Researchers at TUM have developed a cell-free production method for bacteriophages, which can be used to target and combat specific types of antibiotic-resistant bacteria. The new technology has the potential to produce personalized therapeutic phages for clinical trials, addressing multi-resistant germ infections.
Researchers created a synthetic rotary motor using DNA origami, allowing for targeted movement and mechanical work. The nanomotors can be controlled to rotate in one direction and achieve unprecedented mechanical capabilities.
Researchers used chemoproteomics to profile 53 HDAC drugs and found many had additional targets beyond their intended HDACs. The study identified MBLAC2 as a common off-target protein that affects extracellular vesicle accumulation.
A study by TUM researchers found that warmth-loving insect species increased in population trends, while cold-adapted species declined. This is partly due to improvements in water quality benefiting dragonflies, which depend on aquatic habitats.
Researchers developed a biopolymer film that combines anti-bacterial properties, inflammation dampening, and release of active pharmaceutical ingredients in a targeted manner. The film adheres to sensitive surfaces without damaging tissue, speeding up healing process and completely dissolving by itself.
Researchers developed an algorithm to classify patients into disease subtypes based on molecular changes, enabling more targeted treatments. The tool has shown potential in a study on non-alcoholic fatty liver disease, identifying lipid biomarkers for disease progression.
A new method measures individually measurable aerosol values during exercise, revealing moderate aerosol emissions at medium exertion and exponential increases above that point. The study suggests special protective measures are needed for high-intensity training to reduce infection risk.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
A study across eight European countries found that conventional vaccination campaign messages are ineffective due to factors like low health literacy and conspiracy theories. The research suggests a need for targeted messaging strategies tailored to specific groups and communication channels.
Vertical farming enables crops to be grown in vertically stacked layers, conserving land and allowing for multiple harvests per year. This method can significantly reduce water requirements and chemical crop protection, while increasing yields through optimal growth conditions and technologies.
A study by TUM confirms that physically fit primary school pupils perform better in terms of concentration and health-related quality of life. The results show a positive correlation between physical fitness, concentration, and overall well-being.
Researchers at TUM have developed a new process for producing ethanol from waste wood and hydrogen, resulting in a lower cost compared to traditional methods. The process has the potential to reduce greenhouse gas emissions by 75% and can be used as a low-carbon fuel alternative.
Researchers have discovered the opto-ionic effect, where light increases the mobility of ions in ceramic materials, improving the performance of devices such as solid-state electrolytes in fuel cells and lithium-ion batteries. This effect could lead to higher charging speeds and more efficient energy conversion technologies.
Researchers have developed a new approach to micro-computed tomography using phase contrast and high-brilliance x-ray radiation, enabling detailed analysis of microstructures and broad applications in medicine, biology, and material sciences.
Researchers have discovered that magnetic spin waves can propagate on circular paths in certain materials, enabling efficient and compact information transfer. This phenomenon, known as Landau quantization, has significant implications for the development of new electronic components.
A research team at TUM has successfully used specific enzymes to destroy the genetic information of SARS-CoV-2 directly after it penetrates the cell. The study found that targeting the viral genome with siRNAs is most effective when the virus has just penetrated into the cell.
Researchers at TUM have successfully produced succinic acid using the marine bacterium Vibrio natriegens, which has rapid growth and substrate uptake rates. The team is now working to optimize the process for industrial-scale production using renewable raw materials.
Researchers discovered a protein called PHR regulates arbuscular mycorrhiza (AM) symbiosis based on phosphate availability. AM promotes phosphate uptake and other nutrient absorption, enhancing plant resistance to stressors.
Researchers at TUM integrated dark-field X-ray imaging into a clinical CT scanner, providing additional information on fine tissue structures. The new prototype can capture both conventional and dark-field X-ray images in a single scan, potentially improving lung disease diagnosis and kidney stone differentiation.
Researchers at TUM explore the use of living trees in architecture, using photogrammetry and skeleton extraction to design structures that adapt to tree growth. They demonstrate a pavilion with a roof structure optimized to follow the shape of supporting branches.
Scientists at Technical University of Munich discovered a promising combination therapy for mesenchymal PDAC subtype, showing improved T-cell infiltration and cell cycle arrest when using nintedanib with trametinib. The treatment significantly improves the response of highly aggressive mesenchymal PDAC subtypes in mice.
Researchers at TUM discover that intestinal bacteria interact with Paneth cells in the gut mucus layer, leading to chronic inflammation. This finding may lead to new treatments for IBD.
Researchers at Technical University of Munich have developed a new neutron-based method to detect clogs in underwater pipelines non-destructively. This approach uses prompt gamma neutron activation analysis to measure hydrogen concentration, allowing for the detection of blockages and hydrate formation.
A new algorithm, FusionM4Net, has been developed to classify skin lesions with improved diagnostic accuracy. The algorithm uses a multi-stage data fusion process and outperforms previous state-of-the-art algorithms.
Researchers at TUM and MPIMG decipher the molecular mechanisms responsible for deactivating genes in genomic imprinting. By removing known epigenetic 'off switches', they discovered that DNA methylation and Polycomb enzymes play a crucial role in silencing genes.
Plants respond to heat stress by activating a molecular defense pathway involving brassinosteroids, which increase heat stress resistance. Researchers at TUM discovered the role of transcription factor BES1 in this process.
