Articles tagged with Cognitive Disorders
A new therapy, TIPSS, developed by Anka Vujanovic aims to treat both post-traumatic stress disorder (PTSD) and substance use disorders. The study focuses on an integrated treatment that combines elements of standard cognitive-behavioral therapy with a focus on PTSD symptoms.
New York University faculty members Michael Halassa and Jennifer Jacquet have been awarded Sloan Foundation research fellowships to advance their groundbreaking research in neuroscience and environmental science. Their studies aim to crack the neural code of sensory input and explore large-scale cooperation dilemmas, with potential imp...
HIV-associated neurocognitive disorders affect 10-50% of aging patients, causing cognitive impairment and daily challenges. Researchers found that the tat protein disrupts autophagy, a critical disposal process, in neurons.
Researchers found a significant association between atherosclerosis and mild cognitive impairment in a study of nearly 2,000 adults. The study used MRI and CT imaging techniques to measure plaque buildup in arteries and brain health.
A new study shows that stroke patients remain at high risk for repeat strokes and other serious events even after the initial 90-day danger period. After five years, their risk is double that of individuals without a previous stroke or TIA, highlighting the need for longer follow-up and preventive interventions.
Researchers found a unique signature of aging in the choroid plexus, which separates blood from cerebrospinal fluid, and discovered that interferon beta has a negative effect on the brain. Blocking this protein's activity restored cognitive abilities in older mice.
Researchers found heme oxygenase-1 deficiency in HIV-infected brains associated with cognitive decline and increased viral load. Increasing heme oxygenase-1 expression may offer protective benefits against HIV-associated neurocognitive disorders.
A recent study found that APOE ε4 and APOC1 H2 gene polymorphisms are associated with increased risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease. The findings suggest a potential genetic link between these genes and cognitive impairment progression in this population.
A new study published in CMAJ found that people with cognitive impairment have a significantly increased risk of stroke, with a 39% higher risk than those with normal cognitive function. The study analyzed data from 18 studies and observed a higher rate of stroke in individuals with cognitive impairment.
A new study of older men found that poor sleep quality is associated with a 40-50% increase in the odds of clinically significant decline in executive function. Sleep fragmentation and lower sleep efficiency were key predictors of cognitive decline.
Researchers found that higher educational attainment attenuates the negative impact of TBI on cognitive status. The study suggests that intellectually enriching activities may protect against further cognitive decline.
A study published in Science has identified a genetic mutation in almost 75% of cases, linking HSP to other common neurodegenerative disorders like Alzheimer's and ALS. The research found over 50 families with autosomal recessive HSP, providing insight into the biological processes underlying these diseases.
A study by Indiana University and Regenstrief Institute found that cognitively impaired older adults released from the hospital are less likely to be rehospitalized within 30 days if they go to a nursing home. In contrast, those returned to their own homes or family members are more likely to experience readmission.
A study by Concordia University researchers found that individuals who engage in cognitively demanding activities and enjoy doing so tend to experience less cognitive decline later in life. Additionally, those with even mild depressive symptoms are more likely to show a decline in brainpower after retirement.
A study by Evan Fletcher and colleagues found that white matter loss in the fornix may be an early sign of cognitive decline in healthy elderly individuals. Changes in fornix volume were highly significant predictors of cognitive deterioration.
Research from University of Luxembourg finds employment gaps during working life can decrease cognitive reserve, with training and maternity spells associated with slower cognitive decline. The study suggests cognitively stimulating activities during employment gaps may have beneficial effects on cognitive function.
Researchers found that cilostazol decreases hypoxia-inducible factor-1α and heme oxygenase-1 expression levels, protecting against cognitive impairment induced by chronic cerebral ischemic injury. Cilostazol treatment also exhibits an anti-apoptotic mechanism in the context of chronic cerebral ischemia.
Multiple hospitalizations for pneumonia, urinary tract infections, septicemia, and dehydration result in significantly lower survival rates among nursing home residents with moderate to severe cognitive impairment. These findings highlight the need for reevaluation of care goals and resource allocation for this vulnerable population.
Patients with epilepsy and mild cognitive impairment (aMCI) showed earlier cognitive decline than those without epilepsy. Epilepsy increases the risk of seizures and accelerates symptoms in Alzheimer's disease (AD). Identifying and treating epilepsy could improve clinical outcomes for patients.
