Articles tagged with Biopsies
A study suggests that accounting for genetic factors causing normal variations in PSA levels could improve the accuracy of prostate cancer detection. By analyzing data from over 95,000 men, researchers identified a polygenic score that accounted for 7.3-8.7% of variation in baseline PSA levels and was not associated with prostate cancer.
A study of 51,000 US veterans found a significant decrease in prostate cancer biopsies and diagnoses during the COVID-19 pandemic, with no racial disparity observed. The results suggest that the pandemic may have had a protective effect on prostate cancer diagnosis rates among Black and White veterans.
A new study from the University of Eastern Finland shows that liquid biopsy can detect cancer mutations months before recurrent breast cancer is detected. This method uses biomarkers released by cancer cells in serum samples to assess changes in intratumoural heterogeneity and provide a more accurate clinical picture.
A new technology called MediSCAPE has been developed by Columbia Engineers that can capture real-time cellular detail in living tissues. This allows doctors to make informed decisions about tumor removal without needing to remove tissue and wait for pathology results.
A study published in JAMA Network Open found that half of all women will experience at least one false positive mammogram over a decade of annual breast cancer screening with 3D mammography. The risk of false positives is lower for women screened every other year, and non-dense breasts also show a lower false positive risk.
A novel screening platform has successfully detected over 95% of stage 1 pancreatic cancers using artificial intelligence-enabled protein marker analysis, outperforming current liquid biopsy tests in accuracy. This technology holds promise for early cancer detection and reducing mortality from this deadly disease.
A pilot study suggests that an artificial intelligence system called CRANE can help cardiac experts diagnose rejection and estimate its severity more accurately. This could lead to faster diagnosis and treatment, as well as reduced variability in expert agreement, ultimately improving heart transplant outcomes.
A recent study by City of Hope researchers highlights the limitations of Signatera, a popular liquid biopsy test for detecting colorectal cancer recurrence. The study found that standard-of-care CT scan plus CEA blood draw test was more effective in identifying early disease recurrence.
New studies from Michigan Medicine researchers aim to remove financial barriers for patients who receive abnormal test results, enabling them to complete the diagnostic process. The findings suggest that removing cost barriers could save lives by increasing screening uptake, particularly among women and underserved populations.
Researchers have developed a rapid and affordable test to identify specific genetic mutations in cancer cells using SuperSelective PCR primers. This assay can detect rare mutations, enabling targeted therapy and monitoring minimal residual disease. The study demonstrates the potential of this approach for personalized cancer treatment.
Scientists from Japan and USA develop a microfluidic device for purification of tuberculosis genomic DNA fragments, enabling accurate diagnosis of diseases. The device uses transient ITP and electrokinetic trapping to detect and purify small cfDNA fragments.
A retrospective study found that the upgrade rate of architectural distortion on digital breast tomosynthesis (DBT) to malignancy was 10.2% for radial scars without atypia and 28.2% for those with atypia. Imaging surveillance is considered an alternative to surgery for these cases.
Researchers at the University of Illinois have developed a new approach to detect cancer biomarkers in human serum, reducing the detection time from hours to just one minute. This method uses magnetic-plasmonic nanoparticles and photonic resonator absorption microscopy to achieve high selectivity and rapid sample-to-answer analysis.
A novel blood test, Stockholm3, in combination with MRI reduces overdiagnosis of low-risk cancers by 60% and unnecessary biopsies by 9%. This cost-effective approach is recommended for Sweden's organized prostate cancer testing (OPT) pilot projects.
A new study published in Mammalian Biology analyzed the life history data of 13 North Atlantic right whales using genetic samples and photo identification. The researchers found that four calves previously thought to be dead survived, revealing a significant variation in calf separation time from mothers and physical development.
A recent study published in The Journal of Urology found that serum hormone ratios can predict the risk of future infertility in children with cryptorchidism. Researchers discovered that inhibin B levels and anti-Mullerian hormone (AMH) are significant markers of spermatogenesis, helping to identify boys at high risk of infertility.
A pioneering test called AMBLor has been developed to predict the spread or return of skin cancer. By analyzing primary tumor biopsies, the test identifies patients at low risk of disease progression, providing them with more accurate information and personalized prognosis.
The new technology can reliably distinguish between cancerous and healthy liver tissue, aiding diagnosis and potentially reducing errors in biopsies. The researchers plan to continue measuring fluorescence lifetime parameters in patients with different types of tumors to generate real-time diagnostic classifiers.
Researchers developed a new SERS-based multiplexing technique to detect kidney injury biomarkers SLPI and IL-18, achieving high sensitivity and reliability. The approach shows promise for objectively assessing donor kidney quality, potentially reducing discard rates and recipient complications in clinical practice.
