Researchers at La Jolla Institute for Immunology have found that T cells can recognize shared viral targets between multiple coronaviruses, including common cold coronaviruses and SARS-CoV-2. This cross-reactivity could be harnessed to develop vaccines that protect against multiple types of coronaviruses, including SARS-CoV-2.
SourceLa Jolla Institute for Immunology·JournalCell Reports Medicine·TypeExperimental study·DateJun 1, 2023
Researchers found variability in IgA levels between blood and gut samples, suggesting IgA regulates commensal microbes to prevent immune dysregulation. Patients with normal fecal IgA were less likely to develop symptoms, while those deficient in both blood and fecal IgA showed elevated inflammatory cytokines.
SourceChildren's Hospital of Philadelphia·JournalScience Immunology·DateMay 26, 2023
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Scientists at La Jolla Institute for Immunology found that MAIT cells can be tuned to fight different pathogens via their metabolism, with two distinct subtypes responding to sugar and fat. This discovery may inspire new vaccines and cell therapies to boost the immune response against specific pathogens.
SourceLa Jolla Institute for Immunology·JournalNature Cell Biology·TypeExperimental study·DateMay 25, 2023
A recent study published in the Journal of Clinical Immunology suggests that cutaquig infusions at higher infusion rates and volumes are well-tolerated and effective, with reduced infusion time, fewer injection sites, and improved compliance. The study results will be presented at the Clinical Immunology Society 2023 Annual Meeting.
SourceYankee Public Relations·JournalJournal of Clinical Immunology·TypeObservational study·DateMay 18, 2023
Review Commons is expanding its scope and scale with added funding, welcoming Biochemical Journal, Genes & Development, Genome Biology, and Immunology & Cell Biology as new affiliate journals. The platform now supports a diverse range of publishers and enables authors to reuse peer reviews for multiple journal submissions.
A study published in Cell Reports Medicine found that pro-inflammatory cell types dominate the intestinal mucosa of children with inflammatory bowel disease, while protective cells are underrepresented. The results provide new insights into the immunology of IBD and may lead to the development of more effective treatments.
SourceKarolinska Institutet·JournalCell Reports Medicine·DateMay 9, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A recent study led by Children's Hospital of Philadelphia identifies two different regulatory T cell populations, one related to autoimmunity and the other to protective immunity. The findings could pave the way for new treatments that target the immune system selectively.
SourceChildren's Hospital of Philadelphia·JournalScience Immunology·DateApr 7, 2023
Researchers found that probiotic bacteria Lactobacillus reuteri stimulates cancer-killing T cells by secreting indole-3-aldehyde, which activates a receptor in CD8 cells. A diet rich in tryptophan enhances the effect of immunotherapy on shrinking tumors and prolonging survival.
SourceUniversity of Pittsburgh·JournalCell·TypeExperimental study·DateApr 6, 2023
A survey of allergists and immunologists reveals that diagnosing and treating hereditary angioedema can be challenging, particularly for patients in rural areas. Patients living in rural areas are more likely to face barriers to care, including longer travel times to reach medical facilities.
SourceAmerican College of Allergy, Asthma, and Immunology·JournalAnnals of Allergy Asthma & Immunology·TypeSurvey·DateApr 5, 2023
A study published in Nature Immunology found that antibodies from previously infected patients can neutralize variants of the COVID-19 disease, including the Omicron variant. These broadly neutralizing antibodies have unique biochemical and structural features that enable them to block the virus from entering human cells.
SourceNational University of Singapore, Yong Loo Lin School of Medicine·JournalNature Immunology·TypeRandomized controlled/clinical trial·DateMar 21, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at Duke University Medical Center identified the nervous system as a key player in anaphylaxis reactions, which cause sudden drops in body temperature and blood pressure. The study suggests new targets for therapies to prevent or treat severe allergic shock.
SourceDuke University Medical Center·JournalScience Immunology·DateMar 17, 2023
A study published in Nature Immunology found that female mouse and human NK cells have more of a specific epigenetic regulator called UTX, which boosts anti-viral function while repressing NK cell numbers. This suggests that therapies need to be tailored to individual differences, including sex.
