Articles tagged with Population Genetic Models
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Researchers at Stockholm University have uncovered the evolutionary history of the Norwegian lemming, revealing it to be one of the most recently evolved mammal species. The study found that the Norwegian and Siberian lemmings diverged approximately 35,000 years ago, with no evidence of interbreeding between them.
Researchers highlight the potential of AI in diagnosing and treating myopia, detecting risk factors and predicting outcomes. However, challenges such as data quality and patient privacy must be addressed to improve widespread clinical application.
Researchers at Weill Cornell Medicine developed a new AI model that harnesses whole-slide tumor imaging data and gene expression analyses to predict how patients with muscle-invasive bladder cancer will respond to chemotherapy. The model outperforms previous models using a single data type, identifying key genes and tumor characteristi...
Researchers develop AI model to predict novel mutations in protein sequences, combining grammatical and semantic changes. The method uses all available information about the sequence and mutations to create a more accurate prediction model.
Scientists at Johns Hopkins Medicine discovered how bacteria protect themselves from certain phage invaders by seizing genetic material from weakened, dormant phages and forming a biological 'memory' that their offspring inherit. This process allows the bacteria to recognize and fight off similar viruses in the future.
A novel fluorescent biosensor captures spatio-temporal dynamics of STING activation in response to aberrant DNA, enabling visualization of single cell and population responses. This study reveals new insights into the immune response to chromosomally unstable tumours and potential avenues for treatment.
This study found that aging impacts the gut microbiome composition and metabolites differently in male and female rats, influenced by biological sex and mitochondrial DNA. The researchers analyzed fecal samples from genetically diverse rats to assess bacterial changes with age, revealing more significant shifts in females.
A deep learning model, CGMformer, leverages large-scale continuous glucose monitoring (CGM) data to extract individual glucose dynamics. The model captures a continuous picture of glucose fluctuations, identifying patterns that may indicate early metabolic dysfunction.
Researchers identified a unique genetic signature that can predict bacterial antibiotic resistance. The finding could help develop precision-based treatments and reduce overuse of antibiotics.
Research reveals that bacteria form species through a process called homologous recombination, which exchanges genetic material across the entire genome. This exchange acts as a cohesive force, keeping members of the same species similar and maintaining distinct species boundaries.
The book highlights innovative strategies for addressing Latino cancer disparities, including risk assessment, prevention, screening, detection, diagnosis, treatment, survivorship, and policy. It also shares model programs and resources to shape future efforts to address cancer among Latinos and all people.
Researchers at Macquarie University have developed a revolutionary new biological pest control method called the Toxic Male Technique (TMT). This approach genetically engineers male insects to produce insect-specific venom proteins in their semen, significantly reducing female lifespan and disease transmission.
A new AI model developed by researchers at Penn State College of Medicine can predict the progression of autoimmune disease among those with preclinical symptoms up to 1,000% more accurately. The GPS model integrates data from large genetic studies and electronic health records to identify individuals at high risk of disease progression.
A special report identifies actions to enhance justice in genomics, ensuring fair access to research, promoting diversity, and protecting privacy. Researchers can reform practices that perpetuate racism, ensure disability inclusion, and democratize data sharing.
A recent study analyzed genomic variation distribution, genetic diversity, and heterotic group types in modern maize inbred lines. The research found new potential heterotic groups and identified elite breeding loci for traits like yield, plant architecture, and stress resistance.
Researchers developed a new method to build protein sequences from large genetic panels, capturing diversity among cohort participants. This approach can refine medical research to individual profiles and address the challenge of integrating diversity in current data models.
Three Texas A&M biologists have received NIH Maximizing Investigators’ Research Awards to support their research on type IV pili, darter fish social behaviors and bacteriophages. Drs Koch, Moran and Ramsey will explore bacterial behavior, genetic mechanisms and neural basis of paternal care in fish.
A new framework developed by UCLA researchers suggests that genetic data from large libraries of sequenced human genomes can improve the predictive power of genetics in determining how well a patient will respond to commonly prescribed medications and the severity of any side effects. The study, which analyzed data from over 342,000 pe...
A recent study suggests coral heat tolerance adaptation may not keep pace with ocean warming, and some sensitive species may face extinction. The research modelled different climate scenarios, revealing that natural selection may be insufficient to ensure coral survival under expected warming levels.
Researchers found a strong link between depression and menstrual pain in a new study published in Briefings in Bioinformatics. Depression may be a cause of dysmenorrhea, rather than a consequence, according to the findings.