A new blood test developed at Hebrew University of Jerusalem detects immune and inflammatory activity in tissues by monitoring circulating DNA fragments. This method provides accurate information about immune processes in remote tissues, removing the need for invasive measures.
A prospective study found that ultrasound alone adequately completed the diagnostic evaluation of 71.2% of noncalcified lesions, diagnosed 92.1% of cancers, and yielded a sensitivity of 94.9%. Radiologists should consider performing ultrasound first for digital breast tomosynthesis-recalled noncalcified masses.
A survey of 121 fertility specialists in Australia, UK, and New Zealand found that endometrial scratching is still offered by 34% of clinics despite lack of evidence, primarily for psychological benefits. Many respondents considered the procedure's drawbacks, including pain and cost.
Researchers developed an AI system to detect inflammation in ulcerative colitis patients using live colonoscopy videos. The system accurately predicted remission cases with high accuracy, reducing the need for invasive biopsies.
Researchers analyzed 140 neuroblastoma samples to understand the genetic changes associated with the disease. They found that mutations can disappear and reappear, occurring in distinct sections or individual cells, making targeted therapy less effective.
A team from the University of Washington has developed a non-destructive 3D imaging method that can help doctors more accurately diagnose borderline cases of prostate cancer. The new approach uses 3D images to identify complex features in tissue samples, which can increase the likelihood of correctly predicting a cancer's aggressiveness.
A blood test for HPV-associated head and neck cancer was found to be more accurate, faster, and cheaper than conventional methods. The test detected DNA fragments of HPV in the blood and was combined with routine imaging and physical exam findings for a fully non-invasive diagnostic approach.
Pathologists have discovered that some patients with lingering COVID-19 symptoms may have underlying chronic lung disease prior to their infection. This finding suggests that clinicians should carefully consider alternative explanations for respiratory symptoms beyond long COVID.
A new virtual histology technology may reduce the need for invasive skin biopsies, providing a biopsy-free solution for rapid diagnosis of malignant skin tumors. The technology uses deep-learning frameworks to transform images of intact skin into detailed, virtually stained images.
A noninvasive diagnostic method, sonobiopsy, has been developed to detect brain tumors with improved sensitivity. The method uses focused ultrasound to target tumors and injects microbubbles that release biomarkers into the bloodstream.
Researchers developed a blood test that can detect prostate cancer patients who are resistant to chemotherapy drug docetaxel, enabling early detection and personalized treatment. The test analyzes circulating tumor cells in the bloodstream, revealing patterns that predict disease progression and survival.
Optical coherence tomography (OCT) has significant growth potential across various medical applications, including cardiology and dermatology. Miniaturized OCT systems are expected to revolutionize healthcare with compact, mobile, and cost-effective devices.
A new study from the University of Eastern Finland and Kuopio University Hospital found that liquid biopsy can accurately identify patients with poor breast cancer prognosis. High integrity of circulating DNA is associated with a poor prognosis, enabling earlier and more accurate detection of breast cancer. The study's findings have si...
New studies show that patients with abnormal screening results may face significant out-of-pocket costs for follow-up tests, potentially delaying care. For women, colposcopy costs rose sharply over 13 years, with some facing bills of nearly $1,000. Lung cancer screening CT scans also led to high costs for invasive procedures.
A new AI system developed by NYU and NYU Abu Dhabi researchers achieves radiologist-level accuracy in identifying breast cancer in ultrasound images. The system helps decrease false-positive findings and requested biopsies while maintaining sensitivity.
Researchers developed a method to overlay a virtual scale on acquired endoscope images in real-time, allowing accurate estimation of colorectal polyp sizes. The approach uses triangulation principles and minimal image processing, enabling cost-effective diagnosis without adding extra instrumentation.
Researchers developed urine and blood biopsies to diagnose and monitor bladder cancer and peripheral nerve tumors. The tests could help patients avoid unnecessary surgeries and improve cancer management with accurate tumor detection at various stages.
Researchers found that consuming dileucine enhances the metabolic processes driving muscle growth, resulting in a 42% increase in protein synthesis. In contrast, leucine alone showed no significant impact on protein breakdown, highlighting the molecule's potential as a signaling agent for muscle-building pathways.
Researchers developed a topical fluorescent imaging agent targeting PARP1 enzyme in cervical cancer cells, enabling real-time detection with handheld microscopes. This non-invasive method could revolutionize cervical cancer screenings and biopsies, especially in low-resource areas.
A study found that transvaginal ultrasound (TVUS) screening missed over four times more cases of endometrial cancer among Black women compared to White women. The screening tool was not sufficiently accurate or racially equitable for Black women, putting them at a higher risk of false-negative results.
A new study suggests that magnetic resonance imaging (MRI)-based screening can reduce unnecessary biopsies and detect clinically significant tumours while halving overdiagnoses. The results come from a randomized study conducted at Karolinska Institutet in Sweden.
