Articles tagged with Cognitive Disorders
Researchers identified complex brain connectivity patterns in individuals with chronic TBI, explaining long-term higher-order cognitive function deficits. Interactions among networks are critical for daily life tasks like planning and problem-solving.
Researchers found associations between CMV, HSV-2, and Toxoplasma gondii exposure and different aspects of cognitive decline in older people. The study suggests that chronic viral infections may trigger neurotoxic effects, leading to age-related cognitive impairment.
A study published in The BMJ found that internet-based cognitive behavioural therapy (CBT) can effectively treat body dysmorphic disorder, reducing symptom severity and depression. Participants who received BDD-NET showed significant improvements compared to those receiving online supportive therapy.
A new review suggests that stopping driving in older adults can contribute to various health problems, including depression. The decision to stop driving is often accompanied by declining cognitive and physical functions, highlighting the need for personalized plans to maintain mobility and social functions.
Researchers found an increase in healthy ageing, with less cognitive impairment and more years lived in good health. However, the proportion of people with mild disability increased, leading to a larger number of unhealthy individuals.
Studies reveal that children with epilepsy show global differences in cognitive network development, but hubs of these networks are functionally similar to those of healthy peers. Graph analysis also suggests that neural networks linking cognitive skills are not well integrated in children with epilepsy.
A study published in PLOS ONE reveals that the causes of congenital face blindness can be traced back to an early stage in the perceptual process. People with this condition are unable to use facial features to identify others, but their brains respond differently when shown a face.
Breast cancer patients treated with anthracycline-based chemotherapy experienced lower verbal memory and default mode brain network connectivity compared to non-chemotherapy groups. Cognitive dysfunction was also elevated in both treatment groups, highlighting the need for further research into chemotherapy-related neurotoxic effects.
A study at Georgetown University Medical Center found that HIV+ individuals over 50 years old showed cognitive impairments, even if they scored 'cognitively normal' in standard tests. Brain scans revealed deficits in the dorsal anterior cingulate cortex region, a key executive area.
The Kavli HUMAN Project aggregates 20 years of measurements from 10,000 individuals to study the dynamic interplay between biology, behavior, and environment. The project reveals new insights into factors increasing risk for cognitive decline and its impact on daily life, healthcare utilization, and end-of-life decisions.
New Jersey researchers used neuroimaging to investigate reading deficits in patients with subacute left hemispheric stroke. They found associations between phonological deficits and lesions in the anterior temporal lobe and mid-fusiform gyrus. This study may lead to targeted interventions for acquired reading deficits, benefiting indiv...
A University of Miami research team proposes a four-component model of cognitive flexibility, which helps understand autism spectrum disorder and other behavioral/neurological disorders. The study may inform the development of new interventions to improve cognitive flexibility skills in individuals with autism.
Researchers identified a link between cognitive deficits and lesions in areas processing emotions, suggesting a third category of knowledge representation for social groups. This discovery highlights the close relationship between social relations and emotional processing in the human brain.
A systematic evidence review suggests that cognitive decline following invasive heart procedures is unlikely in older adults, with little to no difference found between treatment groups. However, individual study quality was low and more research is needed to confirm these findings.
Research presented at Heart Failure 2015 found that cognitive impairment is common in elderly heart failure patients, occurring in three-quarters of patients. The study also showed that cognitive impairment predicts a worse prognosis, with an increased risk of all-cause death and heart failure readmission.
A new study by Moffitt researchers found that men treated with androgen deprivation therapy for prostate cancer have a higher risk of cognitive impairment. The study also identified a possible genetic link between the GNB3 gene and cognitive problems during ADT treatment.
Two studies presented at the American Heart Association's Quality of Care and Outcomes Research 2015 Scientific Sessions found that more than one in four LVAD patients experience notable cognitive decline. Patients with poor overall health, including death, severe stroke, and poor quality of life, are also common outcomes.
A new therapy, TIPSS, developed by Anka Vujanovic aims to treat both post-traumatic stress disorder (PTSD) and substance use disorders. The study focuses on an integrated treatment that combines elements of standard cognitive-behavioral therapy with a focus on PTSD symptoms.
New York University faculty members Michael Halassa and Jennifer Jacquet have been awarded Sloan Foundation research fellowships to advance their groundbreaking research in neuroscience and environmental science. Their studies aim to crack the neural code of sensory input and explore large-scale cooperation dilemmas, with potential imp...
