Articles tagged with Cardiovascular Disorders
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A study by University of Queensland researchers found a significant link between genetic risk of depression and heart disease in women, even in the absence of a depression diagnosis. The study highlights the need to understand this relationship separately in men and women due to varying risk factors.
Ken Perry, a UTA senior, has been recognized for his research on the connection between high-fat meals and cardiovascular health. He won two awards from the American Physiological Society for his work analyzing data collected from previous studies, which showed a correlation between high-fat consumption and changes in brain blood flow.
A recent Lancet review highlights racial disparities in sudden cardiac arrest and death among athletes, with Black athletes facing a significantly higher risk. The study emphasizes the need for increased research into social determinants of health and adequate pre-participation evaluation to mitigate these disparities.
The Emory University Hospital team successfully implanted the BrioVAD System, a novel magnetically levitated pump designed for patient ease and long-term health. This marks the first-time use of the device in the US, as part of the INNOVATE clinical trial.
Researchers found that GLP-1 receptor agonists reduced the risk of kidney failure by 16% and worsening of kidney function by 22%. The combined reduction in risk was 19%, showing a clear benefit on kidney protection. This study expands current knowledge about this class of drugs, highlighting their role in treating patients with chronic...
A new study maps genetic traits to cellular composition of atherosclerotic plaques, predicting future stroke or heart attack risk. The research improves risk assessment and treatment for patients with atherosclerosis.
Researchers at Monash University have discovered that LXA4 can halve inflammation and scar formation in diabetic hearts, offering a promising new treatment option. The study's findings suggest that LXA4-based therapies could be used to manage diabetic heart disease more effectively.
The Heart Institute is celebrated for delivering unparalleled treatment and support to children with heart conditions. It has consistently provided high-quality cardiac care and specialized disease management for all forms of cardiomyopathy.
A study reveals disproportionate burden of cardiovascular-kidney-metabolic syndrome among certain populations, emphasizing the need for targeted interventions. The research highlights the importance of addressing socioeconomic disparities in cardiovascular health.
A new oral medication, muvalaplin, has shown promising results in lowering lipoprotein(a) levels, a marker of cardiovascular risk. The study's findings suggest that muvalaplin may be a valuable treatment option for individuals with high lipoprotein(a) levels.
A study of 89,530 participants found that more than 10.5 hours of sedentary behavior per day increases the risk of heart failure and cardiovascular death, even among those who meet recommended exercise levels. Replacing excessive sitting time with physical activity can lower heart health risks.
A diet rich in soybean protein β-conglycinin has been shown to increase short-chain fatty acid production, which plays a role in protecting the heart. Analysis of gut bacteria identified an increase in specific SCFA-producing bacteria, further supporting the potential benefits of soy on heart health.
Dr. Jorge A. Miranda joins The Texas Heart Institute as leader of the newly established Limb Preservation Clinic, enhancing cardiovascular care for patients at risk for limb-threatening conditions. The clinic offers a team-based approach addressing immediate and underlying causes of peripheral vascular disease and cardiovascular disease.
A recent study published in the Journal of Vascular Surgery found that non-white patients have twice the risk of dying within 30 days of carotid endarterectomy compared to white patients. The study analyzed data from over half a million patients and highlights persistent racial disparities in medical outcomes.
Dr. Jeffrey Popma joins CRF as Chief Scientific and Strategic Officer, bringing decades of clinical and research experience to drive forward pivotal programs and initiatives. His leadership will shape CRF's future and fuel innovation at the Clinical Trials Center.
A recent study suggests that metabolic surgery can reduce the need for oral diuretics in patients with heart failure, resulting in a 65% decrease in diuretic use at 24 months after surgery. Patients who underwent metabolic surgery also experienced significant weight loss and improved quality of life.
A new study suggests that adding physical activity into daily life can help lower blood pressure. Replacing sedentary behaviors with 20-27 minutes of exercise per day was estimated to lead to a clinically meaningful reduction in blood pressure, while just five minutes of activity a day was also associated with reduced levels.
Symbiosis has developed an adjustable TMVR system, ValSync, which can adapt to complex anatomies. The company aims to overcome current limitations and improve patient eligibility, safety, and procedure time with its three-step process.
Research published in PLOS ONE reveals that prolonged sitting can boost the risk of heart disease and accelerate aging in young adults. The study found that even moderate exercise may not be enough to counteract the negative impacts of prolonged sitting.
Light ex-smokers experience a CVD risk reduction similar to never-smokers within years of smoking cessation. Heavy ex-smokers require longer periods, up to 25 years, for their residual CVD risk to align with that of never-smokers.
