A new imaging strategy combines dissolvable microneedles with a methylene blue-based nanoparticle tracer to produce clearer images of lymphatic vessels and nodes. The system also reveals segmental contractions linked to lymphatic pumping, opening a path toward more refined visualization and functional assessment.
A living reef coastal defense system has been shown to significantly reduce wave power, supporting reef growth and stabilizing shorelines. The hybrid structure combines engineering and natural processes, offering a potential alternative to traditional engineered structures.
Research from the University of Kansas reveals that chronic pain is linked to higher rates of smoking and vaping, particularly among those with more severe pain. The study's findings highlight the need for targeted interventions addressing both chronic pain and tobacco use.
Researchers from Aalto University developed an AI model that simulates human motion from touchscreen logs, providing insights into physically effortful smartphone interactions. The model helps designers create user-friendly interfaces and identifies areas requiring additional effort.
St. Olaf researchers create mechanical computers that can perform simple computations without a computer chip or power source, harnessing their power from physical force. The devices demonstrate proof of design for alternative computing in harsh settings, paving the way for smart materials and responsive artificial limbs.
A specific protein complex regulates protein balance in plants, influencing their response to environmental stress. Researchers discovered that this process, known as N-terminal acetylation, maintains the stability of the plant proteome by controlling protein degradation and recycling.
A new IIASA-led study offers a practical approach to evaluate the distributional implications of climate action, enabling policymakers to assess justice impacts of emissions pathways. The study found that many existing mitigation scenarios are consistent with justice principles, while few explore limits on energy or meat consumption.
A clinical trial aims to evaluate whether laser therapy reduces vaginal dryness caused by breast cancer treatment. The study, REVITALIZE, plans to enroll approximately 250 women with a history of breast cancer who experience moderate to severe vaginal dryness.
Researchers developed an inhaled treatment to reduce lung inflammation and fluid build-up after severe infections. The therapy targets Angiopoietin-like protein 4 (ANGPTL4) and showed promise in preclinical studies.
Oncology services are often excluded from emergency health priorities, resulting in delayed diagnosis and treatment interruptions. Vulnerable populations, including women and children, face advanced disease stages due to delays in care.
Researchers propose a novel THz metasurface-enabled platform for integrated sensing and imaging, overcoming limitations of slow sequential data acquisition. The system achieves 100% binary image reconstruction with nanosecond-scale accuracy, enabling real-time applications in security, semiconductor, and pharmaceutical sectors.
Super-enhancers are densely clustered regions driving oncogene expression in cancer. Targeting BRD4, CDK7, and SE structure with small molecules and CRISPR may offer therapeutic benefits. Combination therapies aim to overcome resistance and improve outcomes.
Researchers at the University of Groningen discovered that protein clustering in cells leads to reduced movement and improved efficiency in amino acid production. This finding has practical implications for designing efficient cell factories and increasing substance production inside cells.
Researchers at VIB–VUB Center for Structural Biology have discovered a counterintuitive principle for designing membrane proteins. Introducing 'imperfections' or negative design enables synthetic membrane proteins to fold and assemble efficiently. This approach can improve the stability of final folded structures without compromising it.
Researchers have developed a method to extract bio-oil from date palm surface fibers, an abundant biomass resource. The study found that the resulting bio-oil consists primarily of aliphatics and aromatics, making it suitable for targeted recovery and bioenergy applications.
A novel machine learning framework integrates high-resolution remote sensing and dynamic climate windows to estimate early-season winter wheat sowing dates. The framework achieved an R² of 0.82 with most estimates within ±5 days of observed values, capturing regional patterns and fine-scale variations.
Researchers used a cabled marine observatory to study plankton abundance and variety over a four-year period. They found that long-term changes in aggregate abundance and plankton diversity were not influenced by ocean turbulence.
The COLIBRE simulations successfully reproduce real galaxies in the present-day universe and early universe as seen by the James Webb Space Telescope. The models include cold gas and cosmic dust, which strongly affect galaxy appearance in telescopes.
Acute liver failure is driven by massive hepatic necrosis, a catastrophic form of liver injury characterized by extensive hepatocyte loss. Liver progenitor cells play a key role in regeneration and functional compensation, enabling patients to survive despite severe liver damage.
Researchers at KIT have developed the NECOC process to convert CO2 emissions into a solid raw material, which can be used in various industries. The process aims to close carbon cycles on-site at industrial plants, reducing greenhouse gas emissions.
