Articles tagged with Cardiovascular Disorders
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A four-year study will track health outcomes among older Black and Hispanic residents in the Bronx to understand how neighborhood redevelopment affects cardiovascular disease. The research team will use medical records, interviews, and data modeling to measure the impact of both medical and nonmedical risk factors on CVD health.
Researchers at The Hospital for Sick Children have discovered that dysregulation of energy production is an early sign of heart failure. They found that lysine demethylase 8 (Kdm8) helps maintain balanced energy use, but its suppression leads to changes in metabolism.
Excessive trabeculation of the left ventricle does not coalesce into a compact myocardial wall, making 'LV non-compaction' an inaccurate term that should be discouraged. The review recommends using 'excessive trabeculation', which can be observed across various health and disease states.
A study published in the journal Nutrients found that regular coffee consumption is associated with lower blood pressure levels, both peripheral and central. The researchers analyzed data from a sample of Italian adults and discovered that moderate coffee drinkers had significantly lower systolic and pulse pressures.
Preterm birth increases the risk of cardiovascular problems; combining steroids with statins could eliminate negative effects while retaining respiratory benefits. Researchers found that combined therapy improved lung function and reduced cardiovascular issues in rat pups.
A new biomaterial has been developed that can be injected intravenously to promote cell and tissue repair, reducing inflammation in damaged tissues. The material has shown promising results in treating heart attacks and traumatic brain injury in animal models.
A new study led by Columbia researchers discovered a link between serotonin and heart valve disease, specifically degenerative mitral regurgitation. The study found that patients taking selective serotonin reuptake inhibitors (SSRIs) were more likely to develop severe mitral regurgitation and require surgery at a younger age.
A study published in JAMA Cardiology found that rurality is associated with a higher risk of heart failure among predominantly low-income individuals in the southeastern United States. The inequity highlights the need for targeted primary prevention efforts for rural populations.
Researchers found that nearly half a million people missed starting medication to lower their blood pressure during the Covid-19 pandemic, leading to thousands of avoidable cardiovascular events. Identifying individuals who missed out on treatment could reduce these events by just over 2,700.
A UCSF study suggests people who identify as lesbian, gay, bisexual, transgender, or non-binary may have a higher risk of stroke at a younger age. Non-traditional stroke risks include HIV and syphilis infections.
Researchers from Osaka University found that tricaprin supplementation leads to remarkable regression of coronary artery plaque and resolution of symptoms in patients with triglyceride deposit cardiomyovasculopathy. The study's findings provide a novel treatment concept for coronary atherosclerosis.
The procedure requires thorough pre-procedural evaluation and assessment of anatomical and hemodynamic data. Long-term results indicate that TPVR can effectively restore RVOT function, while improving survival rates and reducing the need for reintervention across age groups. Vigilant testing is recommended to avoid rare but serious com...
A study of nearly 4,000 patients found that the longer the time between COVID-19 diagnosis and surgery, the greater the risk of major cardiovascular events during or following surgery. This association could inform discussions on optimal surgical timing and perioperative outcomes for patients with a history of COVID-19 infection.
A new study published in JAMA found that choosing a Medicare Advantage plan does not significantly improve heart attack survival rates compared to traditional Medicare. Despite this, Medicare Advantage participants still had higher rates of certain care procedures and lower hospital readmission rates.
Research highlights the need for high-quality studies on tropical cyclones in low- and middle-income countries to understand long-term consequences. The public health impact extends beyond injuries and cardiovascular diseases, affecting neuropsychiatric conditions and infectious diseases.
Inducing a hibernation-like state in mice using Q neuron activation has been shown to protect kidneys from oxygen deprivation and avoid harmful side effects. This technique could lead to new methods of performing heart surgery with reduced organ damage.
A new study published in the New England Journal of Medicine found that semaglutide, an approved obesity drug for adults, also helps adolescents with obesity lose weight and have healthier hearts. After 68 weeks, 72.5% of participants who received semaglutide had achieved at least 5% weight loss compared to just 17% on placebo.
A UCSF-led study sheds light on the mechanisms behind sex differences in ICI-induced myocarditis, a potentially fatal side effect of cancer immunotherapy. The research suggests that immune checkpoint inhibitors may interact with sex hormones to cause cardiac toxicity in female patients.
A large-scale comparison of direct oral anticoagulants has identified apixaban as the drug with the lowest risk of bleeding. The study, published in Annals of Internal Medicine, found that apixaban had a 19-28% lower risk of gastrointestinal bleeding compared to other DOACs.
