Articles tagged with Cardiovascular Disorders
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Researchers have discovered two independent ways genetic variants in HTRA1 increase cardiovascular disease risk, including stroke. The study found that rare and common variants affect protease activity and concentration, respectively.
The study identified specific patterns in blood samples of patients who had different clinical outcomes after a heart attack. These patterns, known as 'immune signatures', are associated with either better or worse recovery of heart function. The findings could lead to the development of new diagnostics and treatments for heart failure.
A new study reveals that high consumption of ultraprocessed foods among young children is strongly associated with increased adiposity and other cardiometabolic risk factors. The findings highlight the need for targeted public health initiatives to encourage healthier eating habits and reduce the burden of diet-related diseases.
The Global Burden of Diseases study reveals a 49.4% increase in global disability-adjusted life years (DALYs) attributable to metabolism-related risk factors between 2000 and 2021. High blood pressure, high blood sugar, and high BMI are key contributors to poor health and early death.
A meta-analysis of seven randomized trials found that transcatheter aortic valve replacement (TAVR) has comparable long-term safety and efficacy to surgical aortic valve replacement (SAVR). However, TAVR was associated with an increased likelihood of needing a pacemaker and moderate-to-severe paravalvular leaks.
A UK Biobank study suggests that adults living with obesity who were underweight or average weight in childhood may be at increased risk of all-cause mortality. The study found that adult men and women who reported being thinner as children had higher mortality risks, with a 63% and 60% increase respectively.
A new study found that elite runners who broke the four-minute mile barrier lived on average almost five years longer than the general population. The study reveals that aerobic fitness has a vital role in longevity and healthy living.
The American College of Cardiology and American Heart Association have released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy. The guideline recommends exercise as part of a healthy lifestyle, including low-to-moderate intensity recreational activities, while also introducing a...
Almost 90% of U.S. adults met criteria for cardiovascular, kidney, and metabolic syndrome (CKM) stage 1 or higher, with 15% meeting advanced stage criteria that did not improve between 2011 and 2020. Advanced stages were associated with increased risk among older age, men, and Black adults.
Jeffrey W. Moses, MD, is recognized for advancing the field of interventional cardiovascular medicine through technical excellence and leadership. Dr. Moses has performed over 20,000 interventional procedures and made significant contributions to clinical research and educational activities in interventional vascular therapy.
Scientists at University of Pittsburgh show that limiting glutamine and serine intake can halt disease progression in rodent models. The findings suggest a potential new therapy for patients with pulmonary hypertension, offering hope for improved treatment options beyond medications.
The American Society for Nutrition's NUTRITION 2024 will bring together thousands of experts to share emerging scientific and policy developments in food, nutrition, and public health. Over 1,600 original research studies will be presented during the meeting.
A new study suggests that stimulating specific areas of the brain can affect heart rate in individuals with depressive disorders. The researchers found high accuracy in identifying optimal treatment spots using heart rate measurements during brain stimulation.
Research suggests that controlling blood pressure through antihypertensive treatment can help prevent newly diagnosed uterine fibroids in midlife. The study of 2,570 participants found an increased risk of fibroids among those with untreated hypertension.
Researchers found that revascularization treatment significantly improves the quality of life for patients with chronic limb-threatening ischemia, a severe form of peripheral artery disease. The study revealed diminished quality of life among these patients, but revascularization restored sufficient blood flow and improved wellbeing.
The updated Fitness to Drive Guidelines recommend driving restrictions for individuals with seven cardiac conditions, including active coronary artery disease and implantable devices. These guidelines aim to support physicians in advising patients on safe driving practices.
A study led by Michigan Medicine found that around 10% of deaths following percutaneous coronary intervention are potentially preventable. Complications during procedures contributed to 20% of the nearly 1,200 deaths reported during the study period.
A recent White Paper published in the Canadian Journal of Cardiology analyzes the current understanding of genetics in atrial fibrillation and recommends screening for genetic heart disease in early onset AF cases. This may lead to identification of life-threatening ventricular cardiomyopathy and channelopathy syndromes, highlighting t...
Researchers used Google Street View to analyze built environment factors and found they can predict 63% of coronary heart disease variation between neighborhoods. Features like green spaces and walkable roads are associated with lower risk, while poorly paved roads with higher risk.
A new Kaiser Permanente study found that a health coaching intervention successfully reduced sitting time for a group of older adults by just over 30 minutes a day. The study also showed meaningful improvements in blood pressure, comparable to the effect of other interventions focused on physical activity.