Researchers found that patients with high educational levels show less impairment on a neuropsychological evaluation compared to those with low educational levels. Higher education was found to be protective against disease-associated cognitive impairment in multiple sclerosis patients.
A study by Northwestern University researcher Robert Hanlon found that impulsive murderers are more mentally impaired than strategic planners. Nearly all impulsive murderers had a history of alcohol or drug abuse and were intoxicated at the time of the crime.
Researchers found that older emergency patients have functional and cognitive problems increase dramatically after arrival. These patients often require specialized training in geriatric care to provide the best assessment and care.
Research published in The Journal of Nuclear Medicine found that highly educated pre-Alzheimer's patients exhibit increased neural reserve and compensation, leading to better coping mechanisms. This suggests that education level plays a crucial role in determining cognitive reserve against the disease.
Researchers found that preterm children's cognitive performance deficits increase with task complexity and decrease with pregnancy duration. The study suggests that educational interventions could be developed to promote academic attainment in preterm children.
A cross-sectional study of 1,870 individuals found that long-lived families have a reduced risk of cognitive impairment consistent with Alzheimer's disease. The study suggests a delayed onset of disease in these families, protecting their members but not later in life.
Researchers found chronic pain to be a common complication of ischemic strokes, associated with greater decline in physical and cognitive function. Significant risk factors for post-stroke pain include increased severity of stroke, female gender, and vascular disease.
A study published by Henry Ford Hospital found that resveratrol can reduce noise-induced hearing loss and cognitive decline in rats. The researchers discovered that resveratrol inhibits the inflammatory process and oxidative stress caused by loud noise, providing protection against age-related hearing and cognitive impairment.
A new study published in Neurology found that people who went hungry as children had slower cognitive decline than those who always had enough food to eat. The study involved over 6,000 participants and found a significant association between childhood hunger and reduced cognitive decline.
People who experienced hunger as children had slower cognitive decline than those who never went hungry, with African American participants showing a significant protective effect. The study suggests calorie restriction or selective survival effects may be responsible for this finding.
Australian researchers discovered that reduced heart rate variability best predicts cognitive disturbances in people with chronic fatigue syndrome. The study found a significant loss of vagal modulation, consistent with the notion that CFS represents a system under stress. This could lead to new ways to improve cognitive difficulties i...
Researchers found that clonazepam alleviated autistic-like behavior in mice with a sodium ion channel defect. The study reveals how the mutated gene leads to overly excited brain circuits and impaired social interactions, shedding light on Dravet syndrome's underlying mechanisms.
A new study published in Annals of Neurology suggests that increased consumption of flavonoid-rich blueberries and strawberries may slow cognitive decline in older adults, delaying aging by up to 2.5 years.
A study by Regenstrief and IU found that screening for cognitive impairment in hospitals does not improve patient outcomes. The study suggests that a more nuanced approach to addressing the issue is needed.
A study by Kelvin Lui and Alan Wong found that frequent media multitaskers outperformed light multitaskers in integrating visual and auditory information. This improvement was attributed to their ability to routinely take in information from multiple sources.
A study published in Archives of General Psychiatry found that persistent depression symptoms may be associated with significant declines in cognitive performance in older patients with coronary artery disease who underwent cardiac catheterization. Patients with persistent depressive symptoms exhibited greater decline in attention/exec...
A recent study published in Neuron reveals that rare genetic mutations, specifically copy number variants, contribute significantly to the risk of early onset bipolar disorder. These findings suggest that de novo mutations play a crucial role in the development of the disease, which appears in childhood or early adulthood.
Researchers identify neurobiological characteristics linked to complex neuropsychiatric disorders as potential biomarkers. Cognitive deficits are recognized as core features of schizophrenia, reflecting a broader, more multidimensional illness than traditional diagnosis.
The National Institutes of Health's Therapeutics for Rare and Neglected Diseases (TRND) program has announced its next round of drug development projects. Six new projects will focus on treatments for rare and neglected diseases, including musculoskeletal disorders, cognitive dysfunction disorders, and parasitic worm infections. The TR...
Two Kessler Foundation researchers received over $100,000 in National Multiple Sclerosis Society grants to investigate cognitive impairments in MS. The studies aim to improve processing speed and understand the relationship between white matter damage and cognitive decline.
Two Wayne State University research groups will lead projects on reducing driver distraction and improving the safety of children, teens, seniors, and pedestrians. The Collaborative Safety Research Center will invest $50 million over five years to enhance vehicle safety.
