Articles tagged with Cerebral Palsy
A new study has identified mutations in single genes that can cause cerebral palsy, challenging the long-held notion that the disorder is caused by environmental factors. The research found that many of these mutations occur randomly and are not inherited from parents, but rather arise during development.
A recent NIH-funded study confirms that about 14% of cerebral palsy cases may be linked to rare genetic mutations, which control brain circuit development during early childhood. The results led to recommended changes in treatment for at least three patients and provide new insights into the disorder.
Cerebral palsy affects children's gross motor skills and muscles, leading to stiffening and weakness. Rehabilitation interventions improve quality of life for individuals with CP, including botulinum toxin injections and robot-assisted gait training.
A large population study found that the risk of cerebral palsy in IVF children has consistently declined over six time-periods, from 12.5 cases per 1000 live born in 1990-1993 to 2.8 per 1000 in 2011-2014. The prevalence dropped more significantly in singletons born from IVF compared to naturally conceived children.
Researchers at Staffordshire University have developed an orthotics breakthrough that fine-tunes splints for children with cerebral palsy, reducing their energy usage while increasing mobility and speed. The study found significant improvements in hip and pelvic function, knee extension, and overall quality of life.
A network of hospitals successfully implemented international cerebral palsy diagnosis guidelines, reducing the average age at diagnosis from 19.5 months to 9.5 months in just one year. The initiative involved five hospital systems and demonstrated the practicality and effectiveness of the guidelines for improving early interventions.
A new study finds that adults with cerebral palsy are 75% more likely to develop a non-infectious disease, such as asthma or stroke. Patients with cerebral palsy were also found to be at higher risk for cardiovascular disease and chronic respiratory disease.
Dr. Xuan Liu has received a $70,000 Switzer Research Fellowship to fund gait retraining research in children with cerebral palsy. The study aims to test two types of biofeedback gait training to correct stiff knee gait patterns.
A new study published in Annals of Internal Medicine highlights the need for increased awareness of mental health disorders among adults with cerebral palsy. The research team found that adults with cerebral palsy have a higher age-standardized prevalence of mental health disorders compared to those without the condition.
A new surgical procedure has been shown to improve movement and quality of life for children with cerebral palsy. The selective dorsal rhizotomy procedure involves cutting sensory nerves to relieve stiffness and pain. The study provided convincing evidence that the procedure helps children, with no significant health risks identified.
A study published in EClinicalMedicine found that preterm babies born without the haptoglobin protein have a higher risk of brain bleeding, cerebral palsy, and death. The absence of the protein may serve as a potential biomarker for increased monitoring or preventive interventions.
A new study reveals that adults with cerebral palsy are at a higher risk of developing depression and anxiety compared to their peers. Intellectual difficulties associated with the condition can exacerbate this risk, with a significant increase in anxiety.
A recent study published in JAMA Neurology found that adults with cerebral palsy are at a higher risk of developing depression and anxiety, particularly those without intellectual disabilities. The study analyzed data from over 1,700 adults with cerebral palsy and 5,100 adults without the condition.
Researchers induced a mild brain injury in mice and used neural precursor cells to show recovery of lesions and improved motor functions. The study suggests that these cells may enable the brain's own cells to repair damaged areas.
A new study led by Dr. Tishya Wren at Children's Hospital Los Angeles aims to understand bone loss in ambulatory individuals with cerebral palsy. The research will assess the bone health of 148 participants, identifying critical periods for intervention and guiding future interventions to maximize bone strength.
Researchers aim to address muscle power deficits in children with cerebral palsy, using a combined impairment and task-specific approach. The study will investigate the effects of PT3 on functional walking capacity, muscle performance, and architecture.
A Delaware team has developed a blood test that can identify spastic cerebral palsy (CP) patients with 73% accuracy, using DNA patterns in circulating blood cells. The study's findings have significant implications for early diagnosis and intervention.
Researchers at the University of Adelaide found a genetic signal common to both cerebral palsy and autism in children. Cell lines from 182 individuals with cerebral palsy showed disruptions in cell signalling and inflammatory pathways, similar to those seen in some children with autism.
A phase two trial showed improved motor function in children with spastic cerebral palsy who received an infusion of their own umbilical cord blood cells. The improvements were greater than those seen in children receiving lower doses or a placebo, and exceeded expected gains from traditional therapies.
A new study published in The Lancet Global Health found that cerebral palsy is more common and has higher mortality in Uganda compared to high-income countries. The study, which analyzed data from over 30,000 children, suggests that cerebral malaria is a major cause of brain damage in infants.