A study by Dr. Felix Hagemeister found a significant link between right-wing populist party victories and an increase in far-right protests, particularly in areas with relatively liberal attitudes.
The Forest Condition Monitor tool uses color-coded visualization to identify areas of high-stress forests across Europe, allowing for targeted conservation efforts and research. Scientists can study these regions to understand eco-physiological processes and warn forest owners of potential risks.
Scientists have developed a fusion protein that successfully blocks replication of SARS-CoV-2 and related viruses in cell culture tests. The protein combines ACE2 with human antibody fragments, providing reliable protection against future mutations.
Physicists at Technical University of Munich discover potential existence of tetra-neutron, a bound state of four neutrons, which could significantly alter our understanding of nuclear forces. The experiment's results suggest a half-life of 450 seconds and stability comparable to the neutron.
Scientists from TUM and Google Quantum AI used a highly controllable quantum processor to simulate exotic particles called anyons, which can emerge as collective excitations in two-dimensional systems. The study reveals the properties of these particles through braiding statistics, a key feature of topologically ordered states.
A study by the Technical University of Munich discovered that pungent substances from chili, ginger, and pepper are transferred to breast milk after consumption. These substances can be detectable in breast milk for several hours, with maximum concentrations being 70- to 350-fold below the taste perception threshold of an adult.
A study by Technical University of Munich found that major tech companies significantly underreported CO2 emissions from their value chain, with 50% of emissions omitted in 2019. The researchers developed a method to identify reporting gaps and estimated the omitted emissions at 751 megatons carbon dioxide equivalents.
A new imaging method measures individual photons, greatly reducing interference and improving spatial resolution by three times. The technology could also reduce radiation exposure during x-ray imaging, making it ideal for medical applications.
Researchers at Technical University of Munich have developed a new X-ray method for respiratory diagnostics using dark-field chest imaging, allowing for early detection and treatment follow-up of respiratory ailments. The technology reduces radiation dose by a factor of fifty compared to traditional computed tomography.
A study by TUM demonstrated the effectiveness of an ear sensor in monitoring COVID-19 risk patients remotely, providing timely hospitalization when necessary. The sensor enabled high-quality monitoring comparable to hospital care, with great patient satisfaction and improved safety outcomes.
A research team at TUM has discovered that the protein TIMP1 is associated with a significantly higher risk of liver metastasis and death in male patients, particularly those with pancreatic, colon, and melanoma cancers. This finding may lead to improved diagnosis and targeted therapy options for men.
Scientists at TUM and LSB developed a new methodology to quantify the flavor profile of cocoa samples. The method provides quantitative data on 66 taste-decisive substances using a single mass spectrometric platform, allowing analysis of 200 samples per week.
Researchers at TUM have successfully tracked immune cells from the gut and skin into the central nervous system for the first time. This breakthrough could lead to new treatments for multiple sclerosis and other autoimmune diseases.
Researchers at Technical University of Munich have developed a new machine learning algorithm that can analyze complex markets and their equilibrium strategies. This breakthrough has potential applications in auction theory, wireless spectrum auctions, and more.
The study reveals that climate change affects the rate of decomposition and insect contributions to deadwood, releasing approximately 10.9 giga-tons of carbon worldwide annually
A new approach has identified T cells in Covid-19 patients, revealing their appearance, number, and activity level against SARS-CoV-2. The study distinguishes between active and dormant T cells, enabling a better understanding of the immune response to the virus.
Researchers studied 13 social enterprises in Munich after refugee arrival, finding two types of founders: idealistic and self-interested. Idealists prioritized rapid support, while self-interested ones focused on long-term business success with flexible organizational structures.
Researchers at TUM developed an enzyme-based method to selectively target and remove non-target DNA from skin samples, allowing for a more accurate analysis of the skin microbiome. This approach has shown promise in identifying microbial biomarkers for certain dermatological illnesses and may lead to new treatments.
Researchers from TUM discovered a toxin in the leafy vegetable Ebolo, which can cause liver damage. They successfully removed the toxin through breeding techniques, paving the way for safer consumption of this nutritious crop.
An interdisciplinary research team at TUM has developed nano-capsules tailored from genetic material using the DNA origami method to engulf and neutralize viruses. The strategy has been tested against hepatitis and adeno-associated viruses in cell cultures and may prove successful against corona viruses.
Researchers at TUM used AI to simulate forest fires in Yellowstone National Park, finding that climate change scenarios predict a 28-59% loss of forest coverage by 2100. The study highlights the urgent need for climate protection measures and their impact on biodiversity and recreational value.
Researchers at TUM used organoids to investigate mechanical influences on organ growth, finding that collective cell movements deform collagen matrix, controlling further growth. This discovery provides a new model for simulating and investigating organ development.
The study found that temperatures between 17 to 24 degrees Celsius are preferable for humans, cattle, pigs, poultry, and agricultural crops. Extreme heat above 32°C with high humidity or 45°C with low humidity can be fatal for humans, while heat stress affects livestock, poultry, and crops at different temperature thresholds.
Research finds that water molecules in zeolites enhance chemical reactions for biomass conversion to biofuel. By optimizing pore sizes and water concentrations, the process can be made more efficient, saving energy.