Researchers investigated metabolic changes across organs in a large animal model of sepsis, identifying common and organ-specific alterations that could inform new therapeutic approaches. The study, published in The American Journal of Pathology, has the potential to reduce mortality and morbidity associated with sepsis.
A team of researchers led by Brittany Dugger will study donated post-mortem brain tissues from diverse individuals with Mexican, Cuban, Puerto Rican, and Dominican heritage to define the neuropathology of Alzheimer's disease in Hispanic cohorts. The goal is to develop specific disease profiles and improve prevention and treatment.
Researchers at DZNE associate oxidative stress with the spreading of abnormal alpha-synuclein protein in Parkinson's disease, a neurodegenerative disorder. The findings suggest that oxidative stress may trigger the formation and aggregation of toxic alpha-synuclein species, leading to progressive pathology and neuronal damage.
The study identified three ways in which the FOXA1 gene mutates to trigger prostate cancer: FAST, FURIOUS, and LOUD. Class 1 mutations cause rapid DNA traversal, class 2 mutations prevent normal FOXA1 from binding, and class 3 mutations create duplications of oncogenes. These alterations have different clinical implications for patients.
Researchers found a link between sleep patterns and Alzheimer's disease pathology, suggesting new diagnostic tools and prevention strategies.
A new protein, CAPON, has been linked to the connection between amyloid-β plaques and tau pathology in Alzheimer's disease. Accumulation of CAPON increases AD-related pathology, while deficiency reduces symptoms. The study uses novel mouse models to explore this link.
Researchers found that new neurons continue to form well into old age, including in people with cognitive impairment and Alzheimer's disease. The study provides evidence that neurogenesis may moderate the effects of brain pathology, suggesting potential therapeutic possibilities.
Researchers found widespread inconsistencies in antibody use, causing unreliable results and wasting $2 billion per year. They call for industry-wide standards to validate antibodies, especially in human tissue research.
A joint report from AMP and CAP provides evidence-based recommendations for designing and validating clinical CYP2C9 assays, promoting standardization and improving patient care. The report defines a minimum set of alleles and their variants that should be included in all clinical CYP2C9 genotyping tests.
A significant rise in oral cancer and pre-cancerous lesion detection by dentists in Ontario is reported, with a nearly doubling of cancers detected between 2005 and 2015. The study suggests that comprehensive training and continuing education programs for oral health professionals may be behind the dramatic increase in detection rates.
A new zebrafish model has been developed to visualize drug responses at single-cell resolution in live animals, identifying a promising treatment for rhabdomyosarcoma. The model allows for the assessment of combination therapies and direct visualization of drug responses, reducing costs and time required for clinical trials.
Researchers from Case Western Reserve University have developed an open-source quality-control tool to assess the quality of digital tissue slides. The tool, called Histo-QC, incorporates measurements and classifiers to flag corrupted images and retain high-quality slides for analysis by computers.
St. Jude scientists discover that ULK1 and ULK2 break down stress granules, which build up toxic proteins that kill muscle and brain cells in diseases including IBM, ALS, and FTD. Boosting these enzymes could help treat the conditions.
Current diagnostic criteria do not account for differences in kappa and lambda light chains, leading to missed diagnoses and false positives. The researchers propose new criteria that take into account the varying levels of these light chains to improve accuracy and detect cases of lambda-associated lesions.
Researchers develop new sequencing technologies to identify genetic causes of Opitz C Syndrome, which can cause significant clinical variability. The study's findings suggest that precise molecular diagnosis is crucial for therapeutic intervention and prenatal counseling.
Researchers found that a vegan-based fasting diet reduced inflammatory bowel disease (IBD) pathology in mice by changing their gut microbiota. The diet, known as the fasting-mimicking diet (FMD), increased stem cell numbers and stimulated protective gut microbiota, leading to reduced intestinal inflammation.
A low-calorie fasting-mimicking diet has been shown to reduce intestinal inflammation and increase intestinal stem cells, promoting the expansion of beneficial gut microbiota. The study suggests that this regimen may have potential in mitigating inflammatory bowel disease (IBD) pathology.
A research team has assembled a detailed atlas of bone marrow cells from AML patients, revealing six stages of white blood cell development and a role for differentiated tumor cells in suppressing immune responses. The study may lead to personalized therapies targeting specific AML cell types.
A new diagnostic technique using infrared imaging and proteomics has identified a protein biomarker called AHNAK2 that can accurately distinguish between bladder cancer and benign inflammation. The technique has been shown to have high sensitivity and specificity in differentiating between various stages of bladder cancer.
Researchers at the Buck Institute have identified a novel molecular mechanism that orchestrates harmful inflammatory signaling in glial cells, contributing to Parkinson's disease pathology. Blocking Furin 1, a catalytic protein, in dopaminergic neurons reduces toxic cross-talk and protects neurons from degeneration.
