Articles tagged with Biopsies
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A new Penn study found that imaging techniques, such as MRI, may help identify which glioblastoma patients are best candidates for liquid biopsies. The research showed a correlation between the blood-brain barrier and macrophage density with circulating DNA levels, suggesting the potential for personalized treatment decisions.
Researchers developed a hybrid microscope that combines optical and infrared measurements with machine learning algorithms to create digital biopsies. The hybrid microscope closely correlates with traditional pathology techniques and outperforms state-of-the-art infrared microscopes in terms of resolution, consistency, and coverage.
A team of researchers from Stanford University has developed a quantitative framework to sonographically differentiate between benign and malignant thyroid nodules. The framework achieved AUC values comparable to those of expert radiologists, suggesting its potential for establishing a fully automated system of thyroid nodule triage.
Biopsies from donated kidneys often show different results than initial readings, casting doubt on decision-making based on these findings. However, a second biopsy performed in standard conditions provided useful information about organ function after transplantation.
Research found subtle structural features of donated kidneys, such as scarring and hardening of vessels, are associated with shorter kidney lifespan after transplantation. These findings may help clinicians evaluate organ quality at time of donation and identify potential predictors of transplant failure.
A recent NRG Oncology study found that breast-conserving treatment without surgery is not feasible based on the study's criteria. The study showed a negative predictive value of 77.5% for tumor bed biopsies, which falls short of the required threshold to support omitting surgery.
Researchers at Children's Hospital Los Angeles have developed a novel way to biopsy retinoblastoma, allowing for more accurate diagnoses and access to studying the disease on a molecular level. This breakthrough discovery has the potential to drastically improve retinoblastoma research and clinical practice.
Researchers developed a blood test that measures cell-free DNA (cfDNA) to predict prognosis in glioblastoma patients. The test correlates with progression-free survival and detects genetic mutations not found in solid tissue biopsies, offering a complementary view of the tumor's molecular profile.
Researchers developed implantable scaffolds that attract and analyze cancer cells, providing unique information on disease progression. The technology has potential to improve early detection and monitoring of cancer treatments.
A study by Yale University found that sentinel lymph node biopsies do not reduce the risk of death from breast cancer or decrease invasive cancer development in women with ductal carcinoma in situ (DCIS), a non-invasive breast cancer. The procedure also increases the risk of pain, wound infection, and lymphedema.
A biomedical engineer at Worcester Polytechnic Institute is creating a new medical robot that uses photoacoustic imaging to detect and analyze three different indicators of prostate cancer. The system aims to be more accurate than current tests like ultrasounds and biopsies, while eliminating the need for radioactive contrast dye.
A new study finds that obtaining a second opinion from board-certified dermatopathologists improves the accuracy of diagnosing melanoma, reducing misclassification rates. The study's findings suggest that expert second opinions provide value in improving diagnostic reliability, especially for complex cases.
A new blood test can identify complex DNA mutations in lung cancer patients, replacing invasive biopsies. The test has shown promise in detecting ALK genetic mutations, which respond well to targeted therapy.
A study published in the American Journal of Roentgenology found that ultrasound screening after digital mammography and digital breast tomosynthesis yielded no significant difference in additional cancer detection rate. The findings suggest that DBT does not obviate additional US screening for women with dense breast tissue.
Researchers validate the hypothesis that IgG autoantibodies are crucial to IgA nephropathy's pathogenic immunodeposits. The study found co-localization of IgA1 and IgG in glomerular deposits, confirming their role in disease progression.
A new blood test detects early cancer cells in the bloodstream, predicting aggressive prostate cancer with high accuracy. Combining this test with the current PSA test reduces unnecessary biopsies and overtreatment of benign conditions.
A new liquid biopsy test can detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating which patients are likely to benefit from immune checkpoint inhibitors. The test produced a specificity of greater than 99% and sensitivity of 78% for MSI, and 67% for TMB.
The NUS-developed STAMP technology enables accurate detection and classification of cancer cells, as well as determination of disease aggressiveness from minimal clinical samples. This breakthrough could lead to earlier diagnoses and more effective treatment decisions.
A clinical study comparing liquid and tissue biopsies finds multiple resistance mechanisms in individual patients, which could explain why targeted therapies often fail. The results suggest possible molecular mechanisms underlying drug resistance, pointing the way to new and more personalized therapeutics.
Researchers used machine learning algorithms to classify kidney biopsy samples, achieving substantial agreement with pathologists' standard classifications. The methods may augment traditional diagnostics of kidney disease by automating and enhancing accuracy, potentially improving organ survival for transplant patients.
Researchers developed a technique combining multiphoton microscopy with automated image analysis to distinguish between healthy and metastatic tissue without invasive biopsies or contrast dyes. The approach identified unique textural features in tissue that reflect cancer metastasis, allowing for early detection and improved treatment.