A recent study found that Viking colonizers of the Faroe Islands and Iceland came from different Scandinavian populations. The researchers analyzed genetic samples from 139 men and compared them to samples from Norway, Sweden, Denmark, Iceland, and Ireland, revealing a 'founder effect' that persists in today's male populations.
A new gene drive technology, known as e-Drive, has been developed to reverse insecticide resistance in pests by replacing mutant genes with native ones. The system is designed to spread and then disappear, leaving only a population of insects susceptible to pesticides.
A team of researchers analyzed historical marking data from the Discovery Marking Program to investigate Antarctic blue whale population structure. They found frequent mixing among ocean basins, indicating a single circumpolar population. This study provides valuable insights into the conservation of this endangered species.
New research links ancient Jomon hunter-gatherer genetic signature to higher body mass index (BMI) among individuals in modern Japan. The study found strong support for the tripartite ancestry model, suggesting a significant influence of Jomon ancestry on BMI across populations.
A study published in Biology Letters reveals that harbor seals in Alaska's Iliamna Lake are genetically isolated from other seal populations across the Pacific. The researchers found significant differences between the lake seals and marine populations, suggesting they may be a unique endemic form of harbor seal.
A study of a 2000-year-old Yayoi individual's genome found that the majority of Japanese immigration came from the Korean Peninsula during the Yayoi and Kofun periods. The discovery provides new insights into the details of ancient immigration patterns to Japan.
Researchers identified three genetic regions strongly associated with increased prostate incidence in a diverse group of African men. The study, the largest of its kind in Africa, may lead to new treatment possibilities and refined screening methods.
Northern elephant seals nearly went extinct due to overhunting but have since recovered to around 225,000 individuals. The recent study found the species' genetic diversity was reduced during this period, which may impair their ability to cope with future environmental changes.
A recent study published in Cell Reports reveals that a pregnant woman's genetic background significantly affects the effectiveness of Non-Invasive Prenatal Tests (NIPTs). The study found that a specific genetic variant in approximately 7% of women increases the odds of inconclusive results and impairs test sensitivity. This discovery ...
A recent FAU study reveals that mesophotic corals can replenish declining shallow reef populations with strong genetic connectivity between shallow and deep zones. The research suggests that deeper corals could be a key source of genetic diversity for shallow reefs, providing valuable opportunities for recovery and restoration efforts.
Researchers identified changes in the UBR4 gene as a key driver of fibromuscular dysplasia, a blood vessel disorder affecting up to five percent of adults. The discovery could lead to therapeutic approaches for the condition, particularly beneficial for women who account for 90% of cases.
Researchers propose a new approach to understanding cancer evolution, acknowledging the importance of environmental influences and epigenetic changes. By refining the clonal evolution model, they aim to develop more effective cancer therapies that consider the full complexity of cancer cell evolution.
Research found that maintaining good cardiovascular health during the first trimester of pregnancy can partially mitigate the risk of adverse pregnancy outcomes. The study's results suggest that preconception and early pregnancy cardiovascular health counseling is crucial for preventing hypertensive disorders of pregnancy.
A comprehensive review of genetic and population studies challenges conventional wisdom about the relationship between genetic risk and cognitive deficits in schizophrenia. Premorbid cognitive impairment is largely explained by non-familial factors rather than inherited genetic variants.
Researchers at FAU aim to identify signatures of natural selection in the human genome, understanding its role in adaptation and disease. The $1.8 million NIH grant will develop powerful tools for complex modes of adaptation from genetic data.
Researchers at the University of Illinois are testing a new genetic framework called the omnigenic model to improve crop breeding. The model divides genes into core and peripheral components, with peripheral genes influencing complex traits through cellular processes.
A recent study published in PNAS explores how plants combine clock signals with environmental cues under naturally fluctuating conditions. The research team developed statistical models that accurately predict gene expression activity under control of circadian clock responses to environmental signals.
A new genetic editing technique called Allele Sail can modify wild populations with greater control and lower risk than existing methods. By introducing genetic changes at low frequencies, researchers can target specific traits without disrupting the population as a whole.
A new index uses inflammatory cell proportions to predict tissue healing and outcomes in patients with ulcerative colitis. The index, called the inflammatory cell enumeration index (ICEI), was developed by analyzing data from 220 patients who achieved healing.
Researchers genetically engineered Toxoplasma gondii to produce and release therapeutic proteins in the human brain, bypassing the blood-brain barrier. The method has potential implications for treating diseases caused by protein deficiencies or abnormal expression.
