Articles tagged with Wnt Pathway
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Researchers at Rice University discovered dynamic molecular signaling waves that prompt cell differentiation and trigger the formation of germ layers in human embryos. The study counters previous theories by showing gradients do not exist in stem-cell colonies and the process is more dynamic than previously appreciated.
Researchers at the University of Arizona Cancer Center successfully repeated findings from a study that challenged current approaches to colon cancer treatment. The team validated therapeutic targeting of LRP6 as a potential strategy for blocking progression of colon cancer, offering new hope for patient care.
A new biomarker, urinary DKK3, has been identified as a predictor of acute kidney injury (AKI) in patients undergoing cardiac surgery. High preoperative levels of DKK3 are associated with lower kidney function and increased risk of AKI.
Researchers discovered that MEK inhibitors activate Wnt signalling pathway in colorectal cancer cells, leading to accumulation of tumor cells with stem cell characteristics. This explains why these drugs are not effective in treating colorectal cancer.
Researchers from FEFU and international partners discover potential targets for glioblastoma multiforme treatment by studying proteins in the WNT signaling pathway. The findings could lead to improved antitumor therapy outcome through suppression of cancer stem cells, accelerating tumor growth rate.
Researchers at UNIGE and UNIL discover clofazimine's efficacy in stopping triple negative breast cancer progression by blocking Wnt cell signaling pathway. The study highlights the need to re-examine existing drugs for potential targeted therapy.
Researchers discovered a way to regulate the beta-catenin-dependent Wnt signaling pathway using a chemically synthesized compound. The inhibitor reduces AAK1's frequency in endocytosis, blocking arbovirus invasion and potentially treating breast and cervical cancer.
Scientists have discovered that electrical activity is the first known step in planarian flatworm regeneration, starting before genetic machinery kicks in. This breakthrough enables cells to communicate and make decisions about their position and overall organ structure.
Researchers discovered that the WNT signaling pathway is more dynamic than previously thought, with different cell types responding differently to the same signals. They found that cells can tune the dynamics of this pathway to perform different functions in different contexts.
Researchers at King's College London found that Wnt signalling can be activated to revive a rudimentary dental lamina (RSDL) in mice, allowing for the formation of additional teeth. This breakthrough demonstrates potential for tooth replacement and provides insights into mammalian evolution and trait restoration.
Cardiff University researchers have identified a specific Fzd receptor called Fzd7 as the predominant Wnt receptor responsible for stem cell function in the stomach and intestine. Deleting this receptor makes gastric cells unable to divide and grow, providing a potential new therapeutic route for gastric cancers.
Researchers discover that embryonic cells retain a memory of chemical signals they encounter during development. Exposure to WNT and Activin signaling is necessary for differentiation, and cells can remember previous exposure to these signals, even if the signal is absent at the time of treatment.
A new study reveals the mechanistic relationship between cytokine IL-1ß, obesity, and colorectal cancer. Increased IL-1ß levels in obese mice activate multiple pathways leading to colon cancer. The study highlights the close linkage of obesity and inflammatory response, reflecting IL-1ß's broad actions.
Researchers at Oklahoma Medical Research Foundation have identified the signaling molecules that activate the Wnt signaling pathway in the lymphatic vascular system. This discovery could lead to better therapeutic options for lymphedema and associated disorders, including cancer and atherosclerosis.
Researchers have found that the Wnt pathway likely functions upstream of and activates the Hh pathway in response to injury, enabling proper tissue regeneration. The study suggests a new mechanism for appendage regeneration, with implications for human limb repair and regeneration.
Researchers at Université libre de Bruxelles have discovered a decoding mechanism for Wnt7 ligands, enabling precise interpretation of cell signals. This breakthrough has significant implications for understanding Wnt signaling and its regulation, potentially leading to new treatments for diseases like cancers and neurovascular disorders.
The human intestine constantly regenerates itself, with 10 billion epithelial cells replaced each day. Researchers have identified the stem-cell niche responsible for providing the activating signal to these stem cells, called Gli1-positive cells surrounding crypts.
Scientists from Brigham and Women's Hospital have developed 3D mini-brains from human stem cells to investigate the effects of a specific gene mutation tied to major mental illnesses. The results show that the mutated mini-brains exhibit structural disruptions, suggesting a potential new target pathway for therapies.
Researchers have discovered that PAWS1 plays a significant impact in controlling the Wnt signalling pathway, which is associated with developmental defects and diseases like alopecia and colorectal cancer. The study found that PAWS1 mutations can inhibit Wnt signalling, leading to potential interventions for these conditions.
Research at EMBL shows that synchronization between Wnt and Notch pathways enables embryo segmentation. Changing their relative timing prevents segment formation.
