A new study aims to improve the transition of stroke patients from hospital to home by assigning social workers to assist in care. The goal is to reduce complications and improve quality of life for patients who face emotional, social, and health challenges after discharge.
Researchers used an epigenetic clock to measure the biological age of liver tissues in obese subjects, finding a significant acceleration of liver aging. The study suggests that obesity may contribute to the premature development of age-related diseases such as liver cancer and insulin resistance.
Researchers will sequence the genomes of 10,000 people with European, Hispanic, and African-American ancestry to better understand two mental health disorders. The goal is to identify genetic targets for drug development and improve disease prediction.
A large study has pinpointed synapse genes with major roles in severe childhood epilepsies, providing a new target for treatment strategies. The research identified 429 de novo mutations, including strong evidence for novel genes involved in synapse function.
A study published in Neurology found that people who notice their memory slipping may be on to something, with 56% of participants reporting changes in their memory. The study suggests a significant window of opportunity for intervention before diagnosable problems show up, approximately 12 years after initial complaints began.
A new study published in the New England Journal of Medicine found that CT scans are no more accurate than ultrasound exams in diagnosing painful kidney stones. The study suggests that ultrasound should be used as the first step in diagnosis, avoiding unnecessary radiation exposure.
A study published by the American College of Cardiology found that higher cardiorespiratory fitness levels can delay the natural increase of systolic and diastolic blood pressure with age. Men with high fitness levels experience a later onset of prehypertension, with systolic blood pressure increasing around age 54 and diastolic blood ...
Researchers have found that cancers exhibit distinct patterns of methylation on the DNA genome, enabling tumor cells to turn genes on or off as needed. These epigenetic changes allow cancer cells to adapt and spread, making them a key factor in tumor development.
The Penn Medicine team found that targeted automated alerts in electronic health records significantly reduced urinary tract infections in hospital patients with urinary catheters. Simplifying the alert design increased the rate of catheter removals, leading to a dramatic decrease in infections.
A new study led by researchers at UCSF analyzed the effect of two widely used osteoporosis drugs on breast cancer risk in post-menopausal women. The findings suggest that low estrogen levels, rather than the drugs themselves, may be protecting against breast cancer.
Researchers have created a comprehensive database to study microRNA regulation of genes and their targets. The multiMiR database combines 50 million records from existing repositories, enabling efficient analysis and identification of new treatment options.
A new study finds that US life expectancy gap between blacks and whites has declined nationally, but still varies across states. Northeastern states have made greater progress in reducing the gap, while western states have seen less improvement.
A new gene variant, PLXNA4, has been linked to an increased risk of developing Alzheimer's disease. The study found that this gene affects the processing of tau protein, a key hallmark of the disease. This discovery may lead to the development of targeted drug treatments for AD.
A recent study published in JAMA Psychiatry has identified the risk factors for post-traumatic stress disorder (PTSD) after an accident. The research found that 9% of injured people develop PTSD, with symptoms such as headaches, pain, and anxiety persisting for months after the incident.
A new study by Henry Ford Health found that robot-assisted surgery can control prostate cancer for up to 10 years. The research followed 483 men who had not spread cancer beyond the prostate and received robot-assisted radical prostatectomy (RARP) as their first treatment, with 98.8% surviving the disease for 10 years.
Researchers found that adding potassium supplementation to loop diuretics increases survival rates by 16 percent in patients receiving at least 40 mg/day of furosemide. The benefit is more pronounced with higher diuretic doses. While the study's findings are promising, further independent studies are needed to confirm these results.
Researchers will analyze data from 6,000 patients with Alzheimer's and 5,000 elderly individuals without the disease to identify rare genetic variants that may protect or contribute to risk. The project aims to develop novel approaches to delay or prevent Alzheimer's disease.
Researchers at the University of Pennsylvania School of Medicine will analyze whole exome and genome sequence data from 6,000 volunteers with Alzheimer's disease to identify rare genetic variants. The goal is to find new therapeutic targets that can reduce the economic and human burden caused by this devastating disease.
A team of researchers from the University of Pennsylvania and four other American universities will analyze genetic data from 6,000 individuals with Alzheimer's disease and 5,000 older individuals without the disease. The goal is to identify rare genetic variants that may protect against or contribute to the disease risk.
Researchers at Case Western Reserve University will analyze genetic data from 11,000 individuals to identify rare variants that may protect or contribute to Alzheimer's risk. The goal is to illuminate the genetic architecture of Alzheimer's and discover therapeutic targets.
