A new study reveals that a family history of obesity is a significant risk factor for early onset and severity of childhood obesity. The research found that the youngest children were the most severely obese and showed signs of insulin resistance, increasing the risk of developing type 2 diabetes.
A UAB-led study published in The Lancet Diabetes & Endocrinology found that denosumab was superior to risedronate in increasing bone density in patients with glucocorticoid-induced osteoporosis. The 12-month study enrolled 795 patients and showed promising results for the new drug.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that girls with recently diagnosed type 2 diabetes had a high rate of menstrual irregularities. Many of these girls also had high testosterone levels, suggesting PCOS as an underlying cause.
The Biochemical Society has announced the winners of its annual awards, recognizing established and early-career researchers in cell biology, endocrinology, and plant sciences. The award recipients include Dr Melina Schuh, Professor Dame Caroline Dean, and Professor R. John Ellis.
A new study published in the Journal of Clinical Endocrinology & Metabolism found that menopausal hormone therapy users tend to have less abdominal fat tissue than other menopausal women. The protective effect disappeared rapidly after treatment stopped.
Low levels of vitamin D during pregnancy and breastfeeding have been linked to differences in social behavior in children later in life. The study found that rats born to mothers with vitamin D deficiency displayed abnormal social behaviors, altered brain chemistry, and impaired learning and memory.
Researchers found that African Americans with a common genetic variation are 30% more likely to develop Alzheimer's disease dementia. In contrast, European Americans without the polymorphism are not at increased risk. Further studies are needed to understand why this correlation only appears in African-Americans.
A new classification of diabetes has been discovered, which can predict the risk of serious complications and provide tailored treatment suggestions. The study, published in The Lancet Diabetes & Endocrinology, reveals that type 2 diabetes consists of several subgroups, each with unique characteristics.
Researchers identified five distinct subtypes of type 2 diabetes and one autoimmune type, each with unique characteristics and associated complications. These findings may enable tailored treatment approaches for patients with diabetes, moving towards precision medicine.
A common rheumatoid arthritis treatment, lefluonamide, lowered blood glucose levels and reversed insulin resistance in mouse models of type 2 diabetes. The study suggests that this therapy could be repurposed as an effective antidiabetic treatment for patients with both diabetes and rheumatoid arthritis.
Researchers at Joslin Diabetes Center discovered that four viruses can produce insulin-like hormones that bind to human insulin receptors and stimulate cellular signaling. This finding opens up a new field of study in microbial endocrinology, potentially revealing biological mechanisms behind diabetes, autoimmune disease, and cancer.
Researchers have discovered a link between male sex hormone levels and vitamin D metabolism that may be targeted to treat osteoporosis in men undergoing prostate cancer therapy. Progesterone receptor blockers could enhance the effectiveness of vitamin D supplements, reducing bone fracture risks.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that women with PCOS have less diverse gut bacteria, which may influence the development of the condition and its impact on quality of life. Elevated testosterone levels in women with PCOS were linked to these changes.
A new nationwide clinical trial aims to make managing type 1 diabetes easier for patients using the world's first hybrid closed-loop system automated insulin delivery device. The trial, funded by Medtronic, will monitor blood glucose levels and adjust insulin doses continuously to help patients maintain stable blood sugar levels.
A recent review found a link between morning sickness, smoking, and healthy pregnancies, suggesting that impaired endokinin activity may be involved in poor placental implantation. Smoking during pregnancy is known to lead to negative outcomes, while morning sickness symptoms may be caused by overspill of endokinin levels in the brain.
Research published in the Lancet Diabetes & Endocrinology found that over 40% of type 1 diabetes cases occur after age 30, and many adults are initially misdiagnosed with type 2. Type 1 diabetes requires insulin treatment to control blood sugar levels, while type 2 can often be managed with diet and medication.
A study published in the Journal of Clinical Endocrinology & Metabolism found that continuous glucose monitors can protect against hypoglycemia episodes, even when the body's defense mechanisms are impaired. The devices raised awareness of low blood sugar threats and reduced severe episodes.
A study published in The Lancet Diabetes & Endocrinology found that diabetes and high BMI were responsible for 544,300 new cancer cases globally in 2012. The authors project a significant increase in the proportion of cancers attributable to these risk factors, particularly in low- and middle-income countries.
A new study published in The Lancet Diabetes & Endocrinology found that diabetes and being overweight or obese are responsible for nearly 800,000 new cancer cases globally. High BMI was linked to twice as many cancers as diabetes, with liver cancer and endometrial cancer being the most common types.
