A recent study found that fully vaccinated individuals with substance use disorders have a significantly higher risk of breakthrough COVID-19 infection compared to the general population. The study, published in World Psychiatry, revealed that patients with cocaine and cannabis use disorder had the highest risks.
Researchers will investigate hidden signs of brain damage in REM behavior disorder, aiming to identify biomarkers that predict impending neurological disease. The goal is to delay the onset or prevent dementia or Parkinsonism through clinical trials.
An international team led by McGill University is developing biomarkers to identify people with REM sleep behavior disorder at risk of developing neurodegenerative diseases such as Parkinson's and dementia. The team will study over 430 participants, including those with the disorder and healthy controls, to develop targeted therapies.
Researchers discovered structural differences in brain regions responsible for decision-making and empathy in adolescents with conduct disorder compared to their unaffected siblings. These findings suggest that small changes in brain function may contribute to the development of antisocial behavior in some siblings.
Patients with bipolar disorder experiencing manic episodes show abnormal brain changes, including faster cortical thinning, compared to those without episodes. The study also found associations between brain ventricle enlargement and accelerated cognitive decline in bipolar patients.
Researchers from University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine found that combining long-term injectable medications with psychosocial intervention improves adherence and symptoms in patients with bipolar disorder. The study enrolled 30 people with bipolar disorder who had adherenc...
A study from OHSU found that almost 8% of patients with opioid use disorder died within 12 months of hospital discharge, comparable to those who suffered heart attacks. The researchers highlight the need for comprehensive addiction care and destigmatizing healthcare systems.
A new study published in the journal Eating Behaviors found a strong association between vaping or e-cigarette use and an increased risk of developing an eating disorder among US college students. The study analyzed over 51,000 participants and highlighted the need for more research and clinical assessment to address this growing concern.
Research reveals that young adults with ADHD are 69% more likely to develop a substance use disorder than their peers without ADHD. More than one-quarter of those with ADHD also experience major depression.
A study found that high-dose buprenorphine administered in emergency departments is safe and tolerable, providing extended withdrawal relief and helping patients navigate barriers to follow-up care. The therapy may enhance opioid use disorder treatment outcomes, particularly for vulnerable populations.
A new study found that diagnosis of post-traumatic stress disorder (PTSD) or genetic predisposition to PTSD is associated with increased risk of suicide death among individuals with bipolar disorder. The research suggests that understanding the genetic contribution to PTSD can help identify different strategies for suicide prevention.
Researchers found that eating disorder behaviors like binge-eating alter brain reward response and food intake control circuitry, reinforcing these behaviors. The study suggests that behavioral traits contribute to eating disorder maintenance and progression by modulating internal reward responses.
A new study found that a special type of brain training based on neurofeedback enables people with attention deficit disorder to improve their ability to concentrate. The training is linked to an enhanced response from the brain's P3 wave, which reflects integration of information in the brain.
A UofSC researcher is conducting a four-year study to improve access to alcohol use disorder treatment for vulnerable populations under Medicaid. The study aims to investigate the effectiveness of these programs and provide guidance on structuring coverage and utilization management parameters.
Researchers found significant alterations in serum amino acid profiles in children with ADHD, including lower levels of histidine, glutamine, and proline, as well as higher levels of aspartic acid and hydroxyproline. These findings may help develop new treatment strategies for the disorder.
Research found that adolescents with higher levels of DHA, an omega-3 fatty acid, were less likely to develop psychotic disorder in early adulthood. Those with lower levels of DHA had a higher risk of developing the condition, even after accounting for other factors.
Researchers from iPSYCH have identified 33 new genetic variants associated with bipolar disorder, more than doubling the number of known genetic risk factors. These variants play a role in brain functions and signalling between nerve cells, providing potential ideas for new treatments.
A study found six key factors that hinder people with bipolar disorder from taking their medication as prescribed. Patient beliefs and knowledge about the condition, as well as fear of addiction and lack of support from healthcare professionals, were among the factors identified.
Researchers found altered connectivity in brain networks associated with goal-directed behaviour and increased executive network activity in women at risk of postpartum psychosis. This could offer a vital marker for resilience to relapse, enabling earlier intervention.
A study published in Nature Genetics found 64 genome regions associated with an increased risk of bipolar disorder, providing new insights into the condition's underlying biology. The research also highlights potential therapeutic targets for future treatments.