Researchers from Boston University School of Medicine will analyze genomic data from 11,000 individuals to identify rare genetic variants that may protect against or contribute to Alzheimer's disease risk. The study aims to uncover the biological pathways underlying the disease and potentially lead to novel therapeutic targets.
A Swedish study using national patient registers found no link between ADHD drug treatment and increased risk of suicide attempts or suicide. Instead, researchers suggest that ADHD medications may have a protective effect against suicidal behaviors.
A UCSF study found that families with an autistic child are one-third less likely to have more children. The study analyzed California state health records and found that reproductive stoppage, or the decision not to have more children due to a genetic disorder, is a real phenomenon.
A new study found a significant decline in speeding-related injuries and fatalities among young men in Ontario since the province's tough laws were introduced in 2007. The study credits the deterrence of swift and severe sanctions for reducing risky driving behavior.
An analysis by Fox Chase Cancer Center has revealed a dramatic increase in the use of chemotherapy before surgery to remove ovarian cancer, with 26.72% of patients receiving it in 2011 compared to 8.94% in 1998.
Researchers found a genetic variant in noncoding DNA that leads to protein overproduction in heart cells, increasing the risk of sudden cardiac death by 40%. The discovery could lead to new drug treatments and improve understanding of cardiac repolarization.
Researchers link BMI at age 25 to increased risk of class III obesity after age 35. Current weight is a better indicator of cardiovascular and metabolic risk than duration of obesity.
A study of over 16,000 patient visits found that physician practice facilitation led to significant improvements in pediatric preventive medical care delivery. Practices with early intervention saw a sixfold increase in obesity screening and a 20-fold increase in fluoride varnish application compared to those without intervention.
A recent study found that Hispanic seniors are 35% less likely to have prescription drug coverage despite the availability of assistance. The researchers attribute this disparity to complex application processes and limited health literacy among Hispanic seniors.
A new study reveals that even light drinking increases the risk of liver fibrosis in people co-infected with HIV and hepatitis C virus (HCV) infection. Researchers found a stark difference between co-infected and uninfected groups, highlighting the importance of counseling patients to reduce alcohol consumption.
A new study published in the Journal of the American College of Surgeons reveals that noncombat-related injuries, such as accidents and burns, are the leading cause of pediatric admissions to U.S. military combat hospitals in both countries. The study analyzed data from over 6,000 children under 14 years old treated at Army support hos...
A genome-wide association study found a strong link between ABCC9 gene variations and an increased risk of Hippocampal Sclerosis of Aging (HS-A). The study also suggests that sulfonylurea medication use is associated with an elevated risk for HS-A. Researchers hope this discovery may inform new strategies to search for cures.
Researchers at Michigan State University have developed a new method to estimate newborn size based on birth records, improving accuracy for clinicians and researchers. The updated thresholds may aid in classifying babies as small or large for gestational age.
A new study from Indiana University School of Public Health-Bloomington found a strong association between heme iron consumption and coronary heart disease. Heme iron intake was shown to increase the risk for coronary heart disease by 57 percent, while nonheme iron had no such link.
A new epidemiology model developed by Brown University researcher Yen-Tsung Huang integrates genomic data from SNPs, gene expression, and methylation to find significant associations with diseases like asthma and brain cancer. The model improves performance and validity across different subjects, paving the way for further applications.
A study published in Neural Regeneration Research found that early rehabilitation significantly improved sensory function, motor function, and activity of daily living in pediatric children with spinal tumors. The research suggests that rehabilitation programs initiated earlier are effective in achieving functional independency levels ...
The draft genome of the loblolly pine is the largest ever assembled, comprising approximately 82% repetitive DNA elements. This achievement marks a significant breakthrough in conifer genome sequencing, enabling future projects to build upon a high-quality reference genome.
The new guidelines are expected to result in 12.8 million more U.S. adults taking statins, with the majority being people over 60 years old. The expanded criteria for statin use are based on a risk-assessment score and may lead to higher statin prescriptions among older men and healthy women.
Patients co-infected with HIV and hepatitis C have an 80 percent higher rate of decompensated cirrhosis than hepatitis C-only patients. Even when ART is effective, they still experience a 60 percent higher risk of serious liver disease compared to those with hepatitis C alone.
A new study found that 21% of transgender people avoid EDs due to fear of negative experiences. Trans-specific negative experiences reported include refusal of care or examination in alignment with their felt/core gender. This highlights the need for better training and safe environments within EDs.