A new international collaboration aims to identify common neurodevelopmental pathways and probable environmental triggers for cerebral palsy. The group is pooling data from genetically and clinically characterized cases to lay the groundwork for clinical trials and better management of the condition.
A recent study found improved survival rates among premature babies, with increased rates of survival without neuromotor and sensory disabilities at 2 years of age. However, a significant risk of developmental delay remains for children born between 24-34 weeks' gestation, with language development delays being the most common concern.
A study found that specific genetic mutations and inherited genes may contribute to hemiplegic cerebral palsy. Mutations in certain parts of an individual's genetic makeup were identified, with some variations being inherited from parents.
A new study found that magnesium sulfate should be administered to obtain a blood level of 3.7-4.4 mg/dL at delivery to prevent cerebral palsy in extremely preterm infants. This tailored approach aims to optimize neuroprotection and reduce cerebral palsy incidence.
A Swedish study found that maternal overweight and obesity during pregnancy are associated with increased rates of cerebral palsy in children. The analysis, which included over 1.4 million children, showed a dose-response relationship between BMI and cerebral palsy risk, with more severe obesity linked to higher rates.
A systematic review and meta-analysis of horseback riding interventions found significant improvements in balance, motor function, and quality of life for children and adults with neuromotor disabilities. The studies also showed benefits for patients with cerebral palsy, multiple sclerosis, and stroke.
A retrospective observational study of 323 children with cerebral palsy reveals that 9.6% had cytomegalovirus (CMV) DNA in their blood, six times higher than previously reported
Researchers studying infant locomotion have discovered common neural primitives used by humans and animals to walk. These findings could lead to new rehabilitation methods for patients with spinal cord injuries and cerebral palsy.
A new quantitative assessment called Walk-DMC predicts which children with cerebral palsy are likely to benefit from invasive surgeries. Higher Walk-DMC scores before treatment correlate with better surgical outcomes.
A new study from the University of Michigan found adults with cerebral palsy are at a higher risk of developing secondary chronic health conditions. The research team analyzed data from over 207,000 adults and found that those with cerebral palsy were up to five times more likely to have conditions like diabetes and hypertension.
Researchers at Kobe University have developed a painless dermal monitoring method to detect neonatal jaundice in preterm infants. The study identified the optimal skin area for monitoring, allowing for continuous long-term tracking of bilirubin levels and reducing cases of cerebral palsy and hearing loss.
A Canadian study found that 10% of children with cerebral palsy have copy number variations affecting genes deemed clinically relevant. This discovery could lead to the integration of genomic analyses into diagnostic assessments for cerebral palsy, providing new insights and treatment options.
Cerebral palsy cases can be attributed to genetic mutations in up to 45% of cases, according to a study by the Australian Cerebral Palsy Research Group. The research suggests that genetic sequencing techniques will increase the identification of genetically caused cerebral palsy cases.
Researchers at the University of Adelaide have discovered that at least 14% of cerebral palsy cases are caused by genetic mutations. This groundbreaking finding has significant implications for the diagnosis, management, and treatment of the condition.
A £250,000 award will support a three-year study on the feasibility and effectiveness of resistance training for youngsters with cerebral palsy. The study, led by physiotherapists at Brunel University London, aims to recruit 60 young people between 12 and 19 years old.
Women with mobility disabilities experience pregnancy-related problems, including falls, urinary issues, and breathing difficulties. The study's findings provide preliminary insights for women and obstetrical practitioners to plan ahead.
The study found that adolescents with cerebral palsy rated their overall QoL as comparable to that of their able-bodied peers. They also reported better QoL in five areas of life, including moods and emotions, self-perception, autonomy, relationships with parents, and school life.
A new study found a possible genetic link between cerebral palsy and family ties, with increased risks seen in twins, first cousins, and closer relatives. The study identified a stronger recurrence rate among co-twins of affected children and families with an affected single child.
A new study confirms a variant in the SERPINE1 gene is linked to cerebral palsy and death in very preterm babies. The findings add to evidence that genes may play a role in brain injury and death risk in preterm infants.
A study of over 1,700 premature babies found that about one in five had cerebral palsy or neurologic impairment by age 2. Babies with serious complications in the NICU also had a higher risk of these conditions.
A comprehensive study analyzing over 3,800 cerebral palsy cases and 1.7 million healthy children found no link between cesarean delivery and reduced risk of cerebral palsy. The causes of cerebral palsy are believed to lie elsewhere, with research focusing on genetic origins and environmental triggers.
