Glacier, one of the single biggest contributors to global sea level rise. The glacier retreated by around 18-20% since the 1940s, adding several kilometers to its landward withdrawal.
A bio-inspired robotic bird is helping researchers unravel the mysteries behind kestrels' exceptional hovering capabilities. By mimicking key movements, the team discovered unique techniques that could improve manoeuvrability of small aircraft and enhance their ability to cope with turbulence.
A 57-year-old MDS patient presented with CD34+ micromegakaryocytes and giant platelets in peripheral blood, raising concerns for acute leukemia misdiagnosis. Follow-up studies showed persistent iron-deficiency anemia and easy fatigability, while laboratory results revealed pancytopenia.
A simple bedside eye test may predict recovery of consciousness in patients with severe brain injuries, according to new research. The late light-off response (LOR) phase of the pupil response predicted improvements in consciousness seven days later.
A new study finds that multiple sclerosis has a substantial impact on social life and work, with 51% of people reporting an effect. The study highlights the need for comprehensive care addressing not only physical health but also daily functioning, employment, and overall wellbeing.
Research presented at the European Academy of Neurology Congress 2026 found that women with Parkinson's disease had significantly greater amyloid plaque burden and neuritic plaque density compared to men. The study suggests that women may be more susceptible to Alzheimer's-related changes in the brain.
Acute leukemias with EWSR1 or FUS gene rearrangements display heterogeneous clinical and pathological characteristics. Cytogenetic karyotyping and fluorescence in situ hybridization remain crucial tools for detecting chromosomal translocations, while advanced molecular diagnostic methods are recommended to improve accurate diagnosis.
A lifecycle framework helps laboratories overcome barriers to digital pathology adoption by integrating infrastructure, workflow redesign, validation, interoperability, and AI readiness. The framework addresses institutional governance, cybersecurity, education, and performance monitoring to ensure durable success.
A study by University of California, Davis researchers found that red-tailed hawks adjust their wing and tail movements to compensate for missing feathers during molt. The findings could inform wildlife rehabilitation efforts and inspire more resilient UAVs.
Declining plankton abundance across the North East Atlantic poses a significant threat to ocean health, impacting marine food webs and carbon cycling. The study found six pelagic habitat-region combinations rated as 'Not Good' and three as 'Uncertain', highlighting the need for climate change mitigation and reduced nutrient pollution.
A team of Penn State researchers has converted waste polyethylene terephthalate (PET) into highly ordered synthetic graphite, a crystalline form of carbon. The formed graphite exhibited large, well-ordered crystallites, indicating a highly organized crystal structure, which is suitable for high-quality anode materials in battery research.
Adults with both epilepsy and hearing loss who use hearing aids have a 23% lower risk of developing dementia. The association was observed consistently across all analyses, suggesting that correcting hearing impairment may have a greater impact on dementia risk in people with reduced cognitive reserve.
Researchers at Texas Tech University used spectroscopy and audio sonification to study the spectacular explosion of NovaV612 Scuti. The team found evidence that gas increased in velocity with each major jump in brightness, revealing new details about the event's dynamics.
A team of researchers at Penn State developed a new design approach to reduce the cost of ultra-high-performance concrete (UHPC) by optimizing metallic fibers, which currently make up 70% of the material's price. The new design can help produce stronger and more environmentally friendly concrete while reducing costs.
A team of engineers developed a soft, shape-shifting mechanical surface that responds to touch, senses its movements, and visually communicates changes in real time. The platform combines magnetic actuation, embedded sensing, and LED-based visual feedback into a single programmable system.
Researchers at the University of Vermont discovered that intestinal epithelial cells restrict Salmonella growth by pumping essential metals away from intracellular bacteria. This finding highlights a new dimension of host-pathogen interactions and suggests potential novel treatments for Salmonella and other food-borne illnesses.
The University of Phoenix College of Doctoral Studies has published a new white paper examining the growing AI fluency gap in the workplace. The paper argues that AI fluency is no longer only a productivity issue but a retention issue, as employees are rapidly building AI skills while organizations struggle to keep pace.
Scientists have found a way to create chiral light in free space using structured beams, enabling simpler control over spin and twist. This breakthrough could lead to new ways of encoding information in light, with potential applications in quantum communication and sensing technologies.
A new PhD thesis from the University of Copenhagen reveals that dishonesty between partners can lead to doubt and distrust, but also potentially help couples solve issues. The study found patterns such as 'vicious cycles' and 'slowburns,' highlighting how dishonesty is embedded in relationship dynamics.
A young woman's quality of life and ability to walk were restored after a specialized procedure at Semmelweis University. The laparoscopic removal of a rare, benign tumor of neurological origin in the lesser pelvis, known as a schwannoma, was performed using intraoperative electrophysiological monitoring.
Insilico Medicine announces a $2.5 billion global R&D collaboration with SK Biopharmaceuticals to discover AI-enabled drug candidates for neuroimmune disorders. The company's Pharma.AI platform will drive target-to-candidate discovery, while SK Biopharmaceuticals will handle late-stage clinical development and commercialization.
