The global cervical cancer vaccine roll-out has shown significant effectiveness in reducing HPV-related diseases. However, there are huge variations in coverage between countries, with high-income nations leading the way and many low- and middle-income countries lagging behind. Globally, only 44% of girls have received at least one dos...
The innovative Integrated Virtual Care (IVC) program successfully connected residents with family physicians in Renfrew County, addressing the rural shortage of primary care providers. Over 2,800 unique patient appointments were conducted, with 70% done virtually, offering comprehensive team-based primary care.
Researchers have developed a urine-based test that detects pieces of DNA fragments released by head and neck tumors, providing a non-invasive alternative to traditional blood-based biomarker tests. The test has been shown to detect cancer recurrences far earlier than would typically happen based on clinical imaging.
Researchers have identified new genetic variants linked to susceptibility of cervical cancer-causing virus, raising the risk of getting cervical cancer from high-risk HPV infection. The study found polygenic risk scores to determine likelihood of having prevalent or persistent HPV infections.
Researchers at Mass General Cancer Center presented advancements in rapid nucleic acid detection for cervical cancer screening using CRISPR technology. They also showcased improvements to CAR T cell therapy for pancreatic cancer, highlighting the importance of dynamic functional control to enhance its efficacy.
Low HPV vaccine uptake among US adults aged 27-45 is a concern, particularly for men and Hispanic individuals. Experts stress the need to address disparities in vaccination rates to prevent cancer cases.
A new study suggests that removing barriers to cervical cancer screening, surveillance, and diagnostic procedures can save lives and reduce disparities. If every eligible person gets the full screening and follow-up tests recommended, up to 23% fewer people would be diagnosed with cervical cancer and 20% fewer would die from it.
A study by Cancer Research UK reveals that mortality rates have dropped by 37% in men and 33% in women, with significant reductions in cervical cancer and lung cancer. However, cancer cases are on the rise overall, and researchers warn of an immense challenge ahead to maintain progress.
Researchers at York University found that women with both high-risk human papillomavirus (HPV) and metabolic syndrome are at a significantly higher risk of mortality. The study analyzed data from over 5,000 individuals and found that those with both conditions had a 2.6 times higher risk for mortality than those without either condition.
Researchers developed gene-edited lymphocytes that target HPV-specific antigens in cervical cancer cells, evading immune responses and achieving strong cytotoxicity. These 'off-the-shelf' therapies offer a promising approach to treating cervical cancer.
A new study published in Oncotarget reveals a higher prevalence of germline BRCA1 and BRCA2 mutations in ovarian cancer patients from the Salento peninsula, with 28.6% having familial cases and 39.7% having sporadic cases. The study found that 29.8% of patients were carriers of BRCA1/2 mutation.
Research finds socioeconomically advantaged parents are less likely to vaccinate their teens against HPV due to safety concerns. Parents from disadvantaged groups cite lack of knowledge as a reason for hesitancy.
Researchers discovered that women with high-risk HPV infection have a significantly increased risk of blocked arteries, heart disease, and stroke. The study highlights the importance of monitoring cardiovascular health in patients with high-risk HPV, particularly those with obesity or other risk factors.
Cancer kills more Black people than White individuals in the Barretos region, whereas in São Paulo city, it is the opposite, according to a study published in Cancer Causes & Control. The disparity is most pronounced for breast and cervical cancer among Black women.
Experts predict a significant increase in bowel cancer death rates among young adults in the EU and UK, driven by rising obesity and heavy alcohol consumption. Death rates are predicted to rise by 26% in men and nearly 39% in women in the UK, with similar increases seen in Italy and other European countries.
Studies published in Nature Medicine show that implementing updated WHO screening guidelines could reduce cervical cancer death rates by over 63% in low-to-middle-income countries. Women with HIV have a sixfold risk of developing cervical cancer, and primary HPV testing can save up to 38 women's lives for every 71 screened.
A study of 562,000 women with endometrial, ovarian, or cervical cancer reveals racial and ethnic disparities in clinical trial enrollment. Underrepresented groups face significant barriers to participation, highlighting the need for continued efforts to address these disparities.
Adding immunotherapy atezolizumab to chemotherapy and bevacizumab improved overall survival by 32.1 months compared to 22.8 months with standard therapy alone. The two-year survival rate was also higher, with 60% in patients treated with the experimental combination.
A recent study published in The BMJ suggests that actively monitoring abnormal cells on the cervix rather than removing them immediately may be associated with a higher long-term risk of cervical cancer. Women who underwent active surveillance had a nearly fourfold higher risk of cervical cancer after 20 years compared to those who rec...
