Articles tagged with Biopsies
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A new study published in JAMA Dermatology reveals that dermatologists are more accurate than Physician Assistants (PAs) in diagnosing early stage skin cancers. For every suspected case of melanoma, PAs needed to biopsy over 39 pigmented lesions compared to just 25 for dermatologists.
A new study has reported a good correlation between an automated image analysis system and an expert reviewer for the identification of key markers of NASH disease activity in a pre-clinical model. The study used deep-learning algorithms applied to open-source pathology software (QuPath1) to accurately identify cell histology patterns ...
The molecular microscope system uses gene chips to read molecules in heart and lung transplant biopsies, providing more precise readings with fewer tissue samples. The system is showing promising results for both heart and lung transplant biopsies, improving patient outcomes and reducing errors.
A new study reveals that prostate MRI scans can reduce the number of invasive biopsies by up to 28% and detect more harmful cancers. The results show that using MRI to target biopsies leads to more significant cancer diagnoses, while also reducing unnecessary diagnoses.
A study presented at the ARRS 2018 Annual Meeting found that screening mammography in women aged 40-49 detects 19.3% more cancers than in older age groups, but also increases callbacks and biopsies by 1.5% and 0.1%, respectively.
A new imaging technology has been developed to grade tumour biopsies, eliminating human subjectivity and variability. The Digistain method uses mid-infrared light to map out chemical changes that signal cancer onset, providing a reliable indicator of disease progression.
A new liquid biopsy platform uses centrifugal microfluidics to isolate and enrich circulating disease biomarkers from patient blood, promising a less invasive diagnostic procedure. The technique, called μCENSE, separates vesicles containing biomarkers using centrifugal force, reducing extraction time from hours to minutes.
A new computer program enables accurate pre-biopsy preparation for lung diseases by visualizing patient airways in 3D. Transbronchial biopsies have shown increased accuracy from 53% to 88% using this technology.
Researchers at University of Texas M. D. Anderson Cancer Center discovered a rare pre-existing mutation in PIK3CA that causes rapid drug resistance in melanoma patients. The study found that this mutation was present in the tumor before treatment and rapidly expanded after treatment, leading to swift disease progression.
A new scanning technology could almost halve the number of liver biopsies carried out on people with fatty liver disease. The study used digital image scanning to diagnose liver disease and found it to be superior to other tests in grading disease severity and excluding patients at increased risk.
A nationwide population-based study analyzed over 120,000 women diagnosed with early-stage breast cancer, finding that only 14.7% required additional biopsies during follow-up care. The study's findings will help physicians counsel patients about breast cancer recurrence rates and the need for future biopsies.
Researchers have created a novel optical biopsy method using resonance Raman scattering to detect diseases like skin cancer and brain cancer at the molecular level. This non-invasive technique provides more detailed information and can detect diseases in mere seconds.
A new AI model based on convolutional neural networks (CNN) significantly improves the analysis of kidney biopsy images, enabling accurate quantification of kidney damage and prediction of life remaining in the kidney. This technology has the potential to act as a surrogate nephropathologist, particularly in resource-limited settings.
Researchers at UT Southwestern Medical Center have developed a new Magnetic Resonance Imaging (MRI) technology that can accurately diagnose the nature and aggressiveness of kidney cancer without the need for invasive biopsies. This breakthrough technology, known as multiparametric MRI, uses multiple types of images to evaluate the chem...
Researchers found significant disparities in liquid biopsy results from Guardant360 and Personal Genome Diagnostics for patients with metastatic prostate cancer. Inconsistencies were found even when analyzing DNA from the same blood sample, highlighting the need for improved certification and quality control.
Researchers propose a revised cancer staging approach that incorporates liquid biopsy to improve diagnosis and treatment accuracy. The new system has shown promising results in guiding cancer care, particularly in detecting early-stage cancer and tracking treatment response.
A new method using single-cell genomics can help identify potentially lethal prostate tumors before surgery, improving risk assessment and treatment decisions. The approach analyzes genomic patterns in biopsy cores, assigning a score based on clonality and genetic aberrations.
Naloxone administered in the field by EMS personnel is safe and effective for reversing opioid overdose symptoms, according to a systematic evidence review. Research is needed to determine the optimal dose and route of administration.
A new study by Einstein Medical Center found that 71% of women surveyed preferred annual mammograms, citing empowerment and education as key factors. The research challenges the USPSTF's biennial screening recommendation, highlighting the importance of women's preferences in healthcare decisions.
The Prostate Health Index test influences physician decisions to perform biopsies, with only 36% of men receiving biopsies when phi testing was included in the assessment compared to 60% before its availability. The study also found a reduction in low-grade prostate cancers detected.
