Articles tagged with Organ Systems
Researchers developed a protein-tracing platform that maps fat and liver cell communication, tracing proteins back to their cells of origin. The platform linked 65 signals to human conditions, including type 2 diabetes and cardiovascular disease.
A recent study published in JAMA found that high-dose intravenous vitamin C did not reduce mortality and persistent organ dysfunction in patients with severe burn injury. Instead, the treatment may be harmful, suggesting alternative approaches for managing burn-related complications.
A new study by the University of Ottawa suggests that a tiny molecule, methylglyoxal, plays a major role in triggering neurological disorders after a heart attack. The molecule accumulates in the brain following a heart attack and is linked to depression, anxiety, and cognitive decline.
Chronic liver disease in the US costs $41.57 billion, with prescription medication expenditures accounting for nearly half of all-cause healthcare expenditures. Poor adherence to antiviral medications is a key factor in preventing disease progression and treatment, with high out-of-pocket costs increasing non-adherence risk.
Scientists at UCSF created a new material that enables more predictable organoid growth, allowing for better study of disease and potential tissue replacement. The dynamic gel, invented by Zev Gartner, mimics the body's soft environment and enables precise 3D printing of stem cells.
A recent study led by Virginia Tech researchers found that certain medium-chain fats in infant formulas can strain the developing liver and lead to early signs of steatotic liver disease. Newborn pigs fed with these formulas accumulated liver fat faster than those fed long-chain fats, despite receiving the same calories and protein.
Researchers from the University of Ottawa have developed a groundbreaking biomaterial that combines strength, adaptability, and biological compatibility for soft tissue repair. The hydrogel is made from synthetic peptides and can be precisely tailored through chemical design, making it an attractive alternative to existing biomaterials.
A cohort study of mRNA COVID-19 vaccine exposure in the first trimester found no association with major congenital malformations. The study supports the safety of mRNA COVID-19 vaccines during early pregnancy.
The study finds that the current transplant system is a net positive for patients, producing an additional 9.29 life-years from transplantation. However, the optimal structure of the matching system could potentially raise this figure to as high as 14.08 life-years.
Researchers propose a new framework describing living matter as a double cascade spanning 18 orders of magnitude in space and time, with critical points marking the emergence of self-replicating machines and complex societies.
Researchers found that adding audio to a moving subway scene increased balance challenges for people with vestibular problems. The study, published in PLOS ONE, suggests that sounds can be a disruptive factor for those with vestibular hypofunction, a condition resulting in impaired balance.
Researchers from Texas A&M University have introduced a novel thermodynamic concept called the 'centotectic,' which investigates the stability of liquids in extreme conditions. The study provides critical information for determining the habitability of icy moons like Europa, with potential implications for planetary exploration efforts.
A new review synthesizes evidence from molecular studies, animal research, and human trials to understand how ayahuasca influences emotional processing and memory systems. Key findings include ayahuasca's dual action through serotonin receptor types 5-HT2A and 5-HT1A.
A team of biomedical engineers from the University of Melbourne has developed a groundbreaking 3D printing system that can fabricate complex human tissues in just seconds. This technology significantly improves the potential to predict and develop new pharmaceutical therapies, reducing the need for animal testing.
A study found that adding dapagliflozin to standard care did not improve clinical outcomes, but wide confidence intervals suggest potential benefits or harms. The results did not support the use of dapagliflozin in critically ill patients with acute organ dysfunction.
A comprehensive report on pediatric long COVID symptoms has been published, revealing clues to risk factors and common symptoms such as fatigue, headaches, and musculoskeletal pain. The study found that older age, more severe initial infection, and underlying medical conditions are associated with an increased risk of long COVID.
A randomized clinical trial involving 126 patients found that landiolol did not prevent organ failure in those with established septic shock. The study concluded that this beta-blocker is not a suitable treatment option for managing tachycardia in these patients.
Scientists have discovered a suitable combination of chemical compounds that can preserve adult zebrafish hearts for up to 5 days at -10°C. This breakthrough could potentially be used for the preservation of other organs before transplantation, revolutionizing organ donation and increasing the chances of successful transplants.
Fish oil supplements often make health claims without sufficient trial data, leading to potential variability in safety and efficacy due to differing doses of eicosapentaenoic acid and docosahexaenoic acid. The study highlights the need for more rigorous regulation of these products.
A nationwide study of nearly 10,000 adults identifies 12 hallmarks of long COVID, including debilitating fatigue, loss of smell or taste, and gastrointestinal symptoms. The findings provide a new scoring system for clinicians to define and investigate treatments for patients with long COVID.
Researchers found that time-restricted eating synchronizes circadian rhythms across multiple systems in mice, activating genes involved in specific diseases like cancer. Nearly 40% of genes in the adrenal gland and pancreas were affected by time-restricted eating, offering guidance for managing diseases.
A study by Harvard Medical School researchers found that organ donations and transplants increase by 21% during the week of large motorcycle rallies, with 26% more transplant recipients per day. The surge in donations does not alleviate the critical shortage of donor organs, highlighting the need for improved safety protocols.
Scientists have developed a new model to track protein signals that enable organ-to-organ communication, which could help understand disease onset and progression. The technology has the potential to identify novel secreted proteins and develop targeted treatments for diseases such as cancer and obesity.
Researchers created genetically edited mice to label and study secretome proteins, facilitating studies of inter-organ communication. The transgenic mice enable scientists to identify specific cell types and organs, providing a valuable resource for mapping and profiling the secretome.
Researchers found that an elephant's folded skin plays a crucial role in its flexible and strong trunk, enabling it to grasp fragile vegetation and rip apart tree trunks. The study suggests that wrapping soft robotics with a skin-like structure could give machines protection and strength while maintaining flexibility.
