Articles tagged with Embryo Implantation
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Scientists have engineered a system replicating the womb lining to investigate embryo-mother interactions during implantation. The new model reveals crucial details about the complex communication between the embryo and endometrium, shedding light on causes of implantation failure and pregnancy complications.
Embryos and the uterus engage in a dynamic dialogue mediated by extracellular vesicles, influencing embryo attachment and implantation. Lipid droplets are also found to play an active role in this communication network.
Researchers at Stowers Institute for Medical Research have identified the precise location where human chromosomes break and recombine to form Robertsonian chromosomes. The study reveals that repetitive DNA sequences play a central role in genome organization and evolution, explaining how these rearrangements form and remain stable.
Scientists have achieved a major breakthrough by 3D bioprinting miniature placentas, which can accurately replicate the human placenta. This technology has the potential to transform pregnancy research by allowing for the study of serious complications like preeclampsia.
Researchers developed a technique to study embryonic implantation in mice by keeping mouse uterine tissue alive outside the body. The method showed over 90% efficacy for implantation and provided insights into the maternal-embryonic signaling process.
Human embryos exert significant forces during implantation to break down surrounding tissue and penetrate the uterus. The study reveals that effective invasion is associated with optimal matrix displacement, highlighting the importance of these forces in the implantation process.
A new international study reveals that male partners over 45 carry significantly increased miscarriage risks and lower live birth rates even when young donor eggs are used. The study found that older paternal age is linked to genetic mutations, sperm DNA fragmentation, and epigenetic changes, impairing embryo development.
Scientists at the University of Copenhagen have created 'super stem cells' that outperform regular stem cells by developing into multiple cell types. These 'super stem cells' show promise in improving fertility treatment, particularly IVF success rates, by producing essential tissue for early embryonic development.
Researchers at the University of Montreal have found that guinea pigs can serve as a reliable and robust small animal model to study human preimplantation development. The study provides new insights into the development of healthy embryos and fetuses, which could lead to improved fertility treatments and reproductive technologies.
Researchers found that a Lactobacillus-dominant uterine environment significantly improves pregnancy outcomes and increases pregnancy success rates. Disruptions in microbiota composition have been linked to conditions such as chronic endometritis, endometriosis, and recurrent implantation failure.
A new study suggests that boosting T-regulatory cells may improve the chance of healthy pregnancy and reduce miscarriage risk. Researchers found that treatment with interleukin-2 and antibodies targeting these cells improved pregnancy outcomes in mice, reducing miscarriage rates from 30% to 11%.
A new study found that the effects of alcohol exposure on an embryo prior to implantation can be detected in the late-gestation placenta. The research revealed significant molecular changes in the placenta, including DNA methylation alterations that could serve as a molecular signature for detecting alcohol exposure.
Researchers from Kumamoto University discovered that prostaglandin receptors in the uterus enhance decidualization, a crucial process for successful pregnancy. This finding opens the door to developing new fertility treatments targeting these receptors.
A uniform lexicon has been developed and endorsed by a multi-medical society panel to describe observations on ultrasound during the first trimester of pregnancy. The new terms aim to minimize bias, clarify findings, and respect patient preferences.
A Chinese Medical Journal study developed an AI-based system to automate embryo selection and eliminate subjectivity in IVF. The system improved human embryo assessment and selection, achieving higher accuracy in embryo aneuploidy screening than experienced embryologists.
A large-scale randomized controlled trial found no difference in live birth rates between time-lapse imaging and standard approaches used in IVF. The study suggests that time-lapse imaging does not improve clinical outcomes for women undergoing fertility treatment, contrary to theoretical benefits.
A new study has found that gestational carriers experience a severe maternal morbidity rate of 7.1%, significantly higher than unassisted conceptions (2.4%) and IVF conceptions (4.6%). Gestational carriers are also at risk for postpartum haemorrhages and hypertensive disorders, which can be serious complications during pregnancy.
A Phase 2 clinical trial demonstrated the effectiveness of OXO-001 in increasing embryo implantation, pregnancy and live birth rates among infertile women. The study showed significant improvements in biochemical, clinical and ongoing pregnancy rates, with a notable increase in live birth rates.
Researchers discovered a breakthrough in mouse embryo development, where primitive endoderm cells can generate an embryo on their own. These cells also have the potential to improve IVF outcomes by developing into stem cell-based embryo models.
A new study from the University of Birmingham and the University of Nottingham found that the UK public is more accepting of adoption and surrogacy methods when one or both parents are infertile. The research showed significant increases in support for these methods, including planned private adoption and double donor surrogacy.