Researchers at UT Austin developed an ancient enzyme that detects full range of RNAs with high accuracy, improving cancer diagnosis. The enzyme, TGIRTs, can be used to monitor disease progression and response to treatment.
A new liquid biopsy technique can detect telltale signs of tumors in children's biofluids, enabling earlier diagnosis and monitoring of aggressive pediatric brainstem cancer. The method has shown high sensitivity and specificity in detecting H3K27M mutant glioma, a form of cancer with poor prognosis.
Researchers have developed an accurate approach for monitoring cancer DNA from blood samples, validating the use of blood samples for studying patients' cancer genomes. Nearly 90 percent of a tumor's genetic features can be detected in blood samples using whole-exome sequencing.
A study published at the International Association for the Study of Lung Cancer (IASLC) conference found that biopsy specimens are a reliable material for evaluating DLL3 expression in small cell lung cancer. High levels of DLL3 expression were correlated with poor survival trends, smoking history, and neuroendocrine differentiation.
Researchers developed a self-propelled catheter that uses peristaltic motion to navigate ultrafine bronchi, improving biopsy accuracy. The catheter's actively curving function helps choose the direction of propulsion and its flexing drive adjusts to changes in line diameter.
Researchers identified genetically targetable alterations in 66% of patients with cancer of unknown primary (CUP), a rare disease. The study used circulating tumor DNA in blood samples to detect these alterations, which could be targeted using existing FDA-approved drugs or therapies currently under investigation.
A simpler biopsy procedure has been developed to reduce stress and improve patient care during gastrointestinal endoscopy. The new method, called endoscopic multiple biopsy (MB), allows for faster diagnosis with equal quality results.
Physicians have evaluated a new fabric-based endocervical curettage device, which uses a hook to collect tissue samples. The device reduces discomfort and increases the number of adequate specimens, leading to better results and fewer repeat biopsies.
A new international study involving 3,500 patients found that removing all lymph nodes in the area closest to the melanoma may not provide a significant survival advantage. The study suggests that patients can be spared from complications and repeat hospitalizations if only their sentinel lymph node is removed.
Researchers at Johns Hopkins Medicine have developed a modified skin biopsy technique to hasten the diagnosis of transthyretin amyloidosis, a rare and lethal nerve disease. The test, which detects protein clumps in skin samples, shows promise for more rapid clinical trials and improved treatment options.
A recent study found that biopsy tests had no impact on kidney function after transplantation from living donors, but did influence outcomes with deceased donor kidneys. Despite this, nearly 20% of organs are still being discarded in the US due to suboptimal biopsy results.
A new study shows that liquid biopsies can provide more information than traditional tissue biopsies, helping doctors tailor care based on individual disease biology. The tests detected genetic mutations that made cancer resistant to treatment, allowing for better patient care.
A new analysis found that delaying lymph node biopsy more than 30 days after melanoma diagnosis does not adversely affect long-term clinical outcomes. The study examined 2,483 patients and found similar results in disease-free survival and melanoma-specific survival.
A new ultrasound scoring system has been developed to identify thyroid nodules that require biopsy or follow-up. The system uses a risk stratification approach to classify nodule appearance and size, reducing unnecessary biopsies and improving cancer diagnosis accuracy.
The EV-FPS test correctly identifies men with aggressive prostate cancer 40% more accurately than current PSA tests. It has the potential to eliminate up to 600-thousand unnecessary biopsies and reduce hospitalizations annually in North America.
A new blood test called Videssa Breast has shown high sensitivity and specificity for detecting breast cancer in women under age 50. The test can help reduce the use of breast biopsies by up to 67 percent, ruling out breast cancer with a positive predictive value of 25.2 percent.
Researchers found that using MRI to detect lesions and guide biopsies increased standardized quality-adjusted life years for patients, and was cost-effective in 94.05% of simulations. This approach could change how doctors identify and sample cancer lesions, reducing unnecessary treatments and costs.
A deep-learning network developed through research at Case Western Reserve University was 100% accurate in determining the presence of invasive breast cancer in whole biopsy slides. The network correctly identified cancerous pixels with 97% accuracy, rendering near-exact delineations of tumors.
A new biopsy technique combining MRI and ultrasound improves prostate cancer detection. Researchers found that patients are willing to pay $1,598 more for a biopsy increasing the likelihood of detecting all types of prostate cancer from 43% to 51%.
Researchers have identified a set of molecules in urine that are present in 90% of prostate cancer patients but not in healthy individuals. This discovery could lead to the development of a non-invasive test for early detection of prostate cancer, potentially reducing unnecessary biopsies and improving patient outcomes.