The study provides a single-cell transcriptome map of 45 tissues and organs from long-tailed macaque monkeys, identifying 113 major cell types. This will improve the ability to pinpoint how to develop potential treatments for human diseases with greater precision.
A study found that omecamtiv mecarbil did not improve exercise capacity or daily physical activity in patients with heart failure with reduced ejection fraction. The drug was well-tolerated, but its effectiveness in improving functional limitations was limited.
Researchers developed tools to measure biological aging of various organ systems using biomarkers, statistical modeling, and machine learning. They found diverse correlations between different bodily systems, with some unexpected findings such as a link between gut microbiota diversity and kidney aging.
A recent review of e-cigarette research highlights the significant health risks associated with vaping, including lung inflammation and injury. The study found that e-cigarettes can cause negative effects in multiple organs, from the brain to the bladder, and may even increase the risk of lung cancer.
Researchers developed a novel multi-organoid system to simulate the human liver-islet axis, enabling 3D co-culture of hiPSC-derived organoids for up to 30 days. The system exhibited cooperative interaction between liver and islet organoids, reflecting the dynamic interplay among organs in type 2 diabetes.
A recent study found that the number of stage 3 AKI kidneys transplanted in the US has increased significantly over the last decade, yet 44% are still discarded. This highlights the need for further efforts to optimize the use of these organs and reduce waste.
Researchers at MUSC identified a potent antifibrotic peptide that reverses scarring in human and mouse tissues by activating an antifibrotic pathway. The E4 peptide has the potential to treat various diseases, including heart disease, lung fibrosis, liver cirrhosis, and chronic kidney disease.
A large international study has identified over 200 symptoms of long COVID, affecting multiple organ systems. The research calls for widening medical guidelines and a national screening programme to address the complex range of symptoms and their impact on daily life.
Researchers analyzed national organ transplant data from 2008 to 2017 and found a wide variation in organ procurement organizations' efficiency. They proposed three new metrics that would give a more accurate and equitable representation of performance, highlighting the need for improved evaluation of the organ donation system.
The researchers developed a system of miniaturized organs that can detect harmful effects of drugs before they are prescribed to patients. The miniature organs, created using biofabrication techniques, mimic human tissues and organs, enabling the detection of toxicity in drugs approved for human use.
The study describes a system that incorporates microscale silicon electronic components and light emitting diodes, with layouts customized to the size and functional heterogeneity of the human brain. The flexible bioelectronic systems enable optoelectronic signaling and/or electrophysiological monitoring.
A new study analyzed nearly 43,000 patients on a kidney transplant wait-list after implementation of the new system in 2014. The research found racial disparities in patient status on the list and sensitivity levels, which can affect transplantation likelihood.
A study by Drexel University researchers found that impaired kidney function is a leading predictor of sepsis patient mortality. The analysis, using data from 210,289 hospital visits, shows that subtle changes in organ function can lead to death, highlighting the need for closer monitoring.
A new study found that around one in 10 people are considering opting out of a proposed new system that aims to increase organ donation by presuming consent. The research suggests that campaigns targeting feelings and emotions may be more effective than interventions that present facts.
Researchers identified a system of communication networks that regulate metabolism, providing a detailed atlas illustrating how the body creates and uses energy. The study shows disruptions in these networks may lead to disease.
Creating a confidential reporting system in Canada about organ transplant tourism could help reduce the practice and disrupt international networks. Physicians can discourage transplant tourism by discussing risks with patients and providing continued care pre- and postoperatively.
Well-developed eyes require between 5% and 15% of an animal's total energy budget, according to a study on Mexican cavefish. The visual system's high energy cost leads to trade-offs with other organ systems in environments where it is not essential.
Researchers discovered an ancestor of modern crustaceans with a sophisticated cardiovascular system, including a heart and blood vessels. The finding sheds light on the evolution of body organization in the animal kingdom and suggests that even ancient creatures had internal systems similar to those found in their modern descendants.
A UC Riverside-led study found significant damage in the liver and lung of mice exposed to third-hand smoke, with wounds taking longer to heal and displaying hyperactivity. The study's findings suggest a critical need for research on human health risks associated with third-hand smoke exposure.
Researchers found that a fatty meal from fast food doubles blood sugar levels when paired with caffeinated coffee, leading to increased risk for people at risk for diabetes. The study suggests limiting saturated fat intake and decaf coffee consumption may help improve glucose tolerance.
Researchers found patients with upper GI complaints visited GPs twice as often and received double the number of prescriptions. High contact frequency was most strongly associated with upper GI symptoms, rather than psychological co-morbidity.
Researchers track autoimmune disease development with bioluminescent imaging of NF-κB activation, revealing pathology in multiple organ systems. Early detection is critical for assessing new treatments and preventing disease progression.
A presumed consent system for organ donation could tackle the UK's growing waiting list by encouraging people to talk about their wishes. This approach aims to increase the supply of organs available for transplant, reducing demand on the black market.
The US donor organ allocation system, MELD score, and its impact on liver transplant outcomes are discussed. Early referral for liver transplant evaluation is found to offer advantages unrelated to waiting time, including early detection and treatment of liver cancer.
A new strategy called domino paired donation can match kidneys from living non-directed donors to recipients who have a willing but incompatible donor. This approach has the potential to increase both quantitative and qualitative benefit of each LND donation, leading to more transplants accomplished.
Recent studies have shown a significant decrease in multiple organ failure (MOF) incidence among severely injured patients over the last decade. Advances in trauma and critical care, including more judicious use of blood transfusions, have led to improved MOF outcomes.
The UW-Siemens image processor enables the creation of multiple diagnostic applications, increasing clinical efficiency. It allows for real-time panoramic imaging of internal organs and their surroundings, revolutionizing diagnosis and treatment.