Research by Valeska Gatica Rojas and colleagues found that children with diplegic cerebral palsy exhibit weaker postural balance control ability and less standing stability compared to hemiplegic cerebral palsy patients. Rehabilitation physicians can benefit from this knowledge to tailor their treatment approaches for improved outcomes.
A recent study published in Obstetrics & Gynecology found that birth defects and poor fetal growth are the most common risk factors for cerebral palsy and infant death. The research suggests that these risk factors, rather than asphyxial birth events, may contribute to the development of cerebral palsy and infant mortality.
Researchers at the University of Strathclyde are working to better understand how cerebral palsy affects children's speech. They hope to develop more effective treatments by analyzing speech patterns in over 40 affected youngsters.
A new clinical trial shows that whole body vibration therapy increases bone-mineral density and muscle mass in adolescents with cerebral palsy, allowing for improved walking ability and overall health. The therapy significantly enhances leg and spine bone-mineral density, while also increasing muscle mass in the legs.
A 2.5-year-old boy with severe brain damage was treated with autologous cord blood and showed significant improvement in symptoms, including learning to speak simple sentences and move. The treatment's effectiveness has sparked hope for alternative therapies for infantile cerebral palsy.
Researchers assessed 491 extremely preterm children at 2.5 years and found that overall 42% had no disability, with moderate or severe disabilities increasing with decreasing gestational age. The study suggests that improved neonatal care may lead to better neurodevelopmental outcomes for these children.
Researchers at SDSU are analyzing the interaction between facial movements and speech-language development in children with cerebral palsy. They are using motion capture technology to collect data on mouth movements, which can help create more effective speech therapy techniques.
Researchers found that children with mild CP can attain moderate levels of physical activity during video game play with full-body movements. The games encouraged repetitive movement and provided feedback through on-screen avatars and scores, promoting neuroplasticity and enjoyment.
Researchers developed nano-devices that successfully crossed the blood-brain barrier and delivered a drug to tame brain-damaging inflammation in rabbits with cerebral palsy. The treatment improved motor skills and reduced neuro-inflammation, holding promise for treating a range of neurologic disorders.
A new study published in Science Translational Medicine suggests that an anti-inflammatory drug delivered via a nanodevice can improve CP symptoms in animal models. The findings indicate a window of opportunity for postnatal treatment to prevent the condition, with potential implications for future treatments of neurological disorders.
A new study from Johns Hopkins Children's Center found that children with cerebral palsy experienced the highest blood loss during corrective spine surgery, while those with idiopathic scoliosis had the least. The study analyzed 617 cases of children aged 10-18 and revealed a link between underlying conditions and blood loss.
Researchers found that high levels of protective protein Nmnat1 reduce brain damage caused by oxygen and blood flow deprivation. The study offers a potential new strategy for treating cerebral palsy, strokes, and other neurodegenerative diseases.
A new rehabilitation approach for children with cerebral palsy, called 'context-focused intervention', has been shown to be equally beneficial as traditional child-focused therapy. The study found no significant differences in daily functioning between the two treatment groups.
A new study by Johns Hopkins Children's Center researchers found that most children with severe cerebral palsy have asymmetric pelvic bones, which can affect surgical procedures. The study highlights the importance of considering pelvic asymmetry in surgeries to correct scoliosis and other spine-related issues.
Researchers found a significant decrease in cerebral palsy diagnoses among premature infants over the past 15 years. The rates dropped from 6.5% to 2.2%, indicating improved care before, during, and after birth.
Research suggests that IVF/ICSI treatment may increase cerebral palsy risk, but a waiting time of over a year reduces this risk. Children born after IVF/ICSI have double the risk of cerebral palsy compared to those conceived spontaneously within two months.
Infants born at 37-38 weeks or after 42 weeks have a higher risk of cerebral palsy compared to those delivered at 40 weeks. The risk is significantly higher for babies born at 37 weeks, with a 3.7 times increased risk of cerebral palsy.
Researchers have found that olfactory ensheathing cells (OECs) transplanted into children and adolescents with cerebral palsy can improve neurological function without causing significant side effects. The study suggests OEC transplantation may be a promising treatment for this incurable disorder.
Researchers at Rutgers University developed a modified PlayStation 3-based system to improve hand functions in teenagers with cerebral palsy. The system improved participants' abilities to perform daily activities such as brushing teeth and dressing.