Researchers at Penn School of Medicine have made significant advancements in liquid biopsies, a non-invasive method for detecting cancer. Studies focus on using fluid in the lungs to test immunotherapy treatments and circulating tumor cells in prostate cancer patients.
Analysis of 355 biopsied tumors found that mutations in non-small cell lung cancer frequently varied between biopsies, with nearly one in five patients harboring multiple genetic resistance mechanisms. Researchers propose improved molecular testing methods for serial testing and rebiopsy to better characterize resistance over time.
Researchers at Carnegie Mellon University and Magee-Womens Research Institute have developed a framework to understand vesicle formation, which can help create non-invasive diagnostic tools like liquid biopsies. The study also provides insights into optimizing artificial vesicles for drug delivery devices.
Researchers developed a minimally invasive tool to measure muscle impairment using fiber-optic technology. The technique accurately assesses muscle properties, enabling personalized treatment plans for patients with movement disorders.
A cost-effectiveness study on selective biopsy of the sentinel ganglion in cutaneous melanoma found no improvement in health outcomes. The technique is not recommended over removing the primary tumour followed by monitoring, regardless of tumour thickness or timeframe.
A new MRI scan test may improve diagnosis and reduce unnecessary biopsies for men with suspected prostate cancer. The test detected aggressive cancers correctly in 93% of cases, while avoiding over-diagnosis by 5%. Men without cancer or harmless cancers were also correctly identified.
A pilot study at MD Anderson Cancer Center found that image-guided biopsies accurately predicted residual disease in breast cancer patients after chemotherapy and/or targeted therapy. The study suggests that certain patients may be able to avoid surgery, paving the way for personalized treatment.
A DNA methylation biomarker called PITX2 has been identified as a reliable predictor of prostate cancer recurrence. The study found that patients with high PITX2 methylation levels were at significantly increased risk for recurrence. This breakthrough could lead to more personalized treatment strategies for prostate cancer patients.
A panel of urologists and radiologists recommends using prostate MRI and MRI targeted biopsy for patients with suspected prostate cancer despite a prior negative biopsy. The recommended guidelines aim to improve detection rates, accuracy, and treatment options for these patients.
Ground-breaking studies demonstrate early benefit of targeted treatments in advanced cancers, with dramatic responses seen in patients who have failed standard therapies. Liquid biopsies enable real-time monitoring of patient progress and treatment efficacy.
Following the USPSTF recommendation against population-based PSA screening, median biopsy volume per urologist decreased by 29% and RP volume decreased by 16%. Prostate cancer diagnostic and therapeutic practice patterns have shifted significantly.
A SWOG study found widespread detection bias in prostate cancer biopsies, affecting younger, healthier men and those with family history or elevated PSA levels. Biases led to inconsistent results on risk factors, highlighting the need for rigorous data analysis and caution against assumptions.
Researchers have developed an imaging technique that can accurately diagnose and prognosticate transthyretin-related cardiac amyloidosis (ATTR-CA), a type of heart failure. The test uses technetium 99m pyrophosphate and has been shown to correctly identify ATTR in 91% of patients, ruling out other forms of amyloidosis.
Researchers analyzed tumor biopsies from 53 melanoma patients treated with immune checkpoint inhibitors to predict treatment response. The study found that adaptive immune responses, such as killer T cells, were significantly higher in responders after treatment began.
A study led by Johns Hopkins pathologists found routine hormone receptor testing for noninvasive breast cancer through needle biopsies is unnecessary and wasteful, costing millions annually. This practice could save up to $35 million yearly.
The first single actuator wave-like robot (SAW) has been developed by engineers at Ben-Gurion University of the Negev. It can move forward or backward in a wave-like motion and climb over obstacles, reaching speeds of up to 22.5 inches per second.
Researchers developed liquid biopsies to detect EGFR mutations in urine, plasma, and blood samples. The tests showed high sensitivity and specificity for identifying patients suitable for targeted treatment and predicting cancer recurrence.
Colorado State University researcher Jesse Wilson is developing a new microscope that can distinguish between benign and malignant pigmented skin lesions without a biopsy. The pump-probe technology uses a simpler laser source that's already widely used in telecommunications applications, making it more realistic for melanoma applications.
A new PET/MRI imaging test has been shown to improve the detection of significant prostate cancer, surpassing current multi-parametric MRI methods. The test's addition of molecular imaging based on F-18-choline positron emission tomography (PET) significantly improves the identification of clinically significant cancers.
The extent of resection in glioblastoma patients was found to be associated with improved overall and progression-free survival. Glioblastoma multiforme (GBM) patients who underwent gross total resection (GTR) showed a significant increase in one-year and two-year survival rates compared to those with subtotal resection or biopsy.