A randomized trial found early TAVR to be safe and effective for patients with asymptomatic severe AS, reducing the risk of composite endpoints and favorable health status outcomes. Patients who received early TAVR had better left-ventricular and left-atrial health compared to those on clinical surveillance.
The ECLIPSE trial found that routine orbital atherectomy had similar outcomes as conventional balloon angioplasty before stent implantation. Procedural complications were largely similar between groups, with no reduction in target vessel failure.
A machine learning algorithm developed by University of Cambridge researchers can detect and grade heart murmurs in dogs with high accuracy, similar to expert cardiologists. The technology has the potential to empower primary care veterinarians to provide early detection and treatment, improving quality of life for dogs.
The Cardiovascular Research Foundation recognizes 29 leading institutions for their contributions to groundbreaking research advancing interventional cardiovascular medicine. The 2024 SET-10 rankings celebrate institutions making significant impacts across various categories, including basic science and clinical research.
A new study suggests that immunotherapy may be an effective treatment strategy for heart failure by blocking scar tissue formation and improving heart function. Researchers identified a type of fibroblast cell responsible for scar tissue and used a monoclonal antibody to reduce its formation, showing promising results in mouse models.
Researchers at Johns Hopkins University developed a fast and accurate blood test that can detect the earliest signs of a heart attack in minutes. The stand-alone test provides results in five to seven minutes, making it more accessible for first responders and people at home.
Researchers at Penn Engineering and PSOM will develop AI systems to predict treatment response in breast cancer, heart attacks, and sepsis. The goal is to support clinicians with accurate and transparent predictions, leading to better health outcomes for patients.
A nationwide mortality data study found Native Hawaiian Pacific Islander (NHPI) adults have the third highest cardiovascular death rate in the US, with approximately 40% of deaths attributed to coronary heart disease. The study highlights a need for focused interventions to promote cardiovascular health among NHPI adults.
Biomedical engineer Jeff Saucerman has received a $3.1 million NIH grant to study low-density lipoprotein receptor 1 and its impact on heart failure and treatment outcomes after a heart attack.
Researchers develop smartphone-adaptable tool to measure impact of nicotine-infused e-cigarettes on cardiovascular health. The study reveals vaping with nicotine accelerates vascular aging and impairs left ventricle function.
Researchers found that patients who consumed caffeine had better vascular health, as measured through endothelial cells. The study suggests that caffeine may play a role in controlling disease progression and improving cardiovascular health.
A new study identifies phosphatidylinositol 4,5-bisphosphate as a key regulator of the SK2 channel, which plays a critical role in cardiac ion channels and heart rhythm. The research provides critical translational insights into possible mechanisms of cardiac arrhythmias in heart failure.
A global study highlights the life-saving impact of Guideline-Directed Medical Therapy (GDMT) in heart failure patients, particularly those with reduced ejection fraction (HFrEF). The study estimates that optimal implementation could save over 1 million lives per year, with significant regional disparities to address.
Research found that babies conceived through assisted reproductive technology have a 36% higher risk of major heart defects compared to naturally conceived babies. The study also showed that multiple births are associated with an even greater risk of congenital heart defects.
Researchers identified changes in the UBR4 gene as a key driver of fibromuscular dysplasia, a blood vessel disorder affecting up to five percent of adults. The discovery could lead to therapeutic approaches for the condition, particularly beneficial for women who account for 90% of cases.
Researchers developed a tri-culture heart-on-a-chip model of cardiomyocytes, fibroblasts, and endothelial cells to mimic in vivo cardiac behavior. The study successfully replicated endothelial cell morphology and functionality, as well as cardiac function with increased contractility.
A new UCLA-led study found that Chinese American immigrants' cardiovascular health increases with length of residence and varies by US location. Participants who resided in Chicago showed lower mortality levels from heart disease compared to those in Los Angeles.
A temporary heart stimulator self-assembles around the heart after injecting nanoparticles, correcting irregular heartbeats and facilitating ECG measurements. The device can operate for up to five days with low power inputs from handheld devices like mobile phones.
Patients with post-COVID-19 mRNA vaccination myocarditis show lower cardiovascular complications at 18 months compared to those with conventional myocarditis. However, affected patients may require medical management for several months after hospital discharge.
A modeling study estimates that cancer screening costs over $40 billion annually in the US, with an emphasis on enhancing equitable access to recommended screenings. However, experts argue that this estimate may underestimate the true cost due to lack of consideration for subsequent testing, ineligible patients, and overdiagnosis.
A new study analyzing health records from 46 million adults in England found that COVID-19 vaccination significantly reduces the incidence of heart attacks and strokes. The incidence was up to 10% lower after the first dose and up to 27% lower after two doses, especially with the AstraZeneca vaccine.