A study by MBL researchers found that genes aiding lamprey spinal cord healing are also active in mammalian peripheral nervous systems. The findings support the idea of harnessing these genes for improved spinal cord injury treatments.
Researchers at the Salk Institute have found a streamlined method to generate functioning heart cells from embryonic stem cells by turning off a single gene, YAP. This discovery offers scientists a simpler protocol for creating cardiomyocytes for research and regenerative therapies.
Researchers found that epigenetic regulation can increase Wnt signaling to promote cell proliferation, leading to resistance to cetuximab. Blocking Wnt signaling may restore responsiveness to the drug in cultured colon cancer cells and mice tumors.
UNC School of Medicine researchers found that faulty cell signaling in progenitor cells can derail cerebral cortex development, potentially leading to autism. The study suggests that disruptions in the Wnt protein pathway may play a crucial role in brain development and autism symptoms.
Researchers at University of Utah Health discovered a molecular pathway responsible for cleft palate formation and identified a new treatment to reverse this defect in mouse pups in-utero. The Wnt-based treatment restored palate fusion in all tested pups without adverse health effects.
Researchers at The Wistar Institute have established a correlation between the Wnt signaling pathway and a novel class of autophagy inhibitors in melanoma therapy. High levels of Wnt5A expression are linked to increased autophagy activation, making cells less sensitive to autophagy inhibition.
Researchers discovered that all hairs can communicate with each other and grow in coordination across the entire body, regulated by a single molecular mechanism. This finding could lead to new treatments for human baldness and unwanted hair growth.
Researchers found that intestinal stem cells lose regenerative capacity with age and that reactivating Wnt signaling can restore healthy function in older people. The study suggests a possible therapeutic approach to address imbalances in food and nutrient absorption, which may be linked to diminished Wnt signaling.
Researchers have successfully rejuvenated old gut stem cells by restoring Wnt signaling, suggesting a potential pathway to target for clinicians. This breakthrough offers new insights into the role of Wnt proteins in controlling stem cell growth and pluripotency in the gut later in life.
Mutations in specific proteins affect tooth enamel formation, leading to increased risk of caries. The study's findings open up new possibilities for preventing caries in patients with defective tooth enamel.
Researchers have successfully generated epicardium cells using human stem cells and Wnt signaling pathway activation. The new method could potentially repair damaged heart tissue in patients who suffer from heart attacks, according to the study published in Nature Biomedical Engineering.
Scientists at Helmholtz Zentrum München discovered that the Wnt5a molecule disrupts lung cells' ability to repair damages in COPD. Stimuli like cigarette smoke lead to increased production of Wnt5a, impairing lung regeneration.
Samumed has been selected for seven presentations in five therapeutic areas at the ACR Annual Meeting. The company's novel Wnt pathway inhibitor compounds show potential for treating diseases such as chronic tendinopathy, degenerative disc disease, scleroderma, osteoarthritis, and psoriasis.
New research reveals that gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with brain connection regulation. Mutations in this gene are linked to reduced synapse numbers and impaired WNT signaling in neurons, leading to heightened anxiety, loss of motivation, and social interaction deficits.
A novel small-molecule Wnt inhibitor named NCB-0846 has been discovered with potential to eradicate colorectal cancer stem cells. The inhibitor targets the Traf2- and Nck-interacting kinase (TNIK) regulatory component of the Wnt signaling pathway, blocking its signal even in colorectal cancer cells with APC gene mutations.
Researchers from the University of Pennsylvania have discovered a link between telomeres and the Wnt signaling cascade, which may hold a treatment option for patients with dyskeratosis congenita. Stimulating the Wnt pathway reversed signs of DC-related dysfunction in human tissues.
Scientists at Sanford Burnham Prebys Medical Discovery Institute made a major advance in understanding how stem cells become specialized. The study shows that the stem cell-specific protein OCT4 primes certain genes that cause differentiation, customizing stem cells' responses to signals.
Researchers at Sandia National Laboratories have discovered that the Rift Valley fever virus uses the Wnt signaling pathway to hijack host machinery and cause infection. This mechanism offers a promising new target for developing therapeutics against this deadly virus, which can cause fatal hepatitis and hemorrhagic fever.
A study found that genes involved in the Wnt signaling pathway are more frequently altered in younger patients with colorectal cancer. This pathway drives the growth and proliferation of cancer stem cells. The research suggests targeting this pathway may be a promising strategy for treating aggressive CRC in young patients
A study by MIT neuroscientists reveals that the Shank gene plays a crucial role in the formation and maturation of synapses. In fruit flies lacking this gene, researchers found reduced functional synapses and improper development, which could impair neural circuit development and contribute to autism symptoms.