The Hong Kong University of Science and Technology (HKUST) has developed the world's first bio-inspired artificial cilia system capable of replicating natural cilia's complex motion. The system uses a 3D-printed hydrogel microactuator with rapid ion transport, enabling fast and precise movement.
Researchers found that squalene-based adjuvants activate distinct pathways for vaccine protection and reactogenicity, including the role of IL-1β in enhancing efficacy and IL-1α in triggering local swelling. The study's findings could lead to safer vaccine design by targeting specific immune mechanisms.
Researchers at the University of Lausanne uncover a breakthrough in understanding Mount Etna's origin, suggesting that the volcano may have formed through a mechanism similar to petit-spot submarine volcanoes. This discovery opens up new perspectives for understanding how other volcanic systems may form around the world.
Climate change is altering insect emergence timing worldwide, impacting their ability to find food and survive. A study found that insects from cooler regions are particularly vulnerable to warm springs, losing energy quickly and facing poorer starting conditions.
The center offers state-of-the-art facilities for practical skills acquisition, digital technologies integration, and innovation in medical procedures. Future physicians will benefit from cadaver training, real-time imaging, and collaborative research opportunities.
A team led by Professor Julia Beatty explores how feline tumour viruses offer vital insights into human oncology and viral carcinogenesis. Domestic cat hepatitis B virus is strongly associated with feline HCC, mirroring human HBV oncogenic patterns.
A study published in Chinese Medical Journal reveals how mitochondrial activity is regulated in heart muscle cells. Mitochondrial dysfunction disrupts energy production and affects cardiac outcomes, with various proteins managing mitochondrial biogenesis and mitophagy.
A new study from the University of Oxford found that long-term childhood poverty increased sharply among children born after 2013 due to austerity reforms. Nearly one in five children born after this period experience poverty for at least half of their childhood, with severe consequences on education, employment, earnings, and health.
Researchers at Tohoku University have made significant progress in precise nanoscale construction of g-C₃N₄ catalysts, which enables efficient photocatalytic H₂O₂ evolution. The study highlights the importance of nanoarchitectonics in scaling up industrial production.
Researchers have developed a novel sh2isu1 sweet maize germplasm using CRISPR/Cas9 cytosine base editor, offering multiple advantages. The approach enables the rapid generation of desired phenotypes without transgenic components within 1-2 years.
Researchers developed a natural, biodegradable wash that removed up to 96% of pesticide residue from fruit and slowed browning and moisture loss. The coating also showed antimicrobial effects and added nutritional value.
Researchers at the University of Würzburg have directly measured the 'waiting time' in a two-dimensional material, which lasts exactly 24 billionths of a second. This knowledge increases the accuracy of atomic sensors and paves the way for future medical diagnostics.
Researchers have developed a water-soluble cellulose ethyl phosphite (CEP) adhesive that integrates high bonding strength, environmental tolerance, and recyclability. The CEP adhesive demonstrates remarkable thermal stability and resistance to moisture-related degradation, making it suitable for various applications.
PhytoCell, an ensemble learning framework, analyzes plant single-cell RNA sequencing data to identify marker genes and assign cell types accurately. The framework achieves precise annotation of cell subpopulations and effectively removes redundant noise.
Entomologist Mark Moffett observes harvester ants congregating with smaller cone ants in Arizona's Chiricahua Mountains. The unusual behavior involves the cone ants licking and nibbling the harvester ants' body surfaces, possibly consuming calorie-rich dust-size morsels.
The new guidance provides practical routes forward for AI use in every publishing role, promoting accountability, transparency, risk-awareness, and innovation. It introduces structured checkpoints and ready-to-use tools to make responsible AI use practical, not theoretical.
Current large language models struggle with early diagnostic reasoning and cannot be relied upon for patient-facing clinical decisions. The study highlights the need for further improvement in these areas to enhance patient care.
A new USC study found that in-store pharmacies filled less than 2% of mifepristone prescriptions since the FDA eased dispensing requirements, with mail-order pharmacies accounting for most fills. The study suggests significant access gaps in states with stronger legal protections for abortion.
A new study found that school-age children and adolescents with medically diagnosed traumatic brain injury (TBI) have higher rates of anxiety/depression. Family resilience was associated with decreased odds of depression after TBI, suggesting a crucial role in recovery.
A study of 21 large language models found that they excel at accurate final diagnoses but falter at differential diagnoses, highlighting the need for human oversight in healthcare. The researchers developed a novel measure, PrIME-LLM, to evaluate AI's clinical competency across different stages of reasoning.
