Researchers at HUG-CELL identified a microRNA inhibitor that reduces tumor size and improves survival in mice with aggressive brain tumors. The synthetic miR-367 inhibitor prevents the regulation of proteins involved in cell growth, leading to an attenuation of tumor aggressiveness.
UTSW researchers identified a novel mechanism regulating fat creation in mammals. The miR-26 family of microRNAs strongly protects against weight gain and metabolic issues by controlling FBXL19 protein levels.
Researchers have identified microRNA-204 as a biomarker for early beta cell death in Type 1 diabetes, which can identify disease onset in children and adults with recent-onset Type 1 diabetes. Serum miR-204 levels were found to be elevated in individuals with Type 1 diabetes and inversely correlated with remaining beta-cell function.
Researchers at UT Health San Antonio have identified a novel way to kill cancers caused by inherited BRCA1 mutations. Adding back microRNA 223-3p forces BRCA1-mutant cancer cells to die, offering a potential treatment for inherited breast and ovarian cancer.
A new study reveals that a simple genetic system controls complex motor movements in fruit flies, which shares similarities with human movements such as rolling in babies. This discovery provides insights into the molecular basis of motor control and its relationship to diseases like Huntington's and Parkinson's.
A new study by McGill's Goodman Cancer Research Centre uncovers novel microRNA polycistron functions and their impact on cancer. Researchers discovered a mysterious step in microRNA biogenesis that occurs in cell nuclei, shedding light on the role of microRNAs in cancer.
Researchers at Temple University Health System have discovered that a small RNA molecule can reactivate heart cell proliferation and improve heart function in mice with severe heart attacks. The study, published in Circulation Research, shows that miR-294 treatment reawakens an embryonic signaling program in adult heart cells.
Researchers at UNC McAllister Heart Institute develop stable platform to reprogram human fibroblast cells into cardiomyocytes, creating high-resolution molecular roadmap. The approach identifies key genetic facilitators and signaling molecules driving cell fate development, offering new insights into human cardiac reprogramming.
Researchers identified a key molecule, mir-135b-5p, found elevated in the brain's emotional memory processor that drives PTSD symptoms. Suppressing this molecule enables faster recovery from trauma, and it may also serve as a novel biomarker for treatment.
Yale scientists identify two proteins P300 and Brd4 as essential for activating the zebrafish genome after fertilization, allowing embryonic development to proceed. The discovery provides new insights into how life begins at a molecular level.
Scientists have pioneered a new genomic methodology to identify and map bacterial species on the International Space Station, aiming to safeguard astronauts' health. The approach has applications in environmental management and healthcare, and will enable researchers to explore new microbiome environments.
Researchers from the University of Edinburgh discovered a protein that switches on an immune response in stem cells, protecting them from viruses. This finding could help develop more efficient stem cell therapies to treat diseases like Parkinson's and diabetes.
Researchers used protein sequence-based methods to diagnose an ancient and atypical form of Paget's disease in medieval skeletons. The study found extensive pathological changes, high disease prevalence, and low age-at-death estimations for affected skeletons.
Researchers have identified two microRNA family members that can provide both immediate and long-term protection against heart damage. The therapy targets the miR-19a/b microRNAs, which regulate proliferation of cardiomyocytes and reduce inflammation, leading to improved heart function.
A recent study published in Nature Metabolism identified a novel pathway regulating drug tolerance in non-small-cell lung cancers with a specific mutation. MicroRNA miR-147b was found to mediate resistance to EGFR-based treatments, suggesting a potential new approach for treatment of lung cancer.
A Johns Hopkins study using a new computer modeling method simulates asteroid collisions and finds that larger objects are not as easily broken as previously thought. Instead, asteroids retain significant strength after impact due to the formation of a damaged core.
A novel mechanism discovered by researchers at the University of York and Queen Mary University London reveals that miR-132 controls how immune cells respond to infection. This tiny molecule acts as a 'handbrake' on the immune system, preventing over-reaction and promoting protective immunity.
Researchers at Karolinska Institutet have discovered a new skeletal disease linked to an abnormal expression of small RNA molecules. The study reveals that the disease causes skeletal dysplasia, joint pain, and delayed cartilage cell maturation in patients, providing potential diagnostic and therapeutic options.
Researchers found that lung cancer cells acquire resistance to molecular-targeted drugs by transforming epithelial characteristics into mesenchymal ones, leading to reduced miR-200c expression. Sequential treatment with an HDAC inhibitor and a next generation molecular-targeted drug overcomes this resistance, offering new potential for...
Researchers found that food odors impact protein degradation and cell recycling, leading to shorter lifespans. The study used Caenorhabditis elegans, a roundworm model organism, to uncover the role of olfactory neurons and microRNA molecule mir-71 in regulating digestive processes.
