Severe COVID-19 and influenza infections can prime the lungs for cancer development, according to new research. Vaccination, however, largely prevents these changes, suggesting a reduced risk of lung cancer.
A study analyzing 1,158 confirmed mpox cases in adult men from Spain found that people with HIV did not develop more severe forms of the disease. People with HIV more frequently presented with fever and skin lesions, but the disease progression was favourable with no hospitalizations or deaths.
A new approach for welfare states updates policies to prioritize social investments and effectiveness, combining theoretical contributions and comparative studies. The approach aims to generate long-term benefits for individuals and society, with a focus on targeted solutions and systematic monitoring.
Researchers discovered that subtly disrupting cancer cells' protein production triggers a potent antitumor immune response. By targeting the way tumors produce proteins, scientists can render them more susceptible to immune attack, potentially revolutionizing cancer treatment.
A study by the University of Oulu reveals that PXR activation by chemicals like rifampicin can increase SHBG production, influencing testosterone levels and sex hormone availability. The discovery has significant implications for understanding the impact of everyday chemicals on hormonal systems.
Seven scientists from around the world will receive grants to pursue conservation-focused research aimed at strengthening ocean health and communities that depend on it. The fellows' work includes tracing illegal fishing, improving reef restoration, and developing open-source technology to classify nanoplastic pollution.
Patients with type 2 diabetes and brain metastases who used GLP-1 receptor agonists showed a significant reduction in all-cause mortality. The use of these medications was associated with reduced neuroinflammation, preservation of the blood-brain barrier, and lowered oxidative stress and mitochondrial dysfunction.
The study found that wildfire exposure and its socioeconomic consequences were associated with increased psychological distress beyond the burn zone. Integrating mental health care, housing stability, and economic recovery are crucial for disaster response and climate resilience strategies.
Researchers from the University of Kansas used motion capture technology to analyze shooting mechanics, finding that greater flexibility in the preparatory phase is crucial for accuracy. The study's findings will be used to attempt a new world record for most consecutive made three-point shots.
AI chatbots are homogenizing human expression and thought, reducing collective wisdom and adaptability, researchers argue. Incorporating real-world diversity into LLM training sets can help preserve human cognitive diversity and improve chatbots' reasoning abilities.
Vision sensing systems are crucial for intelligent driving, providing critical road condition data and supporting autonomous driving functions. However, automotive-grade cameras face technical challenges such as limited dynamic range, low light performance, and image processing limitations. To address these challenges, researchers prop...
Researchers discovered that bumble bee queens can survive submersion for over a week by combining underwater gas exchange with anaerobic metabolism. After eight days, their metabolic rate spikes before returning to normal levels, allowing them to survive extreme conditions.
A team of researchers at the University of Chicago has made a groundbreaking discovery in the field of nanocrystals, shedding new light on cation exchange reactions. By applying a cellular automaton model, they were able to demonstrate that a single atom can be replaced with another in a tiny crystal, even as all the atoms remain in or...
A new study published in eNeuro found that people remain engaged with stories even in noisy environments. The research team used fMRI scans to examine brain activity while participants listened to engaging stories in background chatter, revealing distinct neural systems involved in naturalistic speech listening.
Researchers developed a fast, non-invasive, and affordable diagnostic tool using retinal images to differentiate between ALS and Alzheimer's disease. The tool, based on polarized light analysis, accurately predicted disease severity and type with high accuracy.
Researchers at CUNY ASRC have created peptide-based crystalline solids that can switch between soft layered and stiff honeycomb architectures in response to humidity. These dynamic solids exhibit large, controllable changes in mechanical and optical properties, enabling unprecedented adaptability.
A new study found that loneliness and social isolation are independently and jointly associated with subjective cognitive decline in perimenopausal women. The study, published in Menopause, suggests that promoting healthy social connections may help mitigate cognitive deterioration during this time.
Researchers have created the first high-resolution molecular atlas of the adult Drosophila melanogaster brain, uncovering how neurons retain a record of their developmental origins. The study found that the genetic diversity of neurons is far greater than previously thought, and that sex differences arise through selective neuronal sur...
A new study found that people are more likely to place bets during weeks with major sporting events when they believe their friends are doing the same. Researchers say early intervention is key to preventing harmful betting patterns, as it can be associated with depression, anxiety, and increased substance use. The study, led by Univer...
Physicists at the University of Colorado Boulder have demonstrated a new kind of vacuum ultraviolet laser that is 100 to 1,000 times more efficient than existing technologies. The device could enable scientists to observe phenomena currently out of reach, such as following fuel molecules in real time as they undergo combustion, spottin...