A new study found that phenylalanine reduces food intake by affecting the gut and brain, suggesting it may be used to treat or prevent obesity. The amino acid suppressed appetite by releasing hormones in the gut and activating areas of the brain involved in appetite regulation.
A study found that pregnant women exposed to high levels of perchlorate, a common environmental pollutant, had lower levels of thyroxine (T4), a thyroid hormone essential for normal foetal brain development. This suggests that exposure to this chemical may lead to potential neurodevelopmental abnormalities in children.
A study found that women with PCOS are more likely to be diagnosed with mental health disorders, including depression, anxiety, and bipolar disorder. The research also showed that children born to mothers with PCOS are at a higher risk of developing ADHD and autism spectrum disorder.
Patients with severe burns who have higher levels of vitamin D recover more successfully than those with lower levels. Vitamin D supplementation may be a simple treatment to improve wound healing and combat infection.
The prevalence of obesity in the UK has almost doubled over two decades, with food taxes being suggested as a measure to correct this trend. However, experts disagree on its effectiveness, with some arguing it is too simplistic and overlooks other factors influencing obesity.
A study found that kisspeptin enhances male sexual attraction and decreases anxiety in male mice by activating specific neurons in the brain. Activation of these neurons increases social interaction and reduces anxiety, while having no effect on copulatory behavior.
A new study published in The Lancet Diabetes & Endocrinology suggests that a diet rich in omega-6 polyunsaturated fats may significantly reduce the risk of developing type 2 diabetes. Researchers found that individuals with higher levels of linoleic acid, the major omega-6 fat, had a lower chance of developing type 2 diabetes.
A global study of over 800 patients with Type 1 diabetes found that dapagliflozin, a Type 2 diabetes medicine, significantly improved blood sugar levels. The results demonstrate the drug's efficacy as an adjunct therapy to insulin, reducing A1C levels by more than 0.5% without severe hypoglycemia.
A study by St. Jude Children's Research Hospital found that abdominal radiation increases the risk of premature ovarian insufficiency in female cancer survivors, which can lead to infertility and poor overall health. Researchers recommend estrogen replacement therapy to mitigate these risks.
The report reveals that type 2 diabetes prevalence in sub-Saharan Africa has reached 22% in some countries, with only half of diagnosed cases receiving treatment. The Lancet commission calls for decisive action to address the growing burden, which could nearly triple to $59 billion by 2030.
A new report predicts that diabetes cases will continue to rise in sub-Saharan Africa, overwhelming health systems and crippling patients' finances. The economic cost of diabetes is expected to more than double, reaching up to $59.3 billion per year by 2030.
A study published in The Lancet Diabetes & Endocrinology found that diabetes prevalence is increasing among low socio-economic backgrounds living in urban areas of affluent states in India. Diabete's rates are higher among people from low socio-economic status, especially in cities with poor access to healthcare.
A new guide from Tulane University aims to address inherent sex bias in pre-clinical research on metabolic diseases. The guide emphasizes the need to consider sex differences in biological mechanisms, not just hormones, to accelerate discovery and treatment.
Research suggests that vitamin D levels combined with good sleep quality can effectively manage conditions like arthritis, menstrual cramps, and chronic back pain. This review highlights the potential benefits of vitamin D supplementation in pain management, offering a new approach to alleviate suffering.
A large population-based study found that 6.5% of thyroid cancer patients experienced general post-operative complications, while 12% had complications specific to thyroid surgery within a year after their operation. Patients over 65 and those with more advanced thyroid cancer were at higher risk for these complications.
The emerging field of conservation endocrinology explores the effects of environmental change on species and ecosystems through hormone analysis. Researchers are developing new techniques to monitor ecological responses and plan future conservation efforts.
Researchers using endocrine markers can monitor ecological responses to climate change and plan conservation efforts. This emerging field aims to improve conservation biology by studying the impact of environmental stressors on species health.
A recent study published in the American Journal of Physiology - Endocrinology and Metabolism suggests that increasing dietary potassium intake can have an equally important effect on hypertension as decreasing sodium intake. Eating foods high in potassium, such as sweet potatoes, avocados, and spinach, may help lower blood pressure.
A new study presents evidence that vitamin D deficiency is associated with increased markers of cardiovascular disease in overweight and obese children. The research found a significant link between low vitamin D levels and higher levels of atherogenic lipids, triglycerides, and non-HDL cholesterol.
Research found disparities in type 1 diabetes care among US military children, with white and officers' kids more likely to use insulin pumps and continuous glucose monitors. These technologies led to better glycemic control, but hospitalizations remained similar between pump users and those using multiple daily injections.