Researchers at Osaka University have developed a mouse model that shows Favine protein can protect against atherosclerosis and thrombosis. The study also found that reduced levels of Favine are associated with calcification and thrombus formation, revealing a new potential therapeutic target for treating atherosclerosis.
Researchers found reduced lung function and scarring in mice exposed to e-cigarette vapor with or without nicotine. Female mice also showed increased body weight in adulthood. The study suggests vaping during pregnancy can have long-term health effects on offspring.
Researchers found that metformin targeted 30 genes associated with atrial fibrillation, showing direct effects on gene expression for eight. The study suggests metformin may be a promising candidate for treating atrial fibrillation due to its potential to reduce the risk of complications such as stroke and heart failure.
A Virginia Tech graduate student has been awarded a two-year grant to explore a synthetic molecule as a basis for treating arrhythmias. The research aims to identify a combination of the molecule that could prevent arrhythmic incidents and potentially even sudden cardiac death.
A new study found that younger women hospitalized with heart attacks had a significantly higher prevalence of cardiac risk factors and comorbidities compared to younger men. This led to higher rehospitalization rates and all-cause readmission rates, emphasizing the need for ongoing efforts to improve prevention strategies.
A cohort study of 4,443 patients with first-time strokes found that early recovery curves and long-term decline patterns varied across functional domains. Clinical factors such as age, sex, and stroke type significantly impacted activities of daily living performance at 60 months.
A new study suggests that spironolactone, a medication for heart problems and high blood pressure, may also be effective in reducing alcohol drinking. The research found that increasing doses of spironolactone decreased alcohol consumption in mice and rats, as well as in humans with excessive alcohol drinking.
Researchers are developing wearable tonometric sensors that can collect blood pressure data without disrupting patients' sleep. The new cuffless monitoring system uses gecko-inspired adhesion technology to provide accurate readings.
Researchers found that eating walnuts early in life is associated with a lower risk of heart disease, obesity, and diabetes. The study suggests that walnuts may act as a 'bridge food' to promote healthy nutrition and lifestyle habits throughout life.
A budget impact analysis found that catheter-based TAVR is an affordable and effective strategy for treating aortic stenosis patients, with lower total costs compared to surgical SAVR. The study showed that the upfront cost of TAVR is partially offset by reduced healthcare resources, making it a more efficient option.
A prospective study in the Canadian Journal of Cardiology found that dedicated women's heart centers can significantly improve clinical and psychological outcomes for women with myocardial ischemia. The study, which followed 154 patients, showed a significant decrease in chest pain frequency and improved quality of life after attending...
Researchers found that transplanted gut bacteria from mice with obstructive sleep apnea caused increased blood pressure and impaired coronary function in recipient mice. Probiotics improved symptoms for the recipients but not the donor mice, highlighting a potential therapeutic strategy to mitigate cardiovascular disease.
A clinical trial found that long-term use of evolocumab led to further reductions in cardiovascular events compared to shorter treatment. Participants who received evolocumab for over 5 years had lower risk of cardiovascular death, myocardial infarction, stroke, and hospitalization.
A Kaiser Permanente study found that patients in home-based cardiac rehabilitation had fewer hospitalizations than those in center-based rehab, with benefits seen across diverse patient populations. The home-based program improved accessibility and outcomes for high-risk patients.
A meta-analysis of nearly 300 studies reveals a higher hypertension prevalence in urban areas but with a narrowing gap over time and socio-economic development, indicating rapid increase in rural areas. The study highlights the need for increased awareness and control measures in rural areas to address the growing burden of hypertension.
The American Heart Association offers important guidance on sleep-disordered breathing and its association with cardiac arrhythmia, highlighting the potential benefits of SDB treatment on patient outcomes. The statement emphasizes the need for more randomized data to confirm the link between SDB and reduced atrial fibrillation recurrence.
Researchers from Massachusetts General Hospital found that wrist-worn devices are more cost-effective than traditional electrocardiograms and pulse palpation for screening individuals with atrial fibrillation. The use of these devices was also associated with a reduction in stroke incidence.
A multisite clinical trial will deliver behavioral interventions to over 1,000 adults aged 50 and older with excess weight and cardiometabolic risk factors. The adaptive treatment model tests an evidence-based video program against a program with problem-solving therapy delivered via videoconferencing.
Researchers at RCSI University have created a new lab-based model to test devices for heart failure with preserved ejection fraction. The model enables testing of the left atrium and ventricle, two independently controlled chambers that simulate blood flow during the resting phase.
A long-term study of 3,926 adults with CKD found that higher levels of physical activity reduced the risk of atherosclerotic events, new-onset heart failure, and death. The association was strongest for incident peripheral arterial disease and reinforces current guideline recommendations.