SourceUniversity of California - Los Angeles Health Sciences·JournalNature Immunology·TypeExperimental study·DateMar 16, 2023
Dr. Tak W. Mak is being recognized for his groundbreaking work on cancer immunology, including the cloning of the human T-cell receptor beta chain and development of CAR T-cell technology. His research has led to significant advances in understanding immune responses and has paved the way for the development of new cancer therapies.
SourceAmerican Association for Cancer Research·DateMar 15, 2023
A study by researchers from the University of Liège shows that group 2 innate lymphoid cells educate alveolar macrophages, reprogramming them to protect against respiratory allergens. This discovery highlights the central role of ILC2s in shaping the alveolar niche and modulating immune responses.
SourceUniversity of Liège·JournalScience Immunology·DateFeb 24, 2023
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
The new grant enables LJI to lead the Human Immunology Project Consortium Data Coordinating Center, providing access to human immunoprofiling data from over 11,000 participants. This will fuel scientific collaboration in understanding immune responses to viruses, autoimmune diseases, and more.
Two studies published in Science Immunology reveal that TE-exon splicing junctions can differentiate tumors from healthy tissue, offering a potential solution to the field of immuno-oncology. The research identifies novel recurrent, cancer-specific targets and validates Mnemo's antigen discovery platform.
SourceInstitut Curie·JournalScience Immunology·DateFeb 3, 2023
A team of scientists led by Thomas Blankenstein presents a mechanism that prevents the immune response from overshooting its mark. The KRKR motif, a short sequence of four amino acids, is crucial in binding to connective tissue and preventing interferon-gamma from spreading throughout the body.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalNature Immunology·TypeExperimental study·DateFeb 3, 2023
Researchers at Saint Louis University found that COVID-19 vaccination does not interfere with cancer immunotherapy in previously vaccinated patients. The study supports recommending vaccination to patients with cancer, including those receiving systemic therapies.
SourceSaint Louis University·JournalFrontiers in Immunology·DateJan 31, 2023
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers at La Jolla Institute for Immunology have discovered the detailed mechanism of action of Inmazeb, a three-antibody cocktail designed to combat Ebola virus infection. The study reveals new information about how the drug interacts with the virus and its potential effectiveness against additional species of Ebolavirus.
SourceLa Jolla Institute for Immunology·JournalCell Host & Microbe·TypeExperimental study·DateJan 30, 2023
A team of leading experts in reproductive biology, microbiome science, and immunology found that the concept of a foetal microbiome is inaccurate. The detection of microbiomes in foetal tissues was attributed to contamination during vaginal delivery, clinical procedures, or laboratory analysis.
SourceUniversity College Cork·JournalNature·TypeData/statistical analysis·DateJan 25, 2023
A study published in Science Immunology has discovered a potential new approach for treating systemic lupus erythematosus (SLE) by targeting iron metabolism in immune system cells. Blocking the iron uptake receptor reduced disease pathology and promoted anti-inflammatory regulatory T cell activity in a mouse model of SLE.
SourceVanderbilt University Medical Center·JournalScience Immunology·TypeExperimental study·DateJan 13, 2023
Researchers at La Jolla Institute for Immunology have discovered that OGT regulates mTOR, a key protein for mitochondrial powerhouses, keeping cells healthy. The study may lead to important medical advances in understanding cancers, diabetes, and cardiovascular disease.
SourceLa Jolla Institute for Immunology·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJan 12, 2023
Racial disparities in atopic dermatitis and food allergy affect people of color, with challenges including comfort level with healthcare providers and access to safe foods. Experts recommend 10 solutions to address these disparities, such as increasing diversity in clinical trials and providing culturally appropriate materials.
SourceAmerican College of Allergy, Asthma, and Immunology·JournalAnnals of Allergy Asthma & Immunology·TypeNews article·DateJan 11, 2023
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Two new yardsticks have been published by the American College of Allergy, Asthma and Immunology to guide practitioners on treating eosinophilic esophagitis and managing cough in adults and adolescents. The yardsticks provide practical, evidence-based recommendations for clinical decision-making.
SourceAmerican College of Allergy, Asthma, and Immunology·JournalAnnals of Allergy Asthma & Immunology·DateDec 20, 2022
Researchers at La Jolla Institute for Immunology have confirmed that the smallpox vaccine MVA-BN (JYNNEOS) can teach T cells to recognize and fight the mpox virus. The study suggests that the JYNNEOS vaccine may provide protection against severe disease and could be effective in immunocompromised individuals.
