A low-calorie fasting-mimicking diet has been shown to reduce intestinal inflammation and increase intestinal stem cells, promoting the expansion of beneficial gut microbiota. The study suggests that this regimen may have potential in mitigating inflammatory bowel disease (IBD) pathology.
Researchers found that a vegan-based fasting diet reduced inflammatory bowel disease (IBD) pathology in mice by changing their gut microbiota. The diet, known as the fasting-mimicking diet (FMD), increased stem cell numbers and stimulated protective gut microbiota, leading to reduced intestinal inflammation.
A research team has assembled a detailed atlas of bone marrow cells from AML patients, revealing six stages of white blood cell development and a role for differentiated tumor cells in suppressing immune responses. The study may lead to personalized therapies targeting specific AML cell types.
A new diagnostic technique using infrared imaging and proteomics has identified a protein biomarker called AHNAK2 that can accurately distinguish between bladder cancer and benign inflammation. The technique has been shown to have high sensitivity and specificity in differentiating between various stages of bladder cancer.
Researchers at the Buck Institute have identified a novel molecular mechanism that orchestrates harmful inflammatory signaling in glial cells, contributing to Parkinson's disease pathology. Blocking Furin 1, a catalytic protein, in dopaminergic neurons reduces toxic cross-talk and protects neurons from degeneration.
Researchers identified Porphyromonas gingivalis as a bacterial pathogen driving Alzheimer's disease pathology in the brains of patients. The study found that Pg infection led to increased production of amyloid beta and neuroinflammation.
A UCL-led study confirms that some vials of discontinued hormone used in medical treatments contained seeds of a protein implicated in Alzheimer's disease. The research found that these seeds can seed amyloid pathology in mice and supports the team's hypothesis that amyloid beta was accidentally transmitted to patients via this treatment.
A study in The American Journal of Pathology reveals the connection between endoplasmic reticulum stress and pseudoachondroplasia, a severe inherited dwarfing condition. Disrupting a self-perpetuating cellular loop of ER stress, inflammation, and oxidative stress may lead to therapeutic advances.
A recent study by the University of Helsinki reveals that pathological tau triggers a safety valve mechanism in cell membranes, leading to accelerated neuronal cell death and loss of synapses. Omega-3 fatty acids have been found to modify the microstructure of cell membranes, capturing tau aggregates within cells.
Researchers will investigate the GI lymphatic system's impact on diabetes reversal after bariatric surgery. The five-year grant aims to shed light on the mechanism involved in reversing diabetes through disruption of lymphatic circulation in an animal model.
The University of Leeds and Leeds Teaching Hospitals NHS Trust will create a digital pathology clinical network and research programme with a £10.1m UK Research and Innovation investment. The project aims to develop artificial intelligence tools for pathology diagnosis, generating over 760,000 images per year.
A genetic variation in TMEM106B has been identified as a potential risk factor for chronic traumatic encephalopathy (CTE) disease severity and pathology. The study found that this variation may predict increased CTE pathology and brain inflammation, and is associated with a higher risk of developing dementia.
A study of male and female mice found that chronic short sleep and chronic fragmentation of sleep accelerate Alzheimer's disease-related tau pathology. Healthy sleep habits during adolescence and early adulthood may help prevent progression of neurodegenerative diseases.
Yongxin Zhao, assistant professor at Carnegie Mellon University, has received a National Institutes of Health (NIH) Director's New Innovator Award. He will use the grant to develop transformative nanoscale imaging techniques for analyzing complex diseases.
A new pathology test using AI can accurately predict clinically significant prostate cancer disease progression following surgery, helping guide treatment decisions. The Precise MD post-op test reclassified 58% of intermediate risk patients as low risk and 42% as high risk for significant disease progression.
Mitochondria use one-way doors called mitochondrial calcium uniporter channel complexes (MCUCs) to control access, but the exit door proteins are abundant only in areas far from the entrances. This separation allows mitochondria to operate at maximum efficiency even when stressed.
A study published in PLOS ONE found that the jaw joint bone structure of carnivorans is more closely related to their body size than their diet. Researchers used 3D printing and CT scans to analyze the mandibular condyle, a key joint in the jaw, and discovered no significant correlation between diet and jaw joint strength or complexity.
Drs. Jonathan Rothberg, Roger Klein and Kevin Halling are being recognized for their groundbreaking work and longstanding commitment to advancing patient care and the field of molecular diagnostics. Drs. Rothberg is receiving AMP's highest honor for his pioneering work in genomics and inventions like massively parallel DNA sequencing.
The Association for Molecular Pathology recommends a minimum of 34 critical genes for high-throughput pan-myeloid sequencing tests to standardize clinical practice and improve patient care. The report provides evidence-based guidelines for the management of chronic myeloid neoplasms, including diagnostic and prognostic information.
