Researchers developed a nanofiber drug delivery system that uses electrospun fiber membranes to deliver multiple drugs in concert, demonstrating improved efficacy against glioblastoma. The system enables localized long-term delivery of drugs directly at the tumor site after surgery.
Researchers at Mount Sinai have found that autoimmunity is responsible for the symptoms of long COVID in a subset of people. The study suggests that therapies already validated for managing autoimmunity, such as IVIG and FcRn inhibitors, could be effective in reducing symptom burden.
A deep learning model combines knowledge from different catalyst families to identify a top-performing green hydrogen catalyst. The AI correctly predicted the activity ranking of 12 tested catalysts within a previously unexplored material family.
The São Paulo School of Advanced Science on Nonlinear and Quantum Photonics will bring together leading global specialists in nanophotonics, nonlinear optics, and quantum optics. The event will provide two weeks of intensive learning on key topics including quantum optics and information.
Researchers discovered that mosquitoes can learn to associate the smell of DEET with food, making them more likely to bite people who smell of DEET. The study found that when exposed to DEET repeatedly, mosquitoes became desensitized to its repellent properties and began to view it as a potential meal source.
A new study found that certain snake species, like pygmy rattlesnakes, are at risk for serious illness and death due to multiple pathogens. Snakes can carry pathogens without showing symptoms, but co-infections increase disease prevalence.
Researchers find popular sodium-ion battery matches performance parameters and production quality of Tesla's lithium-ion batteries. Tweaking the Hina battery to charge more effectively at low temperatures could provide a cost-effective alternative for future electric vehicle batteries.
Researchers develop SiC-based absorbers via dual rare-earth synergistic engineering, achieving remarkable reflection loss values and excellent impedance matching characteristics. The material exhibits distinct polarization loss peaks in low, medium, and high frequency bands.
Diagnostic interviews, long considered the 'gold standard' for identifying mental health conditions, may not be as consistent as previously thought. The meta-analysis found that standardized interviews are only moderately consistent when assessed repeatedly by the same person.
In a cross-sectional study of ambulatory visits, digital after visit summary engagement was found to increase but remained low, especially among unmarried males, non-English-speaking populations, and publicly insured populations. This inefficiency highlights the need to reevaluate postvisit communication in these groups.
Researchers suggest targeting upstream metabolic nodes to regulate mTORC1 signaling and autophagy defects in neurodegenerative diseases. Acetyl-CoA production modulation and p300 acetylation activity regulation may also hold therapeutic promise.
A recent study of over 1,800 infants in Sweden found that most young children have sufficient vitamin D levels, but intake was too low for some. The research also explored the climate impact of foods providing vitamin D, concluding that plant-based alternatives are a climate-friendly source.
Biocomputing harnesses human brain cells to perform computational functions, with applications in energy-efficient computing, drug discovery, and neuromorphic engineering. Early developments in biocomputing hold promise for biomedical research, despite ongoing bioethical concerns.
Researchers at Columbia University Irving Medical Center have identified Sirtuin 1 as a key driver of neuroendocrine prostate cancer, an aggressive form of the disease. Genetic or pharmacological inhibition of Sirtuin 1 prevents tumor growth in mice and lays the groundwork for future clinical studies aimed at developing new treatments.
Researchers discovered a new cave cricket species, Dolichopoda balrogi, thriving in man-made tunnels on the Greek island of Kastellorizo. The species, found exclusively in a tunnel system, highlights the importance of exploring artificial underground environments for unique endemic species.
A new study found that chronic oral inflammation can impair female fertility by triggering a systemic immune response that affects the ovaries. This leads to oxidative damage, reduced egg quality, disrupted follicle development, and reduced live birth rates.
Researchers at Kyushu University used 3D computer simulations to understand the physics behind hub-and-spoke patterns in star-forming regions. The study shows that oblique shocks create invisible channels guiding compressed gas into central filaments, forming the radial shape of baby stars' cradles.
A new Drexel University study finds that most users see AI chatbots as supplements to human therapy, not substitutes. Users express concerns about emotional dependence, misinformation, and overreliance on the technology.
Researchers at PolyU have pioneered a method to store digital data using engineered proteins, achieving high storage efficiency and capacity. They overcame challenges of variable amino acid sequences and degraded proteins by designing a protein template, successfully expressing and retrieving data.
A study published in the International Journal of Child-Computer Interaction found that preschoolers attribute preferences in response to human gaze but struggle with robotic gaze. The research highlights the importance of designing richer interactions for children, beyond just imitating human signals.
Researchers developed a novel one-step sintering method to overcome challenges in BiFeO3-BaTiO3 lead-free piezoceramics. The new approach simplified the fabrication process, dramatically improving reproducibility and performance. The resulting ceramics exhibit exceptional electromechanical properties.