A randomized clinical trial of 31,000 individuals found that direct-mail human papillomavirus (HPV) self-sampling increased cervical cancer screening by more than 14%. The study suggests that systems implementing HPV self-sampling should prioritize direct-mail outreach for under-screened individuals to increase screening adherence.
A new study funded by Cancer Research UK reveals that smoking tobacco causes 20.8 million years of life loss each year, with four preventable risk factors contributing to over 30 million years of life lost annually. The study suggests that action on a global scale could save millions of lives from preventable cancers.
A study published in PLOS ONE found that nitrile gloves can effectively prevent the collapse of speculums during pelvic exams, reducing discomfort and misdiagnosis. The researchers used a physical model to test the effectiveness of gloves versus condoms, with promising results.
A study published in Cell Host and Microbe found that gender-neutral HPV vaccination is effective in preventing cervical cancer by inducing a stronger herd immunity. The vaccine protects against high-risk HPV types 16 and 18, which cause 70% of all HPV-related cervical cancers, and also provides cross-protection against low-risk types.
Research by George Mason University found that women with physical disabilities have lower cervical cancer screening rates, highlighting the need for improved access to preventive health services. The study's findings also reveal disparities in screening rates among different types of disabilities.
A team of researchers at Kyoto University has found that a deficiency in the enzyme B4GALT3 inhibits tumor growth in mice. The study shows that reduced glycosylation on T cell surfaces correlates with increased CD8+ immune cells infiltrating tumors.
The INTERLACE trial found that a short course of induction chemotherapy prior to chemoradiation significantly improves survival and reduces recurrence in locally advanced cervical cancer patients. The study results show a 35% reduction in recurrence, with 80% of patients alive and 73% without cancer return or spread after five years.
Researchers documented a steady increase in cervical cancer incidence and death rates in Appalachian Kentucky from 2000 to 2019. The region's cervical cancer death rate is now twice the national average, with distant-stage cancers increasing by 5.5% per year.
Researchers discovered that lactate-producing intratumoral bacteria drives resistance to radiation therapy. Cancer cells respond to radiation by rewiring metabolic signaling pathways using lactic acid instead of glucose.
A new cancer immunotherapy that targets two immune-evading tumor tactics has shown promising results in an early clinical trial. The drug, tebotelimab, blocks both PD-1 and LAG-3 proteins, leading to a double-digit response rate in patients with advanced solid tumors or blood cancers.
A multilevel primary care intervention, including electronic health record reminders and patient outreach, improved timely follow-up of overdue abnormal cancer screening test results for breast, cervical, colorectal, and lung cancer. The intervention was found to be effective in reducing missed screenings.
Researchers found that short-form videos on TikTok can inform and encourage women to get regular pap tests, particularly when created by doctors. The studies also showed that autonomy-supportive messages improved attitude toward the message and engagement intention.
Researchers found that using electronic prompts during appointment scheduling for seasonal flu and COVID-19 vaccines can identify willing participants for HPV and shingles vaccines. Only 30% of those booking for these vaccines were already vaccinated against HPV, presenting a significant opportunity for targeted campaigns.
Two liquid biopsy tests identified patients with a high risk of cervical cancer recurrence after chemoradiation treatment, allowing for earlier detection and potential improvement in outcomes. The tests detected HPV ctDNA in the blood of patients with residual disease, providing insight before tissue biopsy becomes possible.
Patients who engage in regular sexual activity or vaginal dilation have a lower risk of long-term side effects, including vaginal stenosis. Regular dilation and/or sex were associated with lower risk of moderate-grade vaginal shortening and narrowing five years after treatment.
A new Canadian guideline aims to promote health equity among marginalized groups by providing 16 preventive care recommendations. The guidelines focus on removing barriers to healthcare, prioritizing people from disadvantaged groups, and improving access to essential screenings and interventions.
A new study by Ohio State University found that most gynecologic cancer-related content on TikTok is poor in quality and accuracy. The majority of the content, over 73%, was deemed inaccurate and of poor educational quality, with racial disparities also present.
Chung-Ang University researchers create an electrochemical DNA biosensor that detects HPV-16 and HPV-18 with high specificity, facilitating early diagnosis of cervical cancer. The sensor uses a graphitic nano-onion/MoS2 nanosheet composite to enhance conductivity.
Scientists at Montefiore Einstein Cancer Center have developed a novel HPV test that detects cervical adenocarcinoma and its precursor lesions with high sensitivity. The test assesses methylation levels in cervical tissue samples, offering a more accurate detection method for this common type of cancer.
A new study estimates that cancer screenings have saved the US at least $6.5 trillion and led to 12 million more years of life, with significant economic impact from breast, colon, cervical, and lung cancer screenings.
A study finds that additional recommended cervical cancer screenings before birth are associated with an increased risk of preterm delivery. The findings suggest that cervical cancer screening guidelines should consider the downstream implications for preterm delivery risk when weighing population-level costs against benefits.