Long-term BMI variability was a significant risk marker for adverse cardiovascular events, independent of mean BMI, across major racial and ethnic groups. The study's findings have implications for the phenotype of high BMI variability and potential preventive measures.
A multi-institutional team is creating innovative technologies to reduce complications associated with left ventricular assist devices (LVADs), including infection, thrombosis, stroke, and bleeding. The new LVAD will deliver a physiological response to changes in the recipient's activity levels using a 'smart' Maglev drive technology.
The American Society for Biochemistry and Molecular Biology's annual meeting features exciting research findings on antibacterial compounds, whooping cough infection, nicotine addiction, and more. Complementary on-site press passes will be issued to a limited number of attendees.
A study of over 2,500 adults found a correlation between PFAS levels and unfavorable lipid profiles, increasing cardiovascular disease risk. Researchers suggest stricter regulation of PFAS to protect health.
Researchers aim to address LVAD shortcomings, reducing blood damage and clotting risk through innovative designs and coatings. A novel flexible stented blood inlet and slippery hydrophilic coatings will be used to prevent flow stasis and clot formation.
Researchers found a higher risk of heart disease or stroke among patients who stopped taking aspirin, but no significant difference in major bleeding risk. The study suggests that patients already safely taking aspirin may continue to benefit from its use without increased risk.
Researchers developed a wireless device powered by light that can be implanted to regulate cardiovascular or neural activity in the body. The ultralight membrane is thinner than a human hair and contains no moving parts, offering a minimally invasive surgery alternative.
A new study found that chronic exposure to PM2.5 is associated with increased risk of hospital admission for various cardiovascular conditions, particularly ischemic heart disease and cerebrovascular disease. The study suggests that lowering annual average PM2.5 levels could decrease overall cardiovascular hospitalizations by 15%.
A recent study by Cleveland Clinic researchers discovered a connection between elevated niacin levels and an increased risk of heart disease. The study found that high levels of 4PY, a breakdown product from excess niacin, were strongly linked to the development of heart attacks and strokes.
Researchers discovered that consuming over 22% of daily calories from protein can lead to increased activation of immune cells contributing to atherosclerotic plaque formation. Leucine, an amino acid found in animal-derived foods, plays a disproportionate role in driving pathological pathways linked to atherosclerosis.
Researchers at Michigan State University have developed highly accurate synthetic human mini hearts that can be studied in a dish. This advancement is facilitating the development of new therapies and pharmaceutical drugs to treat various heart-related diseases. The mini heart organoids are becoming increasingly complex and realistic, ...
A new study found that women with migraines and long-term hot flashes or night sweats are at increased risk of heart disease and stroke. However, the research suggests that focusing on prevention and correcting unhealthy habits can help most women mitigate this risk. Women who have experienced both migraines and vasomotor symptoms for ...
A study published in Nature Cardiovascular Research reveals that a dynamic synergy between cell types facilitates cardiac renewal, challenging existing paradigms. Targeting the microenvironment rather than specific cell types is key to healing injured hearts.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
A recent study found that only half of hookah packages included the required nicotine warnings, two years after federal regulation was implemented. The study led by Boston University School of Public Health researcher Dr. Jennifer Ross highlights the importance of warning labels in communicating health risks to consumers.
A new tool, developed with a machine learning-based approach, can predict diuretic response in patients with ADHF. The BAN-ADHF score may lead to personalized strategies for effectively managing congestion in hospitalized patients.
A team of researchers has identified a new signaling pathway involved in the development of atherosclerosis, a chronic inflammatory disease of blood vessels. The study reveals that CCL17, produced by dendritic cells, promotes T cell activity and increases the risk of atherosclerosis.
Researchers developed an AI-driven algorithm that accurately predicts death and complications after percutaneous coronary intervention (PCI). The tool uses patient feedback to provide a patient-centered, individualized risk prediction score.
A new study published in Heart Rhythm found that over 10% of patients taking quetiapine or haloperidol developed heart rhythm disorders. The study highlights the need for vigilant monitoring of patients using these medications to minimize the risk of cardiac complications.
Research from the University of Pennsylvania School of Medicine sheds light on two rare heart conditions, dilated cardiomyopathy and peripartum cardiomyopathy. The study reveals that truncated titin proteins are present in hearts affected by DCM, indicating a potential link between genetic variants and disease development.
A nationwide Danish study found a slightly increased risk of arrhythmia in patients taking medical cannabis for chronic pain. The risk was more than twice that of those not receiving cannabis, with the largest increases observed in older adults and those with pre-existing cardiovascular conditions.