A new fossil discovery fills gaps in fossil history, revealing diverse and complex ecosystems during the late Cambrian period. The discovery of Magnicornaspis garwoodi, a 500-million-old anthropod, joins a growing list of Furongian sites that challenge the notion of a barren world.
Perfectionism has increased among American college students over the past 35 years, with rising rates tied to economic factors such as growing inequality. Higher levels of perfectionism are associated with depression and anxiety, regardless of time period, suggesting a public health risk that needs to be addressed.
A new commentary reveals that most of Africa's biodiversity persists outside formal protected areas, challenging the reliance on fenced reserves and policies like the 30×30 target. Working landscapes, shaped by centuries of human-nature coexistence, often retain higher ecological connectivity and resilience to climate change.
Researchers aim to build a cohort of 2,000 AYA cancer survivors in NYC to study the short- and long-term effects of newer cancer treatments. The study will focus on challenges such as fertility and sexual health concerns, as well as financial stress.
Researchers at Washington State University have identified a key cluster of genes that can be transferred from rhizobia bacteria, allowing non-nitrogen-fixing bacteria to colonize host plants and harvest nitrogen. This breakthrough has the potential to reduce fertilizer use and improve crop yields.
Researchers developed an AI-based score from standard ECGs that reflect biological development on a spectrum rather than in fixed categories. The Electrocardiographic Sex Index (ESI) captures step-by-step changes of normal growth and hormonal changes, offering a more precise way to account for developmental stage.
A new PLOS report proposes a 'knowledge stack' publishing model to better support open science. This model connects articles with associated outputs like data, code, and methods to create a structured, open record of research. The report highlights the need for coordinated action beyond publishing to address challenges in existing models.
A recent study from UT San Antonio reveals that low-cost on-the-job training for frontline health workers can significantly reduce medical supply shortages, resulting in a 30% reduction in stock-outs. This training has the potential to save thousands of lives globally by preventing unintended pregnancies and maternal and newborn deaths.
Scientists studied four subspecies of British Wrens, each found on a specific island in Scotland, to understand the evolutionary paths leading to 'island syndromes'. The study found that two subspecies, those from Shetland and St Kilda, evolved spectacular gigantism.
A study reveals that the Arctic Ocean's chemical makeup is disrupting its food chain due to a sharp decline in nitrate levels, vital for plankton growth. The nutrient's removal limits life support for the ecosystem, with far-reaching consequences for marine ecosystems and carbon storage.
New research reveals that cells slow down heat dissipation due to unique biomolecules, changing our understanding of heat conduction. This phenomenon could affect treatments for conditions linked to body temperature changes.
Astronomers have developed a novel method to estimate the masses of newborn planets using the properties of dust rings around stars. By analyzing the width, brightness peak location, and dust content of these ring structures, researchers can reconstruct planet masses even when those planets are too faint or embedded to observe directly.
A new study reveals that the Antarctic ice sheet responded sharply to climate change following a major shift in Earth's ice age cycles. The simulation found that below a critical atmospheric CO2 level, the amplitude of Antarctic ice variations increases in response to changes in temperatures.
Healthy plants release chemical signals called VOCs that inform neighboring plants about competitive pressure, triggering adjustments in growth and defense strategies. Genetic analysis reveals shifts in biomass linked to changes in stress-response and cellular transport genes.
A new study by the Potsdam Institute for Climate Impact Research finds that reducing car commutes can significantly lower greenhouse gas emissions. By targeting densification of neighborhoods around city centers, planners can reduce emissions and create more sustainable urban environments.
Scientists have created a miniature circuit that mimics the brain and spinal cord connection, showing that previously thought irreversible nerve damage can be reversed. The researchers found that blocking specific genes in mature neurons restored axon regrowth ability.
Researchers developed a disco laser system to enhance data visualization for snow groomers, improving operator comfort and reducing nausea caused by VR headsets. The system also enables better tracking and orientation aids, leading to more efficient and safe operation in challenging conditions.
Researchers developed a physics-based framework to predict power fluctuations from renewables, enabling grid operators to mitigate surges and blackouts. The model correlates atmospheric turbulence with electricity output, allowing for accurate risk assessments of existing turbines and farms.
Researchers at ETH Zurich have developed a novel phononic metamaterial that can precisely control mechanical waves, enabling the harvesting of energy from vibrations and processing signals mechanically. The material features a specific pattern with varying unit cell sizes, allowing it to redirect waves along predefined paths.
