Researchers found that protein AKAP8 inhibits breast cancer metastasis by interfering with proteins that promote metastatic behavior. AKAP8 also predicts metastatic breast cancer outcomes in patients and can inhibit progression in animal models.
Researchers are exploring seawater-based Na-ion batteries as a potential alternative to lithium ion batteries. A new study investigated electrode materials that increase voltage, capacity, and wattage. The development of these batteries could alleviate concerns around cobalt mining and reduce costs.
A study published in Academic Emergency Medicine found that prolonged telemetry (over 12 hours) is a safe alternative to hospitalization for non-low-risk patients with syncope. The sensitivity of ECG monitoring is high, supporting the use of minimum 12-hour monitoring as a diagnostic tool.
Researchers from University of York develop new model to calculate impact of changes to Luftwaffe tactics on the battle's outcome. The study suggests that altering the timing and targeting of airfields could have shifted the battle significantly in Germany's favor.
The MIT-developed model uses anonymized credit card transactions and quarterly reports to predict company earnings, outperforming human analysts on 57% of predictions. The researchers' method tackles the 'small data' problem by combining noisy signals with traditional financial data.
A phase 2 clinical trial has demonstrated an effective alternative to mastectomy for breast cancer patients experiencing recurrence after initial lumpectomy and whole-breast radiation. The treatment involved a second lumpectomy followed by partial breast reirradiation, resulting in long-term cancer control and low toxic side effects.
Professor Dan Adelman proposes an alternative methodology to scoring U.S. hospitals, addressing limitations in the CMS' Hospital Compare ratings. His efficient frontier approach rewards good performance and penalizes poor performance, leading to more equitable comparisons.
Shanjiang Zhu and team to evaluate three alternative modeling approaches for demand responses to tolled and priced lanes, producing detailed technical reports on methods and findings. The study aims to inform FHWA's state-of-art modeling strategies, informing their applicability in different applications.
A review of complementary and alternative therapies for treating infantile colic found some treatments like probiotics, fennel extract, and spinal manipulation to be effective but with limitations due to small sample sizes and subjective measurement methods.
Researchers discussed recent clinical study results comparing fibrinogen concentrate and cryoprecipitate in cardiac surgery, highlighting fibryga as a potential alternative for managing perioperative bleeding. The studies provide important data on fibryga's efficacy and safety in treating acquired fibrinogen deficiency.
Researchers at the University of Texas at Austin have discovered a new material, 2D antimony, which holds promise for manufacturing even smaller computer chips. The material has high charge mobility, making it a suitable alternative to silicon, and its properties could lead to the discovery of even better materials.
A new study by University of Illinois expert J. Ryan Lamare examines how firms use alternative dispute resolution practices to resolve workplace issues. The researchers found that firms with different strategic orientations, such as efficiency and satisfaction, are more likely to use mediation or arbitration.
Scientists at the University of Göttingen have identified an alternative erythropoietin receptor, CRLF3, which triggers protective effects in humans without stimulating red blood cell production. This discovery offers new hope for treating neurodegenerative diseases such as Alzheimer's and Parkinson's.
Researchers discovered an alternative pathway for testosterone production that contributes to the development of male characteristics in human girls with a genetic disorder. The study found this pathway is present and active during fetal development and plays a key role in shaping external genitalia in newborns with CAH.
The UMD CONSERVE Center develops safe, alternative irrigation strategies to sustain food production in a changing climate. Non-traditional water sources like reclaimed water, brackish water, and return flows hold promise, but require additional treatments to reduce microbial and chemical contaminants.
A study published in Mucosal Immunology reveals that ASC and NLRP3 are key players in maintaining innate immune homeostasis in the airway, independent of caspase-1. This alternative mechanism may provide a new understanding of different possible mechanisms involved in airway protection against microbial infections.
Researchers at The Institute of Cancer Research have discovered the three-dimensional structure and function of the 'mix n match' protein DHX8, which helps control a process linked to cancer progression and drug resistance. This study opens up a potentially exciting new way to tackle drug-resistant cancers.
A handheld smartphone-enabled 1-lead ECG showed excellent diagnostic accuracy for detecting atrial fibrillation and flutter. The device's integrated algorithm correctly identified 87% of atrial fibrillation cases and 98% of non-atrial fibrillation cases.
Researchers discovered a potential new treatment for preventing sepsis in burn patients by using the secretions of probiotic bacteria Lactobacillus gasseri to combat antibiotic-resistant Pseudomonas aeruginosa. The study found that applying these secretions to the wound inhibited bacterial growth and prevented biofilm development.
