Researchers developed an AI-guided laser technique to carve micro-pyramids for robots to sense soft surfaces gently. The technique enables the creation of flexible conductive skins with high sensitivity and linearity, outperforming conventional designs.
Soil bacteria, particularly plant growth-promoting rhizobacteria, effectively degrade herbicides and petroleum hydrocarbons through rhizoremediation. This process involves the release of organic compounds from plant roots, which feed bacteria that break down pollutants.
University students accumulate less daily physical activity and more sedentary time than older adults, with significant public health implications. The study highlights the need to rethink public health messaging and redesign urban environments to promote incidental movement in younger generations.
Researchers found that the river has not settled into a stable state, with species disappearing and new ones arriving, despite 23 campaigns of monitoring
Researchers identified ANKRD11 as a key regulator that suppresses CD8+ T cell activity during chronic hepatitis B virus infection and cancer. ANKRD11 deficiency reprograms CD8+ T cell differentiation to enhance immunity in chronic infection and cancer, making it a potential therapeutic target.
Researchers used AI to study the relationship between strain and charge mobility in molecular single crystals, revealing how stretching affects their electrical performance. The study's findings contribute to the design of robust organic crystals for wearable applications.
Marine carbohydrates have shown antiviral, anticoagulant, immunomodulatory, and antitumor activity, with potential applications in drug delivery, wound healing, and tissue engineering. Further research is needed to establish reliable production methods and improve structural and activity-based quality control.
Researchers found that m6A, a small chemical modification on RNA, acts as a molecular delivery tag to transport specific RNAs to distant regions of neurons. The study provides a basis for investigating RNA delivery errors in brain disorders and may inform the development of new therapeutic strategies.
The REZILIENT 3 trial found a six-month improvement in median progression-free survival with the combination of zipalertinib and platinum-pemetrexed chemotherapy. The study showed a 50% reduction in disease progression or death and a substantially higher response rate compared to chemotherapy alone.
The Phase 3 DESTINY-Lung04 trial showed that trastuzumab deruxtecan significantly improves progression-free survival in patients with HER2-mutant non-small cell lung cancer, with a median PFS of 14.3 months compared to 8.3 months with pembrolizumab plus chemotherapy. T-DXd also demonstrated a higher objective response rate and better d...
The eight-year ADAURA update reports a significant overall survival benefit with adjuvant osimertinib in patients with completely resected, EGFR-mutated stage IB-IIIA NSCLC. The study found an eight-year overall survival rate of 74% with osimertinib versus 58% with placebo.
The PAPILLON study demonstrates the longest overall survival for patients with EGFR exon 20 insertion-positive advanced NSCLC using first-line amivantamab-chemotherapy. The study found a median overall survival of 34.3 months with amivantamab-chemotherapy versus 27.9 months with chemotherapy.
The ARROS-1 trial revealed a 94% objective response rate and 94% nine-month duration-of-response rate among TKI-naive patients with advanced ROS1-positive NSCLC. Intracranial activity was also notable, with a 100% intracranial objective response rate and 78% 12-month intracranial duration-of-response rate.
The European Society of Endocrinology is urging policy action to address a widening gap between care demand and workforce capacity. The endocrine workforce faces significant stress, burnout, and limited time for research, threatening timely and high-quality care.
A survey of 17 G20 countries found that 65% of respondents believe the economic system is rigged to favor the rich and powerful, while 69% want major changes. However, only 31% trust their government to make decisions that benefit the majority in the long term.
A large study found that people exposed to higher levels of air pollution face a higher risk of developing glaucoma and cataract. The study suggests that fine particulate matter is a key contributor to these risks, and that reducing air pollution can help prevent these eye diseases.
A new US Medicare pricing policy could reshape global pharmaceutical markets, potentially driving up prices and delaying medicine launches worldwide. The study estimates that Medicare could save $5.2 billion under its initial phase, with savings rising to $21 billion if expanded to all Medicare beneficiaries.
A new study reanalysed data from eight randomised trials on mammography screening, finding overdiagnosis to be less than 5%. The researchers suggest that previous high estimates of overdiagnosis were based on incomplete evidence and taken out of context.
Researchers developed a low-cost smartphone attachment to capture diagnostic-quality eye images, which can be reviewed remotely by ophthalmologists. Community health workers and remote ophthalmologists agreed on 96% of cataract diagnoses, challenging the assumption that specialist presence is necessary for accurate screening.
A study investigated the effects of space exposure on intraocular lenses and surgical equipment, finding that most lenses showed no notable damage after a six-month orbital journey. The research aims to develop better packaging, shielding, and material selection strategies for space missions, as the cost of sending equipment to space i...