The study reveals how a fusion protein found in cancer cells enhances target gene expression by converting microsatellite repeats into active enhancers. Blocking this process prevents tumor growth.
A Massachusetts General Hospital research team has developed a system that incorporates neuroinflammation into their 'Alzheimer's in a dish' model, fully replicating the disease's pathology. The system includes neural cell death and glial cells that provide immune functions.
A new study finds contact sports associated with an increased risk of Lewy Body Disease (LBD), which can cause Parkinson's disease and dementia. LBD was linked to problems with movement, cognition, depression, sleep, and visual hallucinations, independent of CTE pathology.
Research suggests that low-dose aspirin regimens could decrease amyloid plaque pathology in mice by stimulating lysosomes. Activating cellular waste removal mechanisms is a promising strategy for slowing disease progression.
Researchers have developed a rhesus macaque model to study Zika brain pathology, revealing similar brain lesions as in human infants with congenital Zika syndrome. The findings suggest that therapies can be tested using fewer animals, providing hope for the development of new treatments.
The study found that on-site pathology testing reduced the need for medical evacuations by up to 35%, resulting in estimated total cost savings of $21.75 million per year. This technology enabled early diagnosis, treatment, and evacuation for critically ill patients in remote communities.
A recent study published in the Journal of Consulting and Clinical Psychology found that patients' self-reports of personality disorder traits are more accurate than previously believed. The research suggests that clinicians' diagnoses may be less reliable than thought, and that using similar evaluation tools can bridge the gap between...
Researchers at Temple University Health System have discovered a way to reverse memory deficits and tau pathology in mice with dementia. By administering a drug that blocks leukotriene formation, they were able to improve spatial learning and working memory in treated animals.
A team of scientists has created a map of the molecular network in the aging brain, revealing two new Alzheimer's disease target genes that can be deleted or modified to treat the disease. The study provides a unique resource linking molecular changes in nearly 500 older brains to cognition and brain pathology.
Researchers have developed a computer program that can comprehensively determine differences in individuals' blood types with over 99% accuracy. This breakthrough has the potential to prevent serious complications and fatalities from blood transfusion reactions.
A collaborative study led by the University of Miami Miller School of Medicine found that a monoclonal antibody cocktail therapy was effective in clearing the virus from pregnant women's blood but failed to prevent fetal transmission and treat infected fetuses. Researchers are now working on engineering antibodies to target the fetus.
A team of researchers at LSTM has developed a new approach to treating snakebite using antivenom produced from a different species than the one that caused the bite. The study, published in Communications Biology, shows that this approach can be effective in neutralizing certain pathologies caused by venomous snakes.
Janardan K. Reddy, a world-renowned pathologist, has been awarded the ASIP Gold-Headed Cane Award for his significant research contributions to liver biology, particularly peroxisomes and carcinogenesis. He is also recognized for his exceptional teaching and mentoring skills.
A new approach to analyzing prostate gland tissue uses cellular metabolites to differentiate between aggressive and less aggressive tumors. The study found that metabolite levels can predict tumor grade, stage, and recurrence risk, helping guide treatment strategy.
Researchers found that beta-amyloid triggers calcineurin, leading to loss of dendritic spines and synapses in Alzheimer's disease. Rescuing synapses with extra Pin1 or FK506, an FDA-approved drug for transplant rejection, may slow disease progression.
A study published in Biological Psychiatry reveals distinct molecular changes in gene expression between men and women with major depressive disorder, suggesting different pathology and treatment needs.
The Association for Molecular Pathology (AMP) has published consensus-based recommendations for clinical CYP2C19 genotyping allele selection. The guidelines aim to standardize testing across laboratories and improve concordance, enabling better patient care.
Researchers found four cases of amyloid beta pathology in brain blood vessels after childhood neurosurgery, sparking concerns over potential transmission of protein pathology. The study's findings were supported by a review of medical literature and suggest that neurosurgical instruments may be responsible.
A study by Tokyo Medical and Dental University found that protein YAP rescued SCA1 pathology when expressed during development, but not as an adult. The researchers also discovered a link between YAP and the transcriptional co-activator RORα, which plays a crucial role in cerebellum development.
A panel of experts has issued new guidelines for molecular diagnostic testing and treatment decisions in lung cancer. The updates reflect recent advancements and decades of work to identify the genetic underpinnings of lung cancer, helping oncologists match patients with effective therapies.
A Boston University study identified evidence of early Chronic Traumatic Encephalopathy (CTE) brain pathology after head impact, even in the absence of signs of concussion. The researchers found that head impact caused persistent changes in brain electrical functions and damaged blood vessels, leading to CTE.
