Articles tagged with Thyroid Gland
A recent study found that nearly one-third of adults over 65 taking thyroid hormone also use medications known to interfere with thyroid function tests. The study highlights the complexity of managing thyroid hormone replacement in older adults, who often take multiple medications for other conditions.
Researchers have successfully generated lab-grown mini-thyroid organs from patients' own thyroid tissue, which can produce thyroid hormones. The study provides a potentially unlimited source of lab-grown thyroid tissue and may lead to new therapy options for hypothyroidism.
Thyroid hormone doesn't operate as a straight-on/off switch but rather shifts the balance between gene activity, revealing a more nuanced mechanism of action. This discovery has significant implications for understanding metabolic diseases and developing targeted therapies.
A new technique, vocal passive elastography (V-PE), uses ultrasound imaging and singing to determine the presence of a tumor in the thyroid gland. By analyzing the speed of shear waves created by vibrations from a person's voice, researchers can measure the elasticity of surrounding tissue.
A multicentre study found a strong correlation between thyroid function and Takotsubo cardiomyopathy, a condition triggered by extreme emotional stress. The research identified two distinct mechanisms: an overactive thyroid gland promoting heart disease risk and an elevated target value of thyroid regulation related to the stress event.
A new study found that prenatal exposure to maternal thyroid hormones can result in longer telomeres in chicks, making them appear younger at birth. This could have significant implications for understanding the effects of telomere length on aging and mortality risk.
Researchers found that inducing liver regeneration with thyroid hormone boosted CRISPR/Cas9-mediated gene correction, achieving 10.8% and 3.5% efficiency rates in neonatal and adult mice respectively. This discovery could lead to more efficient gene therapy for human diseases.
Researchers have identified phosphorus-containing compounds as markers for thyroid hormone action in tissue using non-invasive magnetic resonance spectroscopy. This allows for the measurement of hormone action in different areas of the body, potentially improving care for patients with thyroid dysfunction.
A study by Kaiser Permanente found no difference in TSH stability between patients taking desiccated thyroid products and those on synthetic levothyroxine, a surprising outcome given concerns about variability among batches of desiccated thyroid. This result has implications for patient-centered approach to managing hypothyroidism.
Researchers detected hydroxylated polychlorinated biphenyls (OH-PCBs) in the fetal brain of a Japanese macaque, revealing their transfer from maternal blood. The study suggests that OH-PCB concentrations may exceed levels that induce adverse effects on neurodevelopment, highlighting the need for further research on human exposure risks.
A recent study has found a significant link between thyroid inflammation and anxiety disorders. Patients with anxiety were found to have thyroid gland inflammation that could be reduced by taking ibuprofen, suggesting that thyroid function may play an important role in the development of anxiety.
Researchers developed a new method to estimate the health risks of PFAS in drinking water. The study found that women are particularly at risk of decreased thyroid hormone T3 levels due to exposure. Around 4% of local women in Ronneby, Sweden, may experience a 10% drop in T3 levels.
A new NIH study found that infants exposed to iodine in the neonatal intensive care unit (NICU) are at higher risk for developing congenital hypothyroidism. Infants with this condition often require thyroid hormone therapy within four weeks of birth, and permanent intellectual disability may result if treatment is delayed.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that up to one in five women with a history of miscarriage or subfertility have mild thyroid dysfunction. Detecting thyroid abnormalities prior to conception may improve pregnancy outcomes for these women.
Researchers at Johns Hopkins Medicine found that perchlorate blocks the sodium/iodide symporter, reducing iodide transport into thyroid cells. The study suggests an acceptable safe concentration of perchlorate in drinking water is 10 times less than previously believed.
Researchers discovered that perchlorate blocks a key route for iodide to enter thyroid cells, leading to reduced hormone production and potential health issues. The study suggests an acceptable safe concentration of perchlorate in drinking water is 10 times less than previously believed.
Researchers found TSH testing performed on most pregnant women without thyroid disease, leading to unnecessary thyroid hormone therapy. The study suggests that minor elevations in TSH may not require treatment, raising concerns about overmedicalization during pregnancy.
Researchers found that L-thyroxine therapy did not improve symptoms, quality of life, or handgrip strength in older adults with subclinical hypothyroidism and high symptom burden. This study's results do not support routine use of L-thyroxine for this population.
A study published by The Endocrine Society found that adults working long hours are more likely to develop hypothyroidism, an underactive thyroid condition. Researchers discovered a significant association between long working hours and the development of hypothyroidism, regardless of socioeconomic status or sex.
According to an analysis of patient forums, desiccated thyroid extract (DTE) is more effective than other thyroid hormone medications for improving symptoms and overall well-being. The treatment, also known as nature thyroid or Armour thyroid, has been used by 10%-25% of people with hypothyroidism.