SourceLa Jolla Institute for Immunology·JournalCell Host & Microbe·TypeExperimental study·DateDec 12, 2022
Researchers at La Jolla Institute for Immunology have found that the inflammatory molecule LIGHT leads to airway remodeling and long-term breathing issues in severe asthma. Therapeutics targeting LIGHT could reverse airway and lung damage, offering a potential long-term treatment for asthma.
SourceLa Jolla Institute for Immunology·JournalJournal of Allergy and Clinical Immunology·TypeExperimental study·DateDec 9, 2022
Research found that while broad T-cell response against SARS-CoV-2 spike protein is currently protective, recognition of seven out of ten T-cell targets mutated in COVID-19 variants is impaired. The study suggests ongoing mutation could lead to decreased overall immune system protection.
SourceUniversity of Birmingham·JournalNature Immunology·TypeObservational study·DateDec 1, 2022
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
A study by the American College of Allergy, Asthma, and Immunology found that pollen levels are lowest during early morning hours, with lower counts occurring between 4:00 a.m. and noon. This information can help individuals with pollen allergies plan their outdoor activities accordingly.
SourceAmerican College of Allergy, Asthma, and Immunology·JournalAnnals of Allergy Asthma & Immunology·TypeData/statistical analysis·DateNov 10, 2022
A new study presented at the American College of Allergy, Asthma, and Immunology Annual Scientific Meeting found that most infants with anaphylaxis were treated appropriately with a single dose of epinephrine. The study reviewed charts for 169 patients under 2 years old who presented with anaphylaxis symptoms in various systems.
SourceAmerican College of Allergy, Asthma, and Immunology·JournalAnnals of Allergy Asthma & Immunology·DateNov 10, 2022
Eczema affects 10-20% of Canadian infants, making it a common condition to manage. Optimally managing atopic dermatitis in infants is crucial, as it impacts the whole family.
SourceCanadian Medical Association Journal·JournalCanadian Medical Association Journal·DateNov 7, 2022
A type of dietary fiber called inulin alters gut bacteria metabolism, triggering type 2 inflammation in the gut and lungs. Inulin boosts Treg cells but also induces higher levels of eosinophils, a classic sign of type 2 inflammation.
SourceWeill Cornell Medicine·JournalNature·DateNov 2, 2022
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers at La Jolla Institute for Immunology discovered a direct link between TET protein loss of function and missing genes in embryonic stem cells, which can lead to cancer growth. The study found that TET proteins are crucial for maintaining genome stability, and their loss results in aneuploidies, a common feature of cancer cells.
SourceLa Jolla Institute for Immunology·JournalNature Communications·TypeExperimental study·DateOct 27, 2022
Researchers at La Jolla Institute for Immunology have developed a new therapy for Lassa fever using a trio of rare human antibodies that can block viral infection. The therapy, called Arevirumab-3, was tested in non-human primates and proved 100% effective in treating the disease.
SourceLa Jolla Institute for Immunology·JournalScience Translational Medicine·TypeExperimental study·DateOct 26, 2022
Researchers used big datasets to show that annual health care costs were significantly higher among children without allergist care for peanut allergy compared to those who received care. Care from an allergist resulted in lower total health care costs, saving $1,923 per child.
SourceUniversity of Colorado Anschutz Medical Campus·JournalJournal of Allergy and Clinical Immunology·TypeData/statistical analysis·DateOct 24, 2022
A new study published in Annals of Allergy, Asthma and Immunology found that targeted cognitive behavioral therapy (CBT) significantly lessens food allergy-related anxiety for both children and parents. The treatment included proximity exposure sessions with the patient, resulting in improved symptoms and quality of life.
SourceAmerican College of Allergy, Asthma, and Immunology·JournalAnnals of Allergy Asthma & Immunology·TypeExperimental study·DateOct 4, 2022
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers at La Jolla Institute for Immunology have discovered a rare T cell defect tied to the risk of developing MAC disease. People with this defect have fewer specialized Th1* cells, which robs them of an effective immune response to MAC bacteria.
