Articles tagged with Estrogen Signaling
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New research reveals that DNA's physical property of supercoiling is crucial for cells to respond to oestrogens. The study found that enzymes called topoisomerases regulate DNA coiling and activate target genes.
A new study found that using vaginal estrogen tablets was not associated with an increased risk of recurrent ischemic stroke among postmenopausal women. The study examined prescription data from over 34,000 women and discovered no increased risk of stroke in this high-risk population.
A new study suggests that chronic stress and an unhealthy diet may work together to fuel the early development of pancreatic cancer. Researchers found that both stress-related neurotransmitters and obesity-related hormones activate a protein called CREB, which is linked to cancer cell growth.
New research found that neuroestrogens produced in the brain help suppress appetite, as confirmed by experiments where aromatase expression was restored specifically in the brain. This suggests a link between neuroestrogen levels and body weight regulation.
A preclinical study led by Weill Cornell Medicine scientists found that estrogen surges promote binge drinking in females, causing them to 'pregame' and consume large quantities of alcohol. The study identifies a neural circuit in the brain where estrogen increases activity, leading to enhanced binge drinking behavior.
Researchers found that prenatal exposure to synthetic cannabinoid led to cardiovascular problems in female rats and increased respiratory sensitivity to carbon dioxide in male rats. Sleep quality also deteriorated in both sexes, with males experiencing sleep fragmentation due to frequent wakefulness episodes.
Researchers at Baylor College of Medicine discovered estrogen's fast actions are mediated by the coupling of ER-alpha with ion channel protein Clic1, controlling chloride ion flux and enabling rapid neuronal responses. This finding sheds light on estrogen's role in regulating various physiological processes.
A new non-hormonal hot flash treatment has been shown to significantly reduce symptom frequency and severity within weeks, while also improving sleep quality and overall well-being. The investigational drug elinzanetant was found to have a favorable safety profile with mild side effects.
A recent study from the Women's Health Initiative found that both obesity and metabolic syndrome increase breast cancer risk, but in distinct ways for different subtypes. The research highlights the importance of controlling waist circumference and metabolic conditions to reduce breast cancer risk.
A novel three-drug combination of an HDAC inhibitor with two types of immunotherapy achieved a 25% overall response rate and 50% progression-free survival in women with advanced HER2-negative breast cancer. Patients with triple-negative breast cancer had a higher response rate, highlighting the need for further clinical evaluation.
Researchers investigated role of estrogen receptors in lateral septum regulating social anxiety in male mice, finding that ERβ plays a crucial role in neural circuitry. Knockdown effects on ERβ gene expression showed increased social anxiety, highlighting its importance in social situations.
Researchers investigated the role of estrogen receptor beta-positive neurons in the medial amygdala, a region involved in social information processing. They found that MeA-ERβ+ neurons exhibit different roles for receptivity-based and sex-based preferences.
Researchers found that African American women with ER-positive breast cancer have decreased levels of amino acids and increased levels of fatty acids compared to non-Hispanic white women. This study may help explain the higher mortality rates in African American women with the disease, suggesting potential new screening strategies.
Researchers have discovered that estrogen promotes tumor growth in ERα-negative cancers, such as triple-negative breast cancer. Anti-estrogenic therapies, when combined with immune checkpoint inhibitors, drastically suppress tumor progression in mice models.
Research identifies key molecular signatures and pathways contributing to skeletal muscle strength loss in females with estrogen deficiency. The study found parallel patterns of inhibition and activation across various signaling pathways, including AMPK and calcium signaling.
A new study shows that estrogen receptor (ER) expression in ductal carcinoma in situ (DCIS) is multi-clonal, meaning it varies across different cells. This finding has significant clinical implications, as it may help avoid overtreatment and undertreatment in DCIS patients.
A new study reveals that preoperative hydroxyprogesterone administration can improve disease-free and overall survival in patients with node-positive breast cancer by modulating cellular stress response and negative regulation of inflammation. Non-coding RNAs, such as DSCAM-AS1, play a regulatory role in this process.
Inflammatory breast cancer is a rare and aggressive form of breast cancer with poor outcomes. Research highlights the role of ERβ as a mediator of estrogen signaling, demonstrating its tumor suppressive effects in preclinical models. ERβ's antimetastatic activity may hold promise for improving treatment options for IBC.
A new review paper suggests ACSL4 status as a biomarker for breast cancer subtype classification and predictor of response to hormone-based therapies. The enzyme may also serve as a target for developing new treatment modalities in quadruple negative breast cancer.