The MAVERICK trial found that MRI surveillance alone significantly improved cognitive failure-free survival by 40% compared to MRI plus PCI in patients with limited-stage and extensive-stage small-cell lung cancer. Serious treatment-related adverse events were also less frequent with MRI surveillance alone.
Researchers developed a wearable electroceutical platform with microneedle electrodes that deliver stable electrical stimulation while reducing the influence of sweat or dead skin cells. The device can be remotely controlled via smartphone and automatically detaches when skin overheats for enhanced safety.
The phase III TAISHAN-302 trial found Tam-Peli to significantly improve overall survival, progression-free survival, and objective response rate in patients with relapsed small-cell lung cancer compared to topotecan. The study also showed a favorable safety profile for Tam-Peli.
The EVOKE-03/KEYNOTE-D46 trial found a numerically longer progression-free survival and higher response rates with sacituzumab govitecan plus pembrolizumab, but no statistically significant benefit in PFS or OS for patients with PD-L1-high metastatic NSCLC
The Phase III ARTEMIS-008 trial shows that risvutatug rezetecan significantly improves overall survival in patients with relapsed small-cell lung cancer. The treatment reduced the risk of death by 54% and improved progression-free survival and response rates compared to topotecan.
A phase 3 trial shows ivonescimab significantly improves overall survival compared to pembrolizumab in patients with PD-L1-positive advanced NSCLC. The median overall survival was 30.8 months with ivonescimab versus 22.6 months with pembrolizumab.
A simple perception test using standard eye testing equipment can accurately predict the success of laser surgery for age-related vision loss. The test identified 1.66% of patients who were not suitable for the treatment, while 96.9% successfully adapted to their laser blended vision.
The phase 1b DeLLphi-308 study found that subcutaneous tarlatamab achieved serum exposures comparable to the approved intravenous dosing while maintaining a favorable safety profile, with 30% preliminary objective response rate in patients with ES-SCLC.
A Phase 1 study showed the investigational therapy demonstrated a manageable safety profile, with 33.3% of patients achieving objective response at the recommended 2.5mg/kg dose. The treatment was well-tolerated, with no treatment-related deaths and only one patient discontinuing due to an adverse event.
Results from the DeLLphi-309 study suggest that extended-interval dosing regimens of tarlatamab may offer patients greater treatment flexibility while maintaining comparable clinical activity. The study found improved overall survival rates with less frequent dosing schedules, but with similar treatment-emergent adverse event rates.
The investigational combination of pumitamig and elfetabart drozuntecan demonstrated encouraging early antitumor activity in patients with small cell lung cancer, with a 70.4% overall response rate. The combination also showed a manageable safety profile, supporting further clinical development.
The Phase 3 IMpower030 trial found that perioperative atezolizumab plus chemotherapy doubled event-free survival to 62.8 months compared to 34.9 months for chemotherapy alone. The study also showed higher pathological response rates with the atezolizumab regimen.
A Phase III trial found that local consolidative therapy after dual immunotherapy did not improve overall or progression-free survival in patients with metastatic NSCLC. The study tested whether reducing residual tumor burden with radiation or surgery after dual immunotherapy could improve systemic disease control.
Researchers at Tokyo Metropolitan University identified how deadly E. coli bacteria spread using a chain-like adherence pattern under flow, and discovered a new gene family mediating this process. This discovery provides new insights into infection mechanisms and potential treatments for LEE-negative strains.
A new study suggests that individuals with diabetes who focus on tightly controlling their blood sugar levels may be missing out on enjoyable activities due to the associated burden. Higher glucose variability and better sleep quality on the previous day were associated with improved quality of life on the following day.
JMIR Publications and ZB MED extend their Flat-Fee Unlimited Open Access Publishing Agreement for two years, covering over 30 Gold Open Access journals with zero Article Processing Charges (APCs) for participating German research institutions. The new agreement provides predictable and sustainable funding for open access publishing.
András Tilcsik, a University of Toronto researcher, has been elected to the College of New Scholars, Artists and Scientists of the Royal Society of Canada. His work on organizations, occupations, and work has been recognized with numerous awards and has appeared in top academic journals.
Researchers have discovered a rare population of neurons in the cortex that can synchronize activity across large areas of the brain and promote sleep. These Sst-Chodl neurons were found to be active during the transition to sleep and could even help drive the process, suggesting that the cortex is not simply passive during sleep.
The American College of Cardiology, Society of Thoracic Surgeons, and Society for Cardiovascular Angiography & Interventions released a joint statement on TAVR national coverage determination. The statement aims to preserve the quality framework that contributed to TAVR's success, emphasizing the importance of collaborations, registrie...