SourceLa Jolla Institute for Immunology·JournalFrontiers in Immunology·TypeExperimental study·DateOct 3, 2022
A diet rich in guar gum fibre has been shown to limit inflammation and delay the onset of multiple sclerosis (MS) symptoms in mice. The study found that only guar gum significantly reduced MS-like symptoms, suggesting its potential as a therapeutic approach for humans.
SourceUniversity of British Columbia·JournalCell Reports·TypeExperimental study·DateSep 27, 2022
A new guideline published in Clinical & Experimental Allergy aims to improve the testing process for penicillin allergies among patients. The guidelines provide recommendations on patient selection, risk stratification, and drug provocation testing, aiming to reduce errors and ensure accurate diagnosis.
SourceWiley·JournalClinical & Experimental Allergy·DateSep 21, 2022
The Hackensack Meridian Center for Discovery and Innovation's CDI laboratory has identified critical regulators controlling T-cell homeostasis. The findings could lead to improved cancer therapies and vaccines of the future by modulating the human immune system.
SourceHackensack Meridian Health·JournalNature Immunology·TypeExperimental study·DateAug 11, 2022
A new study published in Annals of Allergy, Asthma and Immunology found that 36% of YouTube videos on hay fever contained misleading information, leading to increased user interaction. Medical associations were the most reliable source of information, with only 32% of TV show/YouTube channel videos classified as useful.
SourceAmerican College of Allergy, Asthma, and Immunology·JournalAnnals of Allergy Asthma & Immunology·TypeContent analysis·DateAug 10, 2022
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Scientists at La Jolla Institute for Immunology discover how gut barrier cells send secret messages to patrolling T cells, keeping them alive and active. The study sheds light on conditions like inflammatory bowel disease and highlights the importance of HVEM protein in maintaining a healthy gut microbiome.
SourceLa Jolla Institute for Immunology·JournalScience Immunology·TypeExperimental study·DateJul 29, 2022
A new study found that COVID-19 serologically-positive donors had strong antigen-specific memory B cell-associated responses after recovery from natural infection. Post-vaccination, donors showed robust antibody responses against spike protein, which waned over time. The study suggests how long immunity to COVID-19 may last.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalViral Immunology·TypeCase study·DateJul 21, 2022
Researchers developed a new blood test that can indicate cellular immunity to SARS-CoV-2 within 48 hours. The test distinguishes between post-infection and post-vaccination immunity, enabling quick diagnosis for patients unable to produce antibodies. Long-lasting T-cell responses may protect against severe disease in re-infections.
SourceMedical University of Vienna·JournalAllergy·DateJul 20, 2022
Researchers at La Jolla Institute for Immunology have identified a critical protein, GSPT1, that facilitates Lassa virus infection. Targeting this protein with an existing drug candidate, CC-90009, shows promise in reducing Lassa virus growth without cell toxicity.
SourceLa Jolla Institute for Immunology·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJul 19, 2022
Researchers at Gladstone Institutes and Stanford University identified key genes linked to T cell exhaustion. They discovered how to block these genes, resulting in healthier T cells and smaller tumors in mice with cancer. This breakthrough may lead to improved immune-based treatments for cancer patients.
SourceGladstone Institutes·JournalCancer Cell·DateJun 28, 2022
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Scientists locate highly effective memory B cells in the lungs, which can boost the efficacy of vaccines used to protect against viral respiratory diseases. The discovery suggests a promising avenue for increasing vaccine effectiveness.
SourceINSERM (Institut national de la santé et de la recherche médicale)·JournalImmunity·DateJun 28, 2022
A new study published in the Journal of Allergy and Clinical Immunology: In Practice found that infants under 12 months who undergo oral immunotherapy have a better safety profile compared to older preschoolers. The treatment, which involves gradually increasing exposure to peanut flour, is highly effective and safe for this age group.
SourceUniversity of British Columbia·JournalJournal of Allergy and Clinical Immunology: In Practice·TypeObservational study·DateJun 16, 2022
A Monash University study found that microbial fermentation of dietary fibre in the gut protects against allergic skin disease. The researchers used mice with a diet high in fermentable fibre or purified SCFAs, showing that butyrate enhances the metabolism of keratinocytes and fortifies the skin barrier.