Dr. Jeffrey Actor has been awarded $1.7 million to investigate a novel recombinant lactoferrin for use as a preclinical research tool to alter granuloma pathology in tuberculosis. This could limit development of lung disease and slow transmission of organisms between individuals.
Researchers have developed an AI application that can detect lymph node metastases in breast cancer patients with high accuracy, similar to human pathologists. This breakthrough could improve the efficiency of surgical pathology work and provide better prognostication.
Researchers used digital pathology slide images to train computer algorithms that could detect the spread of breast cancer to lymph nodes with high accuracy. The study found that AI algorithms outperformed human pathologists in detecting cancer spread, suggesting potential improvements in diagnosis and treatment outcomes.
A new PET tracer has been developed to effectively gauge the effectiveness of promising Alzheimer's treatments in mouse models. The tracer binds to BACE1, a key enzyme involved in amyloid-β development, and accurately measures its effects on brain metabolism, neuroinflammation, and amyloid-β pathology.
A new microscope technology using ultraviolet light enables fast and accurate imaging of fresh tissue samples, revolutionizing pathology and medical research. This approach eliminates the need for time-consuming slide preparation and preserving tissue, making it an essential tool for improving patient care and research nationwide.
The Universal Genomics Instructor Handbook and Toolkit provides a comprehensive 'how-to' guide for implementing genomics education in various medical specialties. The toolkit contains four exercises and resources for clinicians to gain introductory training in genomic medicine.
The Association for Molecular Pathology publishes consensus recommendations for validating next-generation sequencing bioinformatics pipelines. The guidelines emphasize the critical role of trained molecular laboratory professionals and provide practical advice for laboratories.
Optic nerve hypoplasia is a leading cause of childhood blindness in developed nations, and researchers have discovered the biological mechanism behind it. The condition affects brain growth during development, particularly with the CASK gene, which helps provide architectural support for neuronal communication.
A comprehensive study of heart-spleen and heart-kidney networks reveals the interconnectedness of organ damage after a heart attack. Researchers found histological and cellular changes in the spleen and kidney, as well as bimodal inflammatory responses and irreversible dysregulation in the cardiosplenic and cardiorenal networks.
Researchers found a connection between abnormal glucose breakdown in the brain and the severity of Alzheimer's symptoms, with lower glycolysis rates and higher brain glucose levels correlated to more severe pathology. The study suggests that targeting glycolysis defects could lead to new treatments for Alzheimer's disease.
A collaborative study has found that a combination of three monoclonal antibodies prevents Zika virus infection in primates. The treatment completely blocked the virus from taking hold in the animals, indicating a promising intervention to protect uninfected pregnant women and their fetuses.
A team of scientists has identified a protein called TOX that drives the initiation and growth of an aggressive form of leukemia. TOX is expressed in 95 percent of human T-ALL cases and required for cancer's growth and persistence, offering new targeted treatment approaches.
The Association for Molecular Pathology (AMP) has awarded prestigious honors to Drs. Andrew P. Feinberg, Gregory J. Tsongalis, and Alexis B. Carter for their outstanding contributions to the field of molecular diagnostics. AMP President Federico A. Monzon praised the award recipients for their decades of service to the society.
A comprehensive genomic analysis of Wilms tumor identified genetic mutations involving a large number of genes, converging into two major pathways that lead to cancer. The study offers new opportunities for treatment by targeting these processes instead of individual genes.
The Human Pathology Atlas analyzes human genes in all major cancers, revealing patterns that influence patient survival. The atlas provides a powerful tool for personalized medicine, with potential applications in lung and colorectal cancer.
Aged chimpanzee brains exhibit pathology similar to human Alzheimer's disease, including Aβ plaques and tau lesions. The study provides the most extensive evidence of AD brain pathology in a primate species, shedding light on the evolution and potential targets for therapeutic interventions.
Researchers from Kent State University have identified pathologic hallmarks of Alzheimer's disease in the brains of aged chimpanzees, similar to human Alzheimer's disease brain pathology. The study found amyloid beta plaques and blood vessels in all 20 aged chimpanzee brains, with increasing sizes correlating to age.
A high proportion of former NFL players had neuropathological evidence of CTE, with 110 out of 111 players diagnosed. The study also found a link between CTE and previous football participation, with severe pathology more common among professional players.
Researchers develop a technique called expansion microscopy to physically expand tissues, enabling pathologists to diagnose diseases like early breast cancer with high accuracy and reliability. The method has been shown to improve the resolution of conventional microscopes and can be applied to any type of clinical sample.
Research reveals dose-dependent gadolinium deposits in normal brain tissue of patients who underwent MRI with contrast agents, suggesting a widespread issue. The study's findings contradict previous assumptions about the blood-brain barrier's impermeability to gadolinium.