Researchers identified Porphyromonas gingivalis as a bacterial pathogen driving Alzheimer's disease pathology in the brains of patients. The study found that Pg infection led to increased production of amyloid beta and neuroinflammation.
A UCL-led study confirms that some vials of discontinued hormone used in medical treatments contained seeds of a protein implicated in Alzheimer's disease. The research found that these seeds can seed amyloid pathology in mice and supports the team's hypothesis that amyloid beta was accidentally transmitted to patients via this treatment.
A study in The American Journal of Pathology reveals the connection between endoplasmic reticulum stress and pseudoachondroplasia, a severe inherited dwarfing condition. Disrupting a self-perpetuating cellular loop of ER stress, inflammation, and oxidative stress may lead to therapeutic advances.
A recent study by the University of Helsinki reveals that pathological tau triggers a safety valve mechanism in cell membranes, leading to accelerated neuronal cell death and loss of synapses. Omega-3 fatty acids have been found to modify the microstructure of cell membranes, capturing tau aggregates within cells.
Researchers will investigate the GI lymphatic system's impact on diabetes reversal after bariatric surgery. The five-year grant aims to shed light on the mechanism involved in reversing diabetes through disruption of lymphatic circulation in an animal model.
The University of Leeds and Leeds Teaching Hospitals NHS Trust will create a digital pathology clinical network and research programme with a £10.1m UK Research and Innovation investment. The project aims to develop artificial intelligence tools for pathology diagnosis, generating over 760,000 images per year.
A genetic variation in TMEM106B has been identified as a potential risk factor for chronic traumatic encephalopathy (CTE) disease severity and pathology. The study found that this variation may predict increased CTE pathology and brain inflammation, and is associated with a higher risk of developing dementia.
A study of male and female mice found that chronic short sleep and chronic fragmentation of sleep accelerate Alzheimer's disease-related tau pathology. Healthy sleep habits during adolescence and early adulthood may help prevent progression of neurodegenerative diseases.
A new pathology test using AI can accurately predict clinically significant prostate cancer disease progression following surgery, helping guide treatment decisions. The Precise MD post-op test reclassified 58% of intermediate risk patients as low risk and 42% as high risk for significant disease progression.
Yongxin Zhao, assistant professor at Carnegie Mellon University, has received a National Institutes of Health (NIH) Director's New Innovator Award. He will use the grant to develop transformative nanoscale imaging techniques for analyzing complex diseases.
Mitochondria use one-way doors called mitochondrial calcium uniporter channel complexes (MCUCs) to control access, but the exit door proteins are abundant only in areas far from the entrances. This separation allows mitochondria to operate at maximum efficiency even when stressed.
A study published in PLOS ONE found that the jaw joint bone structure of carnivorans is more closely related to their body size than their diet. Researchers used 3D printing and CT scans to analyze the mandibular condyle, a key joint in the jaw, and discovered no significant correlation between diet and jaw joint strength or complexity.
Drs. Jonathan Rothberg, Roger Klein and Kevin Halling are being recognized for their groundbreaking work and longstanding commitment to advancing patient care and the field of molecular diagnostics. Drs. Rothberg is receiving AMP's highest honor for his pioneering work in genomics and inventions like massively parallel DNA sequencing.
The Association for Molecular Pathology recommends a minimum of 34 critical genes for high-throughput pan-myeloid sequencing tests to standardize clinical practice and improve patient care. The report provides evidence-based guidelines for the management of chronic myeloid neoplasms, including diagnostic and prognostic information.
The study reveals how a fusion protein found in cancer cells enhances target gene expression by converting microsatellite repeats into active enhancers. Blocking this process prevents tumor growth.
A Massachusetts General Hospital research team has developed a system that incorporates neuroinflammation into their 'Alzheimer's in a dish' model, fully replicating the disease's pathology. The system includes neural cell death and glial cells that provide immune functions.
A new study finds contact sports associated with an increased risk of Lewy Body Disease (LBD), which can cause Parkinson's disease and dementia. LBD was linked to problems with movement, cognition, depression, sleep, and visual hallucinations, independent of CTE pathology.
Research suggests that low-dose aspirin regimens could decrease amyloid plaque pathology in mice by stimulating lysosomes. Activating cellular waste removal mechanisms is a promising strategy for slowing disease progression.
Researchers have developed a rhesus macaque model to study Zika brain pathology, revealing similar brain lesions as in human infants with congenital Zika syndrome. The findings suggest that therapies can be tested using fewer animals, providing hope for the development of new treatments.