A new vision condition, EFEMP1-associated late-onset retinal degeneration (L-ORD), has been discovered, causing slow decline in peripheral vision and night vision loss. The p.Arg140Trp variant in the EFEMP1 gene leads to abnormally thick material building up between eye cells, affecting rod photoreceptors' recovery in darkness.
Researchers have discovered tiny constrictions in dendrite extensions of nerve cells, which may enable local information processing and shape synaptic integration. These constrictions, only a few hundred nanometers wide, occur in various types of neurons and are linked to NMDA receptor activation and learning processes.
A giant volcanic eruption 21.9 million years ago buried an entire landscape beneath volcanic deposits, preserving clues to how the Andes were built. The study found that the landscape was built slowly, with rocks pushed upward by 0.26 km every million years.
A new video game, Geode, measures how people with autism understand and interpret information, providing fresh insights into the autistic brain and refining therapy development. The game, which can be played by people across the autism spectrum, includes nonverbal players and was successful in collecting detailed data on sensory input ...
Researchers developed a graph-based approach to directly extract concise and accurate constitutive equations from solid material experimental data. The method outperforms mainstream empirical models in predictive accuracy while preserving explicit, physically interpretable mathematical formulations.
Researchers develop nanoparticles that target tumor-associated macrophages, reprogramming them to attract cancer-fighting T cells. The approach shows promise in reducing immune-suppressing macrophages and increasing cancer-fighting T cells, with potential for improving immunotherapy for solid cancers.
The Frontiers Science House roadshow brings together world leaders and climate experts to address unresolved scientific disputes and policy bottlenecks in governance of climate intervention technologies and power, rewired: building the climate-energy future. The event aims to facilitate discussions and find solutions to pressing issues...
Researchers at CU Anschutz have developed CAR T-cell therapy to target two pathways that help colorectal tumors grow and evade the immune system, B7-H3 and IL-8. The therapy aims to provide a more durable response than traditional chemotherapy.
Kyocera and Tohoku University developed a new technology integrating optical isolators onto silicon photonics chips using laser annealing. This method allows for localized heating, reducing damage to surrounding components. The technology resulted in an isolation ratio of 13.6 dB, confirming its operation as an optical isolator.
Researchers identified a mutant rice variety, chalk2, with increased amylose and protein content, reduced starch and lipid, and higher resistant starch content. SBEIIb enzyme plays a crucial role in regulating starch composition and resistant starch formation, leading to a chalky phenotype and reduced grain yield.
Long-term fertilization increases resource inputs, enhancing functional groups in soil food web. Organic inputs, particularly in combination with mineral fertilizers, primarily drive bottom-up regulation, promoting soil food web complexity and size.
Researchers used finite element analysis to study how eight species of armoured fish, placoderms, caught their prey 385 million years ago. They found that despite differences in jaw shape and size, both the largest and smallest placoderms had evolved strong jaws to handle hard bites.
Researchers developed an automated method to convert standard eye scans into an objective cataract biomarker. The method, tested on 1906 eyes, demonstrated exceptional diagnostic discrimination and strong correlation with a standard cataract grading system.
A new review in Science Bulletin outlines how multimodal AI can integrate molecular, cellular, and clinical data to refine treatment choices and predict side effects. The approach aims to address challenges in cancer treatment, including primary resistance and immune-related adverse events.
Researchers propose a new concept of societal listening to transform environmental data into public awareness and collective action. The concept connects environmental sensing to sensory experience, public imagination, and institutional responsibility, aiming to make environmental change perceptible and shareable.
A new study found that ocean acidification can undermine the health of diatoms, crucial organisms for oxygen production and carbon capture. The research highlights the need for better understanding of complex processes in seawater to find solutions for ocean conservation.
The study identifies potential seismogenic asperities along western Ordos margin faults by analyzing sparse earthquake segments, b-value anomalies, and crustal velocity structures. Regions with overlapping sparse earthquake segments and low b-value areas are interpreted as highly-stressed locked fault sections.
Plant roots change anatomy to adapt to microbes, influencing root-microbiome interactions and nutrient uptake. Researchers identified mechanisms that enable roots to remodel themselves in response to bacterial colonization, paving the way for developing new agricultural strategies.
A review of 15,886 scientific publications highlights the importance of early diagnosis and treatment in rheumatoid arthritis. Consistent treatment and regular monitoring of disease activity can prevent joint damage and improve patient quality of life.
A Finnish study found that remote workers sleep 15 minutes longer and spend 45 minutes more sitting and lying down than office workers. This increase in sedentary behavior is attributed to less standing and increased sitting in a home setting.
Researchers have proposed a superfluid helium-based qubit design that could reduce error rates by 100 times, making it more resilient to electromagnetic noise. The SHOQ device could work alongside existing superconducting technologies, enabling a hybrid quantum system with improved performance.