HIV-associated neurocognitive disorders affect 10-50% of aging patients, causing cognitive impairment and daily challenges. Researchers found that the tat protein disrupts autophagy, a critical disposal process, in neurons.
Researchers found a significant association between atherosclerosis and mild cognitive impairment in a study of nearly 2,000 adults. The study used MRI and CT imaging techniques to measure plaque buildup in arteries and brain health.
A new study shows that stroke patients remain at high risk for repeat strokes and other serious events even after the initial 90-day danger period. After five years, their risk is double that of individuals without a previous stroke or TIA, highlighting the need for longer follow-up and preventive interventions.
Researchers found a unique signature of aging in the choroid plexus, which separates blood from cerebrospinal fluid, and discovered that interferon beta has a negative effect on the brain. Blocking this protein's activity restored cognitive abilities in older mice.
Researchers found heme oxygenase-1 deficiency in HIV-infected brains associated with cognitive decline and increased viral load. Increasing heme oxygenase-1 expression may offer protective benefits against HIV-associated neurocognitive disorders.
A recent study found that APOE ε4 and APOC1 H2 gene polymorphisms are associated with increased risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease. The findings suggest a potential genetic link between these genes and cognitive impairment progression in this population.
A new study published in CMAJ found that people with cognitive impairment have a significantly increased risk of stroke, with a 39% higher risk than those with normal cognitive function. The study analyzed data from 18 studies and observed a higher rate of stroke in individuals with cognitive impairment.
A new study of older men found that poor sleep quality is associated with a 40-50% increase in the odds of clinically significant decline in executive function. Sleep fragmentation and lower sleep efficiency were key predictors of cognitive decline.
Researchers found that higher educational attainment attenuates the negative impact of TBI on cognitive status. The study suggests that intellectually enriching activities may protect against further cognitive decline.
A study published in Science has identified a genetic mutation in almost 75% of cases, linking HSP to other common neurodegenerative disorders like Alzheimer's and ALS. The research found over 50 families with autosomal recessive HSP, providing insight into the biological processes underlying these diseases.
A study by Indiana University and Regenstrief Institute found that cognitively impaired older adults released from the hospital are less likely to be rehospitalized within 30 days if they go to a nursing home. In contrast, those returned to their own homes or family members are more likely to experience readmission.
A study by Concordia University researchers found that individuals who engage in cognitively demanding activities and enjoy doing so tend to experience less cognitive decline later in life. Additionally, those with even mild depressive symptoms are more likely to show a decline in brainpower after retirement.
A study by Evan Fletcher and colleagues found that white matter loss in the fornix may be an early sign of cognitive decline in healthy elderly individuals. Changes in fornix volume were highly significant predictors of cognitive deterioration.
Research from University of Luxembourg finds employment gaps during working life can decrease cognitive reserve, with training and maternity spells associated with slower cognitive decline. The study suggests cognitively stimulating activities during employment gaps may have beneficial effects on cognitive function.
Researchers found that cilostazol decreases hypoxia-inducible factor-1α and heme oxygenase-1 expression levels, protecting against cognitive impairment induced by chronic cerebral ischemic injury. Cilostazol treatment also exhibits an anti-apoptotic mechanism in the context of chronic cerebral ischemia.
Multiple hospitalizations for pneumonia, urinary tract infections, septicemia, and dehydration result in significantly lower survival rates among nursing home residents with moderate to severe cognitive impairment. These findings highlight the need for reevaluation of care goals and resource allocation for this vulnerable population.
Patients with epilepsy and mild cognitive impairment (aMCI) showed earlier cognitive decline than those without epilepsy. Epilepsy increases the risk of seizures and accelerates symptoms in Alzheimer's disease (AD). Identifying and treating epilepsy could improve clinical outcomes for patients.
Researchers found that patients with high educational levels show less impairment on a neuropsychological evaluation compared to those with low educational levels. Higher education was found to be protective against disease-associated cognitive impairment in multiple sclerosis patients.
A study by Northwestern University researcher Robert Hanlon found that impulsive murderers are more mentally impaired than strategic planners. Nearly all impulsive murderers had a history of alcohol or drug abuse and were intoxicated at the time of the crime.
Researchers found that older emergency patients have functional and cognitive problems increase dramatically after arrival. These patients often require specialized training in geriatric care to provide the best assessment and care.
Research published in The Journal of Nuclear Medicine found that highly educated pre-Alzheimer's patients exhibit increased neural reserve and compensation, leading to better coping mechanisms. This suggests that education level plays a crucial role in determining cognitive reserve against the disease.