The American Diabetes Association and Michigan Medicine have released updated guidelines for the prevention, treatment, and management of diabetic neuropathy. The guidelines provide recommendations for primary care physicians on preventing this complication and suggest guidelines to manage and treat each form of diabetic neuropathy. Th...
A study led by Wei Guo has identified Sec3 as a key activator that speeds up the binding of SNAREs, allowing vesicles to fuse with the plasma membrane. The researchers used a combination of molecular biology and crystallography to understand the mechanism of exocytosis and have potential implications for endocrinology, neurotransmissio...
A new study found that most endocrinologists have never received formal training on caring for transgender individuals, despite growing demand for such services. The Endocrine Society is now developing guidelines to address the need for education and training in this area.
Severely obese teenagers who undergo gastric bypass surgery experience significant weight loss and improved health outcomes, including reduced diabetes and high cholesterol risks. However, some patients may need additional surgery or develop vitamin deficiencies, highlighting the importance of long-term follow-up and support.
Researchers at Beth Israel Deaconess Medical Center discovered that a subset of neurons anticipates the effects of drinking by preparing the body for an influx of water seconds before consumption. This 'top-down' control helps regulate intake and prevent negative consequences.
The American Association of Clinical Endocrinologists and American College of Endocrinology have released new osteoporosis guidelines recommending that all postmenopausal women aged 50 and older be evaluated for osteoporosis risk. Successful treatment is defined as stable or increasing bone mineral density with no evidence of new fract...
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism reveals that menopausal hormone therapy (MHT) improves both bone mass and structure, with benefits persisting for at least two years after treatment ends.
A recent study suggests that treating mild hypothyroidism in pregnant women with levothyroxine may lower the risk of low-weight babies and early caesarean sections. However, there was no significant difference in other obstetric outcomes between treated and untreated groups.
Research reveals that individuals with medical conditions causing low oxytocin levels perform poorly on empathy tasks. Oxytocin replacement may improve psychological well-being in those living with low levels.
A Japanese research team has identified a hormone that limits liver fibrosis in nonalcoholic steatohepatitis (NASH) and cirrhosis. Administering growth hormone alleviated NASH conditions caused by adult growth hormone deficiency, and treatments were effective on model animals.
A randomized trial found that using an activity tracker did not increase physical activity enough to benefit health, even with financial incentives. Despite initial increases in exercise levels, participants stopped using the devices once incentives were removed.
French children born between 1914 and 1916 whose fathers were killed or severely injured during WWI lost approximately one year of adult life expectancy. Research suggests that negative early life experiences, including maternal psychological stress, may contribute to increased mortality in adulthood.
Researchers found that measuring blood levels of irisin may help diagnose PCOS in teenagers, potentially reducing unnecessary treatments and improving symptoms management. High irisin levels in teens with PCOS are associated with higher testosterone levels, a key marker of the condition.
Women who undergo gastric bypass surgery for weight loss may give birth to babies with lower average birth weights due to nutrient deficiencies. The study found that 23% of newborns were small for their gestational age and had lower levels of key nutrients like calcium and zinc.
After decades of research, scientists have made significant progress in understanding and treating PCOS, identifying potential biomarkers and developing new diagnostic tests. The review highlights innovative approaches, including genetic testing and hormone analysis, to improve early treatment strategies and prevent long-term complicat...
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that a combination of three medications—dapagliflozin, liraglutide, and insulin—helped people with Type 1 diabetes improve blood sugar control and lose weight. The therapy also showed impressive improvements in blood glucose management.
A large placebo-controlled study found that testosterone therapy significantly improved sexual interest and function in older men with low libido and low testosterone levels. The study, the largest of its kind, showed consistent improvement in most types of sexual activity among those who received testosterone therapy.
Researchers at Cincinnati Children's Hospital Medical Center found significant changes in total brain gray matter volume and specific brain regions in teenagers with type 2 diabetes. These changes are associated with reduced cognitive abilities, particularly in pronunciation and language skills.
Researchers have discovered that adults born in the 1940s with diabetes are living longer and with less disability, performing day-to-day tasks, compared to those born a decade earlier. This trend is attributed to improvements in diabetes management and healthy lifestyle choices.
Eating a Mediterranean diet rich in vegetable fats like olive oil and nuts has been shown to have little effect on bodyweight or waist circumference compared to a low-fat diet. The study suggests that current health guidelines recommending low-fat diets may be creating unnecessary fear of healthy fats.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism has found that obese teenagers have lower levels of the hormone spexin, which may contribute to weight gain and obesity. The study suggests that spexin may play a role in regulating body fat mass and energy balance.