A large study has found that thyroid hormone replacement therapy in older adults is associated with a higher risk of death compared to no treatment. The study, published in the Journal of the Endocrine Society, suggests that age-specific TSH reference intervals can help determine the threshold for thyroid hormone treatment.
A new study found that cancer treatment with immune checkpoint inhibitors is associated with an increased risk of thyroid dysfunction, affecting up to 40% of patients. The type of cancer and specific combination of medications used can impact the likelihood of developing thyroid problems.
The American Association of Endocrine Surgeons has published comprehensive clinical guidelines for surgical treatment of thyroid disease in adults. The guidelines emphasize personalized, evidence-based care and focus on optimizing patient outcomes.
Radioactive iodine is now the recommended frontline treatment for patients with thyroid gland overactivity, including Graves' disease. The new guidelines, developed by University of Birmingham researchers, show that radioactive iodine improves cardiovascular outcomes and cures 90% of cases.
A study on the developmental origins of the frog urostyle reveals that thyroid hormone-mediated ossification played a crucial role in tail loss and rearrangement of the dorsal aorta. This process allowed for evolutionary novelty, shaping the body plan of Anura, including frogs.
A team of researchers from Stanford University has developed a quantitative framework to sonographically differentiate between benign and malignant thyroid nodules. The framework achieved AUC values comparable to those of expert radiologists, suggesting its potential for establishing a fully automated system of thyroid nodule triage.
Research published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that older adults with hypothyroidism are 26% more likely to die from all causes than their peers without the condition. However, this increased risk was not observed in individuals with milder forms of thyroid disease.
A new guideline from the Canadian Task Force on Preventive Health Care recommends against routine screening for thyroid dysfunction in nonpregnant adults without symptoms or risk factors. The evidence suggests that this type of screening has no health benefits and may lead to unnecessary testing, medication, and follow-up appointments.
A new study compares two surgical approaches to endoscopic thyroid removal, finding no significant differences in outcomes between the oral vestibular approach and the breast approach. Both methods are safe and effective, with the oral vestibular approach offering a better cosmetic result due to its scarless nature.
Researchers developed a novel noninvasive imaging technique using multispectral optoacoustic tomography (MSOT) and ultrasound to diagnose thyroid disorders. MSOT/ultrasound images revealed significant biomarker changes in Graves' disease and malignant thyroid nodules, showing promise for improved diagnostics.
A UVA Health interventional radiologist has created a virtual reality experience to increase the adoption of thermal ablation for benign thyroid nodules. The procedure offers a less-invasive alternative with reduced scarring and recovery time, and the VR training aims to improve physician awareness and interest.
Researchers developed a new metabolic thyroid test that is faster and more accurate than current diagnostic tests. The test uses mass spectrometry imaging to identify diagnostic fingerprints produced by cancerous cells, preventing thousands of unnecessary surgeries each year.
A new machine learning-based model evaluates immunohistochemical characteristics in patients with suspected thyroid nodules, achieving excellent performance for individualized noninvasive prediction. The model improves thyroid nodule diagnoses and helps identify papillary thyroid cancers earlier.
A University of Cincinnati study found that abnormal thyroid function is present in just over 6% of psychiatrically hospitalized youth. The research suggests that targeted screening should focus on patients with a family history of thyroid disease, recent weight gain, or treatment with specific medications.
A method developed by Brazilian and US researchers confirms a three-fold increase in thyroid cancer incidence among WTC responders compared to the general population. The four-biomarker panel distinguishes between malignant and benign tumors with no false positive results, enabling early detection and treatment.
A panel of international experts recommends against routine hormone treatment for adults with subclinical hypothyroidism, as it does not improve quality of life or symptoms. The guideline applies to most adults with the condition, except those trying to become pregnant or with severe symptoms.
The guidelines present key areas for research, including biomarkers of thyroid action in cardiovascular tissues and clinical trials involving thyroid medications. The connection between thyroid and cardiac function has been identified as a crucial area for further investigation.
The EDC-MixRisk project reveals that current regulations underestimate health risks associated with combined exposures to endocrine disrupting chemicals, affecting fetal development and neurodevelopmental outcomes. The study highlights the need for a novel approach to mixture risk assessment and emphasizes the importance of considering...
A large study published in The New England Journal of Medicine found that treating women with thyroid antibodies and normal thyroid function with Levothyroxine did not improve the chances of live birth. The study showed similar outcomes in both groups, with 56.6% and 58.3% becoming pregnant, respectively.
A large study led by the University of Birmingham found that treating women with normal thyroid function and thyroid peroxidase antibodies with Levothyroxine did not increase live-birth rates. The researchers suggested that previous recommendations to use Levothyroxine in these women may have been based on limited evidence.