Researchers from Michigan Medicine discovered that photoreceptor cell death is reversible and can be rescued by removing damaged mitochondria. The study found that mitophagy, a process that removes dysfunctional mitochondria, plays a crucial role in this recovery process.
A new study from Columbia University Vagelos College of Physicians and Surgeons has found that analyzing the APOL1 gene in Black patients with kidney disease can provide more accurate diagnoses. The study suggests that incorporating M1 into routine APOL1 genetic testing could help doctors determine the true cause of a patient's kidney ...
The University of Cambridge has launched a major strategic partnership with IonQ to develop the UK's most powerful quantum computer, accelerating research and discovery in quantum science and technology. The partnership will support the creation of the IonQ Quantum Innovation Centre, housing a state-of-the-art 256-qubit quantum computer.
The latest issue of Current Pharmaceutical Analysis features advanced analytical characterization and emerging trends in pharmaceutical science. Open access articles can be freely viewed and downloaded on ScienceDirect.
A new experimental rat model reproduces creeping fat in Crohn's disease, characterized by mesocolic adipose tissue hyperplasia with macroscopic, histological, immunological, and molecular similarities to human disease. The model supports the hypothesis that intestinal microbiota contributes to remodelling of mesenteric adipose tissue.
A 16-year study found that 87% of children with single-ventricle heart disease either died or developed a major health problem over time. The study provides new direction for improving care and offers guidance for tailoring therapies to each child.
A study in mice suggests that matcha may reduce the need to sneeze in people with nasal allergies, suppressing brainstem neuronal activation without changing major immune markers. The findings provide a potential, food-based option to complement standard care for allergic rhinitis symptoms.
A UK study found that a 12-week ketogenic metabolic therapy program led to significant reductions in depression and anxiety scores. The program, delivered remotely, showed a 62% reduction in depression symptoms and a 46% reduction in anxiety, with 100% of participants completing the program.
A study published in Environmental Science & Technology reveals distinct roles of NO2 versus NO in β-myrcene photooxidation and their synergistic interactions with SO2. NO2 enhances SOA yield and increases oxygen-to-carbon ratio, while NO suppresses particle nucleation and promotes particle growth.
A new VR app is being developed to tackle violence against women and girls, using virtual reality to raise awareness and educate people about harassment. The app places users in realistic scenarios commonly experienced by women, aiming to educate people about attitudes and behaviours towards women and girls.
Researchers have found magnesium-containing materials to be effective in cognitive improvement and neural regeneration for neurological disorders. These materials, including magnesium oxide nanoparticles and magnesium alloys, have neuroprotective properties and can modulate the gut-brain axis.
Researchers developed hybrid spheroids with biodegradable nanogels to improve stem cell function and survival in injured swallowing muscles. The approach significantly improved muscle regeneration, cell retention, and functional recovery in a rat model.
Research finds that fasting induces accumulation of TCA cycle metabolites in brain lysosomes, suggesting a dynamic metabolic node for coping with fluctuating nutrient availability. This new understanding reframes lysosomes as active contributors to neuronal metabolism.
A joint international research team has identified the core principle by which specific inhibitory neurons in the prefrontal cortex regulate cocaine-seeking behavior. The study revealed that addiction relapse is not due to a decline in brain function, but rather an imbalance in specific neural circuits.
Researchers at SKKU develop hafnium oxide-based ferroelectric transistor arrays for AI hardware, achieving high endurance and precise analog weight control. The devices demonstrated scalable operation and stable synaptic learning behavior, paving the way for next-gen in-memory computing technologies.
A national study published in the Journal of the American College of Surgeons found that breast cancer stage at diagnosis differs sharply across rural US regions, with geographic, racial, and insurance factors influencing stage. The study analyzed data from 52,287 rural women diagnosed with breast cancer between 2004 and 2021, revealin...
A conductive bioglue was developed to ensure firm adhesion and stable electrical signaling within the human body. It overcomes challenges in connecting damaged tissues or attaching bioelectronic devices, promoting muscle and nerve regeneration and stable implant stability.
Researchers at the University of Jyväskylä have developed new synthetic molecules that capture sulfate with exceptional efficiency, rivaling natural protein binding sites. The unique architecture of the molecules, known as
Genethon's GNT0004 gene therapy shows long-term efficacy in patients with Duchenne muscular dystrophy, maintaining clinical efficacy and safety at two years. The trial included 72 boys aged 6-10 with retained walking ability, treated with GNT0004 at a therapeutic dose.
Researchers develop Fourier ptychographic coherence scanning interferometry for high-aspect-ratio micro-trenches, achieving high-resolution 3D topography and lateral resolution beyond the incoherent diffraction limit. The method overcomes challenges of strong optical modulation, enabling robust and accurate measurements.