Researchers at Nagoya University have found that ATP, an energy 'currency' within cells, acts as a neurotransmitter in the brain and causes mammalian ovulation. Administering ATP to rats induced the LH surge leading to ovulation, suggesting a potential new treatment for infertility.
Researchers discovered that androgen therapy alters the organization of cells within breast tissue, reducing signs of estrogen influence and changing protein production. The findings could lead to new therapies for estrogen receptor-positive breast cancer.
A University of Jyväskylä study found that estrogen deficiency affects systemic signaling in response to exercise. Exercise typically induces changes in micro-RNA molecules, but estrogen levels impact this process in postmenopausal women.
Researchers at Rice University have discovered a new way protein structures communicate with each other to regulate hormone activity. This finding could lead to improved therapies for breast cancer and other diseases.
Females with more subcutaneous fat are protected against brain inflammation, a risk factor for dementia and stroke. Removing subcutaneous fat increases brain inflammation in females, even on low-fat diets.
A large cohort study found that hormone replacement therapy for breast cancer survivors is not associated with an increased risk of recurrence. The study included over 8,400 Danish postmenopausal women and found no link between vaginal estrogen or menopausal hormone therapy and breast cancer reoccurrence.
Abemaciclib, a CDK4 & 6 inhibitor, showed profound inhibition of cell proliferation and triggered senescence and apoptosis in breast cancer cells. Continuous dosing provided sustained inhibition with irreversible effects through apoptosis, supporting the differentiated safety and efficacy profile.
A population-based study found that patients with estrogen receptor-positive breast cancer who experienced hot flashes while on adjuvant hormone therapy had worse outcomes and a higher risk of early treatment discontinuation. The study suggests that managing side effects may not be enough to prevent treatment discontinuation, highlight...
Researchers at Johns Hopkins Medicine discovered a molecular connector, BASP1, that helps cocaine latch on to brain cells, even at low doses. This finding may explain why women are more susceptible to cocaine addiction and could lead to new treatments.
A mutated gene in more than 20% of breast cancer recurrences promotes metastasis and resistance to hormone therapy. Researchers identify potential vulnerabilities, leading to the development of personalized treatment approaches.
Researchers identified an estrogen-activated neurocircuit that stimulates thermogenesis and physical activity, increasing energy expenditure and preventing obesity. The circuit responds to changes in ambient temperature and nutritional status, and its conservation in males suggests a potential role in weight regulation.
A recent study found that patients with hormone receptor-positive breast cancer who experience rising ESR1 mutations before disease progression can benefit from an early switch to fulvestrant plus palbociclib. This approach yields a statistically and clinically significant gain in progression-free survival, potentially justifying its a...
A study on Saudi Arabian breast cancer patients identified somatic mutations in tumor suppressor genes, including BRCA1, BRCA2, and PIK3CA. The findings highlight the importance of routine genetic sequencing for precision therapies in the region. Novel mutations were also discovered, with potential implications for targeted treatments.
A new imaging test can reliably distinguish breast cancer patients who are unlikely to benefit from hormone therapy. The test measures estrogen receptor functionality, and a PET scan detects increased progesterone receptors in response to estrogen stimulation.
Researchers found that some PFASs mimic estrogen's ability to activate transcription, while others inhibit expression, but block natural hormone activity when present. A computational model predicted that PFASs bind to distinct sites on the receptor surface, potentially blocking estrogen's action
Researchers at IRB Barcelona have identified CPEB2 as a crucial factor in the development of luminal breast cancer. The study found that CPEB2 is essential for protein synthesis after hormonal stimulation, leading to less cell proliferation and better prognosis in patients with low expression levels.
Researchers have discovered 21 gene variants associated with estrogen signaling pathways in the brain of transgender individuals, suggesting a potential biological link to gender dysphoria. These variants may disrupt normal masculinization of the brain during critical periods of development.
Experimental studies reveal a strong interplay between liganded and non-liganded transcriptional activations of ERs. Natural estrogens can restore DNA surveillance in tumor cells via harmonized transactivation of AF1 and AF2 domains.
A recent study published in Menopause found a gene variant associated with hot flashes in postmenopausal women. The study examined genetic variations across the human genome and discovered that specific variants on chromosome 4 linked to the tachykinin receptor 3 were more common among women experiencing hot flashes.
Researchers discovered that progesterone receptor dramatically alters how estrogen receptors interact with cell's DNA, leading to inhibition of cellular proliferation and metastasis. Combining tamoxifen with a progestin antagonist showed added benefit in shrinking tumors.
EPFL scientists have developed an animal model for estrogen receptor-positive breast cancer that faithfully captures the disease. The new model has been tested on human breast tissue in a pre-clinical context, providing crucial factors such as hormone action and molecular responses to therapies.