A genome study has identified regional adaptations in American chestnut trees, informing restoration efforts and climate resilience. The research provides guidance for conserving genetic diversity across the Appalachian region, with a focus on preserving the most genetically diverse southern population.
Researchers identified abnormalities in sex determination pathways of intersex mosquitoes, which can help develop strategies to create all-male populations to control mosquito numbers. Understanding these genetic factors also aids in identifying genes affecting female mosquito behavior.
A study of nearly half a million women found that endometriosis was associated with a higher risk of ovarian cancer. The risk was particularly elevated among women with ovarian endometriomas or deep infiltrating endometriosis, with a 19-fold increased risk for certain types of ovarian cancer.
Researchers found evidence of multiple waves of genetic intermingling between modern humans and Neanderthals, challenging previous theories. The study reveals a more intimate connection between early human groups than previously believed.
Researchers, including Assistant Professor James Lewis, are studying the evolution of butterfly wing color patterns as a model for understanding population adaptation to environmental changes. The study aims to understand why some Heliconiine butterflies lose their mimicry phenotype and how this affects their survival.
A study using hyperspectral data and DCGANs improves the estimation of rice grain protein content, achieving high validation accuracy and identifying genetic loci related to GPC. This approach demonstrates the potential for combining hyperspectral technology and DCGANs for efficient genetic analysis and selection of high-quality rice v...
A team of researchers uncovered the geographical origins of farmed foxes and understood the role of genetic diversity in their domestication. The study found that every captive population originated from wild North American foxes, with greater genetic diversity observed in Eurasian populations.
The COVICAT study, involving a Spanish cohort of 9,218 individuals, used innovative approaches to analyze the interplay between genetic predispositions and environmental stressors in determining depression risk. Key findings include the importance of considering both genetic and environmental factors when addressing depression risk.
Researchers developed a method to collect and plant genetically diverse red spruce seeds, resulting in higher establishment success and increased forest resilience. The approach pools multiple seed sources, increasing evolvability and minimizing deleterious mutations.
A new study presents an evolutionary-biophysical model that sheds light on the evolution of collaborative non-self recognition self-incompatibility in plants. The model introduces promiscuous molecular interactions, enhancing our understanding of genetic diversity and evolution in hermaphroditic plants.
A new study highlights the limitations of current brain health models, which may not apply to diverse populations in Latin America. The research emphasizes the need for tailored and personalized models that consider unique factors such as genetic admixture, socioeconomic inequities, and social determinants.
Researchers developed a metabolic health score based on clinical parameters and used it to explore its genetic underpinnings in mice, validating findings in human data. The study identified two significant genetic regions linked to metabolic health and pinpointed candidate genes associated with metabolic traits.
Researchers developed Epitope Binning-seq to analyze epitopes in monoclonal antibodies. The method accurately classified antibodies into distinct epitope bins, providing valuable insights into their binding patterns and streamlining early antibody drug development.
Researchers found metal-tolerant trout populations in British and Irish rivers are genetically distinct due to high levels of metal pollution. The lack of genetic diversity in these populations makes them more susceptible to environmental changes.
A study led by Spanish researchers reveals Bonelli's eagles colonized the Mediterranean 50,000 years ago due to early human settlement, displacing golden eagles as the dominant species. Human activities now threaten the eagle's survival.
Researchers confirm Atlantic cownose ray (Rhinoptera bonasus) has made a novel migration to Bermuda, using citizen science and morphological/data analysis. The species likely resides in Bermuda for extended periods due to the islands' mild sea temperatures.
A University at Buffalo-led research team has found that the same genes whose mutations gave rise to a low functioning male gorilla reproductive system may also be responsible for human male infertility. Researchers identified 109 reproductive-related gorilla genes that are often mutated when present in infertile men.
The research group found that the Japanese population can be divided into three clusters, with different concentrations in Okinawa, Northeastern Japan, and Western Japan. They also identified genetic variants associated with hereditary breast cancer and provided insights into gene sequences derived from Neanderthals and Denisovans.
Researchers found a strong association between favorable survival outcomes and high populations of tissue-resident memory T cells in melanoma patients. The study identified 11 distinct gene signatures that correlate with T cell abundance and patient survival, suggesting a crucial role for T cells in immunomodulation.
Researchers warn of potential corporate uses of polygenic scores for risk assessment and business profits, highlighting the need for policy safeguards. Current laws and policies are inadequate to address ethical concerns surrounding the use of genetic data.