Researchers from Boston Medical Center will study neurological and brain abnormalities in former extremely low gestational age newborns (ELGANS) with a $13 million NIH grant. The study aims to identify infants at high risk for neurodevelopmental disorders and establish a method for prophylactic interventions.
Multiple lifestyle improvements can reduce the risk of developing diabetes by up to 80%, according to a study of over 100,000 men and women. Additionally, researchers warn that Babesia, a parasitic disease, poses a threat to the nation's blood supply, highlighting the need for donor-screening strategies.
A large, long-term study confirms that medications with anticholinergic activity cause cognitive impairment. The research also identifies a possible link between these drugs and risk of death.
A new study published in Annals of Neurology found that residents of the Stroke Belt, a southern region of the US, have a higher incidence of cognitive decline than other regions. The research team believes shared risk factors are to blame and suggests investigating regional patterns contributing to modifiable risk factors.
Recent analysis of children and adolescents with FASD reveals significant volume reductions in deep gray matter structures. These findings suggest that the brain's relay stations, responsible for efficient communication between regions, are disproportionately affected by alcohol exposure during fetal development.
A literature review suggests that drinking 100 percent fruit juices may offer disease-fighting benefits similar to whole fruits. The review found a positive association between 100 percent juice intake and reduced risks for several chronic diseases, including cancer, cardiovascular disease, and cognitive decline.
A systematic review of memantine trials found no evidence of benefit for patients with mild Alzheimer's disease, contradicting its frequent off-label use. Increasing acetylcholine levels appears to slow mental decline in AD, but current evidence is insufficient.
A new technique allows scientists to observe herpes simplex virus type 1 (HSV1) infections growing inside cells, revealing a mechanism by which HSV1 leads to Alzheimer's disease. Frequent interactions between viral particles and cellular amyloid precursor protein facilitate viral transport while interfering with normal APP distribution.
Cognitive impairment in liver disease patients may not be fully reversible and can affect driving safety. Doctors are advised to carefully evaluate cirrhotic patients for hepatic encephalopathy and address driving issues with them.
A large-scale study has found that ecstasy users show no signs of cognitive impairment attributable to drug use. The research, funded by $1.8 million from the National Institute on Drug Abuse, aimed to minimize methodological limitations of earlier studies and compared 52 ecstasy users with 59 non-users.
A new study suggests that a personalized multimedia program can reduce falls among older hospital patients without cognitive impairment. The program, which combines videos with one-on-one follow-up, was associated with fewer falls and lower injury rates compared to usual care.
A new study suggests that regular exercise can improve brain function and reduce cognitive decline risk in people carrying a high-risk gene for Alzheimer's disease. Participants who exercised showed greater brain activity in memory-related regions compared to sedentary counterparts.
Researchers used MRI to identify microbleeds and altered iron distribution in the brains of individuals with mild cognitive impairment. These biomarkers predicted disease progression with high accuracy, offering new hope for early diagnosis and treatment of Alzheimer's disease.
A new study found that cognitive skills in children with autism spectrum disorder (ASD) vary from child to child and can improve over time. The research, conducted in Western Australia, assessed 37 children with ASD and 31 typically developing children at ages 5-6 and again three years later.
A new study found that while many with BDD seek cosmetic procedures, only two percent led to improved symptom reduction. The majority of patients continued to experience BDD symptoms despite treatment.
Researchers identified a signature of three biomarkers in cerebrospinal fluid that can correctly classify patients with Alzheimer's disease. The study suggests that these biomarkers can detect the pathogenic process of Alzheimer's disease at an early stage, potentially leading to earlier diagnosis and treatment.
A new study by Yale University researcher Hedy Kober shows that smokers can control their cravings with the help of cognitive strategies, increasing activity in the prefrontal cortex and decreasing craving-related brain activity. Cognitive behavioral therapy has been shown to be an effective tool in treating substance use disorders.
Children with special health care needs are at higher risk of developing oral disease. Poor diets, frequent use of sugary syrups, and inadequate oral hygiene can exacerbate the issue.
An independent panel by the NIH determined that mental stimulation, exercise, and dietary supplements have insufficient evidence to delay or prevent Alzheimer's disease. The panel emphasized the need for research on objective measures of cognitive function and collaboration between clinicians and researchers.
A special issue of the Journal of Vocational Rehabilitation focuses on the potential of autistic young adults, highlighting their ability to form relationships and enjoy employment benefits. Researchers provide case studies and programs to support practitioners in working with this population.