A liquid biopsy assay demonstrated high accuracy in detecting microsatellite instability (MSI) status in cancer patients, with an overall accuracy of 98.4%. The study showed that the assay could identify MSI-high tumors and predict clinical outcomes, offering potential benefits for personalized treatment planning.
Research suggests that primary care physicians trained in dermatoscopy can detect melanoma earlier and more accurately, reducing the need for invasive biopsies. The study found that a dermatoscope can improve diagnosis by four times compared to unaided eye inspection.
Researchers at UVA are using machine learning algorithms on biopsy images to diagnose environmental enteric dysfunction, a disease that affects hundreds of thousands of children worldwide. The technology has the potential to provide insights that evade human eyes, validate pathologists' diagnoses and shorten treatment times.
A Rutgers University scientist has developed a new 'virtual biopsy' device that can quickly determine a skin lesion's depth and potential malignancy without using a scalpel. The device, called vibrational optical coherence tomography (VOCT), uses sound vibrations and near-infrared light to create a 3-D map of the lesion under the skin.
Researchers at UCLA Health Sciences have developed a more effective method for detecting prostate cancer by combining biopsy strategies. The new approach, which includes MRI-guided biopsy, increased the rate of cancer detection to up to 33% compared to traditional methods.
A study found that only 15% of men in North Carolina with low or intermediate-risk prostate cancer who chose active surveillance followed recommended monitoring guidelines. This suggests that patients may not be adhering to the guidelines, which include regular PSA tests and biopsies. The study's authors call for further research into ...
Researchers at The Royal Marsden NHS Foundation Trust developed a liquid biopsy test that detects DNA fragments shed by tumors into the bloodstream. The test identified 74% of patients with early-stage rectal cancer who were at risk of metastatic disease, and those with persistent DNA were more likely to develop metastatic disease.
A new study published in the Journal of Urology found that transperineal prostate biopsies (TPBx) under local anesthetic are the safest method for testing and diagnosing prostate cancer, with fewer complications and improved patient tolerability.
A retrospective study found an 82.5% relative increase in radial scar diagnoses after transitioning to tomosynthesis, but a significant decrease in upgrade rates for invasive cancer or ductal carcinoma in situ. This suggests it may be safe to follow-up pure radial scars diagnosed on core biopsy without surgery.
A study found high negative predictive values for mammography architectural distortion without ultrasound or MRI correlate, suggesting safe follow-up rather than biopsy. The results indicate that this approach can reduce the need for intervention and lower healthcare costs.
A significant rise in oral cancer and pre-cancerous lesion detection by dentists in Ontario is reported, with a nearly doubling of cancers detected between 2005 and 2015. The study suggests that comprehensive training and continuing education programs for oral health professionals may be behind the dramatic increase in detection rates.
Researchers at RMIT University have developed a new technique to produce microscopic 3D images of tissue inside the body using existing optical fibre technology. This approach enables clinicians to examine living tissue in real-time, paving the way for minimally-invasive 3D optical biopsies.
Researchers at CNIO have discovered biomarkers in surgically treated patients' fluid that reveal specific mutations and help determine cancer recurrence risk. The new liquid biopsy technique may enable earlier detection and more targeted treatment for melanoma patients.
A study found that contrast-enhanced MRI significantly benefited patient care by successfully triaging patients with discordant benign biopsy results to surgical or nonsurgical management. The test showed high sensitivity and specificity in detecting malignancies, with a false-positive rate of 6.7%.
Researchers have developed a new method to detect small fragments of cancerous genetic material in blood samples from lung cancer patients. The method, called liquid biopsy, uses ultra-deep next-generation sequencing and machine learning to identify genetic variants driving the cancer or making it resistant to treatment.
A new study published in Radiology found that digital breast tomosynthesis (DBT) significantly reduces the number of women who undergo breast biopsy for non-cancerous lesions. DBT detected 142 cancers with a biopsy rate of 69%, while reducing false positive biopsies by 52%.
A new web tool, PREDICT Prostate, helps patients make informed decisions about treatment for early prostate cancer by providing a personalized prognosis and treatment options. The tool uses data from over 10,000 UK men to estimate survival rates and potential side effects of treatment.
A multi-center study by MD Anderson Cancer Center reveals that a liquid biopsy test, Guardant360, is comparable to standard tissue biopsies in detecting guideline-recommended biomarkers for advanced NSCLC. The test identified four mutations for which FDA-approved drugs exist and offers faster turn-around time.
A new screening method using sensor particles and a urine test can catch organ rejection earlier and more comprehensively than traditional biopsies. The test detects T cell attacks on transplanted organs through fluorescent signals in the urine, allowing for early detection and potential adjustments to immunosuppressant medications.