Researchers discovered a direct link between Wbp2 and progressive high-frequency hearing loss in mouse models and human clinical cases. The study found that Wbp2 expression loss leads to reduced hormone receptor expression and hearing impairment.
A new meta-analysis shows breastfeeding is associated with a lower risk of developing hormone-receptor negative breast cancer. Women who breastfed had a reduced risk of up to 20%, making it a protective strategy against the most aggressive subtypes.
Research suggests that lactation may reduce the risk of estrogen receptor-negative and triple-negative breast cancers in African American women. Parous women had a higher chance of developing these aggressive subtypes if they never breastfed, particularly those with four or more births.
Researchers at Baylor College of Medicine developed an estrogen-based compound that inhibits binge-like eating behavior in female mice. The study found that the compound, GLP-1-estrogen, works by delivering estrogen to specific brain regions where serotonin neurons are present, reducing binge eating.
Researchers found that geniposide, a component of the Chinese herbal formula Tongluojiunao, protects hippocampal neurons from Aβ1-mediated cell death via a non-classical estrogen signaling pathway. This study suggests a new potential therapeutic approach for Alzheimer's disease.
Researchers discovered that the androgen receptor may play a crucial role in treating estrogen receptor-positive breast cancer. The study found that women with high levels of androgen receptors were more likely to experience cancer recurrence during tamoxifen treatment.
Researchers at UW–Madison have built a version of a parathyroid hormone that can stay around longer and at higher concentrations. This breakthrough could lead to better drugs for osteoporosis and diabetes by protecting peptide hormones from degrading enzymes.
Research published in Neural Regeneration Research found that geniposide, a component of the Chinese herbal formula Tongluojiunao, protects hippocampal neurons from Aβ-mediated death via non-classical estrogen signaling pathway. This suggests a potential therapeutic application for Alzheimer's disease treatment.
High total and saturated fat intake associated with greater risk of ER+PR+ breast cancer and HER2- disease. A high-fat diet increases BC risk, especially receptor-positive disease linked to saturated fat intake.
Researchers identified a young woman with an estrogen receptor-α mutation that blocks the hormone's action, resulting in high estrogen levels and reproductive issues. The study found that the woman had significantly elevated estrogen levels compared to normal ranges, despite having no effect from estrogen.
A study by University of Texas Medical Branch at Galveston researchers found that combining low doses of multiple xenoestrogens can have a dramatically greater effect on hormone signaling than any one compound alone. The combination of bisphenol A, bisphenol S and nonylphenol was found to gang up on estradiol and thwart its response.
Researchers from Scripps Research Institute have identified a class of compounds that can modify cell signaling activity, including anti-inflammatory effects, which could lead to innovative treatments for breast cancer. The study focuses on compounds interacting with the estrogen receptor-α, a key target in breast cancer treatment.
Researchers identified a set of genes associated with lipid metabolism that may help identify women at risk for hormone receptor-negative breast cancer. These genes were found to be overexpressed in the unaffected breasts of women with estrogen receptor-negative disease.
A recent study by University of Texas Medical Branch researchers found that BPA substitute BPS disrupts cellular responses to estrogen, changing patterns of cell growth and death and hormone release. The study showed that low levels of BPS exposure can have similar effects as BPA, posing a concern for human health.
Researchers at UC San Diego School of Medicine found that BPA's metabolite MBP interacts more strongly with estrogen receptors than BPA itself, posing a greater health threat. This discovery could lead to the development of new drugs targeting excessive estrogen activity linked to diseases.
A new study suggests that estrogen reduces the activity of a protective lipid pathway, leading to slower wound healing in women. The research provides new clues for treating inflammatory diseases such as dry eye disease and scleroderma.
Researchers have engineered new sensors that can detect estrogenic compounds in human cells, which is crucial for understanding the potential health risks associated with these substances. The sensors, developed by a team led by Huimin Zhao, were found to reliably detect estrogenic compounds within hours, even at low levels.
Researchers found that prolonged estrogen deprivation in aging rats reduces brain receptors for the hormone and its ability to prevent strokes. Early estrogen replacement therapy can forestall this damage. The study's results suggest a critical window for estrogen therapy, either right before or right after menopause.
Researchers presented data on natural S-equol, a soy-based compound that mimics some activities of estrogen, to alleviate menopause symptoms. The study findings suggest potential benefits of S-equol for women experiencing diminished estrogen production during menopause.
African American women with higher vegetable intake have a lower risk of developing estrogen receptor-negative breast cancer. High cruciferous and carrot consumption may play a role in reducing breast cancer risk through their effects on estrogen metabolism and antioxidant properties.