The study combines clinical data, molecular analyses, and bioinformatic methods to identify patterns in the gut microbiome. This information can help predict disease progression and suggest personalized treatment options.
Researchers documented over 200 marine ecosystem disruptions in a year of unprecedented ocean warming, highlighting the need for year-round monitoring and assessment to support conservation efforts. Impacts were not limited to traditional summer heatwaves, with evidence of ecological disruption across seasons.
Researchers developed a multimodal rehabilitation platform combining virtual reality with targeted sensory nerve stimulation to improve arm and hand function in stroke patients. The platform showed greater improvements in motor impairment, sense of touch, and perception of the affected arm compared to conventional rehabilitation.
Researchers analyzed data from 3 million US cancer survivors to understand patterns of subsequent primary cancers (SPCs), finding risks varied by cancer type, sex, and generation. The study emphasizes the importance of long-term monitoring and informs prevention strategies for cancer survivors.
Researchers developed formulations to improve 10H2DA skin penetration, increasing it by more than tenfold. Higher skin hydration correlated with greater 10H2DA delivery efficiency.
A comprehensive review reveals that varicella-zoster virus inflicts lasting nerve damage, leading to chronic pain through central sensitization. The study supports earlier treatment and links each mechanism to targeted therapies.
The journal addresses ethical challenges, best practices, and scientific integrity issues through metascience and evidence-based research standards. Emerging technologies like AI are transforming how researchers conduct, communicate, and disseminate their work.
A Hospital for Special Surgery (HSS) study has identified a previously unknown role for skin immune cells in shaping the development of the lymphatic system. Langerhans cells play a critical role during early life in helping lymphatic vessels grow and develop properly, influencing lifelong immune function.
Researchers present a roadmap for developing Tregs as adaptable therapies to restore immune balance and support tissue repair. This approach holds promise for treating conditions such as metabolic and cardiovascular disease, as well as neurodegeneration.
Researchers at New York University have developed a way to measure and visualize brainwaves of thousands of people during live face-to-face communication, finding that synchrony can be used to guide and improve social interactions. This phenomenon, known as social synchrony, is linked to healthy relationships and learning.
The global burden of viral skin diseases has risen significantly since 1990, driven by population growth and aging. Children under 15 years old bear the highest burden, with incidence rates increasing by 44.2%. Targeted interventions for vulnerable populations are crucial to reduce the global burden.
Viral skin diseases cause significant disability globally, with annual incidence increasing 32.27% to 84.7 million and prevalence growing 36.29%. Children under 15 bear the highest burden, with adults aged 50-65 and 85-95 also experiencing significant increases.
The review discusses key AI concepts, including algorithms, models, architectures, machine learning, deep learning, and multimodal models. It highlights their clinical applications, such as detection of lymph node metastases, Nottingham grading, biomarker quantification, risk stratification, and prognostic prediction.
Single-cell sequencing resolves responses in various tissues and organs, identifying cells that respond to different exercise modes and doses. This technology enables the development of precision exercise biomarkers for applications in muscle repair, immune regulation, and chronic disease research.
A new case report details a painful lesion on a finger diagnosed with nodular basal cell carcinoma. The study emphasizes the need for clinicians to maintain a high index of suspicion for this rare but real skin cancer in atypical locations.
Researchers found insect-made holes in bone remains revealing that titanosaurus carcasses were exposed for extended periods, unlike previously thought. This discovery improves understanding of palaeoecosystems and fossilization processes at the Lo Hueco site.
The Goethe Science Diplomacy Award honors researchers who strengthen academic freedom, international cooperation, and dialogue in challenging contexts. Prof. Hande Birkalan-Gedik and Dr. Ulrich Kuch received the award for their contributions to building bridges between academia and civil society.
A study by Nikolai Kunitsõn shows that participatory theatre can bridge the gap between Estonian- and Russian-speaking young people's civic skills. The method, called forum theatre, allows young people to practice debating, resolving differences of opinion, and taking a stand in a playful way.
A study found that secukinumab significantly improved skin scores in moderate-to-severe plaque psoriasis patients with subclinical enthesitis, reducing inflammation before irreversible damage occurs. Ultrasound revealed marked thinning at enthesial sites, particularly the right Achilles tendon.
Researchers propose protein coronas as a dynamic navigation interface to shape how nanomedicines are recognized and delivered across the blood-brain barrier. The corona can be manipulated to bias circulation, targeting ligands, and intracellular trafficking for improved brain delivery.
Researchers at Penn State and NIST developed a new way to build tinier, smarter glass sensors filled with highly precise and stable atoms. These sensors can measure high-frequency electromagnetic signals, including millimeter-wave radiation, and offer improved navigation accuracy and reliability.
A new AI framework reduces operational costs by 6% and improves grid reliability through coordinated energy source management. The approach uses distributed reinforcement learning to optimize hydrogen storage and minimize coal consumption.
Researchers developed genetically engineered CAR T cells specifically targeting bladder cancer cells and delivered them directly to the bladder via a catheter. This approach shows promise in controlling bladder tumors in mice and may be effective in humans, offering an alternative to life-altering procedures like bladder removal.