Researchers from Korea University Medicine have discovered a potential therapeutic target for overcoming cisplatin resistance and neuropathic pain in cervical cancer. By inhibiting TRPV1, they found that resistant tumors became vulnerable to cisplatin, improving the outlook for patients.
Rice University engineers developed a low-cost, point-of-care DNA test for HPV infections that can be used to screen for cervical cancer. The test, which requires just two pieces of equipment and delivers results in 45 minutes, has the potential to make cervical cancer screening more accessible in low- and middle-income countries.
A new study published in the Journal of the American College of Surgeons found that people who live in historically redlined areas are less likely to be screened for breast, colorectal, and cervical cancer. The legacy of redlining continues to contribute to significant disparities in cancer screening rates.
A new study found that obesity is associated with an increased risk of certain cancers, with stronger links in female patients for gallbladder and endometrial cancer. The study also revealed differential effects between sexes on colorectal, esophageal, and liver cancer.
A new study found significant reductions in breast, colorectal and prostate cancers as well as melanoma diagnoses in Alberta during the COVID-19 pandemic. Diagnoses dropped by 43% for melanoma, 36% for colorectal and prostate, and 33% for breast cancer during the 'state of emergency' phase.
A new study published by LSU Health New Orleans found that a diet high in fruits, dark-green vegetables, and beans can significantly lower the risk of genital high-risk-HPV infection, which is associated with cervical cancer. The research also showed that women who eat healthily tend to practice other healthy behaviors.
Scientists have identified a specific gene mutation that triggers an inflammatory cascade, driving the development of treatment-resistant cancers. The study reveals a molecular circuitry by which mutations in the STK11 gene cause inflammation to spiral out of control.
Researchers found mailing HPV self-collection tests and offering assistance improved cervical cancer screening nearly two-fold among low-income women. Screening uptake increased to 72% among women who received mailed HPV kits, compared to 37% for those with scheduling assistance alone.
A Phase 3 trial found that mailing HPV self-collection kits and scheduling assistance increased cervical cancer screenings among under-screened, underserved women. The study demonstrated the effectiveness of this approach in breaking down access barriers to screening.
A US-based clinical trial found that mailing high-risk human papillomavirus (hrHPV) sampling kits to low-income, under-screened women increased cervical cancer screening uptake by nearly double. The study used intensive community outreach campaigns and mailed HPV kits with effective help scheduling in-person appointments.
A new study found that remote outreach involving interactive education and follow-up support via telephone increased breast, cervical, and colorectal cancer screening rates among rural women. The combination of a remotely delivered interactive DVD and patient navigation services resulted in a six-fold increase in screenings.
Researchers at Oregon State University have created a new model for evaluating potential cervical cancer drugs. The study, led by Kaitlin Fogg, enables the simultaneous and rapid testing of multiple drug compounds, opening the door to large-scale screenings that can uncover new therapies and personalized medicine options.
Researchers identified ARID1A and PIK3CA as potential targets for drug development in recurrent and metastatic cervical cancer. The study found that these mutations were associated with improved survival rates, suggesting their potential as new treatment options.
The NRG-GY017 trial found that atezolizumab improved 2-year disease-free survival rates (79% vs. 59%) and pathologically complete or partial responses (69% vs. 40%) for patients with locally advanced cervical cancer. The study also showed a favorable immune response, including positive PD-L1 scoring and T-cell receptor clonal expansion.
A study published in The Lancet Public Health found that women with mental illness are twice as likely to develop cervical cancer due to low screening rates and increased incidence of precancerous lesions. Researchers highlight the need for proactive measures to address inequality in care.
Researchers found that miR-145 suppresses cervical cancer cell growth and inhibits aerobic glycolysis. Targeting miR-145 is expected to be an effective strategy for cervical cancer treatment, according to the study.
A study of 19,000 female participants found mailing HPV self-sampling kits to be an efficient way to increase screening rates among eligible women. This cost-effective approach supports the use of mailed HPV kits as an outreach strategy for U.S. healthcare systems.
A new smoking cessation intervention, MAPS, has been shown to increase smoking abstinence rates in patients with cervical cancer or precancerous disease by over two-fold. The study found that extended treatment and sustaining the program may be necessary for long-term abstinence.
A study of nearly 24,000 individuals reveals insurance status as a modifiable risk factor for racial and ethnic inequities in advanced cervical cancer diagnosis. Expanding access to care may mitigate these inequities.
A global study aims to better understand the burden of Human papillomavirus (HPV) among girls and women in low- and lower middle-income countries. The study will inform effective strategies to prevent infection and introduce HPV vaccine into national programs, protecting the health of girls and women and reducing rates of cervical cancer.