A biopsy needle with a tiny fiber-optic camera has been tested in humans to help surgeons identify and avoid blood vessels in the brain during surgery. The device detected blood vessels with high accuracy (91.2% sensitivity and 97.7% specificity), reducing the risk of brain bleeds.
A new study found that combining mammography with a novel imaging technique called three-compartment breast (3CB) imaging can significantly reduce unnecessary breast biopsies. The technique uses AI algorithms to analyze tissue composition, improving the ability to predict cancer and reducing recalls by up to 36%.
A new medical software system, SmartTarget, enhances prostate cancer detection by overlaying MRI scans onto ultrasound images, guiding surgeons during biopsies. The technology has shown that combining both techniques can detect clinically relevant cancers missed with current methods.
Researchers have successfully detected brain tumor DNA in cerebrospinal fluid (CSF) using a cheap and widely available technique, opening up new possibilities for monitoring and treating brain tumors. The test has the potential to increase detection rates and provide more tailored treatment approaches for patients with brain tumors.
A recent study found that procurement biopsies taken when kidneys are procured from donors were not reliable for determining suitability for transplantation. This lack of reliability may result in unnecessary kidney discard and reduced organ utilization, prompting a need to re-examine the role of such biopsies in organ allocation.
A new blood test offers a safer approach than surgical biopsies and allows doctors to monitor treatment effectiveness even before changes are identified on scans. The study found that circulating tumor DNA in the blood or cerebrospinal fluid can reveal a driver mutation in 42 of 48 patients, indicating the tumor's genetic signature.
Researchers found that a blood test identified significantly more treatable mutations in non-small cell lung cancer (NSCLC) than a tissue biopsy alone. Patients with actionable mutations detected by the liquid biopsy responded favorably to targeted therapies, achieving high clinical response rates.
A new study finds that mastectomies do not completely eliminate the need for postoperative imaging and biopsy. For 10% to 15.5% of patients, subsequent imaging is required, and 6-8% undergo biopsy, with low malignancy rates.
Researchers at UCLA will use a new liquid biopsy tool to test individuals at risk of lung cancer, with the goal of detecting the disease earlier. The technology aims to differentiate between cancerous and benign lung lesions, reducing unnecessary procedures and improving patient outcomes.
Yongxin Zhao, assistant professor at Carnegie Mellon University, has received a National Institutes of Health (NIH) Director's New Innovator Award. He will use the grant to develop transformative nanoscale imaging techniques for analyzing complex diseases.
Researchers at the University of Würzburg have identified viral microRNA molecules that can serve as ideal biomarkers for detecting human herpesvirus 6 (HHV-6) reactivation. The discovery was made using a novel method that allows for early detection of viral activation, potentially leading to improved clinical interventions.
A new international guideline has been developed to aid in the diagnosis of idiopathic pulmonary fibrosis (IPF), a rare and often fatal lung disease. The guidelines provide evidence-based criteria for diagnosis and recommend multidisciplinary discussions to facilitate accurate diagnosis.
Researchers developed a diagnostic test using needle biopsies to detect malignant hyperthermia, a fatal genetic condition caused by muscle protein mutations. The new test is less invasive and can be performed on children, providing potential early diagnosis.
A consortium of nine labs across the US and Netherlands standardized RNA sequencing methods to improve consistency and accuracy in liquid biopsies. The study found that different methods produced varying results, highlighting the need for standardized protocols to facilitate reproducible data and progress in the field.
The International Association for the Study of Lung Cancer (IASLC) has issued a statement paper on liquid biopsy for advanced non-small cell lung cancer, recommending its use for molecular analysis in guiding clinical management. The paper aims to provide general oncologists and clinicians with access to the latest information on liqui...
A new blood test called IsoPSA has been shown to be more accurate in predicting overall risk of prostate cancer than standard PSA tests. The study found that nearly 40 percent of biopsies could have been avoided with the use of IsoPSA, potentially lowering overtreatment rates and reducing unnecessary procedures.
Researchers aim to develop a virtual biopsy tool that can guide patient care without the need for invasive skin cuts. The technology uses multiphoton microscopy and machine learning techniques to provide high-quality images of melanin, enabling doctors to diagnose melanoma more accurately.
A new study published in Urologic Oncology suggests that MRI fusion biopsy is a more effective method for detecting clinically significant prostate cancer in patients with prior negative biopsies. The study analyzed data from over 700 patients and found that fusion biopsy detected 30.7% of clinically significant cancers, compared to 4....
Researchers have found that blood biopsies provide highly detailed genetic information that agrees well with bone marrow tests. This breakthrough could lead to more personalized treatment plans for patients with multiple myeloma, as the disease's progression can vary over time.
Researchers have developed a groundbreaking technique to detect tumor biomarkers in brain tumors through a simple blood test, potentially eliminating the need for surgical biopsies. The method uses focused ultrasound and tiny bubbles to release tumor-specific biomarkers into the bloodstream.