A study published by the Endocrine Society found that testosterone therapy was often prescribed without adequate diagnostic testing, highlighting opportunities for quality-improvement efforts. The research suggests that targeted interventions may be needed to improve guideline-concordant prescribing practices and prevent avoidable risks.
A study found that testosterone alone is not enough to prevent type 2 diabetes in older men; lifestyle interventions are crucial for improving blood sugar control and reducing obesity. Testosterone treatment can improve body composition and sexual desire, but its benefits diminish over time.
Researchers found that eliminating sugar from a low-fat diet can lead to impaired glucose control, insulin resistance, and gut microbial imbalance. Balanced dietary carbohydrates are essential for supporting gut and immune homeostasis.
A recent study of 42,000 adults taking blood pressure medications and GLP-1s found higher rates of hypotension events, including dizziness and fainting. The study highlights a potential safety concern for patients aged 65 and older and those with diabetes.
A new AI model analyzed 30 years of EHR data to identify patients with primary aldosteronism, a common cause of high blood pressure. The model correctly flagged over 90% of cases while missing fewer than 10%, suggesting it could improve screening for this condition.
A comprehensive analysis of solid-organ transplant recipients found that both existing and new-onset diabetes significantly increase mortality risk. Organ transplant recipients who developed or have diabetes after surgery had a higher risk of death compared to those without diabetes, with kidney recipients having the highest risk.
A study found that adults taking GLP-1 receptor agonist medications experienced significant decreases in daily step counts and moderate-to-vigorous physical activity, highlighting the need for targeted interventions to promote exercise alongside obesity treatment.
Children who start puberty earlier than usual may not need the same level of testing or treatment, according to a new Endocrine Society Clinical Practice Guideline. The guideline suggests different approaches for various subgroups, including monitoring girls with slow progression and using simpler testing methods.
A new DNA test offers a much more complete picture of DNA than current standard diagnostics, leading to a diagnosis more often. The test can replace fifteen other tests, making it faster and more efficient for rare genetic disorders.
A large-scale Phase 3 trial of CRISPR therapy has shown an 87% reduction in attacks for patients with hereditary angioedema. The treatment also improved quality-of-life scores and reduced the need for on-demand medication, paving the way for future genetic therapies.
Leading child psychologist Dr. Barish argues that grandparents have a crucial role to play in helping children develop a sense of purpose beyond personal success and in providing emotional support. He recommends practices like volunteering together and frequent family conversations about kindness and understanding.
Researchers create PhishLumos AI system to detect phishing campaigns by analyzing infrastructure clues, achieving 8-day faster detection than experts. The system uncovered over 190,000 new links, with 92% later flagged as malicious, outperforming content-centric approaches.
A new non-invasive prenatal testing technique, called non-invasive foetal sequencing (NIFS), detects a high proportion of genetic variants associated with clinically important conditions. NIFS is estimated to be cheaper and safer than current invasive methods, while providing earlier access to genetic information.
Researchers at UCSF built a robotic system to treat thousands of mini tumors, identifying shared features among persister cells that could help explain why cancer comes back. Nine drugs consistently weakened persister cells, suggesting common vulnerabilities.
The FDA has approved pembrolizumab and belzutifan as an adjuvant treatment for adult patients with renal cell carcinoma at intermediate-high or high risk of recurrence following nephrectomy. The combination resulted in a 28% decrease in risk of recurrence, metastasis or death, and 81% of participants remained cancer-free after 24 months.
A new study uses deep learning to predict how fast biochar materials break down antibiotic contaminants, offering a faster path toward cleaner water and smarter environmental remediation. The model reveals key mechanistic insights, including catalyst properties contributing 59.3% of the predictive power.
A new study reveals that thiol-modified biochar can maintain long-term mercury immobilization in contaminated soils even when subjected to repeated drying and rewetting. The research found that TMB strongly reduced mercury mobility, lowered bioavailable mercury, and redistributed mercury into less available forms.
Malcom Brenner, a renowned physician-scientist, will lead the new center. He brings expertise in cell and gene therapy to advance therapies for various diseases.
A new study published in Biochar reports a promising approach to address food safety and climate challenges at the same time. A titanium dioxide-loaded biochar material reduces arsenic mobilization and methane emissions in flooded paddy soil, offering a two-in-one strategy for safer rice and lower greenhouse gas emissions.
A new study by UC San Francisco found that women with HIV are more likely to die from preventable trauma-related conditions like substance use and mental illness. The researchers say these causes are largely missing from official death records, highlighting the need for broader goals in HIV care beyond just controlling the virus.