Scientists have discovered new messenger molecules, miR-494-3p, that regulate genes involved in maintaining neuron health. The study found that introducing this micro-RNA into astrocyte-motor neuron cultures significantly improved neuron survival rates, potentially leading to new therapies for ALS and other neurodegenerative diseases.
A new method of using multiple microRNAs to weaken cancer cells has shown promising results in preclinical models, increasing survival in a murine model of glioblastoma by five-fold when combined with chemotherapy. The treatment strategy weakens tumor cells but does not directly kill them, making it an advantage for further treatment.
Scientists have isolated a gene, miR-I35B, linked to both inflammation and gastric cancer. The study suggests that miR-135B plays a role in the development of gastric abnormalities and may help develop diagnostic tools for early detection.
Researchers discover microRNAs miR-146a and miR-146b play crucial role in suppressing NF-κB activation, which leads to excessive cell cycle progression and rapid tumorigenesis. The study found differences in cancer outcomes depending on the absent microRNA, offering new insights into cancer development.
A state-by-state analysis reveals that melanoma survival rates differ substantially across the US, with states having more practicing physicians and higher percentage of Caucasians experiencing lower survival rates. The study highlights the need for targeted approaches to improve care and reduce deaths associated with melanoma.
Researchers at MIT have developed an inhalable form of messenger RNA that can be delivered directly to the lungs, showing promise for treating various lung diseases. The aerosol-formulated mRNA was found to induce lung cells in mice to produce a target protein, paving the way for potential treatments.
Researchers Max Mikel-Stites and Anne Staples investigated Ant-Man's microscale respiration, finding that superhero suits contain a combination of air pumps, compressors, and molecular filters to breathe while insect-sized. Their study could lead to new microfluidic technologies with potential consumer benefits.
Researchers at UC San Diego School of Medicine developed a method to turn B cells into factories that assemble and secrete vesicles containing tumor-suppressing microRNAs. In mice, breast tumors treated with this approach were significantly smaller than untreated tumors, and the treatment was long-lasting.
In a breakthrough study, researchers successfully delivered a microRNA called miR-126 via a nanocarrier to improve survival rates in a preclinical model of sepsis. The treatment resulted in over 67% of mice being alive at seven days compared to just 25% of untreated mice.
Researchers discovered MiR-584-5p, a tiny molecule, can kill medulloblastoma and sensitizes cancer to chemotherapy and radiation. This could lead to treating the tumor with one-tenth the current required dose.
Researchers developed a novel computational tool called ADmiRE to annotate human microRNA variants and determine their potential contribution to diseases. The tool successfully identified microRNA mutations in miR-142 and miR-21 linked to hematologic cancers and esophageal cancer, respectively.
Researchers identified a link between MIR-137 and complex brain disorders like autism spectrum disorder (ASD) and schizophrenia. Mice lacking MIR-137 displayed learning and memory deficits, repetitive behaviors, and impaired sociability, suggesting potential treatment targets.
Day's research develops layer-by-layer assembled nanoshells to deliver tumor suppressor miR-34a into cells, reducing cancer cell growth. Gleghorn discovers TRPV4 regulates airway development in fetal lungs, potentially leading to new therapeutic targets for bronchopulmonary dysplasia.
Researchers pinpointed microRNA-31 as a predictive indicator of clinical outcome and functional relevance in driving the disease. The study uses an artificial gut to culture human biopsy samples and track molecular abundance, offering a personalized testing platform for therapeutic agents.
Researchers at Tokyo University of Agriculture and Technology have developed a simple technique to identify Small Cell Lung Cancer (SCLC) earlier using nanopore technology and DNA computing. The method recognizes specific microRNA patterns associated with SCLC, enabling early detection without invasive cell biopsies.
Researchers discovered that brain-enriched miRNA (miR-124) plays a crucial role in neuronal survival, contrary to previous assumptions. The study identified 98 miR-124 targeted genes that have direct physiological functions, protecting neurons from death.
Researchers found that low colonic miR-31 expression is associated with worse disease outcomes in adults and future development of strictures in children. This discovery has the potential to improve clinical trial designs and develop more personalized therapeutic strategies for Crohn's disease patients.
Scientists from the University of Luxembourg have identified a molecular mechanism responsible for colon cancer cell spread and metastasis. A small molecule cluster, miR-371~373, was found to regulate colon cancer metastasis in aggressive, fast-growing cancer cells. Reactivation of this cluster slowed down metastatic cell growth.
Osaka University researchers successfully delivered microRNAs to immune response cells in inflamed intestinal tracts using a super carbonate apatite (sCA), reducing inflammatory cytokines. The study showed that sCA could be used to treat a wide range of immunity and allergic disorders caused by immune responses.
Researchers have identified a gene variant linked to chronic pain after traumatic injury, specifically the FKBP5 gene, which regulates the stress response and is affected by microRNA miR-320a. Individuals with this variant are more likely to experience increased pain due to altered cortisol levels and nerve sensitization.