A study found that thyroid hormones hindered the ability of early mammals to regenerate their heart tissue, leading to modern humans' susceptibility to irreparable damage. The researchers discovered a connection between these hormones and the transition from ectothermic to endothermic animals.
A recent study at Vanderbilt University Medical Center has established a link between normal variations in thyroid function and increased risk of atrial fibrillation. The study found that even within a physiologically acceptable range, genetically determined variation in thyroid function can increase AF risk.
A European collaborative project SCREENED aims to develop new 3D in vitro tests to predict the effects of endocrine disruptors (EDs) on thyroid function. The tests will mimic the structure and function of the native thyroid gland, allowing for selective identification of male and female responses to ED exposure.
A new retrospective study shows that thyroid surgery readmissions are highest within a week of the procedure, with patients experiencing severe symptoms such as tremors and muscle spasms being most at risk. The study identifies risk factors that can be addressed to prevent these readmissions, including timely follow-up using telehealth.
A genetic test called ThyroSeq has been shown to reliably distinguish between benign and cancerous thyroid nodules using a small sample of cells. The test correctly identified cancerous nodules as positive 94% of the time and detected benign nodules as negative 82% of the time, preventing unnecessary diagnostic surgeries.
A new review highlights growing evidence that universal thyroid testing in early pregnancy can reduce obstetric complications and safeguard fetal brain development. However, the risks of overdiagnosis and overtreatment must be carefully considered to avoid unwarranted patient anxiety and potential harm.
A genetic polymorphism in the D2 enzyme affects thyroid hormone conversion, leading to hypothyroidism-like symptoms in mice and potentially affecting human patients. The study aims to develop a new treatment agent to address this issue.
Researchers at Rush University Medical Center developed a metal-coordinated molecule, poly-zinc-liothyronine (PZL), which works well in laboratory studies and may provide an improved therapy for all hypothyroid patients. PZL's slow release of active hormone can supplement standard therapy, offering a more effective solution for treatme...
A recent study analyzing 21 randomized clinical trials with 2,200 participants found that thyroid hormone therapy was not associated with improved quality of life or thyroid-related symptoms in adults with subclinical hypothyroidism. The results suggest that routine use of thyroid hormone therapy may not be necessary for this condition.
USC research reveals that air pollution alters thyroid development in fetuses, increasing the risk of health impacts later in life. Thyroid hormone levels were found to increase with exposure to particulate matter, highlighting a potential link between air pollution and fetal growth and metabolism.
A meta-analysis of 99 studies found that levothyroxine, a common medication for hypothyroidism, is inadequate in controlling high cholesterol levels. The study's findings suggest that patients may require additional therapies or adjustments to their treatment plans.
A microRNA panel developed by researchers identified 19 microRNAs that can categorize indeterminate thyroid nodule samples into malignant and benign. The panel showed high sensitivity, specificity, and accuracy in diagnosing cancer in patients with suspicious thyroid nodules.
Research supports thyroid screenings during early to mid-pregnancy due to increased risk of gestational diabetes and adverse health outcomes. Higher thyroid hormone levels in the first half of pregnancy are tied to development of gestational diabetes, affecting up to 2-10% of pregnancies.
Universal thyroid testing for pregnant women could detect mild thyroid problems that are currently missed in up to 75% pregnancies. However, experts debate the potential risks and benefits of this approach, with some arguing it may not provide significant improvements in pregnancy outcomes.
A Loyola Medicine study found that new ultrasound guidelines can reliably identify children who need a biopsy for thyroid cancer. The American College of Radiology's system grades nodules on a scale, with higher scores indicating more suspicious cancer.
Scientists at FAU have found a strong connection between autoimmune thyroiditis and depression/anxiety disorders. Patients with AIT are 3.5 times more likely to suffer from depression, or 2.3 times more likely to suffer from anxiety. Early diagnosis and treatment can help alleviate symptoms.
A new study of 45 years reveals that Alaska Natives have a similar incidence of thyroid cancer as the U.S. white population, but their tumors tend to be larger and have spread beyond a localized area. The study suggests that differences in access to healthcare may contribute to these discrepancies.
Researchers at NYITCOM propose thyroid hormone therapy as a safe and effective alternative to beta blockers for patients who cannot tolerate these medications. The study found that thyroid hormone treatment improved heart function, reduced infarction size, and enhanced vessel function.
Researchers found a crucial link between chronic fatigue syndrome and lower levels of key thyroid hormones. CFS patients had lower serum levels of T3 and T4, but normal thyroid-stimulating hormone, and higher levels of reverse T3, which may indicate reduced tissue T3 levels.
A large population-based study found that patients on levothyroxine had lower quality of life and more comorbidity than those not taking the hormone. The study also showed that comorbidity had a greater negative impact on the quality of life of LT4 users.