Researchers at Dartmouth College found that fruit fly oocytes can renew chromosome-linking proteins, potentially helping older women reduce pregnancy complications. The discovery could lead to new therapeutic strategies for enhancing protein rejuvenation in human eggs.
A study published in PLOS Medicine found that children born via frozen embryo transfer have similar metabolic profiles to those born via fresh embryo transfer. The research compared over 4,000 children aged 2-5 years and found no differences in blood glucose, insulin, or cholesterol levels.
Cell contraction, not adhesion, drives human embryo compaction, a crucial step in normal development. Defective contractility prevents implantation and ART success.
Researchers used 'mini-placentas' to understand how the placenta interacts with the uterus, which is critical for fetal growth and development. The study identified key proteins involved in successful implantation and found clues on how pre-eclampsia occurs.
A new study published in PLOS Medicine found no association between assisted reproductive technologies and body mass index in children, except when using frozen embryos. The study analyzed data from Denmark and other countries, providing insights into the health outcomes of children born through assisted reproductive technologies.
Researchers created an immunodeficient mouse model of physiological ovarian aging, mirroring female fertility decline with age. The study found decreased oocyte quality, impaired follicle activation and growth, and increased mitochondrial dysfunctions in Old mice.
Researchers found a 30% higher likelihood of live births when eggs were collected in summer rather than autumn. They also discovered that bright sunshine on the day of egg collection increased the chances of a successful pregnancy.
A new UMass Amherst study aims to develop a more robust understanding of the effects of ambient air pollution on women's reproductive health. The researcher will analyze data from 1,228 participants to identify mechanisms and susceptible reproductive processes across the menstrual cycle and early pregnancy.
Researchers discovered that ZC3H11A is essential for regulating metabolic genes in embryos and their absence leads to complete lethality. The study's findings suggest that ZC3 may be a promising therapeutic target for the development of anti-viral agents against medically significant human viruses.
A team of investigators created embryo-like structures from monkey embryonic stem cells and transferred them into female monkeys, which implanted and elicited a hormonal response similar to pregnancy. The study provides new tools and perspectives for exploring primate embryos and reproductive medical health.
Research from Texas A&M University reveals that male alcohol use has a significant negative influence on in vitro fertilization (IVF) success rates. The study highlights the importance of expanding fertility and prepregnancy messaging to emphasize the reproductive dangers of alcohol use by both parents.
A pooled data analysis found that deep brain stimulation reduced OCD symptoms by 47% and improved substantial outcomes in two-thirds of participants. This treatment approach showed promising results in addressing severe OCD with substantial improvement in approximately half of the patients.
Researchers at KU Leuven have developed a new model of human extraembryonic mesoderm cells, which closely resemble their natural counterparts in early embryos. This breakthrough enables scientists to study processes previously inaccessible during development.
A large Nordic study found that children born after frozen-thawed embryo transfer had a higher risk of cancer than those conceived naturally or through fresh embryo transfer. The most common types of cancer seen were leukemia and central nervous system tumors.
A new prenatal test called STORK can determine if a fetus or embryo has the right number of chromosomes in under two hours, reducing time and cost. The test is about 10 times less expensive to process per sample and can improve treatment options for women trying to get pregnant.
Researchers using 'blastoids' - in vitro models of the blastocyst - discovered that early embryonic signals induce placental development and prepare the uterus. The findings may contribute to a better understanding of human fertility and potentially improve IVF procedures, fertility drugs, and contraceptives.
A large study analyzing over 4.5 million pregnancies found that frozen embryo transfers in IVF are associated with a substantially higher risk of hypertensive disorders, particularly pre-eclampsia, compared to naturally conceived pregnancies. The risk was roughly doubled for FETs, while fresh embryo transfers had similar outcomes.
A study found that 70% of women who froze eggs at age 38 and thawed had a baby, compared to fewer than 30% undergoing IVF at age 40. Egg freezing resulted in higher pregnancy success rates than using fresh embryos.
A comprehensive review of 38 interventions performed at embryo transfer found that bed rest post-procedure decreased pregnancy rates by 15%. The use of ultrasound guidance and soft catheters increased pregnancy chances by 26% and 12%, respectively. The study calls for more research into promising interventions to optimize IVF success.
Researchers found that women are less likely to undergo common heart procedures and more likely to die in the hospital after receiving them. The study analyzed data from over 2 million hospitalizations for heart procedures between 2016 and 2019, revealing significant disparities in treatment and outcomes based on sex and race.