Researchers at NYU Langone Health have identified a molecular signal that controls skin and hair color, which could lead to therapies targeting vitiligo and gray hair. The study found that stimulating this pathway increases melanocyte stem cell pigment production and corrects discoloration around scars.
A study reveals that Frizzled7 is uniquely controlled by the Notch signaling pathway in human breast epithelial cells. This interaction may provide a new target for treating breast cancer. The researchers hope their findings will help identify an underlying cause of breast carcinogenesis.
Researchers from CNIO have discovered a link between psoriasis and bone loss, finding that the disease causes widespread and progressive bone tissue loss. Treating psoriasis patients with IL-17 blockers could have benefits for bone health, and the study suggests potential implications for other autoimmune disorders.
Researchers have discovered a molecule that blocks cancer stem cells' ability to survive and replicate. The compound, LF3, targets the Wnt signaling pathway and reduces tumor growth in living animals.
Researchers at Rockefeller University discover a new signaling mechanism that instructs cells to become stem cells during embryonic development. The finding suggests that stem cells may exist before the niche is formed and has implications for understanding skin cancer treatments.
Researchers found that adding NELL-1 to BMP2 therapy produces tightly woven trabecular bone within the defect area, whereas BMP2 alone leads to adipose tissue interspersed with sparse trabecular bone. The combination treatment inhibits adipogenesis and promotes osteogenesis.
Scientists have discovered a surprising role of Wnt signaling in controlling male fertility. The research found that Wnt protects proteins from degradation, allowing sperm to mature and move forward. This discovery has potential implications for the treatment of infertility and contraception.
Researchers from the University of Southampton developed a new type of drug that activates stem cells in bones, causing them to divide and produce more bone cells. This approach may lead to faster and more effective bone healing, particularly for people undergoing hip replacement surgery.
Researchers have developed an injectable drug that inhibits the Wnt pathway, causing endogenous stem cells to regenerate knee cartilage in animals. Clinical data suggest slowing joint space narrowing and increased joint space, indicating potential preservation or regrowth of cartilage.
Proteins in the Wnt signaling pathway play a critical role in driving kidney scarring, which can lead to chronic kidney disease. Boosting expression of Wnt proteins in healthy kidneys may be an effective strategy for treating chronic kidney disease.
Researchers found that Wnt and Activin pathways work together to activate essential genes for stem cells to differentiate. This discovery could improve regenerative therapies and understanding of cancer development.
Researchers at Helmholtz Munich have developed a new method to validate drug targets for chronic obstructive pulmonary disease (COPD) treatment. The technique enables the study of lung tissue repair mechanisms in patient-derived tissues, providing valuable insights into COPD pathologies and potential therapeutic avenues.
By disabling the Wnt signaling pathway, researchers may be able to repair damaged white matter in the brain, a potential breakthrough in treating cerebral palsy and multiple sclerosis. The study's findings suggest that targeting the Daam2/PIP5K interaction could accelerate oligodendrocyte differentiation and promote myelination.
The study of zebrafish at the European Zebrafish Resource Center has shown that signaling molecules are transmitted in bundles via long filopodia, influencing signaling properties and tissue development. This precise control enables cells to develop their special structure and function.
Belgian researchers used patient-derived stem cells to model frontotemporal dementia, a condition that affects about half of dementia cases before age 60. The study found a targetable defect in the Wnt signaling pathway, which can be corrected with genetic therapy or compounds inhibiting this pathway.
Researchers discovered that WNT signaling molecules are crucial for cellular reprogramming, a process similar to regenerative processes in organisms. This finding has significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments.
Researchers identified RNF43 mutations in 20% of colorectal and endometrial cancers, suggesting a potential biomarker for targeted treatments. The mutation affects the Wnt signaling pathway, making tumors sensitive to new inhibitors currently in clinical trials.
A study published in Science Signaling found that JAK inhibitors can effectively treat over 80% of bowel cancers with a genetic mutation present in more than 80% of cases. The researchers discovered that these inhibitors block tumour growth by targeting the Wnt signaling pathway, with minimal impact on normal cells.
Researchers at Mayo Clinic have discovered a defect in the Wnt signaling pathway that contributes to both overproduction of toxic protein and loss of communication between neurons in Alzheimer's patients. Targeting this specific defect with drugs may rejuvenate or rescue the pathway, potentially preventing or treating Alzheimer's disease.
A study published in Neural Regeneration Research found that acupuncture and moxibustion can reduce neuronal edema in Alzheimer's disease rats. The treatment modality targets axin and β-catenin protein expression, a key pathway involved in Wnt signaling.