This special issue highlights advances in multidisciplinary approaches, emerging technologies, and best practices that support accurate identification of human remains. The publication features 22 scientific contributions from experts worldwide, addressing challenges such as the future evolution of forensic sciences.
Researchers at Washington University in St. Louis discovered that the mesencephalic command-associated nucleus (MCA) acts as a central timing hub, coordinating changes to sensory inputs across species. This finding highlights the importance of studying unusual sensory abilities in animals like weakly electric fish.
By identifying three distinct developmental stages of photoreceptor cells, researchers aim to determine which cell population is most capable of forming neuronal connections in the eye. This may lead to improved treatment outcomes for late-stage blinding conditions through cell-based therapies.
Researchers identified distinct brain activity patterns in people with depression, which may contribute to the experience of feeling stuck. The study suggests depression involves a form of brain-state entrapment, where the brain becomes more likely to enter certain patterns of activity and less likely to transition out of them.
Researchers at Princeton University used AI to analyze how drugs affect cell structures, finding new shapes linked to disease and discovering a novel drug effect. The neural network identified cap, necklace, and flower shapes, with the latter indicating a previously unknown role of an enzyme in maintaining nucleolar organization.
A deadly hantavirus cluster on a cruise ship has sparked global alarm, but new research highlights the overlooked risk of agricultural and wildlife farming environments. The study calls for a One Health approach to protect agricultural workers worldwide from this preventable occupational risk.
A molecular geneticist at Montana State University has discovered a previously unknown system in mammalian cells that can produce cysteine without the primary disulfide reductase system. This backup system may help humans survive by protecting cells from toxins, and could also make cancer cells more susceptible to therapies.
Researchers at UC Riverside link immune signaling to disrupted brain function and cognition after concussion, finding a crucial link between TLR4 and MMP-9. Blocking these pathways may limit changes in brain circuits and improve long-term neurological outcomes.
Research on targeted radioactive gold nanoparticles shows promise against aggressive brain tumors. Ultra-high-resolution PET scanners provide detailed views of mouse brains. New imaging tracers target key drivers of prostate cancer growth.
Researchers found a strong association between gut microbiome composition and bone health in patients with primary hyperparathyroidism. Bifidobacterium longum was identified as a key microbial driver of bone loss through immune-mediated mechanisms.
The University of Oklahoma is establishing the Oklahoma Center of ImmunoEngineering with an $11.5 million NIH award. The center will integrate wet lab science and data science to accelerate disease research. Four early-career faculty members are selected as research project leaders, and the center offers training workshops, seminars an...
Researchers found that people are less likely to notice negative spoken words than neutral ones when focused on a visual task. The study suggests the brain's unconscious mind filters out harmful information to prevent distractions and mental fatigue.
Researchers at Shanghai Jiao Tong University developed a novel solid-state 3D printing process that produces ultra-tough aluminum components. The screw extrusion-plasticizing friction stir deposition (SEFSD) method bypasses the melting phase, resulting in homogeneous structures with exceptional strength and ductility.
A new study found that even as oak trees continue to photosynthesize late into the year, their growth stops by mid-summer. This decoupling between photosynthesis and growth suggests that increased carbon uptake may not translate to greater wood production, reducing long-term carbon storage in forests.
Engineers at University of Texas at Austin developed a jacket that collects moisture and funnels it to detachable harvesting units, producing 400-900ml of drinkable water per day. The fabric shows a three- to 10-fold improvement at scale, making it a significant advancement in atmospheric water harvesting.
Researchers found that pramipexole, a Parkinson's disease medication, improved symptoms of anhedonia in patients with treatment-resistant depression. The therapy was associated with positive effects on the brain's reward system and increased physical activity.
A new study reveals that mountainous landscapes can store significantly more carbon in the soil than previously believed. Researchers found that soils in landslides can be up to 5 meters deep and contain twice as much carbon as predicted by previous global models.
A comprehensive study has identified 100 species with documented migratory behaviour in dragonflies, while another 85 are likely to migrate. Dragonfly migrations reveal an unseen world above our heads, with insects undertaking journeys that can rival those of birds, and provide insights into ecosystem changes and climate shifts.
A new study found that replacing beef with salmon once a week can save up to 28% of carbon emissions, equivalent to a return flight to Marrakech. The researchers suggest simple diet changes could contribute to national targets of reduced carbon emissions.