SourceMonash University·JournalMucosal Immunology·TypeExperimental study·DateJun 7, 2022
Researchers develop targeted delivery system to boost regulatory T cells, which manage inflammation and reduce brain damage. The treatment increases IL2 levels, allowing regulatory T cells to survive and reducing cognitive impairment.
SourceBabraham Institute·JournalNature Immunology·TypeExperimental study·DateMay 26, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A recent study published in Annals of Allergy, Asthma and Immunology found that longer durations of exclusive breastfeeding are associated with lower odds of current asthma. The study analyzed over 2,000 mother-child pairs and discovered a 'dose-response' effect depending on how long the mother breastfed.
SourceAmerican College of Allergy, Asthma, and Immunology·JournalAnnals of Allergy Asthma & Immunology·TypeSurvey·DateMay 25, 2022
Researchers identified a blood biomarker that predicts severe Crohn's disease and is detectable up to seven years prior to diagnosis. The biomarker neutralizes protective effects of a cytokine, leading to intestinal damage and weakening the immune system.
SourceUniversity of Toronto·JournalGastroenterology·TypeExperimental study·DateMay 24, 2022
Researchers found that ZBP1, a gene involved in innate immunity, contributes to negative effects of interferon treatment and high interferon levels in some COVID-19 patients. Deleting the gene Zbp1 in mice infected with coronavirus prevented cell death and mortality during interferon therapy.
SourceSt. Jude Children's Research Hospital·JournalScience Immunology·TypeExperimental study·DateMay 20, 2022
Researchers at St. Jude Children's Research Hospital have discovered a DNA-independent mechanism that allows CD8+ T cells to produce both effector and memory cells, enabling the immune system to mount an immediate and long-term response to infections. The study reveals how a specific protein complex guides translation of an important i...
SourceSt. Jude Children's Research Hospital·JournalMolecular Cell·TypeExperimental study·DateMay 20, 2022
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Studies found people infected and vaccinated had similarly robust antibody responses against variants alpha through omicron; Immune memory cells against common cold coronaviruses may be markers of longer immunity. Researchers hope to improve vaccines with these insights.
SourceBrigham and Women's Hospital·JournalScience Immunology·TypeExperimental study·DateMay 19, 2022
A new study published by the American College of Allergy, Asthma, and Immunology shows that COVID-19 has increased anxiety and asthma symptoms among adults with asthma, while reducing food allergy-specific anxiety for parents of children with food allergies.
SourceAmerican College of Allergy, Asthma, and Immunology·JournalAnnals of Allergy Asthma & Immunology·TypeSurvey·DateMay 5, 2022
Scientists discovered that intermittent dosing of PI3Kδ inhibitors can reduce toxicity while maintaining anti-tumor immunity in patients with head and neck cancers. This finding holds promise for improving treatment outcomes and saving lives.
SourceLa Jolla Institute for Immunology·JournalNature·TypeExperimental study·DateMay 4, 2022
Researchers have identified a genetic cause of lupus, a chronic autoimmune disease that affects 50,000 people in the UK. The TLR7 gene mutation causes inflammation in organs and joints, leading to debilitating symptoms. This discovery paves the way for new treatments targeting the mutated gene.
SourceThe Francis Crick Institute·JournalNature·TypeExperimental study·DateApr 27, 2022
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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers at Gladstone Institutes and UC San Francisco have developed a comprehensive rule book for designing therapeutic cells with improved specificity and safety. The new receptor system, dubbed SNIPRs, is small enough for cost-effective engineering into human cells and can detect and respond to even small amounts of its target. T...
A new study reveals that a specific bacterium breaks down xanthan gum in the human gut, leading to the production of short-chain fatty acids. The widespread consumption of xanthan gum may alter the gut microbiome, potentially affecting intestinal health and total caloric intake.
SourceMichigan Medicine - University of Michigan·JournalNature Microbiology·DateApr 14, 2022
Researchers from Trinity College Dublin have discovered how SARS and MERS coronaviruses block the induction of antiviral proteins, preventing a strong immune response. This finding has potential implications for developing new therapeutic options to treat COVID-19 and future deadly coronaviruses.
SourceTrinity College Dublin·JournalViruses·DateApr 12, 2022