A clinical trial has shown that stent placement can effectively treat post-thrombotic syndrome, a common complication of deep vein thrombosis. The study found significant improvements in venous symptoms and overall quality of life for patients who received the procedure.
Research evaluates collagen's hierarchical structure, cross-linking kinetics, and biomechanical adaptability for high-performance ophthalmic repair materials. The study highlights collagen's transition from a replacement material to a platform for functional ocular regeneration.
Research at UChicago Medicine found that clinicians who perceive patients with sickle cell disease as opioid users are more likely to experience bias and provide lower quality care. The study highlights the need for increased awareness and education on overcoming biases related to chronic pain management.
A new review paper proposes that brain categorization is part of a predictive process to efficiently meet needs, rather than an intellectual exercise comparing sensory inputs to a fixed prototype. This approach predicts the world and anticipates actions, allowing for efficient survival and thriving in a fast-paced environment.
Researchers identified previously unseen changes in motor coordination that result from incomplete spinal cord injuries. Motor units, nerve-to-muscle connections, struggle to spread signals smoothly across muscles at low exertion after the injury.
A 76-year-old woman developed spinal mixed histiocytosis after multiple relapses of BRAF-mutated unifocal skull Langerhans cell histiocytosis. She was treated successfully with targeted therapy, highlighting the importance of routine PET/CT screening and genetic testing for refractory cases.
Critical thinking skills are crucial for teenagers to spot fake news, resist online addiction and harms like sextortion and bullying. Parents and educators can equip teens with practical skills to evaluate sources, seek multiple perspectives and make informed decisions.
Ovarian cancer cells induce adipose tissue dysfunction and ADSC senescence, creating favorable conditions for tumor metastasis. Targeting senescent ADSCs with dasatinib plus quercetin or resveratrol achieves remarkable efficacy in delaying tumor progression and reducing metastases.
A study published by the American Psychological Association found that people consistently underestimate how interesting and enjoyable conversations about boring topics would be. People reported enjoying these conversations much more than they had predicted, even when both parties agreed the topic was boring.
Researchers have identified a critical molecular mechanism that shuts down the heart's repair system after cardiac arrest, leaving it unable to recover. The study aims to develop new treatments for devastating medical conditions such as heart attack and stroke during major surgery.
Researchers found that obesity significantly impaired antibody production to a Pseudomonas aeruginosa vaccine in mouse models. The study suggests prioritizing tissue-resident immunity to boost protection against infections. Understanding this relationship addresses a significant gap in current vaccine research.
The Korea University Institute for Environmental Medicine hosted a delegation from the Uzbekistan Ministry of Health for an institutional visit and strategic discussions. The visit aimed to deepen mutual understanding and expand collaboration in healthcare and medical education between the two countries.
Fungal endophytes from cacti have been found to boost drought tolerance in cacao plants by controlling stomatal conductance and retaining more water. These microbes could provide a novel strategy for addressing climate change's impact on cacao production.
A team of Weill Cornell Medicine investigators is creating a dual-track program to train clinical oncology fellows and cancer research scientists in AI tools and cancer biology. The goal is to develop scientists who can use the latest tools to deliver on the promise of personalized cancer therapies.
A recent study found that 15% of Chinese immigrants use China-based telehealth apps for medical advice while living in the US. These apps are preferred due to lower costs, ease of access, and language support. However, reliance on foreign-based services raises concerns about patient safety, continuity of care, and regulatory oversight.
Researchers from Colorado State University found that tiny particles bubbling up from melting sea ice in the Arctic sky can create clouds, providing a platform for water vapor to freeze onto. This discovery sheds light on why Arctic clouds behave differently and could help improve weather modeling and climate change predictions.
A new method, MIDA, uses physics-based ground motion simulations tied to earthquake magnitude to better assess seismic performance of near-fault structures. This approach reduces subjectivity and nonphysical distortion, providing a more stable and realistic prediction of structural response.
By striking a gold nanorod off-center with an electron beam, researchers created rotating circular polarization in light, a property useful for controlling information encoding and transmission. This simple approach could enable new ways to encode, route, and process information using light.
A study found that repeated use of low-cost mobile breathalyzers led to changes in drinking behavior, with heavy drinkers reducing blood-alcohol concentrations. The device's introduction allowed individuals to track their intoxication levels in real-time, enhancing self-awareness and leading to improved decision-making.
Researchers have shown that PEPITEM supplementation can prevent or delay inflammatory arthritis by regulating the immune system. The study found that PEPITEM reduced arthritic joint swelling and inflammatory changes comparable to current standard care.