A study reveals that alternative splicing controls the identity and function of nerve cells, allowing for a complex neuronal network with limited genes. The research team mapped splice variants in different types of neurons, identifying unique repertoires that shape their characteristics.
Researchers found strong evidence that cannabis alleviates pain, with users experiencing a significant drop in pain suffering after consumption. The study highlights the potential of cannabis as a safe and effective alternative to opioids for treating chronic pain.
Connected areas of high-quality forest running through oil palm plantations may help support increased levels of biodiversity and protect species like orangutans. The researchers recommend improving the quality of these set-asides to contribute to landscape connectivity.
The FDA has approved erdafitinib as a targeted therapy for patients with advanced bladder cancer who have specific gene mutations in the FGFR3 gene. The drug achieved a 40% overall response rate and was well-tolerated, offering an alternative to existing treatments.
Researchers found music to be as effective as midazolam in lowering anxiety before anesthetic procedures. The study used Marconi Union's 'Weightless' song and noise-canceling headphones to reduce anxiety levels.
A clinical trial suggests music can reduce anxiety before peripheral nerve block, with similar effects as midazolam. However, patients in the music group were less satisfied due to limited music choice, and communication was harder.
Researchers at Durham University used supercomputer simulations to test Chameleon Theory, an alternative model for gravity. The findings suggest that galaxies like the Milky Way can form even with different laws of gravity, providing a new perspective on galaxy formation and dark energy.
The introduction of new female external catheter technology at NYC Health + Hospitals/Coney Island significantly reduced CAUTIs by 51.7%, while also decreasing the number of Foley days. This innovation provides a safer alternative to indwelling catheters, reducing the risk of infection.
A survey of psoriasis patients found that they often turn to complementary and alternative therapies, such as vitamins D and B12, when traditional medications fail. Despite limited evidence supporting these treatments, patients report therapeutic benefits from Dead Sea treatments.
A recent study published in Plants revealed that electrons flowing through the reaction center chlorophyll (P700) in photosystem I undergo a charge recombination, producing chemical energy used in photosynthesis. This finding suggests an alternative pathway to suppress reactive oxygen species production and mitigate plant stress.
A world-first study uses 'good viruses' to eliminate targeted bacteria in green sea turtles without harming non-targeted 'good bacteria'. Researchers have identified the potential for phage therapy as an alternative treatment for bacterial infections in marine animals.
A new microorganism, Vibrio sp. dhg, has been successfully developed to rapidly metabolize alginic acid in algae and genetic engineering techniques optimized for this new microorganism based on omics analysis.
A recent study published in The FASEB Journal found that some cancer cells switch to alternative molecular mechanisms to evade anti-cancer therapies. Researchers identified several existing and new drugs that specifically target these 'cancer cell escape routes'.
A NIST study identified 22 chemical blends that could serve as alternative refrigerants with lower global warming potential and reduced risk of fire, compared to the current standard R-134a. The blends combine R-134a with other commercial refrigerants and offer a reduction in GWP of up to 99%.
A human enzyme named FANCM is essential for the survival of cancer cells using an alternative telomere lengthening pathway. ALT tumor cells require FANCM activity to prevent telomere instability and cell death.
A team of geoscientists has discovered alternative raw materials that can replace limestone in cement production, significantly reducing greenhouse gas emissions. The new sustainable materials can be used to produce high-quality cements with the same beneficial properties as traditional cement.
A Stanford study of California teens found that owning marketing materials for e-cigarettes and other alternative tobacco products increases their likelihood of trying these products. The study suggests that stricter regulations are needed to restrict such marketing, which can lead to nicotine addiction.
A new study published in The Lancet has identified levetiracetam as a safe and effective alternative to phenytoin for treating convulsive status epilepticus (CSE) in children. The trial, conducted by the EcLiPSE Team, involved over 300 children and found that levetiracetam may be considered as an alternative treatment to phenytoin.
Researchers identified risks associated with popular alternative treatments like kratom, Imodium, and Xanax, which can cause substantial side effects and high abuse rates. The study also found that 'stacks' or kits combining substances are being used to combat withdrawal symptoms.
Research shows low-intensity ultrasound can modulate normal brain function, affecting counterfactual thinking and alternative choice. This technique may revolutionize non-invasive treatment for mental health conditions like depression and Parkinson's.
One-third of cancer patients use complementary and alternative medicines such as meditation, yoga, acupuncture, and herbal supplements. Many patients do not disclose their use to doctors due to lack of knowledge or perceived need for disclosure.