A $4 million NIH grant will help UC Davis researchers develop and test bioengineered grafts infused with ligands to treat neurogenic bladders in children. The grafts, designed to grow their own blood supply, have the potential to reduce complications after standard bladder augmentation surgery.
Elsevier has launched its Ebola Information Center, providing free access to critical clinical and research information to support the global response to the outbreak. The center combines evidence-based clinical guidance, peer-reviewed research, and AI-assisted tools to aid in rapid evidence discovery and response coordination.
NYU Abu Dhabi and Cleveland Clinic Abu Dhabi researchers have developed an injectable device that can control nerve activity without surgery or wires. The device delivers controlled electrical signals that influence how nerves behave, allowing for precise control and minimal invasiveness. This new technology complements existing treatm...
Researchers propose a new framework to model critical infrastructure resilience, focusing on AI-integrated infrastructures. The study identifies key performance indicators (R-KPIs) and provides a ten-step operational framework for analysts to assess resilience.
Researchers from Sun Yat-sen University discover a novel mechanism by which tsRNA-Gly promotes hepatocyte regeneration in ACLF. The study reveals that tsRNA-Gly activates GRHL1 and upregulates CCND1, driving liver regeneration.
A new anti-inflammatory molecule has shown promising results in protecting neurons and delaying disease progression in mice with Parkinson's disease. The study, published in Neuropharmacology, found that the Ac2-26 peptide mitigated neuroinflammation and protected against cell death.
Researchers developed a new approach using NASA's PACE satellite data to observe fall colors, producing detailed leaf color maps and tracking changes. The study improves traditional greenness indices by identifying precise markers of the end of the growing season.
A new study found that horse owners' psychological characteristics, including attachment styles and personality traits, shape how frequently they ride, train, and spend quality time with their horses. Owners who spent more time with their horses tended to be more emotionally connected, while those with higher avoidant attachment styles...
A large meta-analysis has consistently shown that social inequality, such as poverty and racism, accelerates biological aging measured by epigenetic clocks. Newer biological aging measures are most sensitive to social conditions, with second- and third-generation clocks showing stronger associations with socioeconomic conditions.
An international team published a white paper on embryonic models based on stem cells, proposing guidelines for research and regulation. These models can mimic early human development stages, potentially aiding in understanding infertility conditions.
A novel operator learning framework tackles the ill-posedness in inverse thermal problems by employing two synergistic deep learning components. The framework accurately estimates spatial material properties and filters high-frequency noise to project the final-state thermal field back to its initial distribution.
The study focuses on the Lamm-Riviere system, a fourth-order geometric elliptic system including both extrinsic and intrinsic biharmonic maps into manifolds. Researchers investigated the inhomogeneous Lamm-Rivireè system and proved the angular energy identity for this system.
Researchers have developed a new theory that enables the description and simulation of non-reciprocal interactions, which are essential for studying complex systems like flocks and swarms. By introducing auxiliary degrees of freedom, physicists can now accurately model these systems using established methods.
The ASCEND project aims to develop next-generation catalysts using AI, simulations, and nanotechnology. The five-year initiative accelerates scientific experimentation and enables more sustainable chemical processes.
The book 'Human Identities in the Archaeological Record' reconstructs past identities from evidence like skeletons, belongings, and material culture. Researchers investigate how people ate, grew up, and were affected by disease and inequality.
The Journal of Research on Research aims to support evidence-informed change in research systems through a unique dual role as both a publisher and researcher. It will occupy a dual role: publish and conduct research on research, providing access to data on publishing processes across its portfolio.
A University of Birmingham scientist creates a 'mini universe' with ultracold atoms to test ideas in quantum cosmology and gravity. The experiment demonstrates that time can emerge from changes within a quantum system, revealing a version of time known as 'entropic time', which flows consistently and orders events.
Researchers reconstructed millipede evolution history, tracing origins to nearly 460 million years ago. They also discovered that one group of millipedes may have developed chemical defenses 260 million years ago.
Research finds that advanced maternal age reduces autophagy in embryos from aged female mice, leading to impaired embryonic development. Supplementation with Rapamycin improves early embryonic development by regulating metabolic pathways.
A new model developed by KAIST reveals that a shortage of agricultural workforce can limit farmland utilization in most regions, posing a significant risk to future food security. The study's findings suggest that sustainable development models and migration policies are crucial to addressing this issue.
Researchers at the University of Zurich have identified 10 biomarkers in saliva that can detect acute sleep deprivation. The study uses machine-learning methods to analyze metabolic changes in saliva, providing a new milestone for forensic research.