Researchers found that preterm children's cognitive performance deficits increase with task complexity and decrease with pregnancy duration. The study suggests that educational interventions could be developed to promote academic attainment in preterm children.
A cross-sectional study of 1,870 individuals found that long-lived families have a reduced risk of cognitive impairment consistent with Alzheimer's disease. The study suggests a delayed onset of disease in these families, protecting their members but not later in life.
Researchers found chronic pain to be a common complication of ischemic strokes, associated with greater decline in physical and cognitive function. Significant risk factors for post-stroke pain include increased severity of stroke, female gender, and vascular disease.
A study published by Henry Ford Hospital found that resveratrol can reduce noise-induced hearing loss and cognitive decline in rats. The researchers discovered that resveratrol inhibits the inflammatory process and oxidative stress caused by loud noise, providing protection against age-related hearing and cognitive impairment.
A new study published in Neurology found that people who went hungry as children had slower cognitive decline than those who always had enough food to eat. The study involved over 6,000 participants and found a significant association between childhood hunger and reduced cognitive decline.
People who experienced hunger as children had slower cognitive decline than those who never went hungry, with African American participants showing a significant protective effect. The study suggests calorie restriction or selective survival effects may be responsible for this finding.
Australian researchers discovered that reduced heart rate variability best predicts cognitive disturbances in people with chronic fatigue syndrome. The study found a significant loss of vagal modulation, consistent with the notion that CFS represents a system under stress. This could lead to new ways to improve cognitive difficulties i...
Researchers found that clonazepam alleviated autistic-like behavior in mice with a sodium ion channel defect. The study reveals how the mutated gene leads to overly excited brain circuits and impaired social interactions, shedding light on Dravet syndrome's underlying mechanisms.
A new study published in Annals of Neurology suggests that increased consumption of flavonoid-rich blueberries and strawberries may slow cognitive decline in older adults, delaying aging by up to 2.5 years.
A study by Regenstrief and IU found that screening for cognitive impairment in hospitals does not improve patient outcomes. The study suggests that a more nuanced approach to addressing the issue is needed.
A study by Kelvin Lui and Alan Wong found that frequent media multitaskers outperformed light multitaskers in integrating visual and auditory information. This improvement was attributed to their ability to routinely take in information from multiple sources.
A study published in Archives of General Psychiatry found that persistent depression symptoms may be associated with significant declines in cognitive performance in older patients with coronary artery disease who underwent cardiac catheterization. Patients with persistent depressive symptoms exhibited greater decline in attention/exec...
A recent study published in Neuron reveals that rare genetic mutations, specifically copy number variants, contribute significantly to the risk of early onset bipolar disorder. These findings suggest that de novo mutations play a crucial role in the development of the disease, which appears in childhood or early adulthood.
Researchers identify neurobiological characteristics linked to complex neuropsychiatric disorders as potential biomarkers. Cognitive deficits are recognized as core features of schizophrenia, reflecting a broader, more multidimensional illness than traditional diagnosis.
The National Institutes of Health's Therapeutics for Rare and Neglected Diseases (TRND) program has announced its next round of drug development projects. Six new projects will focus on treatments for rare and neglected diseases, including musculoskeletal disorders, cognitive dysfunction disorders, and parasitic worm infections. The TR...
Two Kessler Foundation researchers received over $100,000 in National Multiple Sclerosis Society grants to investigate cognitive impairments in MS. The studies aim to improve processing speed and understand the relationship between white matter damage and cognitive decline.
Two Wayne State University research groups will lead projects on reducing driver distraction and improving the safety of children, teens, seniors, and pedestrians. The Collaborative Safety Research Center will invest $50 million over five years to enhance vehicle safety.
Researchers from Boston Medical Center will study neurological and brain abnormalities in former extremely low gestational age newborns (ELGANS) with a $13 million NIH grant. The study aims to identify infants at high risk for neurodevelopmental disorders and establish a method for prophylactic interventions.
Multiple lifestyle improvements can reduce the risk of developing diabetes by up to 80%, according to a study of over 100,000 men and women. Additionally, researchers warn that Babesia, a parasitic disease, poses a threat to the nation's blood supply, highlighting the need for donor-screening strategies.
A large, long-term study confirms that medications with anticholinergic activity cause cognitive impairment. The research also identifies a possible link between these drugs and risk of death.