Researchers used digital checkout data from Montreal neighborhoods to monitor food choices and socioeconomic factors. The study found that lower-income neighborhoods consume more soft drinks, highlighting the need for targeted efforts to encourage healthier diets.
A recent study found that patients with invasive lobular carcinoma receive less benefit from standard adjuvant therapies compared to those with ductal carcinoma. The research indicates a potential target for drug therapy in future clinical trials, which could lead to more effective treatment options for this subtype of breast cancer.
Researchers at CWRU develop technology to connect patient records, enabling tracking of patterns in patient outcomes and improved transfer decisions. The system integrates data from 42 areas, streamlining the process and allowing for faster analysis.
The five Neimark Award winners explore biostatistics, molecular plant sciences, and particle astrophysics among other areas. Their research in second language acquisition also sheds light on human cognition.
A large registry study found that up to half of transport accidents involving adult men with ADHD could be avoided if they were taking medication. The results demonstrate a significant decrease in risk of serious transport accidents among men with ADHD who received medication, with a 45% increased risk compared to those without ADHD.
Research suggests that walking at a brisk pace prior to diagnosis may improve prostate cancer outcomes by having more regularly shaped blood vessels. Men with faster walking paces had 8% more regularly shaped blood vessels compared to those with slower paces.
Women aged 50-64 who are screened regularly have a lower risk of cervical cancer into their eighties. Screening up to age 65 greatly reduces cervical cancer risk, but protection weakens with time.
A new study found that bed bug infestations in Philadelphia increased by 4.5% per month from 2008 to 2011, with reports peaking in August and lowest in February. The researchers mapped hotspots and suggest treating during warmer months or winter when numbers are down.
A Yale study estimates that 8 million lives have been saved in the US as a result of anti-smoking measures introduced 50 years ago. The study found that these efforts have significantly reshaped public attitudes and behaviors concerning cigarettes, resulting in an estimated 157 million years of life being saved.
A comprehensive new checklist aims to fill the need for practical steps and resources in guideline development. The checklist, published in CMAJ, includes 18 topics and 146 items with links to resources and training materials.
A new clinical trial, sponsored by Cancer Research And Biostatistics (CRAB), has been launched to test innovative treatments for lung cancer. The trial, which combines efforts from frontline treating oncologists and pharmaceutical companies, aims to improve patient outcomes and extend overall survival.
A study found that 74.8% of obese patients were poor sleepers, with significant associations between sleep quality and mood disturbance, as well as anxiety and depression. The study highlights the importance of screening for sleep problems in individuals with severe obesity to improve quality of life.
A team of researchers from The Wistar Institute and the University of Pennsylvania are working on a five-year project to better understand melanoma biology and develop more effective treatments for the disease. They aim to overcome drug resistance by targeting different mutations and combinations of therapies.
A Penn Medicine study found that an automated prediction tool can accurately identify patients at risk of being readmitted within 30 days of discharge. The tool, developed by researchers, uses prior hospital admissions as a key predictor, and has been shown to reduce readmissions by 31% compared to those without the flag.
Research suggests that age-adjusted rates of dementia have declined for people born later, particularly those at higher risk. Lifestyle factors such as exercise and diet are being studied as potential contributors to this trend.
African Americans with APOL1 gene variant experience faster chronic kidney disease progression and increased risk of kidney failure compared to those without the variant. The study found that APOL1 risk variants increase CKD progression in African Americans, regardless of their diabetes status.
A recent study by Gladstone researchers reveals that specific stretches of DNA, called human accelerated regions (HARs), control the development of uniquely human characteristics. HARs were found to be crucial in human ancestors becoming distinct from our closest primate relatives.
A Swedish study found that teenagers and young adults diagnosed with cancer are at a 60% increased risk of suicide or attempted suicide. The risk is highest during the first year after diagnosis, with suicidal behavior being 1.5-fold higher among cancer patients compared to the general population.
A UCLA study has identified a biological clock embedded in the human genome that can accurately measure the age of diverse organs, tissues, and cell types. The clock found that some parts of the anatomy, like breast tissue, age faster than the rest of the body.
A UC San Francisco researcher recommends prioritizing dietary calcium intake over supplements to prevent osteoporosis and fractures. The recommended daily dose is 1,200 mg per day, with foods like dairy products, kale, broccoli, and Bok Choy providing essential calcium.