Researchers develop injectable hydrogel electrodes for treating ventricular arrhythmia, providing a potential solution to painful defibrillation and improving quality of life. The novel pacing modality addresses the pathophysiology of re-entrant arrhythmia and offers a promising alternative to existing therapies.
Researchers have discovered a way to predict which individuals will respond to blood pressure treatments that lower sodium in the body. This breakthrough could lead to a 25% reduction in hypertension prevalence, resulting in significant cost savings for the Australian government.
A study revealed that natto consumption significantly reduced atherosclerotic lesions in mouse models, altering intestinal microflora and regulating cytokine production. High vitamin K2 natto showed the most significant effect, decreasing pro-inflammatory cytokines while increasing anti-inflammatory IL-10 production.
Researchers have developed a stem cell-derived model of heart tissue that provides insight into tachycardia, a condition where the heart beats out of control. The engineered tissues were used to study how fast heart rates affect the heart and uncover the inner workings of the body's engine.
Research suggests that childhood sedentariness contributes to elevated cholesterol levels and premature heart attack or stroke in mid-life. Engaging in light physical activity for 3-4 hours/day may be effective in reducing high cholesterol.
Researchers have developed an AI-powered algorithm that can detect the risk of atrial fibrillation (AFib) with high accuracy, even in people with infrequent AFib episodes. This new tool has the potential to reduce the incidence of stroke and heart failure by identifying patients at increased risk and guiding targeted interventions.
A vegan diet has been shown to improve cardiovascular health in just eight weeks, according to a study led by Stanford Medicine. The researchers found that participants who followed a vegan diet had lower LDL-C levels, insulin, and body weight compared to those on an omnivore diet.
A study of 438,000 U.S. adults found that smoking cessation can significantly reduce cardiovascular, cancer, and respiratory mortality rates. Within a decade of quitting, former smokers' risk of cardiovascular death was approximately one-third that of continuing smokers.
A new study from Aarhus University found no association between working up to seven night shifts per month and the risk of coronary heart disease. The study, which analyzed data from over 250,000 employees, suggests that international studies may have been flawed due to reliance on questionnaires.
Researchers have identified a new therapeutic target for pulmonary hypertension treatment by discovering an epigenetic pathway mediated via the protein SPHK2 that can reduce and potentially reverse vascular remodeling. This discovery offers new hope for treating pulmonary hypertension, which is a complex and often fatal condition.
A study of US neighborhoods found a strong association between environmental burden and higher rates of cardiovascular risk factors and diseases. Socially vulnerable neighborhoods showed the strongest associations, highlighting the need for initiatives to address poor environmental conditions and improve cardiovascular health.
Patients with heart failure treated with dapagliflozin experienced frequent initial estimated glomerular filtration rate declines, but without increased cardiovascular or kidney event risks. The study suggests that sodium-glucose cotransporter-2 inhibitors can be safely continued in patients experiencing eGFR decline.
A recent clinical trial found that semaglutide significantly reduced cardiovascular events in adults with overweight or obesity who do not have diabetes. The medication was shown to lower the risk of death from cardiovascular causes, nonfatal heart attacks, and strokes by 20% compared to placebo.
A study published in JAHA found that sleep-related hypoxia is associated with a higher risk of developing atrial fibrillation over time. Regular screening and treatment of sleep apnea may help reduce the likelihood of AFib, especially in those already at high risk.
A study published in the European Heart Journal found that replacing sedentary behavior with moderate-vigorous activity reduces the risk of cardiovascular disease. Even small changes, such as taking a short walk or doing some light exercise, can have a significant impact on heart health.
A new study found that workplaces implementing flexible work arrangements can reduce employees' cardiometabolic risk, equivalent to a reduction of 5-10 years in age-related changes. The intervention had no negative impact on productivity and was particularly beneficial for low- and middle-wage workers.
A new analysis from Penn researchers projects a significant increase in US cardiovascular deaths due to extreme heat over the next four decades. Older adults and Black adults will experience greater increases in excess cardiovascular deaths due to extreme heat, according to the study.
The Canadian Cardiovascular Society has adopted a new classification system for heart attacks based on the extent of tissue damage, which aims to improve patient outcomes by guiding treatment and predicting disease progression. The four-stage classification outlines varying levels of injury following a heart attack.
A large real-world analysis provides vital insights into the safety of novel therapies for pulmonary embolism. Ultrasound-assisted catheter-directed thrombolysis emerged as the preferred approach due to its lower risk of complications, particularly major bleeding. The study also highlights the importance of individual patient character...