Researchers have discovered that bioprosthetic heart valve patients develop an immune response against foreign sugars in the valves, leading to calcification and deterioration. By genetically engineering these sugars out of the valves, durability can be increased, offering a potential solution for patients.
Researchers from Tel Aviv University have engineered 3D human spinal cord tissues and implanted them in lab models with long-term chronic paralysis, resulting in an 80% success rate in restoring walking abilities. The team aims to conduct clinical trials in human patients within a few years to make the treatment commercially available.
A survey of 121 fertility specialists in Australia, UK, and New Zealand found that endometrial scratching is still offered by 34% of clinics despite lack of evidence, primarily for psychological benefits. Many respondents considered the procedure's drawbacks, including pain and cost.
Researchers have discovered molecules that could be candidates for contraceptives or fertility enhancers using human blastoid models. These models also show promise in improving the self-organization of stem cells during IVF procedures.
A study found that many IVF embryos with chromosomal abnormalities have the potential to lead to successful pregnancies. Embryos with low-grade mosaicism had similar live birth rates and miscarriage rates as euploid embryos.
Researchers at the University of Kent identified strong evidence-based benefits of preimplantation genetic testing for aneuploidy (PGT-A) in IVF. Live birth rates per embryo transferred and per treatment cycle were significantly higher with PGT-A compared to regular IVF, especially in women over 40.
Researchers at CNIC have identified the essential role of GPR126 in placental development, revealing its critical function in fetal growth and viability. The study also highlights a possible link between GPR126 dysfunction and pregnancy complications such as preeclampsia.
A new study has identified a transposon promoter that plays a crucial role in the development of mice and may also be essential for human viability. The discovery suggests that ancient viral DNA has been domesticated to regulate key biological processes, such as cell proliferation and embryo implantation.
Researchers found that selecting the embryo with the lowest predicted risk score reduces disease risk more effectively than eliminating high-scoring embryos. However, polygenic embryo screening offers no guarantees about a baby's health and has limited effectiveness depending on factors like ancestry and age.
Researchers at RMIT University have discovered a Teflon-like molecule on the womb's surface that decreases at a certain point in the menstrual cycle, opening the 'golden window' for pregnancy success. This finding could lead to improved IVF success rates and potentially treat underlying causes of infertility.
Scientists have identified a trigger for human embryo 'head-to-tail' axis development between days 7 and 14 of gestation. The hypoblast cells send a message to the embryo that initiates body axis formation, leading to changes in gene expression.
A randomized trial demonstrates that TAVI with a self-expanding supraannular bioprosthesis is comparable to surgical aortic valve replacement in terms of mortality and stroke risk at 24 months. Additionally, the study reveals that TAVI is superior to surgery in terms of valve hemodynamics but not in pacemaker implantation rates.
A study reviewed 286 patients who underwent ICD implantation between 2013 and 2016, assessing appropriateness based on AUC. The results showed a high rate of appropriate ICD implantations and very low prevalence of rarely appropriate implantations.
Subcutaneous S-ICD therapy is explored as an option for patients with congenital heart disease and high risk of sudden cardiac death. A case study reports successful S-ICD implantation in a patient with ccTGA and DDD pacemaker, without interference between systems.
An artificial intelligence system developed by Brigham and Women's Hospital can differentiate and identify embryos with the highest potential for success better than trained embryologists. The system achieved an accuracy of 90% in choosing high-quality embryos, outperforming experts in this field.
A large-scale assessment of long-term survival and reintervention after aortic ViV found that smaller failed bioprostheses were associated with lower survival rates. The type of transcatheter valve used also influenced the need for reintervention, with EBEV being a significant risk factor.
Two researchers received a prestigious award for their innovative methods in reducing animal use in poultry red mite testing and developing human and mouse embryonic stem cell cultures. Their work has significantly reduced the number of animals used in these fields, paving the way for further improvements in 3Rs research.
A new study suggests that local doctors in rural areas can safely and effectively care for patients with left ventricular assist devices, reducing travel burdens and improving survival rates. Shared medical care eliminates the need for extensive travel, eases financial and emotional strains on patients.
A recent study explored how some mammals postpone embryonic development to await better conditions. The research, led by Abdiasis Hussein, advances understanding of delayed embryo implantation and suggests a link to rapidly dividing cells in tumors.
Researchers discovered that bone marrow-derived cells contribute to embryo implantation and pregnancy by differentiating into decidual cells in the uterine environment. The study suggests a potential role of these cells in human implantation and pregnancy, potentially leading to new treatments for recurrent implantation failure and pre...