Scientists discover that expanding subcutaneous white fat tissue can improve insulin sensitivity and reduce inflammation in obese individuals. A microRNA called miR-30a plays a crucial role in this process, protecting fat cells from inflammation and leading to improved metabolic health.
A new blood test can quickly detect early signs of liver disease in dogs, enabling prompt treatment and reducing the need for invasive biopsies. The test is based on insights from human patients and has been successfully tested on 250 dogs.
Researchers from Brigham and Women's Hospital discovered a neuroprotective microRNA, miR-132, which shows promise in treating tauopathies like Alzheimer's. The study found that miR-132 supplementation reduced toxic forms of tau and glutamate excitotoxicity, providing new avenues for potential treatments.
Researchers at Louisiana State University Health Sciences Center have identified miR-27b, a microRNA, as a potential therapeutic target for breast cancer treatment. The study found that suppressing miR-27b enhances the expression of PDHX, a protein involved in cell metabolism, which helps suppress tumor progression.
Researchers at Columbia University Irving Medical Center found a potential link between microRNAs and sepsis, identifying two molecules that silence inflammatory gene expression. These biomarkers could help diagnose patients at risk of organ failure and death, allowing for faster treatment and potentially saving lives.
Researchers identified dysregulation of the gene NEUROG2 as a key factor in the development of focal cortical dysplasia, a common cause of drug-resistant epilepsy. The study found that overexpression of NEUROG2 was linked to reduced expression of microRNA hsa-miR-34a, leading to nerve cell differentiation failure.
Researchers identified abnormal RNA activity linked to enlarged left atrium and atrial fibrillation. They found microRNA-21-3p levels associated with adverse heart growth, enabling potential targeted medications.
A NASA and NIST study found that traditional smoke detectors may not effectively detect smoke particles in space due to unique microgravity properties. The study investigated five common materials used on spacecraft and found that some detectors struggled to detect smaller particles, posing a concern for fire safety.
Researchers at Sanford Burnham Prebys Medical Discovery Institute discovered that PKC zeta deficiency promotes liver metastasis through the inactivation of enzyme ADAR2, leading to increased secretion of miR-200s. Treatment with a compound inhibiting miR-200s reduced liver metastasis in mice with colorectal cancer.
Astronaut David Wolf shares his experience of worsening eye sight after space missions, citing a possible connection between microgravity and visual impairment. Researchers are using advanced imaging techniques to find solutions for the effects of space travel on vision, critical for future long-duration missions.
Dr. Christian Marín-Muller developed a microRNA treatment for pancreatic cancer and founded Speratum CR, a biotech company with the goal of creating effective therapies. The company has successfully completed preclinical studies and is planning to initiate its first human trial.
A new study finds that the microRNA family miR-17-92 plays a critical role in regulating T-cell and B-cell pathogenicity, leading to chronic graft-vs-host disease. The research also suggests that blocking this miRNA may be an effective way to reduce cGVHD symptoms.
Researchers discover microRNA molecule miR-940 that alters bone structure in late-stage prostate cancer. The molecule promotes osteoblastic lesions, which can cause severe pain and structural weakness.
Researchers developed nanoparticles to target liver sinusoidal endothelial cells with miR-20a, restoring normal behavior and reducing tumor growth. The study found an 80% reduction in liver metastasis caused by colon cancer, highlighting a potential complementary treatment strategy.
Researchers at the University of Sussex have identified a specific molecule that plays a key role in forming long-term memories. By controlling this molecule, a drug could be developed to relieve the block on new memories in dementia patients and help repress painful memories in post-traumatic stress disorder sufferers.
Researchers found elevated mir-24-3p in breast cancer patients destined to metastasize despite best available therapy. High expression of mir-24-3p correlated with poor survival rate and specific gene expression signature in TCGA.
A study published in Hypertension Journal found that targeting a specific miRNA-mRNA pathway may reduce cocaine-induced cardiovascular disease. The researchers discovered that activating this pathway leads to increased reactive oxygen species, causing damage and cell death.
Researchers have identified two distinct types of vision-degrading glaucoma and pinpointed key genes associated with the condition. The study also suggests that exercise can help reduce eye pressure and provides a potential new point of intervention for treating glaucoma.
Researchers at Purdue University found that microRNA miR-223 can help control inflammatory disease by regulating the NF-kB pathway, which is critical in human bronchial epithelial cells. Supplementing this microRNA to epithelial cells may provide a new treatment option for asthma and cancer.
Researchers discover that low levels of microRNA miR-125a-5p correlate with high levels of protein TIMP-1 in human lung cancer cells. Increasing miR-125a-5p levels reduces cancer spread and increases cell death. TIMP-1's role is also explored, revealing its dual function in promoting or inhibiting tumor growth.