A new study has identified CCL27 and TNFRSF14 as genetic markers in inflammation that may contribute to stroke recurrence. These findings could lead to novel drug targets to mitigate disability and mortality after a first stroke.
Researchers discovered that docosahexaenoic acid (DHA) inhibits the Orai1 channel, a store-operated Ca2+ channel, reducing gastric fundus smooth muscle contractions. DHA also prevents excessive gastric motility by targeting two types of Ca2+ entry channels.
A major study found that people who gained excess weight from their 20s onwards had less healthy hearts by the time they were in their 60s. The researchers linked weight gain in young and middle-aged adults to enlarged hearts that pump blood less well, over and above the effect of being overweight in later years.
Researchers found that inhibiting the AGTR1 receptor with losartan disrupted cancer growth, slowed development and prolonged survival in mice. This targeted gene therapy also protected the heart against chemotherapy-induced cardiotoxicity.
Researchers found that men with a higher proportion of blood cells missing the Y chromosome have a higher risk of dying from heart failure. Elevated Y chromosome loss is associated with decreased treatment response in patients with transthyretin cardiac amyloidosis, a progressive disease causing heart failure and death.
Researchers at the Lewis Katz School of Medicine will investigate how injured heart cells communicate with other cells throughout the body using microvesicles known as exosomes. The study aims to understand how specific molecules, such as microRNAs, facilitate communication pathways between cells in the heart and vasculature.
Researchers discovered a step-by-step process of calcification in aortic valves, revealing two defense mechanisms: osteopontin and collagen fibers. The study provides new insights into understanding cardiovascular calcification and potential therapeutic applications.
A Canadian Journal of Cardiology review article finds that plant-based meat alternatives tend to reflect a heart-healthy dietary pattern, improving cholesterol levels and blood pressure. The authors recommend incorporating PBMAs into a healthy diet as an excellent protein source, with options lower in saturated fat and sodium.
A new study by Harvard T.H. Chan School of Public Health found that chronic loneliness may significantly raise the risk of stroke among older adults. The research suggests that loneliness, experienced chronically, plays an important role in stroke incidence and is associated with a higher risk of long-term disability and mortality.
A study using induced pluripotent stem cells has revealed that inflammation triggered by retrotransposons and interferon signaling causes atherosclerosis in Werner syndrome patients. The researchers propose targeting the interferon signaling pathway as a potential treatment for reducing stroke and heart attacks.
A study by Linköping University researchers found that disturbed blood flow can cause inflammation and breakdown of the vessel wall in cases of aortic dilation. This discovery could lead to better diagnosis and treatment options for patients at risk of serious complications.
In individuals with a diabetes duration of 10 years or less, bariatric metabolic surgery was associated with greater weight loss and reduced mortality compared to first-generation GLP-1RAs. No differences were observed between treatment modalities in patients with longer diabetes duration.
A recent Cleveland Clinic-led study found that high levels of the sugar alcohol xylitol are associated with an increased risk of cardiovascular events like heart attacks and strokes. The research team identified a link between xylitol consumption and elevated platelet activity, which can lead to blood clots and thrombosis.
Researchers at Uppsala University found that macrophages in injured muscle tissues transform into cells resembling mural cells, promoting restoration of blood flow and healing. This finding highlights the potential for immunotherapies to enhance vascular integrity and tissue repair.
A study published in Heart Rhythm examined the potential dangers of energy drink consumption in patients with genetic heart diseases. The research found a temporal relationship between energy drink consumption and sudden cardiac arrest events, but caution is advised due to the small relative risk.
Researchers found a significant association between higher Mediterranean diet intake and lower risk of death from cancer and cardiovascular disease. The study's findings suggest that modest changes in established risk factors can yield substantial long-term benefits from following a Mediterranean diet.
Patients who received COVID-19 vaccines after acute coronary syndromes had similar rates of primary composite end point and major adverse cardiovascular events (MACE) compared to unvaccinated patients. Retrospective studies have shown a short-term reduction in MACE risk after COVID-19 vaccination.
Researchers at the University of Florida found that orange peel extracts can reduce harmful chemicals in the body. The study identified a compound called feruloylputrescine that inhibits the enzyme responsible for TMA production, paving the way for developing functional foods enriched with bioactive compounds.
The SELECT Trial found semaglutide to significantly reduce the risk of kidney-related complications and improve kidney function in individuals with overweight or obesity and cardiovascular disease. The study revealed that semaglutide's ability to prevent macroalbuminuria was a key factor in reducing kidney-related events.