A study published in Nutrients found associations between high homocysteine levels and fatigue-related outcomes, including physical fatigue in men and decreased motivation in women. Maintaining a well-balanced diet rich in vitamin B12 and folate is essential to prevent homocysteine level increases.
A novel study shows that adults with atopic dermatitis, particularly those with childhood onset, report significantly greater limitations in their educational and professional choices. The findings highlight the need for comprehensive, early, and multidimensional care to address the long-term impact of AD on life trajectories.
Researchers identified a specific gut microbial group that can dramatically worsen sepsis by excessively sensitizing immune cells. A Muribaculaceae-enriched microbiota was found to exacerbate TLR4-dependent Acinetobacter baumannii-induced hyperinflammatory sepsis.
Researchers measured hydrogen's hyperfine splitting in antihydrogen, a tiny energy difference that could reveal a hidden difference between matter and antimatter. The study confirmed the symmetry between the two, but future measurements aim to improve precision and potentially break current physics understanding.
China's air quality has shown significant improvement in 2025, with a decrease in PM2.5 and O3 concentrations compared to the 2022-2024 average. However, high-impact air pollution events such as severe pollution episodes, dust storms, and compound pollution events remain major challenges.
Researchers from The University of Osaka created a cobalt-based honeycomb structure that exhibits strong magnetic interactions and ferromagnetic-like behavior. This breakthrough may lead to lower-cost quantum computing materials using relatively cheap and widely available cobalt.
A large study of nearly 40,000 women found that plant-based diets with lower insulinemic potential can help women manage their weight and reduce the risk of obesity during menopause. Women who followed a diet rich in whole grains, nuts, legumes, and vegetables had a significantly lower risk of developing obesity.
Researchers are using 3D cardiac constructs to model cardiovascular diseases and test new drugs. These constructs can capture the complexity of human cardiac tissue, including its electrical activity, metabolism, and cellular communication. The field is advancing with biomaterials, AI-assisted screening, and improved standardization.
Researchers found that glutamine is not the primary amino acid for muscarine biosynthesis, but rather a triple methylation of L-lysine and later L-alanine. This discovery could lead to the identification of further intermediates with pharmaceutical potential.
A new study demonstrates a tandem catalytic approach that converts waste polyethylene and carbon dioxide into separable liquid aromatics and carbon monoxide under atmospheric pressure. The catalyst system achieves high selectivity toward separable aromatics, with an aromatic yield of up to 75.3 wt%.
A new study by Griffith University introduces 'target trial emulation,' a rigorous and practical approach to conducting research in rural areas. This method utilizes real-world data from routine care to produce robust evidence, addressing workforce constraints and limited infrastructure.
Researchers have developed new chemical recycling methods for polyurethane (PU) foams, including hydrogenation, acidolysis, and chem-solvolysis. These approaches can recover polyols and aromatic amines, which can be used to produce new PU materials.
Researchers develop a two-step catalytic process to upcycle PET plastics into lactic acid and 1,4-cyclohexanedicarboxylic acid without external hydrogen. The method yields high-value chemical intermediates with improved economic viability of chemical plastic recycling.
Researchers establish kinetics-guided depolymerization of polyethylene terephthalate (PET) to produce high-performance thermoplastics with improved sustainability. The approach yields well-defined oligomers suitable for direct repolymerization, simplifying operations and reducing energy consumption.
Researchers developed a surface polarity reconstruction method using silane coupling agents to modify conventional supported metal catalysts. This approach enhances the hydrogenolysis of waste polyolefins by optimizing catalyst surface polarity and reducing polymer chain entropy, leading to improved catalytic activity.
Researchers developed an Insect Synergy Circuit that integrates body movement and internal physiological information to guide insect navigation. The system achieved high accuracy in classifying environmental conditions, enabling gentle control over the insect's movements.
Emerging biocatalytic strategies for plastic depolymerization leverage AI-enabled enzyme design and multi-enzyme cascades to enhance sustainable recycling. Researchers develop novel biocatalysts through de novo design, overcoming constraints with structural similarity to natural hydrolases.
A comprehensive review of biochar-hydrogel composites reveals that their effectiveness lies in the surface chemistry of advanced composite materials. The study identifies function-specific performance and emphasizes the need for standardized durability testing to ensure long-term stability and scalability.
Researchers have found that karst reservoirs are exceptionally effective at capturing and storing atmospheric carbon due to a unique combination of geology and biology. The study reveals that these ecosystems produce a large amount of organic carbon, which is then efficiently converted and locked away in a highly stable form.
Researchers propose alternative to dark energy as cause of the accelerating expansion of the universe, based on instability in Einstein-Euler equations. The study suggests a more natural explanation for cosmic acceleration within the framework of Einstein's original theory.