Researchers at the University of Missouri found that drivers with shift work sleep disorder are three times more likely to be involved in a vehicle accident than those without the condition. The study analyzed real-world driving data and found that shift work sleep disorder increased the risk of traffic crashes by nearly 300%.
A new study published in JAMA Network Open suggests that extended-release formulations of buprenorphine may improve treatment satisfaction for patients with opioid use disorder. The study found that the extended-release injection was well-tolerated and produced more positive patient-reported outcomes compared to daily oral buprenorphine.
A new study from Aarhus University finds that almost half of parents with children to a parent with schizophrenia or bipolar disorder also meet the criteria for a mental disorder. This can impact family life and child development. The study suggests increased attention is needed for these families, with specialized efforts recommended.
A study found that babies born to mothers with cannabis use disorder were more likely to experience negative health outcomes, including preterm birth and low birth weight. Infants born to these mothers were also at a higher risk of infant mortality.
The Baszucki Brain Research Fund has launched a multimillion-dollar program to advance therapeutic discovery for bipolar disorder, aiming to improve treatment options for affected individuals. The grant program will provide up to $200,000 per year to support pilot research and translational efforts.
Researchers at University of Wisconsin-Madison discovered a disrupted Akt protein pathway in men with bipolar disorder, leading to memory problems and weakened brain connections. The findings offer a new target for treating bipolar disorder's often-overlooked cognitive impairments.
A multinational study of nearly 200,000 people found significant sex-dependent differences in the genetics of schizophrenia, bipolar disorder, and major depressive disorders. The findings suggest that interactions between genes and sex may affect disease risk and progression.
A new study found that 58% of healthcare workers met the threshold for any mental health disorder, with 22% experiencing post-traumatic stress disorder. The research highlights the need for immediate additional mental health support and long-term planning to meet staff needs.
Researchers found that astrocytes from patients with bipolar disorder secrete more IL-6, which worsens symptoms and negatively impacts neuronal activity. The study highlights the potential role of astrocyte-mediated inflammatory signaling in psychiatric diseases.
Patients taking buprenorphine for opioid use disorder who also take benzodiazepines experience a 40% lower risk of overdose, according to research published in The American Journal of Psychiatry. This finding suggests that buprenorphine can protect patients from overdose even when taking benzodiazepines.
Researchers found that financial incentives encouraged hospitals to enact rapid system and practice changes to support treatment for opioid use disorder. However, smaller or independent hospitals struggled to invest in resources due to internal barriers.
A new national study found that excessive social media use is associated with a higher risk of binge-eating disorder in US preteens. Children who spend more time on social media are more likely to develop the disorder, with each additional hour linked to a 62% increased risk.
A NUI Galway study found that problem and non-problem gamblers differ in the gratifications they seek from mobile gambling. Problem gamblers use apps to facilitate social interaction and avoid boredom, while non-problem gamblers do not.
A new study found that people with depression and anxiety may experience dementia symptoms about two years earlier than those without these conditions. Those with bipolar disorder or schizophrenia may start experiencing symptoms three to seven years earlier.
Researchers investigated dynamic changes to DNA methylation in shift workers, finding that rest and recovery can restore gene function. The study suggests that insufficient sleep and related inflammatory consequences may mediate shift work disorder, highlighting the importance of sufficient rest for overall health.
A large-scale study from Lund University found that psychotherapy for panic disorder produces lasting improvements in symptoms and quality of life. Two years after treatment, 70% of patients were clearly improved and 45% were remitted.
Researchers found modest differences in gene expression between individuals with a mental disorder and those without, but more pronounced differences in transcript levels. The study identifies specific transcripts associated with each disorder, providing insights into their distinctness and potential treatment responses.
A new study published in The Lancet HIV found that integrating opioid use disorder treatment with HIV care in Vietnam can be effective. The study suggests that countries aiming to expand treatment should consider interventions supporting retention on treatment through family networks, peers, and community health workers.
A recent study published in the Proceedings of the National Academy of Sciences found that defects in mitochondria may contribute to autism spectrum disorder. The researchers introduced a mild missense mutation into a mouse strain and observed impaired social interactions, increased repetitive behaviors, and anxiety-like traits.
Researchers have identified a stable biomarker for ADHD in brain connectivity, allowing for near-perfect detection of the disorder. A machine learning model achieved 99% accuracy in identifying adults diagnosed with ADHD as children.
Researchers at Swansea University found a six-fold increase in brain pressure disorder cases among women between 2003 and 2017. Obesity rates in Wales rose significantly during this period, and women from deprived areas had a higher risk of developing the condition, independent of body mass index.