A Mendelian randomization study found that PCSK9 inhibitors may reduce low back pain risk, while HMGCR and NPC1L1 inhibitors showed no association. The study validated known lipid-lowering effects on coronary heart disease risk, providing new insights into PCSK9 pleiotropy.
To halt sea-level rise and cumulative CO2 releases, global emissions would need to become net-negative and remain so for centuries. This conclusion is based on studies assessing the impact of delayed climate changes, which require long-term carbon removal commitments.
A study on mouse incisors reveals a cellular mechanism behind the unique decussation patterns of tooth enamel, which form the enamel's hardness through directional sliding and coordinated migration of ameloblasts. The findings provide new insights into how dental stem and progenitor cells maintain and repair enamel-forming tissues.
Researchers discovered temperate trees, including oak, elm, and hazel, in Doggerland over 16,000 years ago, revealing a surprisingly hospitable environment. The study suggests that Doggerland may have supported early Mesolithic communities prior to flooding, shedding light on the region's ecological history and human settlement patterns.
A study by UC San Diego finds that California wildfire smoke events are becoming more frequent, with communities in Southern and Central California experiencing shorter recovery times between smoke events. These communities are also disproportionately vulnerable, with higher proportions of racial and socioeconomic minority residents.
Researchers have discovered that compounds from seaweed can block norovirus infection by creating a shield in the human body. Fucoidan, a compound found in brown seaweed, showed the strongest blocking activity against two major norovirus strains, GII.4 and GII.17.
A prospective multicenter study found Woven EndoBridge therapy safe and effective for unruptured wide-necked bifurcation aneurysms in Chinese patients. The therapy promotes durable aneurysm occlusion with minimal risks.
A new study by the University of Bristol found that the UK's disposable vapes ban may lead to an increase in cigarette smoking among young adults. The research, published in PLOS Global Public Health, suggests that some individuals may turn to cigarettes as an alternative to disposable vapes.
The study reveals that small Goss grains can engulf surrounding large grains through elastic interaction and molar volume difference, leading to abnormal growth. This phenomenon is driven by the increasing elastic anisotropy of ferrite with temperature rise, resulting in preferential growth of surface Goss grains.
A recent study found that adults with total or near-total vision loss who also experience hearing loss report lower confidence in their sound localization abilities, despite receiving specialized training. The researchers suggest that clinicians should account for hearing status during vision rehabilitation training to address individu...
A team of researchers from Dalian Institute of Chemical Physics developed a novel catalyst enabling thermocatalytic conversion of N2 and H2 to NH3 at room temperature and ambient pressure. The Li/Ru interface exhibits a synergetic effect promoting N2 activation and hydrogenation steps.
Kyushu University researchers observed individual polymer chains' behavior on solid surfaces, revealing non-equilibrium dynamics and thermal fluctuations. The study contributes to enhancing adhesive performance and lightweighting of materials.
A large Australian study of over 417,000 women found that fertility treatments were not linked to higher overall cancer rates, but some cancers were slightly more common, while others were less common. Women who received fertility treatment were more likely to develop uterine and ovarian cancer, as well as melanoma, but the overall ris...
A new study found that augmented reality job coaching significantly improves job performance for individuals with intellectual and developmental disabilities. The AR-based application delivered real-time guidance, enabling participants to complete complex tasks with minimal external support. This innovative approach has the potential t...
Wavelogix, a concrete sensor manufacturer, has received a $500,000 grant from the National Science Foundation to refine and scale its Rebel concrete strength sensing system. The system enables faster, data-driven decisions through real-time concrete strength monitoring.
A Johns Hopkins study found that 42.3% of people with medical debt delayed dental care, 23.0% delayed medical care, and 14% delayed mental health care. Medical debt contributes to unmet need for treatment across health needs, regardless of insurance coverage.
A working group of scholars and experts proposes three principles - transparency, credit, and accountability - to form the foundation for responsible authorship. The principles aim to address issues of gift, ghost, and coercive authorship and promote a culture of transparency and accountability in scientific research.
A new study reveals that prior authorization requirements for heart failure medications can significantly delay pharmacy fills, particularly for those with lower socioeconomic status or Medicaid insurance. The study found that patients with prior authorization prescriptions took three times as long to fill their ARNI prescriptions and ...
Anand Balasubramani joins AAI with expertise in scientific publishing, program development, and community engagement. As CSPO, he will shape AAI's scientific agenda and oversee publications, education, and scientific affairs.
Jeonbuk National University researchers have developed DDINet, a lightweight and scalable model that can accurately predict drug-drug interactions for new, unseen drugs. This approach avoids overfitting to training data and is designed to handle binary and multi-classification tasks.