A new AI system has been developed to recognize the specific pattern of epidermolysis bullosa acquisita, a debilitating blistering disease that can cause scarring and blindness. The system achieved an accuracy of 89.3% in recognizing the disease, outperforming human doctors.
A new study suggests that AI can visually distinguish between euploid and aneuploid embryos based on their cell activity, potentially removing the need for cell biopsy in embryo testing. The AI-based system achieved 73% sensitivity and specificity in its results, offering a fast and economical alternative to current non-invasive methods.
Researchers have identified a gene variant that contributes to unnecessary bone marrow biopsies in African Americans. The study found that 63% of African Americans carry the variant, which lowers white blood cell levels and is associated with Benign Ethnic Neutropenia.
A new study uses liquid biopsy analysis to detect and classify childhood tumors based on their unique epigenetic signatures. This approach enables minimally invasive diagnosis and monitoring without the need for tumor biopsies, holding promise for improved treatment outcomes and personalized therapies.
A new study finds that non-invasive cell-free DNA tests can detect early rejection in heart transplant patients with high sensitivity and specificity. The assay is clinically viable, reducing the need for routine surveillance biopsies.
Researchers have developed a new urine test called ExoGrail, which shows how aggressive prostate cancer is and can reduce unnecessary biopsies. The test uses biomarkers to provide risk scores and identify patients who need invasive biopsies.
Researchers have developed ultrasonically oscillating needles that provide sufficient tissue samples for 21st century diagnostic needs, potentially reducing pain and trauma. The technology increases biopsy yields by 3 to 6 times compared to traditional needles, enabling high-tech cancer treatment options.
A study of renal transplant biopsies found that blood pressure thresholds above 180/95/116 mmHg don't increase complication risk, but combined high pressures do
A research team from MedUni Vienna has confirmed a threshold value for a non-invasive imaging biomarker in breast cancer screening. This can be incorporated into short standard MRI scans to reduce biopsy rates by 30%. DWI, a special MRI technique, measures the motion of water molecules and can indicate whether a biopsy is necessary.
A new study shows that liquid biopsies can detect lingering disease in patients with oligometastatic colorectal cancer, guiding treatment decisions. The biopsies identify patients who may benefit from immune therapies or targeted treatments based on mutations detected in blood samples.
The new risk score, developed by HKBU and CUHK researchers, uses urine spermine levels to estimate a patient's risk of developing prostate cancer. The test has been shown to accurately identify high-risk patients and help reduce unnecessary biopsies.
A new advanced computing technique enables doctors to take fewer, more accurate tumour biopsies by combining computed tomography (CT) scans with ultrasound images. This method captures the patchwork of different cancer cell types within a tumour, critical for selecting the best treatment.
A new study found that US kidney biopsies don't add value beyond standard donor and recipient characteristics in predicting survival. Many discarded kidneys would likely benefit US patients awaiting a transplant, with some matching transplantation outcomes in Europe.
A US study finds that many donor kidneys are discarded due to low-quality tissue, yet can function acceptably when transplanted. The study suggests that procurement biopsies add little value and may even reduce the supply of available kidneys.
A study of 514 men undergoing active surveillance for early-stage prostate cancer found that those with negative biopsies had more favorable clinical characteristics and excellent long-term outcomes. Negative biopsies indicated low-volume disease with lower rates of disease progression, supporting continued active surveillance.
A study published in the American Journal of Roentgenology found that ultrasound-guided percutaneous needle biopsy is highly accurate for diagnosing small pleural lesions with nodular morphology or thickness over 4.5 mm. The procedure yielded a diagnostic accuracy rate of 85.4% and a 96.4% yield rate for nodular CT lesions.
Researchers at Princess Margaret Cancer Centre found that over 80% of advanced NSCLC patients had genomic alterations detected in cfDNA. Liquid biopsies were shown to be a timely and effective method for diagnosing and monitoring the disease, with actionable alterations detected in over 56% of treatment-naïve patients.
A pilot study comparing liquid biopsy with tissue-based test found that liquid biopsy results were approximately 10 days faster than tissue biopsy. Liquid biopsy identified actionable genes in 14 cases, while tissue biopsy only detected them in 11 cases.
Cryoablation, a less-invasive treatment technique, offers a promising alternative to surgery for prostate cancer control. According to the study, cryoablation provided a high rate of effective prostate cancer control in 82% of patients at 18-month follow-up.
Researchers at Tokyo University of Agriculture and Technology have developed a nanopore technique that can detect single-point mutations in circulating tumor DNA (ctDNA) with high accuracy. The method uses statistical analysis to identify the position of genetic mutations, paving the way for earlier and safer tumor detection.