A nationwide survey found that 33.3% of cancer patients used complementary and alternative medicines, with herbal supplements being the most common. Many participants did not disclose their CAM use due to lack of physician inquiry or perceived unnecessary information.
A new study compared traditional Illumina platforms to an alternative BGISEQ-500 short-read sequencing platform for single-cell transcriptomics. The authors found that BGISEQ-500 was highly comparable in sensitivity, accuracy, and reproducibility of detected RNA molecules.
A new study warns London cyclists of high black carbon levels on main routes during evening commutes, recommending alternative routes with green infrastructure. The research found that cyclists exposed to the dirtiest air suffered twice as much pollution as those taking a cleaner route.
Scientists at the University of Rochester's LLE have successfully turned a liquid metal into a plasma, exhibiting classical properties at high temperatures. This discovery has implications for better understanding stars and planets, as well as realizing controlled nuclear fusion, a promising alternative energy source.
Researchers have discovered a squid protein that can be processed into fibers and films for applications in health monitoring, self-healing recyclable fabrics and sustainable textiles. The protein's unique properties make it an eco-friendly alternative to plastics.
The AFLEET Tool and its online version enable fleet managers to compare the costs and benefits of alternative fuels and vehicle technologies, optimizing their purchasing decisions. With over 8,000 users, the tool is based on Argonne's GREET model and provides a comprehensive and easier way to make informed decisions.
Scientists at Nagoya Institute of Technology discovered Na2V3O7, a material with fast charging performance and long battery life, offering an alternative to lithium-ion batteries. However, further research is needed to improve the material's stability throughout the entire charging duration.
Researchers at the University of Groningen have developed an enzyme-based polymerization method to create a more environmentally friendly alternative to traditional polyethylene terephthalate (PET). By using a commercially available enzyme, they successfully produced furan-based copolyesters with improved properties.
A new EU Horizon 2020 project aims to produce therapeutic substances in baker's yeast, providing an eco-friendly alternative to traditional methods. Researchers will map the biosynthetic pathways of Indian snakeroot to create a sustainable production route.
Retailers in minority and low-income communities are more likely to sell alternative tobacco products, such as cigars and e-cigarettes, due to consumer demand. These products have been found to be more accessible in predominantly White neighborhoods with higher retailer density.
A systematic review of 15 studies found no strong evidence to support the effectiveness and safety of diverting low-need patients from emergency departments. The strategy was also not effective in reducing subsequent use of emergency care services.
New research published in the Canadian Medical Association Journal found that trazadone is associated with a comparable risk of falls and major osteoporotic fractures to atypical antipsychotics. This finding challenges the assumption that trazodone is a safer alternative for treating behavioral symptoms in seniors with dementia.
Researchers at The Wistar Institute developed novel synthetic DNA-encoded monoclonal antibodies targeting PCSK9, which significantly reduced cholesterol levels in preclinical studies. This approach may provide a less frequent and cost-effective alternative to statins for treating high cholesterol and reducing cardiovascular risk.
A study by Stanford University researchers found that surgery remains the best treatment option for appendicitis, despite being more expensive upfront. Patients treated with antibiotics alone had higher rates of hospital readmissions and abdominal abscesses, highlighting the risks of this alternative approach.
A survey found that 16% of adults in England used complementary and alternative medicine, with unequal access to these treatments. CAM use was more common among women and those in higher socioeconomic groups, particularly in the south of England.
Donnelly Centre researchers have identified a genetic network linked to autism, revealing a mechanism underlying alternative splicing events. The study reveals that microexons, small protein-coding gene segments, are disrupted in autism and could be targeted for therapeutic applications.
The ANRS NAMSAL study has compared the efficacy of dolutegravir-based treatment with efavirenz 400 mg in over 600 participants living with HIV. The results show that dolutegravir-based treatment is not inferior to efavirenz, and it is considered a valid treatment option for first-line treatment in low and middle-income countries.
A study by RAND Corporation and American Medical Association found that physician practices struggle with data skills, financial risks, and administrative burdens. The report suggests a slower pace of change and design involvement in payment methods could improve engagement and patient care outcomes.
Researchers from the University of Queensland recreated 450-million-year-old enzymes to accelerate chemical reactions, offering a cheaper alternative to current processes. The ancient enzymes showed improved performance at high temperatures, lasting about 100 times longer than natural enzymes.
A new tool, Recovery Explorer, was developed to help conservation scientists make informed decisions on how to allocate limited funds for species recovery. The tool evaluates potential consequences of alternative resource allocation strategies and allows decision makers to examine alternative approaches.