The study found that on-site pathology testing reduced the need for medical evacuations by up to 35%, resulting in estimated total cost savings of $21.75 million per year. This technology enabled early diagnosis, treatment, and evacuation for critically ill patients in remote communities.
A recent study published in the Journal of Consulting and Clinical Psychology found that patients' self-reports of personality disorder traits are more accurate than previously believed. The research suggests that clinicians' diagnoses may be less reliable than thought, and that using similar evaluation tools can bridge the gap between...
Researchers at Temple University Health System have discovered a way to reverse memory deficits and tau pathology in mice with dementia. By administering a drug that blocks leukotriene formation, they were able to improve spatial learning and working memory in treated animals.
A team of scientists has created a map of the molecular network in the aging brain, revealing two new Alzheimer's disease target genes that can be deleted or modified to treat the disease. The study provides a unique resource linking molecular changes in nearly 500 older brains to cognition and brain pathology.
Researchers have developed a computer program that can comprehensively determine differences in individuals' blood types with over 99% accuracy. This breakthrough has the potential to prevent serious complications and fatalities from blood transfusion reactions.
A collaborative study led by the University of Miami Miller School of Medicine found that a monoclonal antibody cocktail therapy was effective in clearing the virus from pregnant women's blood but failed to prevent fetal transmission and treat infected fetuses. Researchers are now working on engineering antibodies to target the fetus.
A team of researchers at LSTM has developed a new approach to treating snakebite using antivenom produced from a different species than the one that caused the bite. The study, published in Communications Biology, shows that this approach can be effective in neutralizing certain pathologies caused by venomous snakes.
Janardan K. Reddy, a world-renowned pathologist, has been awarded the ASIP Gold-Headed Cane Award for his significant research contributions to liver biology, particularly peroxisomes and carcinogenesis. He is also recognized for his exceptional teaching and mentoring skills.
A new approach to analyzing prostate gland tissue uses cellular metabolites to differentiate between aggressive and less aggressive tumors. The study found that metabolite levels can predict tumor grade, stage, and recurrence risk, helping guide treatment strategy.
Researchers found that beta-amyloid triggers calcineurin, leading to loss of dendritic spines and synapses in Alzheimer's disease. Rescuing synapses with extra Pin1 or FK506, an FDA-approved drug for transplant rejection, may slow disease progression.
A study published in Biological Psychiatry reveals distinct molecular changes in gene expression between men and women with major depressive disorder, suggesting different pathology and treatment needs.
The Association for Molecular Pathology (AMP) has published consensus-based recommendations for clinical CYP2C19 genotyping allele selection. The guidelines aim to standardize testing across laboratories and improve concordance, enabling better patient care.
Researchers found four cases of amyloid beta pathology in brain blood vessels after childhood neurosurgery, sparking concerns over potential transmission of protein pathology. The study's findings were supported by a review of medical literature and suggest that neurosurgical instruments may be responsible.
A study by Tokyo Medical and Dental University found that protein YAP rescued SCA1 pathology when expressed during development, but not as an adult. The researchers also discovered a link between YAP and the transcriptional co-activator RORα, which plays a crucial role in cerebellum development.
A panel of experts has issued new guidelines for molecular diagnostic testing and treatment decisions in lung cancer. The updates reflect recent advancements and decades of work to identify the genetic underpinnings of lung cancer, helping oncologists match patients with effective therapies.
A Boston University study identified evidence of early Chronic Traumatic Encephalopathy (CTE) brain pathology after head impact, even in the absence of signs of concussion. The researchers found that head impact caused persistent changes in brain electrical functions and damaged blood vessels, leading to CTE.
Dr. Jeffrey Actor has been awarded $1.7 million to investigate a novel recombinant lactoferrin for use as a preclinical research tool to alter granuloma pathology in tuberculosis. This could limit development of lung disease and slow transmission of organisms between individuals.
Researchers used digital pathology slide images to train computer algorithms that could detect the spread of breast cancer to lymph nodes with high accuracy. The study found that AI algorithms outperformed human pathologists in detecting cancer spread, suggesting potential improvements in diagnosis and treatment outcomes.
Researchers have developed an AI application that can detect lymph node metastases in breast cancer patients with high accuracy, similar to human pathologists. This breakthrough could improve the efficiency of surgical pathology work and provide better prognostication.
A new PET tracer has been developed to effectively gauge the effectiveness of promising Alzheimer's treatments in mouse models. The tracer binds to BACE1, a key enzyme involved in amyloid-β development, and accurately measures its effects on brain metabolism, neuroinflammation, and amyloid-β pathology.
The Universal Genomics Instructor Handbook and Toolkit provides a comprehensive 'how-to' guide for implementing genomics education in various medical specialties. The toolkit contains four exercises and resources for clinicians to gain introductory training in genomic medicine.