A combination of injectable naltrexone and oral bupropion was found to be effective in treating adults with moderate or severe methamphetamine use disorder. Participants responded at a significantly higher rate to the treatment, with an NNT of 9, indicating its potential as a promising addition to current approaches.
Researchers analyzed Medicaid databases to identify predictors of timely enrollment in treatment for opioid use disorder among Medicaid recipients. Prior overdose, alcohol use disorder, and back problems were associated with non-enrollment, while frequent emergency room visits or primary care provider visits were linked to timely enrol...
Researchers found that individuals with gambling disorder focus on irrelevant information from previous gambles, rather than considering optimal probabilities and prize sizes. This impaired decision-making can lead to continued gambling despite mounting losses.
Researchers applied the Perturb-Seq method to study dozens of genes associated with autism spectrum disorder, identifying how specific cell types in the developing mouse brain are impacted by mutations. The study found that both neurons and glia are directly affected by different sets of risk genes.
A new University of Michigan study finds that over half of lesbian, gay, and bisexual individuals who misuse alcohol or tobacco also have a co-occurring psychiatric disorder. Women are particularly affected, with higher rates of anxiety, mood disorders, and PTSD compared to heterosexual women.
A study of 1 million Danish children found that growing up in low-income families increases the risk of developing mental disorders later in life. Children born into the lowest parental income quintile had a 25.2% chance of developing a clinically diagnosed mental disorder by age 37.
A study published in eLife found that individuals with bipolar disorder who exhibit pessimistic beliefs are more likely to experience relapse. The study suggests that the way patients update their beliefs can be used as a risk prediction tool, allowing for timely intervention and improved outcomes.
A study by Aarhus University finds that COVID-19 exacerbates obsessive thoughts and compulsions in children and young people with OCD. The condition often worsens due to anxiety about illness or loss, particularly among younger children who are more dependent on others.
Scientists identified changes in the brain that drive alcohol abuse among people with PTSD, highlighting sex-specific differences that could lead to targeted treatments. Researchers found that males and females exhibit different symptoms and brain features of PTSD and alcohol use disorder.
A new study by researchers from Florida Atlantic University and Geisinger shows that electronic health records can help pinpoint patients with opioid use disorder. By analyzing EHR data, researchers were able to identify more patients with moderate-to-severe opioid use disorder than relying on diagnostic codes alone.
A NIH-funded study identified neuronal abnormalities in cortical cells from individuals with 22q11.2 deletion syndrome, a genetic disorder associated with mental illnesses and developmental delays. The study suggests that overexpression of the DGCR8 gene and exposure to certain antipsychotic drugs can restore normal cellular functioning.
Researchers at Medical University of South Carolina found that genetic variation in three specific brain genes can predict the effectiveness of naltrexone in treating alcohol use disorder. Patients with certain combinations of gene variations showed consistently reduced drinking when taking naltrexone, making personalized medicine a po...
A machine learning system has been developed that can predict the development of Bipolar Disorder up to 4 years before onset in young people. The system identified risk factors such as suicidal tendencies and financial problems, allowing doctors to take preventative measures.
A large Swedish study found no association between H1N1 influenza vaccination during pregnancy and an increased risk of autism spectrum disorder in the offspring. Researchers adjusted for potential confounders to minimize influence from other factors.
Researchers developed a blood test predicting psychosis development risk with 93% accuracy. The test identifies early changes in the immune system involved in inflammation.
A study from the Danish psychiatry project iPSYCH identified genetic risk factors for developing bipolar disorder and psychoses among people with depression. The results may contribute to ensuring correct diagnosis is made earlier, leading to better treatment outcomes.
A new AI algorithm can identify environmental and psychological factors that contribute to substance abuse among homeless youth, allowing for personalized rehabilitation programs. The model, developed by Penn State researchers, found adverse childhood experiences and PTSD to be strong predictors of substance use disorder.
A new study found that yoga significantly improved symptoms for those with generalized anxiety disorder, but not as effective as cognitive behavioral therapy. Yoga was more effective than stress management, with 54% of participants experiencing improved symptoms compared to 33% in the control group.
A study suggests that a single point mutation in the Cav1.2 channel, G406R, may explain the mechanism of autism spectrum disorder (ASD). The mutation causes abnormal calcium overload leading to heart problems and spontaneous gene activation, resulting in uncontrolled long-term dysregulations.