A newly expanded data set of brain scans from stroke patients called ATLAS now includes 1,271 MRI images with manually segmented lesions, facilitating large-scale stroke recovery research. Researchers hope to develop algorithms to automate lesion segmentation, enabling clinicians to predict patient responses to therapies.
Research reveals associations between cardiovascular risk factors, low physical fitness, and decreased neural activity in the social brain network, leading to social cognitive function decline. A healthy lifestyle may mitigate this decline through targeted interventions.
Researchers found that using advanced image-guided technology didn't lead to better outcomes for patients, but rather put them at higher risk of strokes. The study suggests that a simpler approach may be more effective in treating atrial fibrillation.
A recent review article highlights the crucial role of macrophages in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The study suggests that targeting specific signaling pathways and altering macrophage activation can prevent renal fibrosis and CKD. Therapeutic strategies such as clodronate liposomes an...
A study found that US adults receiving hemodialysis with high air pollution exposure have more heart attacks and strokes compared to those with low exposure. The strongest associations were noted among patients who were Asian, older, or had chronic lung disease at dialysis initiation.
Researchers have created a new electrical test to screen hundreds of gene mutations, pinpointing harmful mutations that cause inherited heart disorders and sudden death. The breakthrough can identify genetic variants associated with neurological conditions, muscle and kidney diseases.
A large-scale study found that having multiple heart-related conditions significantly increases dementia risk, even for those with high genetic risk. Researchers analyzed data from over 200,000 people and discovered widespread brain damage among those with more than one cardiometabolic condition.
Research finds no significant increase in cardiovascular events among men with low testosterone undergoing testosterone treatment. Testosterone was found to reduce serum total cholesterol and triglycerides, but no significant differences were seen in other parameters.
Patients with primary glomerular diseases have a significantly higher risk of cardiovascular events, including coronary artery disease and stroke. The study found that inclusion of kidney-specific risk factors improved the prediction of cardiovascular events.
Researchers at Keck School of Medicine of USC are testing the efficacy of 3K3A-APC as a cerebroprotectant to reduce brain bleeds in acute ischemic stroke patients. The experimental drug has shown promising results in Phase 2 clinical trials, reducing incidence of brain hemorrhage by nearly 20%.
Patients with a history of unprovoked venous thromboembolism who stop treatment after negative D-dimer tests experience an eight-fold increased risk of recurrence compared to those on low-dose apixaban. Low-dose apixaban was found safe and effective for these patients
A new study published in Open Heart found that patients with asymptomatic severe aortic stenosis benefit from early valve replacement surgery to prevent irreversible heart muscle damage. The research showed that timing of surgery is crucial in reducing mortality and hospitalization rates.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
Researchers studied cavefish genome-wide map of liver tissue to understand metabolism evolution and its potential applications for humans. The study found striking similarities in metabolic adaptations among cavefish populations, raising questions about universal adaptation mechanisms that could be triggered in other species like humans.
A study by Kobe University researchers has illuminated the characteristics of Myeloid immune cells in coronary plaque, a major contributor to acute coronary syndrome. The findings suggest that macrophages and monocytes accumulate in the plaques of patients with acute coronary syndrome, leading to increased inflammation.
Researchers discovered a connection between atherosclerotic plaques and the central nervous system, involving immune cells, nerves, and cardiovascular tissues. This 'ABC' circuit can be modulated or disconnected, potentially leading to innovative therapies for treating atherosclerosis.
Researchers found that AI-enhanced diagnosis helps doctors accurately detect fetal congenital heart disease, with fellows making the most accurate diagnoses. The new system uses graphical charts to represent the AI's analysis of ultrasound videos, improving accuracy and trust among medical professionals.
A Cleveland Clinic-led trial found that an experimental 'gene silencing' therapy significantly reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 96%-98%. The therapy targets the gene responsible for Lp(a) production and has shown strong efficacy with no major safety concerns reported.
Researchers found smokers have significantly lower A1AT levels, which may reduce cardiac tissue protection during a heart attack. No difference was detected in hypertensive and non-hypertensive individuals.
The trial evaluated the use of mavacamten as an alternative to heart surgery or alcohol septal ablation for treating hypertrophic cardiomyopathy. Findings showed significant reduction in left ventricular outflow tract pressure gradient and improvements in quality-of-life measures.
The Experimental Biology (EB) 2022 meeting features live presentations and a moderated Q&A session on groundbreaking studies. The virtual press conference reveals potential treatments for Parkinson's disease, COVID-19 vaccine-associated side effects, and alleviating food allergies.